Syamal K. Bhattacharya, PhD

Professor of Medicine, Surgery and Neurology
Executive Director, NIH-Sponsored Medical Students Research Program

Office: B318 Coleman College Of Medicine Building
Tel: (901) 448-5676
sbhattachary@uthsc.edu

Research Interests

Molecular pathogenesis and therapeutic strategies in membrane-mediated cellular degeneration in cardiovascular and neuromuscular diseases, with a special emphasis on excessive intracellular calcium accumulation, mitochondrial pathophysiology, cellular energetics and cell death. Mechanism and regulation of intrinsically coupled calcium and zinc dyshomeostasis in aldosteronism with accompanying oxidative stress and cardiac remodeling by calcium channel blockers, calcitropic hormones, aldosterone receptor blockers and antioxidants. Application of atomic spectroscopy in medicine. Roles of macro- and micronutrients in congestive heart failure, hypertensive heart disease, chronic metabolic disorders, morbid obesity, organ transplantation, thermal injuries and trauma. Trace mineral toxicities and deficiencies in human health and diseases.

Biographical Information

Dr. Bhattacharya is a tenured Professor of Medicine (Cardiovascular), holds joint appointments as a Professor of Surgery, Professor of Neurology (Neuromuscular), and Professor of Pharmaceutical Sciences, and has been the Founding Director of the Chemistry and Nutrient Data Output (CAN-DO) Laboratory since 1982, Director of the Surgical Research Laboratories (1982-2003), and Executive Director of the NIH-Sponsored Medical Students Research Fellowship Program at the University of Tennessee Health Science Center (UTHSC). Dr. Bhattacharya provided extensive patient care service to 16 local, regional and national hospitals and clinical laboratories (1982-2003) as an exclusive consultant in special chemistry (trace minerals/vitamins) and surgical pathology. He is also an Adjunct Professor of Biomedical Engineering at the University of Memphis, and served as an Adjunct Professor of Surgery (1988-98) at New York Medical College, Associate Professor of Anatomy & Neurobiology (1988-97) at the UTHSC, and R & D Chemist in Bombay (1970-74). Dr. Bhattacharya received his B.Sc. Honors degree in chemistry from the University of Calcutta, M.S. in physical chemistry from Murray State University, A.M. in nuclear chemistry from Washington University in St. Louis, and Ph.D. in bioanalytical chemistry from the University of Memphis, with a focus on atomic spectroscopy. He was a recipient of an Indian National Merit Scholarship, and National Research Service Award from the NIH for his work in neuromuscular diseases. Dr. Bhattacharya spent sabbaticals as a Visiting Scholar in Neonatology at Washington University School of Medicine (1976-77), Visiting Scholar in Cardiothoracic Surgery at Yale in 1985, Visiting Professor of Physiology at UCLA in 1986, Visiting Professor of Pediatric Surgery at the Johns Hopkins in 1987, and Visiting Professor of Microbiology at the Bose Institute, Calcutta, in 1999 and 2001. Dr. Bhattacharya served as a member on the Board of Directors and later as a Commissioner on the National Certification Commission in Chemistry & Chemical Engineering (1983-95), and on the Board of Directors and later as the Vice-President and President of the National Registry in Clinical Chemistry (1991-2000), both are credentialing bodies in the USA and Canada; and on the Pathology-A Study Section (1993-96) at the NIH. Since 1979, Dr. Bhattacharya’s research has been supported by numerous funding agencies, including NIH, MDA, AHA and Varian Techtron Ltd, Melbourne, Australia. He has trained and mentored more than 80 graduate and medical students, pre- and post-doctoral research fellows, medical residents and clinical fellows, as well as junior faculty members. Many of his trainees have distinguished themselves being outstanding clinicians, scientists and mentors.

Publications

  1. Kamalov, G, Bhattacharya, SK, Weber, KT. Congestive heart failure: where homeostasis begets dyshomeostasis. J Cardiovasc Pharmacol, 56 (3), 320-8, 2010.
  2. Zia, AA, Kamalov, G, Newman, KP, McGee, JE, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. From aldosteronism to oxidative stress: the role of excessive intracellular calcium accumulation. Hypertens Res, 2010.
  3. Shahbaz, AU, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, McGee, JE, Weber, KT. Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. J Hypertens, 28 Suppl 1, S25-32, 2010.
  4. Gandhi, MS, Kamalov, G, Shahbaz, AU, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Cellular and molecular pathways to myocardial necrosis and replacement fibrosis. Heart Fail Rev, 2010.
  5. Kamalov, G, Ahokas, RA, Zhao, W, Zhao, T, Shahbaz, AU, Johnson, PL, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Uncoupling the coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria seen in aldosteronism. J Cardiovasc Pharmacol, 55 (3), 248-54, 2010.
  6. Kamalov, G, Ahokas, RA, Zhao, W, Shahbaz, AU, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. Am J Physiol Heart Circ Physiol, 298 (2), H385-94, 2010.
  7. Shook, MS, Zafarullah, H, Nelson, MD, Bhattacharya, SK, Davis, RC, Newman, KP, Weber, KT. Normoglycemia in nondiabetic African Americans hospitalized with heart failure. Am J Med Sci, 338 (4), 255-8, 2009.
  8. Kamalov, G, Holewinski, JP, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Nutrient dyshomeostasis in congestive heart failure. Am J Med Sci, 338 (1), 28-33, 2009.
  9. Kamalov, G, Deshmukh, PA, Baburyan, NY, Gandhi, MS, Johnson, PL, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. J Cardiovasc Pharmacol, 53 (5), 414-23, 2009.
  10. Dishmon, DA, Dotson, JL, Munir, A, Nelson, MD, Bhattacharya, SK, D'Cruz, IA, Davis, RC, Weber, KT. Hypovitaminosis D and Valvular Calcification in Patients With Dilated Cardiomyopathy. Am J Med Sci, 2009.
  11. Brown, RO, Morgan, LM, Bhattacharya, SK, Johnson, PL, Minard, G, Dickerson, RN. Potential aluminum exposure from parenteral nutrition in patients with acute kidney injury. Ann Pharmacother, 42 (10), 1410-5, 2008.
  12. Gandhi, MS, Deshmukh, PA, Kamalov, G, Zhao, T, Zhao, W, Whaley, JT, Tichy, JR, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism. J Cardiovasc Pharmacol, 52 (3), 245-52, 2008.
  13. Carbone, LD, Rosenberg, EW, Tolley, EA, Holick, MF, Hughes, TA, Watsky, MA, Barrow, KD, Chen, TC, Wilkin, NK, Bhattacharya, SK, Dowdy, JC, Sayre, RM, Weber, KT. 25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation. Metabolism, 57 (6), 741-8, 2008.
  14. Selektor, Y, Parker, RB, Sun, Y, Zhao, W, Bhattacharya, SK, Weber, KT. Tissue 65Zinc Translocation in a Rat Model of Chronic Aldosteronism. J Cardiovasc Pharmacol, 51 (4), 359-364, 2008.
  15. Selektor, Y, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism. Am J Med Sci, 335 (2), 105-10, 2008.
  16. Newman, KP, Bhattacharya, SK, Munir, A, Davis, RC, Soberman, JE, Ramanathan, KB. Macro- and micronutrients in patients with congestive heart failure, particularly African-Americans. Vasc Health Risk Manag, 3 (5), 743-7, 2007.
  17. Alsafwah, S, Laguardia, SP, Arroyo, M, Dockery, BK, Bhattacharya, SK, Ahokas, RA, Newman, KP. Congestive heart failure is a systemic illness: a role for minerals and micronutrients. Clin Med Res, 5 (4), 238-43, 2007.
  18. Thomas, M, Vidal, A, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone. Am J Physiol Heart Circ Physiol, 293 (4), H2361-6, 2007.
  19. Newman, KP, Neal, MT, Roberts, M, Goodwin, KD, Hatcher, EA, Bhattacharya, SK. The importance of lost minerals in heart failure. Cardiovasc Hematol Agents Med Chem, 5 (4), 295-9, 2007.
  20. Arroyo, M, Laguardia, SP, Bhattacharya, SK, Nelson, MD, Johnson, PL, Carbone, LD, Newman, KP, Weber, KT. Micronutrients in African-Americans with decompensated and compensated heart failure. Transl Res, 148 (6), 301-8, 2006.
  21. Myers, LK, Bhattacharya, SD, Herring, PA, Xing, Z, Goorha, S, Smith, RA, Bhattacharya, SK, Carbone, L, Faccio, R, Kang, AH, Ballou, LR. The isozyme-specific effects of cyclooxygenase-deficiency on bone in mice. Bone, 39 (5), 1048-52, 2006.
  22. Laguardia, SP, Dockery, BK, Bhattacharya, SK, Nelson, MD, Carbone, LD, Weber, KT. Secondary hyperparathyroidism and hypovitaminosis D in African-Americans with decompensated heart failure. Am J Med Sci, 332 (3), 112-8, 2006.
  23. Goodwin, KD, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements. Am J Med Sci, 332 (2), 73-8, 2006.
  24. Sun, Y, Ahokas, RA, Bhattacharya, SK, Gerling, IC, Carbone, LD, Weber, KT. Oxidative stress in aldosteronism. Cardiovasc Res, 71 (2), 300-9, 2006.
  25. Bhattacharya, SK, Ahokas, RA, Carbone, LD, Newman, KP, Gerling, IC, Sun, Y, Weber, KT. Macro- and micronutrients in African-Americans with heart failure. Heart Fail Rev, 11 (1), 45-55, 2006.
  26. Weber KT, Sun Y, Bhattacharya SK, Ahokas RA, Gerling IC. Remodeling of the cardiac interstitium in heart failure. In: Greenberg BH, Hosenpud JD, eds. Congestive Heart Failure. 3rd ed. Philadelphia: Lippincott, Williams & Wilkins, 147-166, 2006.
  27. Vidal, A, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, Weber, KT. Calcium paradox of aldosteronism and the role of the parathyroid glands. Am J Physiol Heart Circ Physiol, 290 (1), H286-94, 2006.
  28. Runyan, AL, Sun, Y, Bhattacharya, SK, Ahokas, RA, Chhokar, VS, Gerling, IC, Weber, KT. Responses in extracellular and intracellular calcium and magnesium in aldosteronism. J Lab Clin Med, 146 (2), 76-84, 2005.
  29. Runyan, AL, Chhokar, VS, Sun, Y, Bhattacharya, SK, Runyan, JW, Weber, KT. Bone loss in rats with aldosteronism. Am J Med Sci, 330 (1), 1-7, 2005.
  30. Law, PH, Sun, Y, Bhattacharya, SK, Chhokar, VS, Weber, KT. Diuretics and bone loss in rats with aldosteronism. J Am Coll Cardiol, 46 (1), 142-6, 2005.
  31. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation, 111 (7), 871-8, 2005.
  32. Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cells. Circulation, 111 (1), 51-7, 2005.
  33. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Loss of bone minerals and strength in rats with aldosteronism. Am J Physiol Heart Circ Physiol, 287 (5), H2023-6, 2004.
  34. Lu Y, Beheshti B, Zhang J, Squire JA, Yang XJj, Gu W, Bhattacharya SK, Jennings LK. Characterization of a novel apoptosis-inducing gene in prostate cancer. In: Lucas JN, ed. Progress in Prostate Cancer Research. New York: Nova Science Publishers, 23-50, 2004.
  35. Ahokas, RA, Warrington, KJ, Gerling, IC, Sun, Y, Wodi, LA, Herring, PA, Lu, L, Bhattacharya, SK, Postlethwaite, AE, Weber, KT. Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface. Circ Res, 93 (10), e124-35, 2003.
  36. Gerling, IC, Sun, Y, Ahokas, RA, Wodi, LA, Bhattacharya, SK, Warrington, KJ, Postlethwaite, AE, Weber, KT. Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotype. Am J Physiol Heart Circ Physiol, 285 (2), H813-21, 2003.
  37. Roy, ME, Nishimoto, SK, Rho, JY, Bhattacharya, SK, Pharr, GM. The distribution of osteocalcin, degree of mineralization, and mechanical properties along the length of Cyprinus carpio rib bone. J Mater Sci Mater Med, 12 (8), 699-702, 2001.
  38. Roy, ME, Nishimoto, SK, Rho, JY, Bhattacharya, SK, Lin, JS, Pharr, GM. Correlations between osteocalcin content, degree of mineralization, and mechanical properties of C. carpio rib bone. J Biomed Mater Res, 54 (4), 547-53, 2001.
  39. Bhattacharya, SK, Johnson, PL, Thakar, JH. Reversal of impaired oxidative phosphorylation and calcium overloading in the skeletal muscle mitochondria of CHF-146 dystrophic hamsters. Mol Chem Neuropathol, 34 (1), 53-77, 1998.
  40. Bhattacharya, SK, Johnson, PL, Li, HJ, Handa, RK, Adamec, TA. Reduced sarcolemmal dystrophin distribution and upregulation of utrophin in the cardiac and skeletal muscles of CHF-146 dystrophic hamsters. Mol Chem Neuropathol, 31 (2), 187-206, 1997.
  41. Bhattacharya, SK, Johnson, PL, Thakar, JH. Reversal of impaired oxidative phosphorylation and calcium overloading in the in vitro cardiac mitochondria of CHF-146 dystrophic hamsters with hereditary muscular dystrophy. J Neurol Sci, 120 (2), 180-6, 1993.
  42. Johnson, PL, Bhattacharya, SK. Regulation of membrane-mediated chronic muscle degeneration in dystrophic hamsters by calcium-channel blockers: diltiazem, nifedipine and verapamil. J Neurol Sci, 115 (1), 76-90, 1993.
  43. Bhattacharya, SK, Thakar, JH, Johnson, PL, Shanklin, DR. Isolation of skeletal muscle mitochondria from hamsters using an ionic medium containing ethylenediaminetetraacetic acid and nagarse. Anal Biochem, 192 (2), 344-9, 1991.
  44. Bhattacharya SK, Crawford AJ, Thakar JH, Johnson PL. Pathogenetic roles of intracellular calcium and magnesium in membrane-mediated progressive muscle degeneration in Duchenne muscular dystrophy. In: Fiskum G, ed. Proceedings of the VII International Symposium on Cell Calcium Metabolism 1987 - Physiology, Biochemistry, Pharmacology & Clinical Implications. New York: Plenum Press, 513-525, 1989.
  45. Palmieri GMA, Hinton AB, Bertorini TE, Bhattacharya SK, Nutting DF. Muscle calcium accumulation in muscular dystrophy. In: Bader H, Gietzen K, Rosenthal J, Rudel R, Wolf HU, eds. Intracellular Calcium Regulation. Manchester, UK: Manchester University Press, 335-347, 1989.
  46. Bhattacharya, SK, Crawford, AJ, Pate, JW, Clemens, MG, Chaudry, IH. Mechanism of calcium and magnesium translocation in acute pancreatitis: a temporal correlation between hypocalcemia and membrane-mediated excessive intracellular calcium accumulation in soft tissues. Magnesium, 7 (2), 91-102, 1988.