Yao Sun, MD, PhD

Professor of Medicine

Office: B324 Coleman College Of Medicine Building
Tel: (901) 448-4921
yasun@uthsc.edu

Education

  • PostDoc, University of Melbourne, Australia, Medical Science
  • Ph.D., Harbin Medical University, China, Biomedical Science
  • M.S., Harbin Medical University, China, Histology
  • M.D., Harbin Medical University, China, Medicine

Research Interests

The cellular and molecular mechanisms regulating myocardial repair/remodeling in infarcted heart, a cause of chronic heart failure. Studies focus on the mechanisms by which reactive oxygen species promotes cardiac remodeling and the importance of the activated cardiac renin-angiotensin system on oxidative stress following infarction.

Biographical Information

Dr. Sun is a Professor of Medicine of the Division of Cardiovascular Diseases at the University of Tennessee Health Science Center. She received her MD and PhD from Harbin Medical University of China. After two years postdoctoral training at the University of Melbourne, Australia, she joined the University of Missouri as a research fellow and was appointed Assistant Professor a year later in 1993, becoming Associate Professor of Medicine in 1999. In 2000, Dr. Sun joined the University of Tennessee Health Sciences Center.

Dr. Sun’s research interests (NIH funded) have focused on pathogenesis and pathophysiology of tissue repair/remodeling involving the heart and kidney. In vivo and in vitro studies address cellular and molecular mechanisms responsible for tissue inflammation, fibrosis and angiogenesis. Dr. Sun is an author with over 140 publications. She serves on several editorial boards. 

Publications

  1. Zhao, T, Zhao, W, Meng, W, Liu, C, Chen, Y, Sun, Y. Vascular endothelial growth factor-C: its unrevealed role in fibrogenesis. Am J Physiol Heart Circ Physiol, 306 (6), H789-96, 2014.
  2. Meng, W, Zhao, W, Zhao, T, Liu, C, Chen, Y, Liu, H, Sun, Y. Autocrine and Paracrine Function of Angiotensin 1-7 in Tissue Repair During Hypertension. Am J Hypertens, 2014.
  3. Kamalov, G, Zhao, W, Zhao, T, Sun, Y, Ahokas, RA, Marion, TN, Al Darazi, F, Gerling, IC, Bhattacharya, SK, Weber, KT. Atrophic cardiomyocyte signaling in hypertensive heart disease. J Cardiovasc Pharmacol, 62 (6), 497-506, 2013.
  4. Gerling, IC, Ahokas, RA, Kamalov, G, Zhao, W, Bhattacharya, SK, Sun, Y, Weber, KT. Gene Expression Profiles of Peripheral Blood Mononuclear Cells Reveal Transcriptional Signatures as Novel Biomarkers for Cardiac Remodeling in Rats with Aldosteronism and Hypertensive Heart Disease. JACC Heart Fail, 1 (6), 2013.
  5. Zhao, T, Zhao, W, Chen, Y, Liu, L, Ahokas, RA, Sun, Y. Differential expression of vascular endothelial growth factor isoforms and receptor subtypes in the infarcted heart. Int J Cardiol, 167 (6), 2638-45, 2013.
  6. Khan, MU, Zhao, W, Zhao, T, Al Darazi, F, Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. NEBIVOLOL, A MULTIFACETED ANTIOXIDANT AND CARDIOPROTECTANT IN HYPERTENSIVE HEART DISEASE. J Cardiovasc Pharmacol, 2013.
  7. Zhao, W, Zhao, T, Chen, Y, Qu, Y, Gerling, IC, Sun, Y. Modification of oxidative stress on gene expression profiling in the rat infarcted heart. Mol Cell Biochem, 379 (1-2), 243-53, 2013.
  8. Zhao, T, Zhao, W, Chen, Y, Li, VS, Meng, W, Sun, Y. Platelet-derived growth factor-D promotes fibrogenesis of cardiac fibroblasts. Am J Physiol Heart Circ Physiol, 304 (12), H1719-26, 2013.
  9. Zhao, W, Zhao, T, Chen, Y, Sun, Y. Angiotensin 1-7 Promotes Cardiac Angiogenesis Following Infarction. Curr Vasc Pharmacol, 2013.
  10. Weber, KT, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC. Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol, 10 (1), 15-26, 2013.
  11. Khan, MU, Cheema, Y, Shahbaz, AU, Ahokas, RA, Sun, Y, Gerling, IC, Bhattacharya, SK, Weber, KT. Mitochondria play a central role in nonischemic cardiomyocyte necrosis: common to acute and chronic stressor states. Pflugers Arch, 464 (1), 123-31, 2012.
  12. Zhao, W, Zhao, T, Huang, V, Chen, Y, Ahokas, RA, Sun, Y. Platelet-derived growth factor involvement in myocardial remodeling following infarction. J Mol Cell Cardiol, 51 (5), 830-8, 2011.
  13. Deshmukh, PA, Bellary, SR, Schwender, FT, Kamalov, G, Magotra, M, de Jongh Curry, AL, Sun, Y, Weber, KT. Spironolactone prevents the inducibility of ventricular tachyarrhythmia in rats with aldosteronism. J Cardiovasc Pharmacol, 58 (5), 487-91, 2011.
  14. Zhang, F, Michaelson, JE, Moshiach, S, Sachs, N, Zhao, W, Sun, Y, Sonnenberg, A, Lahti, JM, Huang, H, Zhang, XA. Tetraspanin CD151 maintains vascular stability by balancing the forces of cell adhesion and cytoskeletal tension. Blood, 118 (15), 4274-84, 2011.
  15. Cheema, Y, Sherrod, JN, Zhao, W, Zhao, T, Ahokas, RA, Sun, Y, Gerling, IC, Bhattacharya, SK, Weber, KT. Mitochondriocentric pathway to cardiomyocyte necrosis in aldosteronism: cardioprotective responses to carvedilol and nebivolol. J Cardiovasc Pharmacol, 58 (1), 80-6, 2011.
  16. Shahbaz, AU, Zhao, T, Zhao, W, Johnson, PL, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Calcium and zinc dyshomeostasis during isoproterenol-induced acute stressor state. Am J Physiol Heart Circ Physiol, 300 (2), H636-44, 2011.
  17. Shahbaz, AU, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, McGee, JE, Weber, KT. Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. J Hypertens, 28 Suppl 1, S25-32, 2010.
  18. Zhao, T, Zhao, W, Chen, Y, Ahokas, RA, Sun, Y. Vascular endothelial growth factor (VEGF)-A: role on cardiac angiogenesis following myocardial infarction. Microvasc Res, 80 (2), 188-94, 2010.
  19. Zhao, T, Zhao, W, Chen, Y, Ahokas, RA, Sun, Y. Acidic and basic fibroblast growth factors involved in cardiac angiogenesis following infarction. Int J Cardiol, 2010.
  20. Watsky, MA, Weber, KT, Sun, Y, Postlethwaite, A. New insights into the mechanism of fibroblast to myofibroblast transformation and associated pathologies. Int Rev Cell Mol Biol, 282, 165-92, 2010.
  21. Sun, Y. Intracardiac renin-angiotensin system and myocardial repair/remodeling following infarction. J Mol Cell Cardiol, 48 (3), 483-9, 2010.
  22. Kamalov, G, Ahokas, RA, Zhao, W, Shahbaz, AU, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. Am J Physiol Heart Circ Physiol, 298 (2), H385-94, 2010.
  23. Zhao, W, Zhao, T, Chen, Y, Ahokas, RA, Sun, Y. Reactive oxygen species promote angiogenesis in the infarcted rat heart. Int J Exp Pathol, 90 (6), 621-9, 2009.
  24. Bhattacharya, SK, Gandhi, MS, Kamalov, G, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Myocardial remodeling in low-renin hypertension: molecular pathways to cellular injury in relative aldosteronism. Curr Hypertens Rep, 11 (6), 412-20, 2009.
  25. Sun Y. Myocardial repair/remodelling following infarction: roles of local factors. Cardiovasc Res, 81 (3), 482-90, 2009.
  26. Zhao, W, Zhao, T, Chen, Y, Ahokas, RA, Sun, Y. Oxidative stress mediates cardiac fibrosis by enhancing transforming growth factor-beta1 in hypertensive rats. Mol Cell Biochem, 317 (1-2), 43-50, 2008.
  27. Lu, L, Chen, SS, Hassid, A, Sun, Y. Cardiac fibrogenesis following infarction in mice with deletion of inducible nitric oxide synthase. Am J Med Sci, 335 (6), 431-8, 2008.
  28. Zhao, W, Chen, SS, Chen, Y, Ahokas, RA, Sun, Y. Kidney Fibrosis in Hypertensive Rats: Role of Oxidative Stress. Am J Nephrol, 28 (4), 548-554, 2008.
  29. Zhao, W, Zhao, D, Yan, R, Sun, Y. Cardiac oxidative stress and remodeling following infarction: role of NADPH oxidase. Cardiovasc Pathol, 2008.
  30. Sun, Y. Oxidative stress and cardiac repair/remodeling following infarction. Am J Med Sci, 334 (3), 197-205, 2007.
  31. Sun, Y, Ahokas, RA, Bhattacharya, SK, Gerling, IC, Carbone, LD, Weber, KT. Oxidative stress in aldosteronism. Cardiovasc Res, 71 (2), 300-9, 2006.
  32. Zhao, W, Ahokas, RA, Weber, KT, Sun, Y. ANG II-induced cardiac molecular and cellular events: role of aldosterone. Am J Physiol Heart Circ Physiol, 291 (1), H336-43, 2006.
  33. Sun, Y, Weber, KT. Animal models of cardiac fibrosis. Methods Mol Med, 117, 273-90, 2005.
  34. Law, PH, Sun, Y, Bhattacharya, SK, Chhokar, VS, Weber, KT. Diuretics and bone loss in rats with aldosteronism. J Am Coll Cardiol, 46 (1), 142-6, 2005.
  35. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation, 111 (7), 871-8, 2005.
  36. Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cells. Circulation, 111 (1), 51-7, 2005.
  37. Lu, L, Quinn, MT, Sun, Y. Oxidative stress in the infarcted heart: role of de novo angiotensin II production. Biochem Biophys Res Commun, 325 (3), 943-51, 2004.
  38. Zhao, W, Lu, L, Chen, SS, Sun, Y. Temporal and spatial characteristics of apoptosis in the infarcted rat heart. Biochem Biophys Res Commun, 325 (2), 605-11, 2004.
  39. Lu, L, Chen, SS, Zhang, JQ, Ramires, FJ, Sun, Y. Activation of nuclear factor-kappaB and its proinflammatory mediator cascade in the infarcted rat heart. Biochem Biophys Res Commun, 321 (4), 879-85, 2004.
  40. Lu, L, Zhang, JQ, Ramires, FJ, Sun, Y. Molecular and cellular events at the site of myocardial infarction: from the perspective of rebuilding myocardial tissue. Biochem Biophys Res Commun, 320 (3), 907-13, 2004.
  41. Sun, Y, Zhang, J, Lu, L, Bedigian, MP, Robinson, AD, Weber, KT. Tissue angiotensin II in the regulation of inflammatory and fibrogenic components of repair in the rat heart. J Lab Clin Med, 143 (1), 41-51, 2004.
  42. Gerling, IC, Sun, Y, Ahokas, RA, Wodi, LA, Bhattacharya, SK, Warrington, KJ, Postlethwaite, AE, Weber, KT. Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotype. Am J Physiol Heart Circ Physiol, 285 (2), H813-21, 2003.
  43. Sun, Y, Weber, KT. RAS and connective tissue in the heart. Int J Biochem Cell Biol, 35 (6), 919-31, 2003.
  44. Sun, Y, Zhang, J, Lu, L, Chen, SS, Quinn, MT, Weber, KT. Aldosterone-induced inflammation in the rat heart : role of oxidative stress. Am J Pathol, 161 (5), 1773-81, 2002.
  45. Sun, Y, Kiani, MF, Postlethwaite, AE, Weber, KT. Infarct scar as living tissue. Basic Res Cardiol, 97 (5), 343-7, 2002.
  46. Sun, Y. The renin-angiotensin-aldosterone system and vascular remodeling. Congest Heart Fail, 8 (1), 11-6, 2002.
  47. Sun, Y, Zhang, J, Zhang, JQ, Weber, KT. Renin expression at sites of repair in the infarcted rat heart. J Mol Cell Cardiol, 33 (5), 995-1003, 2001.
  48. Sun, Y, Zhang, J, Zhang, JQ, Ramires, FJ. Local angiotensin II and transforming growth factor-beta1 in renal fibrosis of rats. Hypertension, 35 (5), 1078-84, 2000.
  49. Sun, Y, Weber, KT. Infarct scar: a dynamic tissue. Cardiovasc Res, 46 (2), 250-6, 2000.