STEPHEN W. WHITE, Ph.D., B.Sc.

Professor
Dept of Micr, Immun, & Biochem

Office: D1024E ST JUDE CHILDREN'S RESEARCH HOSPITAL
332 NORTH LAUDERDALE STREET
MEMPHIS TN 381050000
Tel: (901) 495-3040
n/a
SWWHITE

Education

  • Ph.D., University of Oxford, UK, Molecular Biophysics
  • B.S., University of Bristol, UK, Biochemistry

Publications

  1. Miller, DJ, Jerga, A, Rock, CO, White, SW. Analysis of the Staphylococcus aureus DgkB structure reveals a common catalytic mechanism for the soluble diacylglycerol kinases. Structure, 16 (7), 1036-46, 2008.
  2. Kerr, ID, Sivakolundu, S, Li, Z, Buchsbaum, JC, Knox, LA, Kriwacki, R, White, SW. Crystallographic and NMR analyses of UvsW and UvsW.1 from bacteriophage T4. J Biol Chem, 282 (47), 34392-400, 2007.
  3. He, X, van Waardenburg, RC, Babaoglu, K, Price, AC, Nitiss, KC, Nitiss, JL, Bjornsti, MA, White, SW. Mutation of a conserved active site residue converts tyrosyl-DNA phosphodiesterase I into a DNA topoisomerase I-dependent poison. J Mol Biol, 372 (4), 1070-81, 2007.
  4. Yun, MK, Nourse, A, White, SW, Rock, CO, Heath, RJ. Crystal structure and allosteric regulation of the cytoplasmic Escherichia coli L-asparaginase I. J Mol Biol, 369 (3), 794-811, 2007.
  5. Zeitoun, O, Santos, NM, Gardner, LA, White, SW, Bahouth, SW. Mutagenesis within helix 6 of the human beta1-adrenergic receptor identifies Lysine324 as a residue involved in imparting the high-affinity binding state of agonists. Mol Pharmacol, 70 (3), 838-50, 2006.
  6. Zhang, YM, Hurlbert, J, White, SW, Rock, CO. Roles of the active site water, histidine 303, and phenylalanine 396 in the catalytic mechanism of the elongation condensing enzyme of Streptococcus pneumoniae. J Biol Chem, 281 (25), 17390-9, 2006.
  7. Miller, DJ, Zhang, YM, Rock, CO, White, SW. Structure of RhlG, an essential beta-ketoacyl reductase in the rhamnolipid biosynthetic pathway of Pseudomonas aeruginosa. J Biol Chem, 281 (26), 18025-32, 2006.
  8. Zhang, YM, White, SW, Rock, CO. Inhibiting bacterial fatty acid synthesis. J Biol Chem, 281 (26), 17541-4, 2006.
  9. Nitiss, KC, Malik, M, He, X, White, SW, Nitiss, JL. Tyrosyl-DNA phosphodiesterase (Tdp1) participates in the repair of Top2-mediated DNA damage. Proc Natl Acad Sci U S A, 103 (24), 8953-8, 2006.
  10. Delos Santos, NM, Gardner, LA, White, SW, Bahouth, SW. Characterization of the residues in helix 8 of the human beta1-adrenergic receptor that are involved in coupling the receptor to G proteins. J Biol Chem, 281 (18), 12896-907, 2006.
  11. Lu, YJ, White, SW, Rock, CO. Domain swapping between Enterococcus faecalis FabN and FabZ proteins localizes the structural determinants for isomerase activity. J Biol Chem, 280 (34), 30342-8, 2005.
  12. White, SW, Zheng, J, Zhang, YM, Rock,. The structural biology of type II fatty acid biosynthesis. Annu Rev Biochem, 74, 791-831, 2005.
  13. Babaoglu, K, Qi, J, Lee, RE, White, SW. Crystal structure of 7,8-dihydropteroate synthase from Bacillus anthracis: mechanism and novel inhibitor design. Structure, 12 (9), 1705-17, 2004.
  14. Price, AC, Zhang, YM, Rock, CO, White, SW. Cofactor-induced conformational rearrangements establish a catalytically competent active site and a proton relay conduit in FabG. Structure, 12 (3), 417-28, 2004.
  15. Brown, SA, Stambas, J, Zhan, X, Slobod, KS, Coleclough, C, Zirkel, A, Surman, S, White, SW, Doherty, PC, Hurwitz, JL. Clustering of Th cell epitopes on exposed regions of HIV envelope despite defects in antibody activity. J Immunol, 171 (8), 4140-8, 2003.
  16. Price, AC, Rock, CO, White, SW. The 1.3-Angstrom-resolution crystal structure of beta-ketoacyl-acyl carrier protein synthase II from Streptococcus pneumoniae. J Bacteriol, 185 (14), 4136-43, 2003.
  17. Zhang, YM, Marrakchi, H, White, SW, Rock, CO. The application of computational methods to explore the diversity and structure of bacterial fatty acid synthase. J Lipid Res, 44 (1), 1-10, 2003.
  18. Jackowski, S, Zhang, YM, Price, AC, White, SW, Rock, CO. A missense mutation in the fabB (beta-ketoacyl-acyl carrier protein synthase I) gene confers tiolactomycin resistance to Escherichia coli. Antimicrob Agents Chemother, 46 (5), 1246-52, 2002.
  19. Heath, RJ, White, SW, Rock, CO. Inhibitors of fatty acid synthesis as antimicrobial chemotherapeutics. Appl Microbiol Biotechnol, 58 (6), 695-703, 2002.
  20. Li, N, Sickmier, EA, Zhang, R, Joachimiak, A, White, SW. The MotA transcription factor from bacteriophage T4 contains a novel DNA-binding domain: the 'double wing' motif. Mol Microbiol, 43 (5), 1079-88, 2002.
  21. Heath, RJ, White, SW, Rock, CO. Lipid biosynthesis as a target for antibacterial agents. Prog Lipid Res, 40 (6), 467-97, 2001.
  22. Price, AC, Zhang, YM, Rock, CO, White, SW. Structure of beta-ketoacyl-[acyl carrier protein] reductase from Escherichia coli: negative cooperativity and its structural basis. Biochemistry, 40 (43), 12772-81, 2001.
  23. D'Costa, S, Slobod, KS, Webster, RG, White, SW, Hurwitz, JL. Structural features of HIV envelope defined by antibody escape mutant analysis. AIDS Res Hum Retroviruses, 17 (12), 1205-9, 2001.
  24. Xu, Y, Heath, RJ, Li, Z, Rock, CO, White, SW. The FadR.DNA complex. Transcriptional control of fatty acid metabolism in Escherichia coli. J Biol Chem, 276 (20), 17373-9, 2001.
  25. Li, N, Zhang, W, White, SW, Kriwacki, RW. Solution structure of the transcriptional activation domain of the bacteriophage T4 protein, MotA. Biochemistry, 40 (14), 4293-302, 2001.
  26. Surman, S, Lockey, TD, Slobod, KS, Jones, B, Riberdy, JM, White, SW, Doherty, PC, Hurwitz, JL. Localization of CD4+ T cell epitope hotspots to exposed strands of HIV envelope glycoprotein suggests structural influences on antigen processing. Proc Natl Acad Sci U S A, 98 (8), 4587-92, 2001.
  27. Zhang, YM, Rao, MS, Heath, RJ, Price, AC, Olson, AJ, Rock, CO, White, SW. Identification and analysis of the acyl carrier protein (ACP) docking site on beta-ketoacyl-ACP synthase III. J Biol Chem, 276 (11), 8231-8, 2001.
  28. Price, AC, Choi, KH, Heath, RJ, Li, Z, White, SW, Rock, CO. Inhibition of beta-ketoacyl-acyl carrier protein synthases by thiolactomycin and cerulenin. Structure and mechanism. J Biol Chem, 276 (9), 6551-9, 2001.
  29. Davies, C, Heath, RJ, White, SW, Rock, CO. The 1.8 A crystal structure and active-site architecture of beta-ketoacyl-acyl carrier protein synthase III (FabH) from escherichia coli. Structure, 8 (2), 185-95, 2000.
  30. White, SW, Wilson, KS, Appelt, K, Tanaka, I. The high-resolution structure of DNA-binding protein HU from Bacillus stearothermophilus. Acta Crystallogr D Biol Crystallogr, 55 (Pt 4), 801-9, 1999.
  31. Davies, C, Gerstner, RB, Draper, DE, Ramakrishnan, V, White, SW. The crystal structure of ribosomal protein S4 reveals a two-domain molecule with an extensive RNA-binding surface: one domain shows structural homology to the ETS DNA-binding motif. EMBO J, 17 (16), 4545-58, 1998.
  32. Davies, C, Bussiere, DE, Golden, BL, Porter, SJ, Ramakrishnan, V, White, SW. Ribosomal proteins S5 and L6: high-resolution crystal structures and roles in protein synthesis and antibiotic resistance. J Mol Biol, 279 (4), 873-88, 1998.