ZHENG FAN, Ph.D., M.Sc., B.S.E.

Professor
Physiology

Office: 329 TRANSLATIONAL RESEARCH BUILDING
71 SOUTH MANASSAS
MEMPHIS TN 38163
Tel: (901) 448-2872
zfan@uthsc.edu

Education

  • Ph.D., Department of Cardiovascular Diseases, Tokyo Medical and Dental University, Medical Science
  • Ph.D., Tokyo Medical and Dental University, Japan, Physiology
  • M.S., Shanghai Medical University, Biophysics
  • M.S., Shanghai Medical University, Biophysics
  • B.Engr., Shanghai University of Science and Technology, Electrical and Mechanical Engineering
  • B.Engr., Shanaghai University of Science and Technology, Electrical and Mechanical

Research description

ATP plays a pivotal role in the energy economy of the cell. Additionally, in many cell types such as islet b -cells of pancreas and muscle cells, ATP has important roles in transducing cellular signals which involve a particular type of potassium channel called ATP-sensitive potassium channel. In islet b -cells, for example, insulin release which occurs in response to hyperglycemia is mediated by a remarkable inhibition of ATP-sensitive potassium channel. My laboratory is currently working on several interrelated projects concerned with improving our understanding of the molecular basis for the biophysical activity of this channel, as well as increasing our appreciation of how energy metabolism interfaces with cellular processes through this channel under physiologic and pathophysiologic circumstances. The second focus of our research is on the regulatory roles of membrane phospholipids in modulating inwardly rectifying potassium channels including ATP-sensitive potassium channel. This research was built on our previous pioneering studies in this area. Currently we are interested in the cellular and molecular processes associated with, or dependent upon, this regulatory mechanism, and their physiologic relevance. Particular interest has been given to the role of this regulation in cardiac ischemia and myocardial protection.

Research interest/specialty

Phosphoinositides and ATP-Sensitive K+ Channels in Heart.

Research keywords

Phosphoinositides, ATP-sensitive, cardiac ischemia

Research interest/specialty

Phosphoinositides and ATP-Sensitive K+ Channels in Heart.

Research keywords

Phosphoinositides, ATP-sensitive, cardiac ischemia

Research description

ATP plays a pivotal role in the energy economy of the cell. Additionally, in many cell types such as islet b -cells of pancreas and muscle cells, ATP has important roles in transducing cellular signals which involve a particular type of potassium channel called ATP-sensitive potassium channel. In islet b -cells, for example, insulin release which occurs in response to hyperglycemia is mediated by a remarkable inhibition of ATP-sensitive potassium channel. My laboratory is currently working on several interrelated projects concerned with improving our understanding of the molecular basis for the biophysical activity of this channel, as well as increasing our appreciation of how energy metabolism interfaces with cellular processes through this channel under physiologic and pathophysiologic circumstances. The second focus of our research is on the regulatory roles of membrane phospholipids in modulating inwardly rectifying potassium channels including ATP-sensitive potassium channel. This research was built on our previous pioneering studies in this area. Currently we are interested in the cellular and molecular processes associated with, or dependent upon, this regulatory mechanism, and their physiologic relevance. Particular interest has been given to the role of this regulation in cardiac ischemia and myocardial protection.

Publications

  1. Vaithianathan, T, Bukiya, A, Liu, J, Liu, P, Asuncion-Chin, M, Fan, Z, Dopico, A. Direct regulation of BK channels by phosphatidylinositol 4,5-bisphosphate as a novel signaling pathway. J Gen Physiol, 132 (1), 13-28, 2008.
  2. Nishimura, H, Yang, Y, Lau, K, Kuykindoll, RJ, Fan, Z, Yamaguchi, K, Yamamoto, T. Aquaporin-2 water channel in developing quail kidney: possible role in programming adult fluid homeostasis. Am J Physiol Regul Integr Comp Physiol, 293 (5), R2147-58, 2007.
  3. Jiao, Y, Chiu, H, Fan, Z, Jiao, F, Eckstein, EC, Beamer, WG, Gu, W. Quantitative trait loci that determine mouse tibial nanoindentation properties in an F2 population derived from C57BL/6J x C3H/HeJ. Calcif Tissue Int, 80 (6), 383-90, 2007.
  4. Yang, Y, Cui, Y, Fan, Z, Cook, GA, Nishimura, H. Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney. Comp Biochem Physiol A Mol Integr Physiol, 147 (1), 84-93, 2007.
  5. Gao, L, Mi, X, Paajanen, V, Wang, K, Fan, Z. Activation-coupled inactivation in the bacterial potassium channel KcsA. Proc Natl Acad Sci U S A, 102 (49), 17630-5, 2005.
  6. Yang, Y, Cui, Y, Wang, W, Zhang, L, Bufford, L, Sasaki, S, Fan, Z, Nishimura, H. Molecular and functional characterization of a vasotocin-sensitive aquaporin water channel in quail kidney. Am J Physiol Regul Integr Comp Physiol, 287 (4), R915-24, 2004.
  7. Park, K, Mishra, S, Lewis, G, Losby, J, Fan, Z, Park, JB. Quasi-static and dynamic nanoindentation studies on highly crosslinked ultra-high-molecular-weight polyethylene. Biomaterials, 25 (12), 2427-36, 2004.
  8. Nishimura, H, Fan, Z. Sodium and water transport and urine concentration in avian kidney. Symp Soc Exp Biol (54), 129-51, 2004.
  9. Gosmanov, AR, Fan, Z, Mi, X, Schneider, EG, Thomason, DB. ATP-sensitive potassium channels mediate hyperosmotic stimulation of NKCC in slow-twitch muscle. Am J Physiol Cell Physiol, 286 (3), C586-95, 2004.
  10. Xu, J, Rho, JY, Mishra, SR, Fan, Z. Atomic force microscopy and nanoindentation characterization of human lamellar bone prepared by microtome sectioning and mechanical polishing technique. J Biomed Mater Res A, 67 (3), 719-26, 2003.
  11. Nishimura, H, Fan, Z. Regulation of water movement across vertebrate renal tubules. Comp Biochem Physiol A Mol Integr Physiol, 136 (3), 479-98, 2003.
  12. Fan, Z, Rho, JY. Effects of viscoelasticity and time-dependent plasticity on nanoindentation measurements of human cortical bone. J Biomed Mater Res A, 67 (1), 208-14, 2003.
  13. Chen, Q, Rho, JY, Fan, Z, Laulederkind, SJ, Raghow, R. Congenital lack of COX-2 affects mechanical and geometric properties of bone in mice. Calcif Tissue Int, 73 (4), 387-92, 2003.
  14. Fan, Z, Gao, L, Wang, W. Phosphatidic acid stimulates cardiac KATP channels like phosphatidylinositols, but with novel gating kinetics. Am J Physiol Cell Physiol, 284 (1), C94-102, 2003.
  15. Wang, C, Wang, K, Wang, W, Cui, Y, Fan, Z. Compromised ATP binding as a mechanism of phosphoinositide modulation of ATP-sensitive K+ channels. FEBS Lett, 532 (1-2), 177-82, 2002.
  16. Fan, Z, Swadener, JG, Rho, JY, Roy, ME, Pharr, GM. Anisotropic properties of human tibial cortical bone as measured by nanoindentation. J Orthop Res, 20 (4), 806-10, 2002.
  17. Cui, Y, Fan, Z. Mechanism of Kir6.2 channel inhibition by sulfhydryl modification: pore block or allosteric gating. J Physiol, 540 (Pt 3), 731-41, 2002.
  18. Cui, Y, Wang, W, Fan, Z. Cytoplasmic vestibule of the weak inward rectifier Kir6.2 potassium channel. J Biol Chem, 277 (12), 10523-30, 2002.
  19. Fan, Z, Neff, RA. Susceptibility of ATP-sensitive K+ channels to cell stress through mediation of phosphoinositides as examined by photoirradiation. J Physiol, 529 Pt 3, 707-21, 2000.
  20. Qi, G, Pujol, J, Fan, Z. 3-D AE visualization of bone-cement fatigue locations. J Biomed Mater Res, 52 (2), 256-60, 2000.
  21. Fan, Z, Makielski, JC. Phosphoinositides decrease ATP sensitivity of the cardiac ATP-sensitive K(+) channel. A molecular probe for the mechanism of ATP-sensitive inhibition. J Gen Physiol, 114 (2), 251-69, 1999.