SINCLAIR, SCOTT E.

Associate Professor
Medicine-Pulmonary
 
Associate Professor
Anesthesiology

Office: E2229 COLEMAN BUILDING
956 COURT AVENUE
MEMPHIS TN 381632116
Tel: (901) 448-5699
ssincla1@uthsc.edu

Publications

  1. Hill DM, Sinclair SE, Hickerson WL. Rational use and selection of antimicrobials in burn patients.. Clinics in Plastic and Reconstructive Surgery.
  2. Aron A, Sinclair SE. A Young man with lung cancer presenting with persistent cough and hemoptysis.. CHEST.
  3. Heckle MR, Nayyar M, Sinclair SE, Weber KT. Cannabinoids and symptomatic bradycardia. Physiology in Medicine Series. American Journal of Medical Science.
  4. Ghosh MC, Makena PS, Kennedy J, Teng B, Luellen C, Sinclair SE, Waters CM. A Heteromeric molecular complex regulates the migration of lung alveolar epithelial cells during wound healing. Scientific Reports.
  5. Schwingshackl, A, Teng, B, Makena, P, Ghosh, M, Sinclair, SE, Luellen, C, Balasz, L, Rovnaghi, C, Bryan, RM, Lloyd, EE, Fitzpatrick, E, Saravia, JS, Cormier, SA, Waters, CM. Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury. Crit Care Med, 42 (11), e692-701, 2014.
  6. Ghosh MC, Gorantla VK, Makena PS, Luellen C, Sinclair SE, Waters CM. Insulin Like Growth Factor-1 Stimulates Differentiation of ATII Cells to ATI-Like Cells Through Activation of Wnt5a.. Am J Physiol Lung Cell Mol Physiol, 305 (3), 222-8, 2013.
  7. Kadaria, D, Sinclair, SE. A case of acute agitation with a negative urine drug screen: a new wave of "legal" drugs of abuse. Tenn Med, 105 (9), 31-2, 2012.
  8. Schwingshackl, A, Teng, B, Ghosh, M, West, AN, Makena, P, Gorantla, V, Sinclair, SE, Waters, CM. Regulation and function of the two-pore-domain (K2P) potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol, 302 (1), L93-L102, 2012.
  9. Makena PS, Gorantla VK, Ghosh MC, Bezavada L, Balazs L, Luellen CL, Thompson KE, Ichijo H, Waters CM, Sinclair SE. Deletion of Apoptosis Signal Regulating Kinase-1 Prevents Ventilator-induced Lung Injury In Mice.. Am J Respir Cell Mol Biol, 46 (4), 461-9, 2012.
  10. Kadaria D, Sinclair SE. A case of acute agitation with a negative urine drug screen: a new wave of “legal’ drugs of abuse.. Tennessee Medicine, 105 (3), 39-40, 2012.
  11. 26. Roan E, Wilhelm K, Bada A, Makena PS, Parthasarathi K, Gorantla VK, Sinclair SE, Waters CM. Hyperoxia Alters the Mechanical Properties of Alveolar Epithelial Cells.. Am J Physiol Lung Cell Mol Physiol., 302 (12), L1235-41, 2012.
  12. 25. Ghosh MC, Makena PS, Gorantla VK, Sinclair SE, Waters CM. CXCR4 regulates migration of lung alveolar epithelial cells through activation of Rac1 and matrix metalloproteinase-14 (MMP14). Am J Physiol Lung Cell Mol Physiol., 302 (9), 846-56, 2012.
  13. Makena, PS, Gorantla, VK, Ghosh, MC, Bezawada, L, Kandasamy, K, Balazs, L, Luellen, CL, Thompson, KE, Parthasarathi, K, Ichijo, H, Waters, CM, Sinclair, SE. Deletion of Apoptosis Signal Regulating Kinase-1 Prevents Ventilator-induced Lung Injury In Mice. Am J Respir Cell Mol Biol, 2011.
  14. Makena, PS, Gorantla, VK, Ghosh, MC, Bezawada, L, Balazs, L, Luellen, C, Parthasarathi, K, Waters, CM, Sinclair, SE. Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation. J Appl Physiol, 111 (5), 1467-76, 2011.
  15. Crosby, LM, Luellen, C, Zhang, Z, Tague, LL, Sinclair, SE, Waters, CM. Balance of life and death in alveolar epithelial type II cells: proliferation, apoptosis, and the effects of cyclic stretch on wound healing. Am J Physiol Lung Cell Mol Physiol, 301 (4), L536-46, 2011.
  16. Meduri GU, Bell W, Sinclair SE, Annane D. Pathophysiology of acute respiratory distress syndrome. Glucocorticoid receptor-mediated regulation of inflammation and response to prolonged glucocorticoid treatment. La Presse Medicale, 40 (12 part 2), e543-e560, 2011.
  17. Makena, PS, Luellen, CL, Balazs, L, Ghosh, MC, Parthasarathi, K, Waters, CM, Sinclair, SE. Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes. Am J Physiol Lung Cell Mol Physiol, 299 (5), L711-9, 2010.
  18. Meduri, GU, Rocco, PR, Annane, D, Sinclair, SE. Prolonged glucocorticoid treatment and secondary prevention in acute respiratory distress syndrome. Expert Rev Respir Med, 4 (2), 201-10, 2010.
  19. Meduri, GU, Annane, D, Chrousos, GP, Marik, PE, Sinclair, SE. Activation and regulation of systemic inflammation in ARDS: rationale for prolonged glucocorticoid therapy. Chest, 136 (6), 1631-43, 2009.
  20. Sinclair, SE, Polissar, NL, Altemeier, WA. Spatial distribution of sequential ventilation during mechanical ventilation of the uninjured lung: an argument for cyclical airway collapse and expansion. BMC Pulm Med, 10, 25, 2009.
  21. Makena, PS, Pierce, SC, Chung, KT, Sinclair, SE. Comparative mutagenic effects of structurally similar flavonoids quercetin and taxifolin on tester strains Salmonella typhimurium TA102 and Escherichia coli WP-2 uvrA. Environ Mol Mutagen, 50 (6), 451-9, 2009.
  22. Sinclair, SE, Chi, E, Lin, HI, Altemeier, WA. Positive end-expiratory pressure alters the severity and spatial heterogeneity of ventilator-induced lung injury: an argument for cyclical airway collapse. J Crit Care, 24 (2), 206-11, 2009.
  23. Sinclair, SE, Molthen, RC, Haworth, ST, Dawson, CA, Waters, CM. Airway strain during mechanical ventilation in an intact animal model. Am J Respir Crit Care Med, 176 (8), 786-94, 2007.
  24. Desai, LP, Sinclair, SE, Chapman, KE, Hassid, A, Waters, CM. High tidal volume mechanical ventilation with hyperoxia alters alveolar type II cell adhesion. Am J Physiol Lung Cell Mol Physiol, 293 (3), L769-78, 2007.
  25. Altemeier, WA, Sinclair, SE. Hyperoxia in the intensive care unit: why more is not always better. Curr Opin Crit Care, 13 (1), 73-8, 2007.
  26. Sinclair, SE, Kregenow, DA, Starr, I, Schimmel, C, Lamm, WJ, Hlastala, MP, Swenson, ER. Therapeutic hypercapnia and ventilation-perfusion matching in acute lung injury: low minute ventilation vs inspired CO2. Chest, 130 (1), 85-92, 2006.
  27. Sinclair SE, John B, Golden E, Knight J, Carratu P, Umberger R, Meduri GU. nterleukin-8 and soluble intercellular adhesion molecule-1 during acute respiratory distress syndrome and in response to prolonged methylprednisolone treatment. Minerva Pneumologica, 45 (2), 93-104, 2006.
  28. Chapman, KE, Sinclair, SE, Zhuang, D, Hassid, A, Desai, LP, Waters, CM. Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells. Am J Physiol Lung Cell Mol Physiol, 289 (5), L834-41, 2005.
  29. Sinclair, SE, Altemeier, WA, Matute-Bello, G, Chi, EY. Augmented lung injury due to interaction between hyperoxia and mechanical ventilation. Crit Care Med, 32 (12), 2496-501, 2004.
  30. Sinclair, SE, Kregenow, DA, Lamm, WJ, Starr, IR, Chi, EY, Hlastala, MP. Hypercapnic acidosis is protective in an in vivo model of ventilator-induced lung injury. Am J Respir Crit Care Med, 166 (3), 403-8, 2002.
  31. Kreck, TC, Krueger, MA, Altemeier, WA, Sinclair, SE, Robertson, HT, Shade, ED, Hildebrandt, J, Lamm, WJ, Frazer, DA, Polissar, NL, Hlastala, MP. Determination of regional ventilation and perfusion in the lung using xenon and computed tomography. J Appl Physiol, 91 (4), 1741-9, 2001.
  32. Chornuk, MA, Bernard, SL, Burns, JW, Glenny, RW, Sheriff, DD, Sinclair, SE, Polissar, NL, Hlastala, MP. Effects of inertial load and countermeasures on the distribution of pulmonary blood flow. J Appl Physiol, 89 (2), 445-57, 2000.
  33. Sinclair, SE, McKinney, S, Glenny, RW, Bernard, SL, Hlastala, MP. Exercise alters fractal dimension and spatial correlation of pulmonary blood flow in the horse. J Appl Physiol (1985), 88 (6), 2269-78, 2000.
  34. Sinclair, SE, Albert, RK. Altering ventilation-perfusion relationships in ventilated patients with acute lung injury. Intensive Care Med, 23 (9), 942-50, 1997.