STEPHANIA ANN CORMIER

Plough Foundation Chair of Excellence in Pediatrics
Director of Pediatric Asthma Research Program
Director of LSU Superfund Research Program
Professor, Departments of Pediatrics, Infectious Disease
Microbiology, Immunology & Biochemistry
Physiology

Office: 430K TRANSLATIONAL RESEARCH BUILDING
71 SOUTH MANASSAS
MEMPHIS TN 38163
Tel: (901) 448-3071
scormier@uthsc.edu

Education

  • PostDoc, Mayo Clinic, Scottsdale, AZ, Pulmonary Immunology
  • PostDoc, Mayo Clinic, Scottsdale, AZ, Developmental Biology
  • Ph.D., Louisiana State University Medical Center, New Orleans, LA, Biochemistry and Molecular Biology
  • Honors BS, University of Southwestern Louisiana, Lafayette, LA, Biology/Chemistry

Research Interest/Specialty

Early Initiators of Asthma

Neonatal/Infant Respiratory Immunology

Respiratory Tract Viral Infections

Inhalation Exposures and Host Defense

Genome-Environment Interactions in Airways Disease

 

Research Description

The occurrence of inflammatory respiratory diseases, such as asthma and COPD, have increased dramatically in the past decade.  This rate of increase is more than can be accounted for by genetic drift alone and suggests a role for the environment.  Many hypotheses attempt to explain this phenomenon by citing better hygiene, environmental pollution, viral respiratory tract infections, and loss of some protective effect found in a rural lifestyle as culprits in disease initiation and exacerbation.

The main goal of my laboratory is to determine if exposure during infancy to environmental factors (i.e. allergens, pollutants, and respiratory viruses) leads to predisposition, development of, or exacerbation of respiratory disease in the adult.  We believe that adult respiratory diseases result, in part, from environmental impacts that occur during a critical phase of immuno-maturation.  In the short term, we seek: (1) to define the cellular and molecular changes in the pulmonary microenvironment following gestational and/or neonatal exposure to allergens; (2) to determine if urban pollutants (e.g. particulates such as diesel exhaust particles), initiate cellular/molecular events in the developing lung which lead to increased susceptibility to airways disease later in life; and (3) to define the impact of respiratory viral infection on pulmonary pathophysiology of neonatal mice. 

The long-term objective of my laboratory is to realize the initiators of the immune and pathophysiological changes that occur during the early stages of pulmonary airways disease and ultimately to develop effective interventions and therapies. 

My Curriculum Vitae

A complete list of my published works can be found here:

Publications

  1. Sussan, TE, Gajghate, S, Thimmulappa, RK, Ma, J, Kim, JH, Sudini, K, Consolini, N, Cormier, SA, Lomnicki, S, Hasan, F, Pekosz, A, Biswal, S. Exposure to electronic cigarettes impairs pulmonary anti-bacterial and anti-viral defenses in a mouse model. PLoS One, 10 (2), e0116861, 2015.
  2. Jaligama, S, Chen, Z, Saravia, J, Yadav, N, Lomnicki, SM, Dugas, TR, Cormier, SA. Exposure to Deepwater Horizon Crude Oil Burnoff Particulate Matter Induces Pulmonary Inflammation and Alters Adaptive Immune Response. Environ Sci Technol, 49 (14), 8769-76, 2015.
  3. Hrincius, ER, Liedmann, S, Finkelstein, D, Vogel, P, Gansebom, S, Samarasinghe, AE, You, D, Cormier, SA, McCullers, JA. Acute Lung Injury Results from Innate Sensing of Viruses by an ER Stress Pathway. Cell Rep, 11 (10), 1591-603, 2015.
  4. Huang, H, Saravia, J, You, D, Shaw, AJ, Cormier, SA. Impaired gamma delta T cell-derived IL-17A and inflammasome activation during early respiratory syncytial virus infection in infants. Immunol Cell Biol, 93 (2), 126-35, 2015.
  5. Nau, F, Miller, J, Saravia, J, Ahlert, T, Yu, B, Happel, KI, Cormier, SA, Nichols, CD. Serotonin 5-HT₂ receptor activation prevents allergic asthma in a mouse model. Am J Physiol Lung Cell Mol Physiol, 308 (2), L191-8, 2015.
  6. You, D, Siefker, DT, Shrestha, B, Saravia, J, Cormier, SA. Building a better neonatal mouse model to understand infant respiratory syncytial virus disease. Respir Res, 16 (1), 91, 2014.
  7. Schwingshackl, A, Teng, B, Makena, P, Ghosh, M, Sinclair, SE, Luellen, C, Balasz, L, Rovnaghi, C, Bryan, RM, Lloyd, EE, Fitzpatrick, E, Saravia, JS, Cormier, SA, Waters, CM. Deficiency of the two-pore-domain potassium channel TREK-1 promotes hyperoxia-induced lung injury. Crit Care Med, 42 (11), e692-701, 2014.
  8. Cormier, SA, Shrestha, B, Saravia, J, Lee, GI, Shen, L, DeVincenzo, JP, Kim, YI, You, D. Limited type I interferons and plasmacytoid dendritic cells during neonatal respiratory syncytial virus infection permit immunopathogenesis upon reinfection. J Virol, 88 (16), 9350-60, 2014.
  9. Saravia, J, You, D, Thevenot, P, Lee, GI, Shrestha, B, Lomnicki, S, Cormier, SA. Early-life exposure to combustion-derived particulate matter causes pulmonary immunosuppression. Mucosal Immunol, 7 (3), 694-704, 2014.
  10. Birke, L, Cormier, SA, You, D, Stout, RW, Clement, C, Johnson, M, Thompson, H. Hepatitis E antibodies in laboratory rabbits from 2 US vendors. Emerg Infect Dis, 20 (4), 693-6, 2014.
  11. Lee, GI, Saravia, J, You, D, Shrestha, B, Jaligama, S, Hebert, VY, Dugas, TR, Cormier, SA. Exposure to combustion generated environmentally persistent free radicals enhances severity of influenza virus infection. Part Fibre Toxicol, 11, 57, 2014.
  12. Lomnicki, S, Gullett, B, Stöger, T, Kennedy, I, Diaz, J, Dugas, TR, Varner, K, Carlin, DJ, Dellinger, B, Cormier, SA. Combustion By-Products and their Health Effects--combustion engineering and global health in the 21st century: issues and challenges. Int J Toxicol, 33 (1), 3-13, 2014.
  13. Kelley, MA, Hebert, VY, Thibeaux, TM, Orchard, MA, Hasan, F, Cormier, SA, Thevenot, PT, Lomnicki, SM, Varner, KJ, Dellinger, B, Latimer, BM, Dugas, TR. Model combustion-generated particulate matter containing persistent free radicals redox cycle to produce reactive oxygen species. Chem Res Toxicol, 26 (12), 1862-71, 2013.
  14. Wang, P, You, D, Saravia, J, Shen, H, Cormier, S. Maternal exposure to combustion generated PM inhibits pulmonary Th1 maturation and concomitantly enhances postnatal asthma development in offspring. Part Fibre Toxicol, 10 (1), 29, 2013.
  15. Thevenot, P, Saravia, J, Giaimo, J, Happel, KI, Dugas, TR, Cormier, SA. Chronic Alcohol Induces M2 Polarization Enhancing Pulmonary Disease Caused by Exposure to Particulate Air Pollution. Alcohol Clin Exp Res, 2013.
  16. You, D, Marr, N, Saravia, J, Shrestha, B, Lee, GI, Turvey, SE, Brombacher, F, Herbert, DR, Cormier, SA. IL-4Rα on CD4+ T cells plays a pathogenic role in respiratory syncytial virus reinfection in mice infected initially as neonates. J Leukoc Biol, 93 (6), 933-42, 2013.
  17. Thevenot, PT, Saravia, J, Jin, N, Giaimo, JD, Chustz, RE, Mahne, S, Kelley, MA, Hebert, VY, Dellinger, B, Dugas, TR, Demayo, FJ, Cormier, SA. Radical-containing ultrafine particulate matter initiates epithelial-to-mesenchymal transitions in airway epithelial cells. Am J Respir Cell Mol Biol, 48 (2), 188-97, 2013.
  18. Saravia, J, Lee, GI, Lomnicki, S, Dellinger, B, Cormier, SA. Particulate matter containing environmentally persistent free radicals and adverse infant respiratory health effects: a review. J Biochem Mol Toxicol, 27 (1), 56-68, 2013.
  19. Wang, P, Thevenot, P, Saravia, J, Ahlert, T, Cormier, SA. Radical-containing particles activate dendritic cells and enhance Th17 inflammation in a mouse model of asthma. Am J Respir Cell Mol Biol, 45 (5), 977-83, 2011.
  20. Cormier, SA, Kolls, JK. Innate IL-13 in virus-induced asthma. Nat Immunol, 12 (7), 587-8, 2011.
  21. Lord, K, Moll, D, Lindsey, JK, Mahne, S, Raman, G, Dugas, T, Cormier, S, Troxlair, D, Lomnicki, S, Dellinger, B, Varner, K. Environmentally persistent free radicals decrease cardiac function before and after ischemia/reperfusion injury in vivo. J Recept Signal Transduct Res, 31 (2), 157-67, 2011.
  22. Cormier, SA, You, D, Honnegowda, S. The use of a neonatal mouse model to study respiratory syncytial virus infections. Expert Rev Anti Infect Ther, 8 (12), 1371-80, 2010.
  23. Ripple, MJ, You, D, Honnegowda, S, Giaimo, JD, Sewell, AB, Becnel, DM, Cormier, SA. Immunomodulation with IL-4R alpha antisense oligonucleotide prevents respiratory syncytial virus-mediated pulmonary disease. J Immunol, 185 (8), 4804-11, 2010.
  24. Ding, LR, Wang, K, Fahmy, B, Shen, HH, Cormier, S. Airborne fine particulate matter induced pulmonary inflammation as well as oxidative stress in neonate rats. Chin Med J (Engl), 123 (20), 2895-900, 2010.
  25. Balakrishna, S, Saravia, J, Thevenot, P, Ahlert, T, Lominiki, S, Dellinger, B, Cormier, SA. Environmentally persistent free radicals induce airway hyperresponsiveness in neonatal rat lungs. Part Fibre Toxicol, 8, 11, 2010.
  26. Walsh, M, Cormier, S, Varner, K, Dellinger, B. By-products of the Thermal Treatment of Hazardous Waste: Formation and Health Effects. EM (Pittsburgh Pa), 26-30, 2010.
  27. Fahmy, B, Ding, L, You, D, Lomnicki, S, Dellinger, B, Cormier, SA. In vitro and in vivo assessment of pulmonary risk associated with exposure to combustion generated fine particles. Environ Toxicol Pharmacol, 29 (2), 173-82, 2010.
  28. Fahmy, B, Cormier, SA. Copper oxide nanoparticles induce oxidative stress and cytotoxicity in airway epithelial cells. Toxicol In Vitro, 23 (7), 1365-71, 2009.
  29. Balakrishna, S, Lomnicki, S, McAvey, KM, Cole, RB, Dellinger, B, Cormier, SA. Environmentally persistent free radicals amplify ultrafine particle mediated cellular oxidative stress and cytotoxicity. Part Fibre Toxicol, 6, 11, 2009.
  30. Wang, X, Xu, W, Kong, X, Chen, D, Hellermann, G, Ahlert, TA, Giaimo, JD, Cormier, SA, Li, X, Lockey, RF, Mohapatra, S, Mohapatra, SS. Modulation of lung inflammation by vessel dilator in a mouse model of allergic asthma. Respir Res, 10, 66, 2008.
  31. You, D, Ripple, M, Balakrishna, S, Troxclair, D, Sandquist, D, Ding, L, Ahlert, TA, Cormier, SA. Inchoate CD8+ T cell responses in neonatal mice permit influenza-induced persistent pulmonary dysfunction. J Immunol, 181 (5), 3486-94, 2008.
  32. Naura, AS, Hans, CP, Zerfaoui, M, You, D, Cormier, SA, Oumouna, M, Boulares, AH. Post-allergen challenge inhibition of poly(ADP-ribose) polymerase harbors therapeutic potential for treatment of allergic airway inflammation. Clin Exp Allergy, 38 (5), 839-46, 2008.
  33. Wang, K, You, D, Balakrishna, S, Ripple, M, Ahlert, T, Fahmy, B, Becnel, D, Daly, M, Subra, W, McElduff, JS, Lomax, LG, Troxclair, D, Cormier, SA. Sediment from hurricane katrina: potential to produce pulmonary dysfunction in mice. Int J Clin Exp Med, 1 (2), 130-44, 2007.
  34. Cormier, SA, Taranova, AG, Bedient, C, Nguyen, T, Protheroe, C, Pero, R, Dimina, D, Ochkur, SI, O'Neill, K, Colbert, D, Lombari, TR, Constant, S, McGarry, MP, Lee, JJ, Lee, NA. Pivotal Advance: eosinophil infiltration of solid tumors is an early and persistent inflammatory host response. J Leukoc Biol, 79 (6), 1131-9, 2006.
  35. Cormier, SA, Lomnicki, S, Backes, W, Dellinger, B. Origin and health impacts of emissions of toxic by-products and fine particles from combustion and thermal treatment of hazardous wastes and materials. Environ Health Perspect, 114 (6), 810-7, 2006.
  36. You, D, Becnel, D, Wang, K, Ripple, M, Daly, M, Cormier, SA. Exposure of neonates to respiratory syncytial virus is critical in determining subsequent airway response in adults. Respir Res, 7, 107, 2006.
  37. Becnel, D, You, D, Erskin, J, Dimina, DM, Cormier, SA. A role for airway remodeling during respiratory syncytial virus infection. Respir Res, 6, 122, 2005.
  38. Lee, JJ, Dimina, D, Macias, MP, Ochkur, SI, McGarry, MP, O'Neill, KR, Protheroe, C, Pero, R, Nguyen, T, Cormier, SA, Lenkiewicz, E, Colbert, D, Rinaldi, L, Ackerman, SJ, Irvin, CG, Lee, NA. Defining a link with asthma in mice congenitally deficient in eosinophils. Science, 305 (5691), 1773-6, 2004.
  39. Hao, M, Comier, S, Wang, M, Lee, JJ, Nel, A. Diesel exhaust particles exert acute effects on airway inflammation and function in murine allergen provocation models. J Allergy Clin Immunol, 112 (5), 905-14, 2003.
  40. Borchers, MT, Biechele, T, Justice, JP, Ansay, T, Cormier, S, Mancino, V, Wilkie, TM, Simon, MI, Lee, NA, Lee, JJ. Methacholine-induced airway hyperresponsiveness is dependent on Galphaq signaling. Am J Physiol Lung Cell Mol Physiol, 285 (1), L114-20, 2003.
  41. Cormier, SA, Mello, MA, Kappen, C. Normal proliferation and differentiation of Hoxc-8 transgenic chondrocytes in vitro. BMC Dev Biol, 3, 4, 2003.
  42. Shen, HH, Ochkur, SI, McGarry, MP, Crosby, JR, Hines, EM, Borchers, MT, Wang, H, Biechelle, TL, O'Neill, KR, Ansay, TL, Colbert, DC, Cormier, SA, Justice, JP, Lee, NA, Lee, JJ. A causative relationship exists between eosinophils and the development of allergic pulmonary pathologies in the mouse. J Immunol, 170 (6), 3296-305, 2003.
  43. Cormier, SA, Yuan, S, Crosby, JR, Protheroe, CA, Dimina, DM, Hines, EM, Lee, NA, Lee, JJ. T(H)2-mediated pulmonary inflammation leads to the differential expression of ribonuclease genes by alveolar macrophages. Am J Respir Cell Mol Biol, 27 (6), 678-87, 2002.
  44. Denzler, KL, Borchers, MT, Crosby, JR, Cieslewicz, G, Hines, EM, Justice, JP, Cormier, SA, Lindenberger, KA, Song, W, Wu, W, Hazen, SL, Gleich, GJ, Lee, JJ, Lee, NA. Extensive eosinophil degranulation and peroxidase-mediated oxidation of airway proteins do not occur in a mouse ovalbumin-challenge model of pulmonary inflammation. J Immunol, 167 (3), 1672-82, 2001.
  45. Cormier, SA, Larson, KA, Yuan, S, Mitchell, TL, Lindenberger, K, Carrigan, P, Lee, NA, Lee, JJ. Mouse eosinophil-associated ribonucleases: a unique subfamily expressed during hematopoiesis. Mamm Genome, 12 (5), 352-61, 2001.
  46. Denzler, KL, Farmer, SC, Crosby, JR, Borchers, M, Cieslewicz, G, Larson, KA, Cormier-Regard, S, Lee, NA, Lee, JJ. Eosinophil major basic protein-1 does not contribute to allergen-induced airway pathologies in mouse models of asthma. J Immunol, 165 (10), 5509-17, 2000.
  47. Cormier-Regard, S, Nguyen, SV, Claycomb, WC. Adrenomedullin gene expression is developmentally regulated and induced by hypoxia in rat ventricular cardiac myocytes. J Biol Chem, 273 (28), 17787-92, 1998.
  48. Cormier-Regard, S, Egeland, DB, Tannoch, VJ, Claycomb, WC. Differential display: identifying genes involved in cardiomyocyte proliferation. Mol Cell Biochem, 172 (1-2), 111-20, 1997.