Syamal K. Bhattacharya, BSc (Honors), BA, MS, AM, PhD, CLD

Professor of Medicine, Surgery, Neurology and Pharmaceutical Sciences
Executive Director, NIH-Sponsored Medical Students Research Program

Office: B318 COLEMAN COLLEGE OF MEDICINE BUILDING
956 COURT AVENUE
MEMPHIS TN 381630000
Tel: (901) 448-5676
sbhattachary@uthsc.edu

Research Interest: Basic, Clinical and Translational

Dr. Bhattacharya’s investigative thrust spanning over three and a half decades remains focused on the membrane-mediated Ca2+-induced cellular degeneration in cardiovascular and neuromuscular diseases, both in humans and animals, with a special emphasis on its molecular pathogenesis and therapeutic strategies in the regulation of excessive intracellular calcium accumulation (EICA), cellular energetics and cell death. Aspects of related intracellular key events that transpire in degenerating cardiac and skeletal myofibers, such as elevation in myoplasmic free [Ca2+]i and mitochondrial (MIT) pathophysiology with Ca2+ overloading and MIT permeability transition pore (mPTP) opening; loss of sarcolemmal Dystrophin and sarcoGlycans producing the D-G complex instability; dysregulation of L-type slow Ca2+-channels with reduced Ca2+ pumping out of the cells and their MIT; Na+/Ca2+ exchanger and sarcoplasmic reticulum (SR) gene expressions; structural and functional impairments of myofibers and MIT; as well as light microscopic and ultrastructural aberrations, are also of considerable interest.

With physical and nuclear chemistry background his initial research targets were: 1) Application of atomic spectroscopy (AAS) in clinical medicine; 2) Role of PTH in the genesis of EICA, antecedent to adverse myocardial remodeling with necrosis and reparative fibrosis, in hereditary muscular dystrophy (HMD); 3) Develop the concept of EICA which he believed fundamental to life, although transient with varying intensity in health and progressive with loss of myofibers in disease; 4) Role of mitochondriocentric signal-transduction-effector (MSTE) pathway in cellular/subcellular injuries leading to early molecular defects and systemic sequelae with EICA in neuromuscular/ cardiovascular disorders; and 5) Clinical nutrition and trace mineral metabolism in patients with morbid obesity, chronic metabolic syndrome, solid organ failure and transplantation, burns and trauma, and those receiving TPN.

Using molecular biological approaches and in vivo and in vitro myogenic cell culture systems of CHF-146 and BIO-14.6 dystrophic hamsters (DH), the roles of inherent perturbations in subsarcolemmal structural proteins (dystrophin, alpha-, beta-, gamma- & delta-sarcoglycans, and utrophin) and consequent EICA have been explored thoroughly to unravel cellular/molecular mechanisms involved in the pathogenesis of HMD. Pharmacologic mitigation of EICA in HMD with cardiomyopathy has been optimized in vivo, as well as in dystrophic myoblasts and myotubes, by regulating the transmembrane L-type Ca2+-channels and intracellular Ca2+-pumps using slow Ca2+-channel blockers, antioxidants and membrane stabilizers. In vitro studies in myogenic cells of Duchenne muscular dystrophic (DMD) origin or those from analogous animal models, were pursued to gain deeper understanding of the underlying molecular cascades responsible for genetically induced progressive muscle degeneration in several HMD, such as DMD, Baker (BMD), limb-girdle (LGMD), fascioscapulohumeral (FSHMD) & severe childhood autosomal recessive (SCARMD) muscular dystrophies, which heretofore remain without effective treatments and obscure for cure.

During 1979-2003, extensive therapeutic trials in HMD were carried out in his labs using a variety of pharmacologic agents to slow dystrophic pathobiology and lengthen the shorter life span. On the premise of the provocative findings of multiple salutary effects of diltiazem, a slow Ca2+-channel blocker, in DH with HMD & cardiomyopathy (J Clin Invest, 68:646-54, 1981; Muscle & Nerve, 5:73-8, 1982; ibid., 10:168-76, 1987; Exp Neurol, 95:265-276, 1987; J Neurol Sci, 115:76-90, 1993; ibid., 120:180-186, 1993; Mol Chem Neuropathol, 31:187-206, 1997; ibid., 34:53-77, 1998; and Mol Cell Biochem, 238:119-127, 2002), a long-term, placebo-controlled clinical trial of Ca2+-channel blockers in very young boys with DMD is being contemplated. Thus far, Dr. Bhattacharya’s ground breaking work prompted several clinical trials of diltiazem in DMD at UTHSC, Memphis; Universities of Padua and Milano, Italy; Univ of Freiberg, Germany; and Univ of Vienna, Austria.

Ongoing and recent work are: 1) Severity of hypertrophic cardiomyopathy in DBA/2J transgenic mice recapitulating congenital heart disease; 2) Cellular-molecular mechanisms of concerted intracellular Ca2+/ Zn2+ translocations to injured tissues following ischemia-reperfusion, and in chronic aldosteronism and hyper-tensive heart disease (HHD) with neurohormonal activation that eventuate in an immunostimulatory state with a vascular phenotype involving coronary and systemic vasculatures; 3) Mechanism and regulation of adverse myocardial remodeling with EICA and associated pathobiology following infarction, and in congestive heart failure (CHF) by aldosterone receptor blockers, Ca2+-channel blockers, antioxidants and by blocking selective sites on MSTE pathway; 4) Intrinsically coupled Ca2+/Zn2+ dyshomeostasis-linked secondary hyperparathyroid-ism, PTH-mediated EICA and hypovitaminosis-D in African-Americans with CHF and HHD; 5) Role of vitamin-D synthetic analogues with novel antifibrotic activity and their therapeutic potentials in autoimmune arthritis; & 6) Mitochondria-targeted cardioprotective strategies with: i) Carvedilol (MIT Ca2+ uniporter inhibitor); ii) Cyclosporine-A (mPTP inhibitor); iii) Quercetin (MIT-specific antioxidant); and iv) Nebivolol (a dual beta-1 antagonist with novel beta-3 agonistic properties) in CHF, HHD, as well as in other acute & chronic stressor states.

Biographical Information

Dr. Bhattacharya came to UTHSC in 1979, where he is a tenured Professor of Medicine (Cardiology), and holds joint appointments as a Professor of Surgery, Neurology and Pharmaceutical Sciences. He has been the Founding Director of the Chemistry and Nutrient Data Output Laboratory (1982), Director of the Surgical Research Laboratory (1982-2003), and Executive Director of the NIH-Sponsored Medical Students Research Program. Dr. Bhattacharya provided extensive patient care service to 16 local, regional and national hospitals during 1982-2003, as a provider and consultant in special chemistry (trace minerals/vitamins/ELISA-based assays) and surgical pathology. He is also an Adjunct Professor of Biomedical Engineering at the U of Memphis, and served as an Adjunct Professor of Surgery (1988-98) at New York Medical College, Associate Professor of Anatomy & Neurobiology (1988-97) at the UTHSC, and R & D Chemist in Bombay (1970-74). Dr. Bhattacharya received his BSc Honors degree in chemistry and BA (Special) in English from the U of Calcutta, MS in physical chemistry from Murray State U, AM in nuclear chemistry from Washington U in St. Louis, and PhD in chemistry, with a focus on clinical application of AAS, from the U of Memphis. He was a recipient of Indian National Merit Scholarship from the Ministry of Education, and National Research Service Award from the NIH for his work in neuromuscular disease. Dr. Bhattacharya spent sabbaticals as a Visiting Scholar in Neonatology at Washington U School of Medicine and St. Louis Children''s Hospital (1976-77) where he established the first AAS Laboratory for ultramicro quantitation of Ca and Mg from hill-stick neonatal serum; Visiting Scholar in Cardiothoracic Surgery at Yale in 1985; Visiting Professor of Physiology at UCLA in 1986; Visiting Professor of Pediatric Surgery at Johns Hopkins in 1987; and Visiting Professor of  Molecular Mediciine at the Bose Institute, Calcutta, in 1999 and 2001. Dr. Bhattacharya served on the Board of Directors of the National Certification Commission in Chemistry & Chemical Engineering (1983-95), on the Board of Directors and as Vice-President and President of the National Registry in Clinical Chemistry (1991-2000), both are credentialing bodies in the USA and Canada; Pathology-A Study Section at the NIH (1993-96); and AOA Research Fellowships Review Panel (2010-2016). Since 1979, Dr. Bhattacharya’s research has been supported uninterruptedly by numerous funding agencies, including NIH, MDA, AHA and Varian Techtron Ltd, Australia. Despite other institutional responsibilities, one of his most gratifying academic activities has been mentoring and he has mentored more than 110 graduate and medical students, residents, postdoctoral and clinical fellows, as well as junior faculty members. Many of his trainees have distinguished themselves by being outstanding and sought-after clinicians, researchers and mentors.

Publications

  1. Slomka, T, Lennon, ES, Akbar, H, Gosmanova, EO, Bhattacharya, SK, Oliphant, CS, Khouzam, RN. Effects of Renin-Angiotensin-Aldosterone System Blockade in Patients with End-Stage Renal Disease. Am J Med Sci, 351 (3), 309-16, 2016.
  2. Zhao, T, Zhao, W, Meng, W, Liu, C, Chen, Y, Bhattacharya, SK, Sun, Y. Vascular endothelial growth factor-D mediates fibrogenic response in myofibroblasts. Mol Cell Biochem, 413 (1-2), 127-35, 2016.
  3. Zhao, W, Zhao, T, Chen, Y, Zhao, F, Gu, Q, Williams, RW, Bhattacharya, SK, Lu, L, Sun, Y. A Murine Hypertrophic Cardiomyopathy Model: The DBA/2J Strain. PLoS One, 10 (8), e0133132, 2015.
  4. Zhao, T, Zhao, W, Meng, W, Liu, C, Chen, Y, Gerling, IC, Weber, KT, Bhattacharya, SK, Kumar, R, Sun, Y. VEGF-C/VEGFR-3 pathway promotes myocyte hypertrophy and survival in the infarcted myocardium. Am J Transl Res, 7 (4), 697-709, 2015.
  5. Efeovbokhan, N, Bhattacharya, SK, Ahokas, RA, Sun, Y, Guntaka, RV, Gerling, IC, Weber, KT. Zinc and the prooxidant heart failure phenotype. J Cardiovasc Pharmacol, 64 (4), 393-400, 2014.
  6. Al Darazi, F, Zhao, W, Zhao, T, Sun, Y, Marion, TN, Ahokas, RA, Bhattacharya, SK, Gerling, IC, Weber, KT. Small dedifferentiated cardiomyocytes bordering on microdomains of fibrosis: evidence for reverse remodeling with assisted recovery. J Cardiovasc Pharmacol, 64 (3), 237-46, 2014.
  7. Farah, V, Askari, R, Alsafwah, S, Dishmon, DA, Bhattacharya, SK, Weber, KT. Downregulation of the pro-oxidant heart failure phenotype by dietary and nondietary antioxidants: Antioxidants and Aging in Heart Failure. In: Preedy VR, ed. Aging: Oxidative Stress and Dietary Antioxidants. New York; Academic Press, Springer, 203-212, 2014.
  8. Gerling, IC, Ahokas, RA, Kamalov, G, Zhao, W, Bhattacharya, SK, Sun, Y, Weber, KT. Gene expression profiles of peripheral blood mononuclear cells reveal transcriptional signatures as novel biomarkers of cardiac remodeling in rats with aldosteronism and hypertensive heart disease. JACC Heart Fail, 1 (6), 469-76, 2013.
  9. Kamalov, G, Zhao, W, Zhao, T, Sun, Y, Ahokas, RA, Marion, TN, Al Darazi, F, Gerling, IC, Bhattacharya, SK, Weber, KT. Atrophic cardiomyocyte signaling in hypertensive heart disease. J Cardiovasc Pharmacol, 62 (6), 497-506, 2013.
  10. Khan, MU, Zhao, W, Zhao, T, Al Darazi, F, Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. Nebivolol: a multifaceted antioxidant and cardioprotectant in hypertensive heart disease. J Cardiovasc Pharmacol, 62 (5), 445-51, 2013.
  11. Rutledge, MR, Farah, V, Adeboye, AA, Seawell, MR, Bhattacharya, SK, Weber, KT. Parathyroid hormone, a crucial mediator of pathologic cardiac remodeling in aldosteronism. Cardiovasc Drugs Ther, 27 (2), 161-70, 2013.
  12. Seawell, MR, Al Darazi, F, Farah, V, Ramanathan, KB, Newman, KP, Bhattacharya, SK, Weber, KT. Mineralocorticoid receptor antagonism confers cardioprotection in heart failure. Curr Heart Fail Rep, 10 (1), 36-45, 2013.
  13. Weber, KT, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC. Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol, 10 (1), 15-26, 2013.
  14. Adeboye, AA, Newman, KP, Dishmon, DA, Alsafwah, S, Bhattacharya, SK, Weber, KT. A mitochondriocentric pathway to cardiomyocyte necrosis: An upstream molecular mechanism in myocardial fibrosis.. In: Jugdutt, BI, Dhalla, NS, eds. Cardiac Remodeling: Molecular Mechanisms. New York; Humana Press, Springer, 113-125, 2013.
  15. Cheema, Y, Zhao, W, Zhao, T, Khan, MU, Green, KD, Ahokas, RA, Gerling, IC, Bhattacharya, SK, Weber, KT. Reverse remodeling and recovery from cachexia in rats with aldosteronism. Am J Physiol Heart Circ Physiol, 303 (4), H486-95, 2012.
  16. Yusuf, J, Khan, MU, Cheema, Y, Bhattacharya, SK, Weber, KT. Disturbances in calcium metabolism and cardiomyocyte necrosis: the role of calcitropic hormones. Prog Cardiovasc Dis, 55 (1), 77-86, 2012.
  17. Khan, MU, Cheema, Y, Shahbaz, AU, Ahokas, RA, Sun, Y, Gerling, IC, Bhattacharya, SK, Weber, KT. Mitochondria play a central role in nonischemic cardiomyocyte necrosis: common to acute and chronic stressor states. Pflugers Arch, 464 (1), 123-31, 2012.
  18. Komolafe, BO, Khan, MU, Khouzam, RN, Dishmon, DA, Newman, KP, McGee, JE, Bhattacharya, SK, Weber, KT. Magnesium and its interdependency with other cations in acute and chronic stressor states. In: Watson, RR, Preedy, VR, Zibadi, S, eds. Magnesium in Human Health and Disease. Nutrition and Health. New York; Humana Press, Springer, 241-254, 2012.
  19. Borkowski, BJ, Cheema, Y, Shahbaz, AU, Bhattacharya, SK, Weber, KT. Cation dyshomeostasis and cardiomyocyte necrosis: the Fleckenstein hypothesis revisited. Eur Heart J, 32 (15), 1846-53, 2011.
  20. Cheema, Y, Sherrod, JN, Zhao, W, Zhao, T, Ahokas, RA, Sun, Y, Gerling, IC, Bhattacharya, SK, Weber, KT. Mitochondriocentric pathway to cardiomyocyte necrosis in aldosteronism: cardioprotective responses to carvedilol and nebivolol. J Cardiovasc Pharmacol, 58 (1), 80-6, 2011.
  21. Shaheen, M, Cheema, Y, Shahbaz, AU, Bhattacharya, SK, Weber, KT. Intracellular calcium overloading and oxidative stress in cardiomyocyte necrosis via a mitochondriocentric signal-transducer-effector pathway. Exp Clin Cardiol, 16 (4), 109-15, 2011.
  22. Slominski, AT, Li, W, Bhattacharya, SK, Smith, RA, Johnson, PL, Chen, J, Nelson, KE, Tuckey, RC, Miller, D, Jiao, Y, Gu, W, Postlethwaite, AE. Vitamin D analogs 17,20S(OH)2pD and 17,20R(OH)2pD are noncalcemic and exhibit antifibrotic activity. J Invest Dermatol, 131 (5), 1167-9, 2011.
  23. Zia, AA, Komolafe, BO, Moten, M, Ahokas, RA, McGee, JE, William Rosenberg, E, Bhattacharya, SK, Weber, KT. Supplemental vitamin D and calcium in the management of African Americans with heart failure having hypovitaminosis D. Am J Med Sci, 341 (2), 113-8, 2011.
  24. Shahbaz, AU, Zhao, T, Zhao, W, Johnson, PL, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Calcium and zinc dyshomeostasis during isoproterenol-induced acute stressor state. Am J Physiol Heart Circ Physiol, 300 (2), H636-44, 2011.
  25. Cheema, Y, Shahbaz, AU, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Calcium overloading-induced oxidative stress mediated cellular and subcellular remodeling. In: Dhalla NS, Nagano, M, Ostadal, B, eds. Molecular Defects in Cardiovascular Disease. New York; Springer, 3-15, 2011.
  26. Shahbaz, AU, Kamalov, G, Zhao, W, Zhao, T, Johnson, PL, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, Weber, KT. Mitochondria-targeted cardioprotection in aldosteronism. J Cardiovasc Pharmacol, 57 (1), 37-43, 2011.
  27. Weber, KT, Bhattacharya, SK, Newman, KP, Soberman, JE, Ramanathan, KB, McGee, JE, Malik, KU, Hickerson, WL. Stressor states and the cation crossroads. J Am Coll Nutr, 29 (6), 563-74, 2010.
  28. Kamalov, G, Bhattacharya, SK, Weber, KT. Congestive heart failure: where homeostasis begets dyshomeostasis. J Cardiovasc Pharmacol, 56 (3), 320-8, 2010.
  29. Zia, AA, Kamalov, G, Newman, KP, McGee, JE, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. From aldosteronism to oxidative stress: the role of excessive intracellular calcium accumulation. Hypertens Res, 2010.
  30. Shahbaz, AU, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, McGee, JE, Weber, KT. Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. J Hypertens, 28 Suppl 1, S25-32, 2010.
  31. Gandhi, MS, Kamalov, G, Shahbaz, AU, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Cellular and molecular pathways to myocardial necrosis and replacement fibrosis. Heart Fail Rev, 2010.
  32. Kamalov, G, Ahokas, RA, Zhao, W, Zhao, T, Shahbaz, AU, Johnson, PL, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Uncoupling the coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria seen in aldosteronism. J Cardiovasc Pharmacol, 55 (3), 248-54, 2010.
  33. Kamalov, G, Ahokas, RA, Zhao, W, Shahbaz, AU, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. Am J Physiol Heart Circ Physiol, 298 (2), H385-94, 2010.
  34. Bhattacharya, SK. Fibrosi del miocardio nella cardiopatia ipertensiva. In: Proceedings of the 2nd International Cardio Event. Cardiology Towards the Future: Innovation in Cardiology. Florence, Italy, 84-90, 2010.
  35. Bhattacharya, SK, Gandhi, MS, Kamalov, G, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Myocardial remodeling in low-renin hypertension: molecular pathways to cellular injury in relative aldosteronism. Curr Hypertens Rep, 11 (6), 412-20, 2009.
  36. Shook, MS, Zafarullah, H, Nelson, MD, Bhattacharya, SK, Davis, RC, Newman, KP, Weber, KT. Normoglycemia in nondiabetic African Americans hospitalized with heart failure. Am J Med Sci, 338 (4), 255-8, 2009.
  37. Kamalov, G, Holewinski, JP, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Nutrient dyshomeostasis in congestive heart failure. Am J Med Sci, 338 (1), 28-33, 2009.
  38. Kamalov, G, Deshmukh, PA, Baburyan, NY, Gandhi, MS, Johnson, PL, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. J Cardiovasc Pharmacol, 53 (5), 414-23, 2009.
  39. Dishmon, DA, Dotson, JL, Munir, A, Nelson, MD, Bhattacharya, SK, D'Cruz, IA, Davis, RC, Weber, KT. Hypovitaminosis D and Valvular Calcification in Patients With Dilated Cardiomyopathy. Am J Med Sci, 2009.
  40. Brown, RO, Morgan, LM, Bhattacharya, SK, Johnson, PL, Minard, G, Dickerson, RN. Potential aluminum exposure from parenteral nutrition in patients with acute kidney injury. Ann Pharmacother, 42 (10), 1410-5, 2008.
  41. Gandhi, MS, Deshmukh, PA, Kamalov, G, Zhao, T, Zhao, W, Whaley, JT, Tichy, JR, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism. J Cardiovasc Pharmacol, 52 (3), 245-52, 2008.
  42. Carbone, LD, Rosenberg, EW, Tolley, EA, Holick, MF, Hughes, TA, Watsky, MA, Barrow, KD, Chen, TC, Wilkin, NK, Bhattacharya, SK, Dowdy, JC, Sayre, RM, Weber, KT. 25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation. Metabolism, 57 (6), 741-8, 2008.
  43. Selektor, Y, Parker, RB, Sun, Y, Zhao, W, Bhattacharya, SK, Weber, KT. Tissue 65Zinc Translocation in a Rat Model of Chronic Aldosteronism. J Cardiovasc Pharmacol, 51 (4), 359-364, 2008.
  44. Selektor, Y, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism. Am J Med Sci, 335 (2), 105-10, 2008.
  45. Newman, KP, Bhattacharya, SK, Munir, A, Davis, RC, Soberman, JE, Ramanathan, KB. Macro- and micronutrients in patients with congestive heart failure, particularly African-Americans. Vasc Health Risk Manag, 3 (5), 743-7, 2007.
  46. Alsafwah, S, Laguardia, SP, Arroyo, M, Dockery, BK, Bhattacharya, SK, Ahokas, RA, Newman, KP. Congestive heart failure is a systemic illness: a role for minerals and micronutrients. Clin Med Res, 5 (4), 238-43, 2007.
  47. Newman, KP, Neal, MT, Roberts, M, Goodwin, KD, Hatcher, EA, Bhattacharya, SK. The importance of lost minerals in heart failure. Cardiovasc Hematol Agents Med Chem, 5 (4), 295-9, 2007.
  48. Thomas, M, Vidal, A, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone. Am J Physiol Heart Circ Physiol, 293 (4), H2361-6, 2007.
  49. Arroyo, M, Laguardia, SP, Bhattacharya, SK, Nelson, MD, Johnson, PL, Carbone, LD, Newman, KP, Weber, KT. Micronutrients in African-Americans with decompensated and compensated heart failure. Transl Res, 148 (6), 301-8, 2006.
  50. Myers, LK, Bhattacharya, SD, Herring, PA, Xing, Z, Goorha, S, Smith, RA, Bhattacharya, SK, Carbone, L, Faccio, R, Kang, AH, Ballou, LR. The isozyme-specific effects of cyclooxygenase-deficiency on bone in mice. Bone, 39 (5), 1048-52, 2006.
  51. Laguardia, SP, Dockery, BK, Bhattacharya, SK, Nelson, MD, Carbone, LD, Weber, KT. Secondary hyperparathyroidism and hypovitaminosis D in African-Americans with decompensated heart failure. Am J Med Sci, 332 (3), 112-8, 2006.
  52. Goodwin, KD, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements. Am J Med Sci, 332 (2), 73-8, 2006.
  53. Sun, Y, Ahokas, RA, Bhattacharya, SK, Gerling, IC, Carbone, LD, Weber, KT. Oxidative stress in aldosteronism. Cardiovasc Res, 71 (2), 300-9, 2006.
  54. Bhattacharya, SK, Ahokas, RA, Carbone, LD, Newman, KP, Gerling, IC, Sun, Y, Weber, KT. Macro- and micronutrients in African-Americans with heart failure. Heart Fail Rev, 11 (1), 45-55, 2006.
  55. Weber KT, Sun Y, Bhattacharya SK, Ahokas RA, Gerling IC. Remodeling of the cardiac interstitium in heart failure. In: Greenberg BH, Hosenpud JD, eds. Congestive Heart Failure. 3rd ed. Philadelphia: Lippincott, Williams & Wilkins, 147-166, 2006.
  56. Vidal, A, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, Weber, KT. Calcium paradox of aldosteronism and the role of the parathyroid glands. Am J Physiol Heart Circ Physiol, 290 (1), H286-94, 2006.
  57. Runyan, AL, Sun, Y, Bhattacharya, SK, Ahokas, RA, Chhokar, VS, Gerling, IC, Weber, KT. Responses in extracellular and intracellular calcium and magnesium in aldosteronism. J Lab Clin Med, 146 (2), 76-84, 2005.
  58. Runyan, AL, Chhokar, VS, Sun, Y, Bhattacharya, SK, Runyan, JW, Weber, KT. Bone loss in rats with aldosteronism. Am J Med Sci, 330 (1), 1-7, 2005.
  59. Law, PH, Sun, Y, Bhattacharya, SK, Chhokar, VS, Weber, KT. Diuretics and bone loss in rats with aldosteronism. J Am Coll Cardiol, 46 (1), 142-6, 2005.
  60. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation, 111 (7), 871-8, 2005.
  61. Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cells. Circulation, 111 (1), 51-7, 2005.
  62. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Loss of bone minerals and strength in rats with aldosteronism. Am J Physiol Heart Circ Physiol, 287 (5), H2023-6, 2004.
  63. Lu Y, Beheshti B, Zhang J, Squire JA, Yang XJj, Gu W, Bhattacharya SK, Jennings LK. Characterization of a novel apoptosis-inducing gene in prostate cancer. In: Lucas JN, ed. Progress in Prostate Cancer Research. New York: Nova Science Publishers, 23-50, 2004.
  64. Ahokas, RA, Warrington, KJ, Gerling, IC, Sun, Y, Wodi, LA, Herring, PA, Lu, L, Bhattacharya, SK, Postlethwaite, AE, Weber, KT. Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface. Circ Res, 93 (10), e124-35, 2003.
  65. Gerling, IC, Sun, Y, Ahokas, RA, Wodi, LA, Bhattacharya, SK, Warrington, KJ, Postlethwaite, AE, Weber, KT. Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotype. Am J Physiol Heart Circ Physiol, 285 (2), H813-21, 2003.
  66. Kuo, TH, Zhu, L, Golden, K, Marsh, JD, Bhattacharya, SK, Liu, BF. Altered Ca2+ homeostasis and impaired mitochondrial function in cardiomyopathy. Mol Cell Biochem, 238 (1-2), 119-27, 2002.
  67. Roy, ME, Nishimoto, SK, Rho, JY, Bhattacharya, SK, Pharr, GM. The distribution of osteocalcin, degree of mineralization, and mechanical properties along the length of Cyprinus carpio rib bone. J Mater Sci Mater Med, 12 (8), 699-702, 2001.
  68. Roy, ME, Nishimoto, SK, Rho, JY, Bhattacharya, SK, Lin, JS, Pharr, GM. Correlations between osteocalcin content, degree of mineralization, and mechanical properties of C. carpio rib bone. J Biomed Mater Res, 54 (4), 547-53, 2001.
  69. Bhattacharyya, S, Ghosh, S, Jhonson, PL, Bhattacharya, SK, Majumdar, S. Immunomodulatory role of interleukin-10 in visceral leishmaniasis: defective activation of protein kinase C-mediated signal transduction events. Infect Immun, 69 (3), 1499-507, 2001.
  70. Bhattacharya, SK, Johnson, PL, Thakar, JH. Reversal of impaired oxidative phosphorylation and calcium overloading in the skeletal muscle mitochondria of CHF-146 dystrophic hamsters. Mol Chem Neuropathol, 34 (1), 53-77, 1998.
  71. Bhattacharya, SK, Johnson, PL, Li, HJ, Handa, RK, Adamec, TA. Reduced sarcolemmal dystrophin distribution and upregulation of utrophin in the cardiac and skeletal muscles of CHF-146 dystrophic hamsters. Mol Chem Neuropathol, 31 (2), 187-206, 1997.
  72. Sacks, GS, Brown, RO, Dickerson, RN, Bhattacharya, S, Lee, PD, Mowatt-Larssen, C, Ilardi, G, Kudsk, KA. Mononuclear blood cell magnesium content and serum magnesium concentration in critically ill hypomagnesemic patients after replacement therapy. Nutrition, 13 (4), 303-8, 1997.
  73. McNally, EM, Bönnemann, CG, Kunkel, LM, Bhattacharya, SK. Deficiency of adhalin in a patient with muscular dystrophy and cardiomyopathy. N Engl J Med, 334 (24), 1610-1, 1996.
  74. Bhattacharya, SK, Johnson, PL, Thakar, JH. Reversal of impaired oxidative phosphorylation and calcium overloading in the in vitro cardiac mitochondria of CHF-146 dystrophic hamsters with hereditary muscular dystrophy. J Neurol Sci, 120 (2), 180-6, 1993.
  75. Johnson, PL, Bhattacharya, SK. Regulation of membrane-mediated chronic muscle degeneration in dystrophic hamsters by calcium-channel blockers: diltiazem, nifedipine and verapamil. J Neurol Sci, 115 (1), 76-90, 1993.
  76. Bhattacharya, SK, Thakar, JH, Johnson, PL, Shanklin, DR. Isolation of skeletal muscle mitochondria from hamsters using an ionic medium containing ethylenediaminetetraacetic acid and nagarse. Anal Biochem, 192 (2), 344-9, 1991.
  77. Palmieri GMA, Hinton AB, Bertorini TE, Bhattacharya SK, Nutting DF. Muscle calcium accumulation in muscular dystrophy. In: Bader H, Gietzen K, Rosenthal J, Rudel R, Wolf HU, eds. Intracellular Calcium Regulation. Manchester, UK; Manchester University Press, 335-347, 1989.
  78. Bhattacharya SK, Crawford AJ, Thakar JH, Johnson PL. Pathogenetic roles of intracellular calcium and magnesium in membrane-mediated progressive muscle degeneration in Duchenne muscular dystrophy. In: Fiskum G, ed. Proceedings of the VII International Symposium on Cell Calcium Metabolism 1987 - Physiology, Biochemistry, Pharmacology & Clinical Implications. New York: Plenum Press, 513-525, 1989.
  79. Bhattacharya, SK, Crawford, AJ, Pate, JW, Clemens, MG, Chaudry, IH. Mechanism of calcium and magnesium translocation in acute pancreatitis: a temporal correlation between hypocalcemia and membrane-mediated excessive intracellular calcium accumulation in soft tissues. Magnesium, 7 (2), 91-102, 1988.
  80. Falbe, WJ, Brown, RO, Luther, RW, Bhattacharya, SK, Crawford, AJ. Individualized manganese supplementation in patients receiving total parenteral nutrition. Clin Pharm, 6 (3), 226-9, 1987.
  81. Crawford, AJ, Bhattacharya, SK. Excessive intracellular zinc accumulation in cardiac and skeletal muscles of dystrophic hamsters. Exp Neurol, 95 (2), 265-76, 1987.
  82. Bhattacharya, SK, Crawford, AJ, Pate, JW. Electrocardiographic, biochemical, and morphologic abnormalities in dystrophic hamsters with cardiomyopathy. Muscle Nerve, 10 (2), 168-76, 1987.
  83. Burruss, GL, Van Voorst, SJ, Crawford, AJ, Bhattacharya, SK. Small bowel obstruction from an antacid bezoar: a ranitidine-antacid interaction. South Med J, 79 (7), 917-8, 1986.
  84. Williams, JW, Vera, SR, Peters, TG, Luther, RW, Bhattacharya, S, Spears, H, Graham, A, Pitcock, JA, Crawford, AJ, Palmieri, GM. Biliary excretion of aluminum in aluminum osteodystrophy with liver disease. Ann Intern Med, 104 (6), 782-5, 1986.
  85. Bhattacharya, SK, Luther, RW, Pate, JW, Crawford, AJ, Moore, OF, Pitcock, JA, Palmieri, GM, Britt, LG. Soft tissue calcium and magnesium content in acute pancreatitis in the dog: calcium accumulation, a mechanism for hypocalcemia in acute pancreatitis. J Lab Clin Med, 105 (4), 422-7, 1985.
  86. Bhattacharya, SK, Crawford, AJ. Are cytoplasmic calcium concentrations increased in Duchenne myofibers. Neurology, 35 (4), 617-8, 1985.
  87. Bertorini, TE, Cornelio, F, Bhattacharya, SK, Palmieri, GM, Dones, I, Dworzak, F, Brambati, B. Calcium and magnesium content in fetuses at risk and prenecrotic Duchenne muscular dystrophy. Neurology, 34 (11), 1436-40, 1984.
  88. Bhattacharya, SK, Goodwin, TG, Crawford, AJ. Submicro determination of copper and zinc in needle biopsy-sized cardiac and skeletal muscles by atomic absorption spectroscopy using stoichiometric air-acetylene flame. Analytical Letters - Clinical and Biochemical Analysis, 17 (B14), 1567-1591, 1984.
  89. Bertorini, TE, Bhattacharya, SK, Palmieri, GM, Chesney, CM, Pifer, D, Baker, B. Muscle calcium and magnesium content in Duchenne muscular dystrophy. Neurology, 32 (10), 1088-92, 1982.
  90. Bhattacharya, SK, Palmieri, GM, Bertorini, TE, Nutting, DF. The effects of diltiazem in dystrophic hamsters. Muscle Nerve, 5 (1), 73-8, 1982.
  91. Palmieri, GM, Nutting, DF, Bhattacharya, SK, Bertorini, TE, Williams, JC. Parathyroid ablation in dystrophic hamsters. Effects on Ca content and histology of heart, diaphragm, and rectus femoris. J Clin Invest, 68 (3), 646-54, 1981.
  92. Bhattacharya, SK, Williams, JC. Modified method of urinary calcium and magnesium determinations by atomic absorption spectrophotometry using nitrous oxide-acetylene flame. Analytical Letters - Clinical and Biochemical Analysis, 12 (B4), 397-414, 1979.
  93. Bhattacharya, SK, Williams, JC, Palmieri, GMA. Determination of calcium and magnesium in cardiac and skeletal muscle by atomic absorption spectroscopy using stoichiometric nitrous oxide-acetylene flame. Analytical Letters - Clinical and Biochemical Analysis, 12 (B14), 1451-1475, 1979.
  94. Bhattacharya, SK. Simultaneous determination of calcium and magnesium in human blood serum by atomic absorption spectrophotometer. Analytical Letters, 10 (11), 817-830, 1977.