
YI LU, Ph.D., B.S.
Associate Professor
Pathology
![]() 19 SOUTH MANASSAS MEMPHIS TN 381033403 ![]() ![]() |
Education
- PostDoc, Univeristy of Texas M.D.Anderson Cancer Center, Houston, TX, Molecular Biology
- Ph.D., U. of Nebraska Medical Center, Omaha, NE, Biochemistry & Molecular Biology
- B.S., Fudan University, Shanghai, P.R. China, Biochemistry
Publications
- Zangar RC, Bollinger N, Verma S, Karin NJ, and Lu Y.. The NF-kB pathway regulates cytochrome P450 3A4 protein stability.. Mol. Pharmacol. March 11, 2008 issue (In Press).
- Komatsu, DE, Brune, KA, Liu, H, Schmidt, AL, Han, B, Zeng, QQ, Yang, X, Nunes, JS, Lu, Y, Geiser, AG, Ma, YL, Wolos, JA, Westmore, MS, Sato, M. Longitudinal in vivo analysis of the region-specific efficacy of parathyroid hormone in a rat cortical defect model. Endocrinology, 150 (4), 1570-9, 2009.
- Lu, Y, Li, CM, Wang, Z, Ross, CR, Chen, J, Dalton, JT, Li, W, Miller, DD. Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. J Med Chem, 52 (6), 1701-11, 2009.
- Lu, Y, Zhang, X, Beheshti, B, Zhang, J. Adenoviral-mediated pHyde gene transfer and cisplatin additively inhibit human prostate cancer growth by enhancing apoptosis. Prostate, 69 (3), 234-48, 2009.
- DeCuypere, M, Lu, Y, Miller, DD, LeDoux, MS. Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and Parkinson's disease brain. J Neurochem, 107 (5), 1398-413, 2008.
- Zhu, L, Lu, Y, Miller, DD, Mahato, RI. Structural and formulation factors influencing pyridinium lipid-based gene transfer. Bioconjug Chem, 19 (12), 2499-512, 2008.
- Grimes, KD, Lu, YJ, Zhang, YM, Luna, VA, Hurdle, JG, Carson, EI, Qi, J, Kudrimoti, S, Rock, CO, Lee, RE. Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria. ChemMedChem, 3 (12), 1936-45, 2008.
- Kotha, J, Zhang, C, Longhurst, CM, Lu, Y, Jacobs, J, Cheng, Y, Jennings, LK. Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: A novel target for the prevention of neointimal hyperplasia. Atherosclerosis, 2008.
- Chen, J, Wang, Z, Lu, Y, Dalton, JT, Miller, DD, Li, W. Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma. Bioorg Med Chem Lett, 18 (11), 3183-7, 2008.
- Zhang, J, Lu, A, Beech, D, Jiang, B, Lu, Y. Suppression of breast cancer metastasis through the inhibition of VEGF-mediated tumor angiogenesis. Cancer Ther, 5, 273-286, 2008.
- Li, W, Lu, Y, Wang, Z, Dalton, JT, Miller, DD. Synthesis and antiproliferative activity of thiazolidine analogs for melanoma. Bioorg Med Chem Lett, 17 (15), 4113-7, 2007.
- Paoletti, L, Lu, YJ, Schujman, GE, de Mendoza, D, Rock, CO. Coupling of fatty acid and phospholipid synthesis in Bacillus subtilis. J Bacteriol, 189 (16), 5816-24, 2007.
- Jerga, A, Lu, YJ, Schujman, GE, de Mendoza, D, Rock, CO. Identification of a soluble diacylglycerol kinase required for lipoteichoic acid production in Bacillus subtilis. J Biol Chem, 282 (30), 21738-45, 2007.
- Lu, YJ, Zhang, F, Grimes, KD, Lee, RE, Rock, CO. Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase. J Biol Chem, 282 (15), 11339-46, 2007.
- Jun Zhang, Andrew Lu, Derrick Beech, Binghua Jiang, and Yi Lu. Suppression of breast cancer metastasis through the inhibition of VEGF-mediated tumor angiogenesis. Cancer Ther., 5, 273-286, 2007.
- Lu, YJ, Zhang, YM, Grimes, KD, Qi, J, Lee, RE, Rock, CO. Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens. Mol Cell, 23 (5), 765-72, 2006.
- Lu, YJ, Rock, CO. Transcriptional regulation of fatty acid biosynthesis in Streptococcus pneumoniae. Mol Microbiol, 59 (2), 551-66, 2006.
- Jun Zhang, Bogdan Ceacareanu, Haruhito Azuma, Aviv Hassis, Lisa K Jennings, and Yi Lu. Suppression of tumor metastasis by adenoviral-mediated gene transfer of motility related protein-1 (MRP-1/CD9). Cancer Ther, 4, 289-300, 2006.
- Lu, YJ, White, SW, Rock, CO. Domain swapping between Enterococcus faecalis FabN and FabZ proteins localizes the structural determinants for isomerase activity. J Biol Chem, 280 (34), 30342-8, 2005.
- Guimin Chang, and Yi Lu. Adenoviral-mediated overexpression of tumor suppressor gene for BPH gene therapy. Gene Ther. Mol. Biol, 9, 281-290, 2005.
- Zhang, YM, Lu, YJ, Rock, CO. The reductase steps of the type II fatty acid synthase as antimicrobial targets. Lipids, 39 (11), 1055-60, 2004.
- Lu, YJ, Zhang, YM, Rock, CO. Product diversity and regulation of type II fatty acid synthases. Biochem Cell Biol, 82 (1), 145-55, 2004.
- Guimin Chang and Yi Lu. PSA promoter-driven conditional replication-competent adenovirus for prostate cancer gene therapy. Gene Ther. Mol. Biol, 8, 413-422, 2004.
- Yi Lu, Ben Beheshti, Jun Zhang, Jeremy A. Squire, Ximing J. Yang, Weikuan Gu, Syamal K. Bhattacharya, and Lisa K. Jennings. Characterization of a novel apoptosis-inducing gene in prostate cancer. In: Progress in Prostate Cancer Research. (Ed.) John N. Lucas. Nova Science Publishers, Inc.: Hauppauge, NY, 23-50, 2004.
- Yi Lu, Jun Zhang, Derrick J. Beech, Linda K. Myers, and Lisa K. Jennings. p16 downregulates VEGF and inhibits angiogenesis in breast cancer cells. Cancer Ther, 1, 143-151, 2003.
- Weld, KJ, Mayher, BE, Allay, JA, Cockroft, JL, Reed, CP, Randolph, MM, Lu, Y, Steiner, MS, Gingrich, JR. Transrectal gene therapy of the prostate in the canine model. Cancer Gene Ther, 9 (2), 189-96, 2002.
- Zhang, X, Steiner, MS, Rinaldy, A, Lu, Y. Apoptosis induction in prostate cancer cells by a novel gene product, pHyde, involves caspase-3. Oncogene, 20 (42), 5982-90, 2001.
- Lu, Y. Viral based gene therapy for prostate cancer. Curr Gene Ther, 1 (2), 183-200, 2001.
- Zhou, D, Lu, Y, Steiner, MS, Dalton, JT. Cytochrome P-450 2C9 sensitizes human prostate tumor cells to cyclophosphamide via a bystander effect. Antimicrob Agents Chemother, 44 (10), 2659-63, 2000.
- Steiner, MS, Zhang, X, Wang, Y, Lu, Y. Growth inhibition of prostate cancer by an adenovirus expressing a novel tumor suppressor gene, pHyde. Cancer Res, 60 (16), 4419-25, 2000.
- Brimer, C, Dalton, JT, Zhu, Z, Schuetz, J, Yasuda, K, Vanin, E, Relling, MV, Lu, Y, Schuetz, EG. Creation of polarized cells coexpressing CYP3A4, NADPH cytochrome P450 reductase and MDR1/P-glycoprotein. Pharm Res, 17 (7), 803-10, 2000.
- Lu, Y, Steiner, MS. Transcriptionally regulated adenoviruses for prostate-specific gene therapy. World J Urol, 18 (2), 93-101, 2000.
- Allay, JA, Steiner, MS, Zhang, Y, Reed, CP, Cockroft, J, Lu, Y. Adenovirus p16 gene therapy for prostate cancer. World J Urol, 18 (2), 111-20, 2000.
- Lu, Y, Lotan, D, Lotan, R. Differential regulation of constitutive and retinoic acid-induced galectin-1 gene transcription in murine embryonal carcinoma and myoblastic cells. Biochim Biophys Acta, 1491 (1-3), 13-9, 2000.
- Steiner, MS, Wang, Y, Zhang, Y, Zhang, X, Lu, Y. p16/MTS1/INK4A suppresses prostate cancer by both pRb dependent and independent pathways. Oncogene, 19 (10), 1297-306, 2000.
- Steiner, MS, Zhang, Y, Farooq, F, Lerner, J, Wang, Y, Lu, Y. Adenoviral vector containing wild-type p16 suppresses prostate cancer growth and prolongs survival by inducing cell senescence. Cancer Gene Ther, 7 (3), 360-72, 2000.
- Yi Lu, Dafna Lotan, and Reuben Lotan. Differential Regulation of Constitutive and Retinoic Acid-Induced Galectin-1 Gene Transcription in Murine Embryonal Carcinoma and Myoblastic Cells. Biochim. Biophys. Acta, 1491, 13-19, 2000.
- Mitchell S. Steiner, Yu Zhang, and Yi Lu. A fast way to generate recombinant adenovirus: a high-frequency-recombination system. J. Industr. Microbiol. Biotechnol, 24, 198-202, 2000.
- Michell S. Steiner, Xiongwen Zhang, Ying Wang, and Yi Lu. Growth inhibition of prostate cancer by adenovirus expressing a novel tumor suppressor gene pHyde. Cancer Res, 60, 4419-4425, 2000.
- Steiner, MS, Zhang, Y, Carraher, J, Lu, Y. In vivo expression of prostate-specific adenoviral vectors in a canine model. Cancer Gene Ther, 6 (5), 456-64, 1999.
- Lu, Y, Carraher, J, Zhang, Y, Armstrong, J, Lerner, J, Rogers, WP, Steiner, MS. Delivery of adenoviral vectors to the prostate for gene therapy. Cancer Gene Ther, 6 (1), 64-72, 1999.
- Lu, Y, Lotan, R. Transcriptional regulation by butyrate of mouse galectin-1 gene in embryonal carcinoma cells. Biochim Biophys Acta, 1444 (1), 85-91, 1999.
- Yu Zhang, Richard Stein, Wei Wang, Mitchell S. Steiner, and Yi Lu. Comparison of prostate specific adenoviral vectors for prostate cancer gene therapy. Tumor Targeting, 4, 1-12, 1999.
- Lu, Y, Amos, B, Cruise, E, Lotan, D, Lotan, R. A parallel association between differentiation and induction of galectin-1, and inhibition of galectin-3 by retinoic acid in mouse embryonal carcinoma F9 cells. Biol Chem, 379 (11), 1323-31, 1998.
- Lu, Y, Zhang, Y, Steiner, MS. Efficient identification of recombinant adenoviruses by direct plaque screening. DNA Cell Biol, 17 (7), 643-5, 1998.
- Mitchell S. Steiner, Cathy T. Anthony, Yi Lu, and Jeffery T. Holt. Prostate specific antisense c-myc produces tumor regression by suppressing c-myc and bcl-2. Human Gene Ther, 9, 747-755, 1998.
- Goldman, HB, Israeli, RS, Lu, Y, Lerner, JL, Hollabaugh, RS, Steiner, MS. Can prostate-specific antigen reverse transcriptase-polymerase chain reaction be used as a prospective test to diagnose prostate cancer. World J Urol, 15 (4), 257-61, 1997.
- Yi Lu, Laura L. Whitaker, Xiaoli Li, Dafna Lotan, and Reuben Lotan. Co-expression of galectin-1 and its complementary glycoconjugates laminin and lysosome-associated membrane proteins in murine PCC4.aza1R embryonal carcinoma cells induced to differentiation by butyrate. Mol. Cell. Differ, 3, 175-191, 1995.
- Yi Lu, Jill Pelling, and William Chaney. Tumor cell surface ß1-6 branched oligosaccharides and lung metastasis. Clin. Exp. Metastasis, 12, 47-54, 1994.
- Yi Lu. Relationship of expression of asparagine-linked beta1-6 branched oligosaccharides to tumor cell metastasis. Diss. Abstr. Int, 53, 3453, 1993.
- Yi Lu and William Chaney. Induction of N-acetylglucosaminyl-transferase V by elevated expression of activated or proto- Ha-ras oncogenes. Mol. Cell. Biochem, 122, 85-92, 1993.
- Yi Lu and William Chaney. Expression of cell-surface Asn-linked ß1-6 branching oligosaccharides and mammary tumor-cell metastasis. FASEB J, 6, 1348, 1992.
- Zhixing Zhang, Mili Gu, Yi Lu, and Yulin Sun. Direct DNA hybridization on agarose gel.. J. Chinese Cell Biol, 7, 171-174, 1985.