YI LU, Ph.D., B.S.

Associate Professor
Pathology

Office: Rm 218 Cancer Research Building
Tel: (901) 448-5436
ylu@uthsc.edu

Education

  • PostDoc, Univeristy of Texas M.D.Anderson Cancer Center, Houston, TX, Molecular Biology
  • Ph.D., U. of Nebraska Medical Center, Omaha, NE, Biochemistry & Molecular Biology
  • B.S., Fudan University, Shanghai, P.R. China, Biochemistry

Publications

  1. Zangar RC, Bollinger N, Verma S, Karin NJ, and Lu Y.. The NF-kB pathway regulates cytochrome P450 3A4 protein stability.. Mol. Pharmacol. March 11, 2008 issue (In Press).
  2. Komatsu, DE, Brune, KA, Liu, H, Schmidt, AL, Han, B, Zeng, QQ, Yang, X, Nunes, JS, Lu, Y, Geiser, AG, Ma, YL, Wolos, JA, Westmore, MS, Sato, M. Longitudinal in vivo analysis of the region-specific efficacy of parathyroid hormone in a rat cortical defect model. Endocrinology, 150 (4), 1570-9, 2009.
  3. Lu, Y, Li, CM, Wang, Z, Ross, CR, Chen, J, Dalton, JT, Li, W, Miller, DD. Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. J Med Chem, 52 (6), 1701-11, 2009.
  4. Lu, Y, Zhang, X, Beheshti, B, Zhang, J. Adenoviral-mediated pHyde gene transfer and cisplatin additively inhibit human prostate cancer growth by enhancing apoptosis. Prostate, 69 (3), 234-48, 2009.
  5. DeCuypere, M, Lu, Y, Miller, DD, LeDoux, MS. Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and Parkinson's disease brain. J Neurochem, 107 (5), 1398-413, 2008.
  6. Zhu, L, Lu, Y, Miller, DD, Mahato, RI. Structural and formulation factors influencing pyridinium lipid-based gene transfer. Bioconjug Chem, 19 (12), 2499-512, 2008.
  7. Grimes, KD, Lu, YJ, Zhang, YM, Luna, VA, Hurdle, JG, Carson, EI, Qi, J, Kudrimoti, S, Rock, CO, Lee, RE. Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria. ChemMedChem, 3 (12), 1936-45, 2008.
  8. Kotha, J, Zhang, C, Longhurst, CM, Lu, Y, Jacobs, J, Cheng, Y, Jennings, LK. Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: A novel target for the prevention of neointimal hyperplasia. Atherosclerosis, 2008.
  9. Chen, J, Wang, Z, Lu, Y, Dalton, JT, Miller, DD, Li, W. Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma. Bioorg Med Chem Lett, 18 (11), 3183-7, 2008.
  10. Zhang, J, Lu, A, Beech, D, Jiang, B, Lu, Y. Suppression of breast cancer metastasis through the inhibition of VEGF-mediated tumor angiogenesis. Cancer Ther, 5, 273-286, 2008.
  11. Li, W, Lu, Y, Wang, Z, Dalton, JT, Miller, DD. Synthesis and antiproliferative activity of thiazolidine analogs for melanoma. Bioorg Med Chem Lett, 17 (15), 4113-7, 2007.
  12. Paoletti, L, Lu, YJ, Schujman, GE, de Mendoza, D, Rock, CO. Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis. J Bacteriol, 189 (16), 5816-24, 2007.
  13. Jerga, A, Lu, YJ, Schujman, GE, de Mendoza, D, Rock, CO. Identification of a soluble diacylglycerol kinase required for lipoteichoic acid production in Bacillus subtilis. J Biol Chem, 282 (30), 21738-45, 2007.
  14. Lu, YJ, Zhang, F, Grimes, KD, Lee, RE, Rock, CO. Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase. J Biol Chem, 282 (15), 11339-46, 2007.
  15. Jun Zhang, Andrew Lu, Derrick Beech, Binghua Jiang, and Yi Lu. Suppression of breast cancer metastasis through the inhibition of VEGF-mediated tumor angiogenesis. Cancer Ther., 5, 273-286, 2007.
  16. Lu, YJ, Zhang, YM, Grimes, KD, Qi, J, Lee, RE, Rock, CO. Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens. Mol Cell, 23 (5), 765-72, 2006.
  17. Lu, YJ, Rock, CO. Transcriptional regulation of fatty acid biosynthesis in Streptococcus pneumoniae. Mol Microbiol, 59 (2), 551-66, 2006.
  18. Jun Zhang, Bogdan Ceacareanu, Haruhito Azuma, Aviv Hassis, Lisa K Jennings, and Yi Lu. Suppression of tumor metastasis by adenoviral-mediated gene transfer of motility related protein-1 (MRP-1/CD9). Cancer Ther, 4, 289-300, 2006.
  19. Lu, YJ, White, SW, Rock, CO. Domain swapping between Enterococcus faecalis FabN and FabZ proteins localizes the structural determinants for isomerase activity. J Biol Chem, 280 (34), 30342-8, 2005.
  20. Guimin Chang, and Yi Lu. Adenoviral-mediated overexpression of tumor suppressor gene for BPH gene therapy. Gene Ther. Mol. Biol, 9, 281-290, 2005.
  21. Zhang, YM, Lu, YJ, Rock, CO. The reductase steps of the type II fatty acid synthase as antimicrobial targets. Lipids, 39 (11), 1055-60, 2004.
  22. Lu, YJ, Zhang, YM, Rock, CO. Product diversity and regulation of type II fatty acid synthases. Biochem Cell Biol, 82 (1), 145-55, 2004.
  23. Guimin Chang and Yi Lu. PSA promoter-driven conditional replication-competent adenovirus for prostate cancer gene therapy. Gene Ther. Mol. Biol, 8, 413-422, 2004.
  24. Yi Lu, Ben Beheshti, Jun Zhang, Jeremy A. Squire, Ximing J. Yang, Weikuan Gu, Syamal K. Bhattacharya, and Lisa K. Jennings. Characterization of a novel apoptosis-inducing gene in prostate cancer. In: Progress in Prostate Cancer Research. (Ed.) John N. Lucas. Nova Science Publishers, Inc.: Hauppauge, NY, 23-50, 2004.
  25. Yi Lu, Jun Zhang, Derrick J. Beech, Linda K. Myers, and Lisa K. Jennings. p16 downregulates VEGF and inhibits angiogenesis in breast cancer cells. Cancer Ther, 1, 143-151, 2003.
  26. Weld, KJ, Mayher, BE, Allay, JA, Cockroft, JL, Reed, CP, Randolph, MM, Lu, Y, Steiner, MS, Gingrich, JR. Transrectal gene therapy of the prostate in the canine model. Cancer Gene Ther, 9 (2), 189-96, 2002.
  27. Zhang, X, Steiner, MS, Rinaldy, A, Lu, Y. Apoptosis induction in prostate cancer cells by a novel gene product, pHyde, involves caspase-3. Oncogene, 20 (42), 5982-90, 2001.
  28. Lu, Y. Viral based gene therapy for prostate cancer. Curr Gene Ther, 1 (2), 183-200, 2001.
  29. Zhou, D, Lu, Y, Steiner, MS, Dalton, JT. Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect. Antimicrob Agents Chemother, 44 (10), 2659-63, 2000.
  30. Steiner, MS, Zhang, X, Wang, Y, Lu, Y. Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde. Cancer Res, 60 (16), 4419-25, 2000.
  31. Brimer, C, Dalton, JT, Zhu, Z, Schuetz, J, Yasuda, K, Vanin, E, Relling, MV, Lu, Y, Schuetz, EG. Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein. Pharm Res, 17 (7), 803-10, 2000.
  32. Lu, Y, Steiner, MS. Transcriptionally regulated adenoviruses for prostate-specific gene therapy. World J Urol, 18 (2), 93-101, 2000.
  33. Allay, JA, Steiner, MS, Zhang, Y, Reed, CP, Cockroft, J, Lu, Y. Adenovirus p16 gene therapy for prostate cancer. World J Urol, 18 (2), 111-20, 2000.
  34. Lu, Y, Lotan, D, Lotan, R. Differential regulation of constitutive and retinoic acid-induced galectin-1 gene transcription in murine embryonal carcinoma and myoblastic cells. Biochim Biophys Acta, 1491 (1-3), 13-9, 2000.
  35. Steiner, MS, Wang, Y, Zhang, Y, Zhang, X, Lu, Y. p16/MTS1/INK4A suppresses prostate cancer by both pRb dependent and independent pathways. Oncogene, 19 (10), 1297-306, 2000.
  36. Steiner, MS, Zhang, Y, Farooq, F, Lerner, J, Wang, Y, Lu, Y. Adenoviral vector containing wild-type p16 suppresses prostate cancer growth and prolongs survival by inducing cell senescence. Cancer Gene Ther, 7 (3), 360-72, 2000.
  37. Yi Lu, Dafna Lotan, and Reuben Lotan. Differential Regulation of Constitutive and Retinoic Acid-Induced Galectin-1 Gene Transcription in Murine Embryonal Carcinoma and Myoblastic Cells. Biochim. Biophys. Acta, 1491, 13-19, 2000.
  38. Mitchell S. Steiner, Yu Zhang, and Yi Lu. A fast way to generate recombinant adenovirus: a high-frequency-recombination system. J. Industr. Microbiol. Biotechnol, 24, 198-202, 2000.
  39. Michell S. Steiner, Xiongwen Zhang, Ying Wang, and Yi Lu. Growth inhibition of prostate cancer by adenovirus expressing a novel tumor suppressor gene pHyde. Cancer Res, 60, 4419-4425, 2000.
  40. Steiner, MS, Zhang, Y, Carraher, J, Lu, Y. In vivo expression of prostate-specific adenoviral vectors in a canine model. Cancer Gene Ther, 6 (5), 456-64, 1999.
  41. Lu, Y, Carraher, J, Zhang, Y, Armstrong, J, Lerner, J, Rogers, WP, Steiner, MS. Delivery of adenoviral vectors to the prostate for gene therapy. Cancer Gene Ther, 6 (1), 64-72, 1999.
  42. Lu, Y, Lotan, R. Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal carcinoma cells. Biochim Biophys Acta, 1444 (1), 85-91, 1999.
  43. Yu Zhang, Richard Stein, Wei Wang, Mitchell S. Steiner, and Yi Lu. Comparison of prostate specific adenoviral vectors for prostate cancer gene therapy. Tumor Targeting, 4, 1-12, 1999.
  44. Lu, Y, Amos, B, Cruise, E, Lotan, D, Lotan, R. A parallel association between differentiation and induction of galectin-1, and inhibition of galectin-3 by retinoic acid in mouse embryonal carcinoma F9 cells. Biol Chem, 379 (11), 1323-31, 1998.
  45. Lu, Y, Zhang, Y, Steiner, MS. Efficient identification of recombinant adenoviruses by direct plaque screening. DNA Cell Biol, 17 (7), 643-5, 1998.
  46. Mitchell S. Steiner, Cathy T. Anthony, Yi Lu, and Jeffery T. Holt. Prostate specific antisense c-myc produces tumor regression by suppressing c-myc and bcl-2. Human Gene Ther, 9, 747-755, 1998.
  47. Goldman, HB, Israeli, RS, Lu, Y, Lerner, JL, Hollabaugh, RS, Steiner, MS. Can prostate-specific antigen reverse transcriptase-polymerase chain reaction be used as a prospective test to diagnose prostate cancer. World J Urol, 15 (4), 257-61, 1997.
  48. Yi Lu, Laura L. Whitaker, Xiaoli Li, Dafna Lotan, and Reuben Lotan. Co-expression of galectin-1 and its complementary glycoconjugates laminin and lysosome-associated membrane proteins in murine PCC4.aza1R embryonal carcinoma cells induced to differentiation by butyrate. Mol. Cell. Differ, 3, 175-191, 1995.
  49. Yi Lu, Jill Pelling, and William Chaney. Tumor cell surface ß1-6 branched oligosaccharides and lung metastasis. Clin. Exp. Metastasis, 12, 47-54, 1994.
  50. Yi Lu. Relationship of expression of asparagine-linked beta1-6 branched oligosaccharides to tumor cell metastasis. Diss. Abstr. Int, 53, 3453, 1993.
  51. Yi Lu and William Chaney. Induction of N-acetylglucosaminyl-transferase V by elevated expression of activated or proto- Ha-ras oncogenes. Mol. Cell. Biochem, 122, 85-92, 1993.
  52. Yi Lu and William Chaney. Expression of cell-surface Asn-linked ß1-6 branching oligosaccharides and mammary tumor-cell metastasis. FASEB J, 6, 1348, 1992.
  53. Zhixing Zhang, Mili Gu, Yi Lu, and Yulin Sun. Direct DNA hybridization on agarose gel.. J. Chinese Cell Biol, 7, 171-174, 1985.