SARKA BERANOVA-GIORGIANNI, Ph.D.

Associate Professor
Pharmaceutical Sciences
 
Assistant Professor
Neurology

Office: 445 PHARMACY BUILDING
881 MADISON AVENUE
MEMPHIS TN 381630000
Tel: (901) 448-5433
sberanova@uthsc.edu

Education

  • Ph.D., University of Akron, Akron, Ohio, Analytical chemistry
  • M.S., Prague Institute of Chemical Technology, Prague, Czechoslovakia, Organic chemistry

Research Keywords

 bioanalytical chemistry; mass spectrometry; proteomics; phosphoproteomics

Research Interest/Specialty

Bioanalytical chemistry; biological mass spectrometry; qualitative and quantitative proteomics; targeted protein and phosphoprotein identification/characterization.

Research Description

  • Mitochondrial proteomics and heart disease
  • Phosphoproteomics of the mammalian pituitary
  • High-sensitivity phosphoprotein characterization
  • Design and development of new and improved analytical platforms for proteomics.

Publications

  1. Dong, Q, Giorgianni, F, Deng, X, Beranova-Giorgianni, S, Bridges, D, Park, EA, Raghow, R, Elam, MB. Phosphorylation of sterol regulatory element binding protein-1a by protein kinase A (PKA) regulates transcriptional activity. Biochem Biophys Res Commun, 449 (4), 449-54, 2014.
  2. Giorgianni, F, Koirala, D, Weber, KT, Beranova-Giorgianni, S. Proteome analysis of subsarcolemmal cardiomyocyte mitochondria: a comparison of different analytical platforms. Int J Mol Sci, 15 (6), 9285-301, 2014.
  3. Giorgianni, F, Usman Khan, M, Weber, KT, Gerling, IC, Beranova-Giorgianni, S. Phosphoproteome mapping of cardiomyocyte mitochondria in a rat model of heart failure. Mol Cell Biochem, 389 (1-2), 159-67, 2014.
  4. Giorgianni, F, Kiorala, D, Beranova-Giorgianni, S.. Proteomics of the human pituitary: bioanalytical methods and applications. Bioanalysis, 2014.
  5. Giorgianni, F, Mileo, V, Desiderio, DM, Catinella, S, Beranova-Giorgianni, S. Characterization of the phosphoproteome in human bronchoalveolar lavage fluid. Int J Proteomics, 2012, 460261, 2012.
  6. Chen, L, Fang, B, Giorgianni, F, Gingrich, JR, Beranova-Giorgianni, S. Investigation of phosphoprotein signatures of archived prostate cancer tissue specimens via proteomic analysis. Electrophoresis, 32 (15), 1984-91, 2011.
  7. Bolen, AL, Naren, AP, Yarlagadda, S, Beranova-Giorgianni, S, Chen, L, Norman, D, Baker, DL, Rowland, MM, Best, MD, Sano, T, Tsukahara, T, Liliom, K, Igarashi, Y, Tigyi, G. The phospholipase A1 activity of lysophospholipase A-I links platelet activation to LPA production during blood coagulation. J Lipid Res, 52 (5), 958-70, 2011.
  8. Wang, X, Tong, Y, Giorgianni, F, Beranova-Giorgianni, S, Penn, JS, Jablonski, MM. Cellular retinol binding protein 1 modulates photoreceptor outer segment folding in the isolated eye. Dev Neurobiol, 70 (9), 623-35, 2010.
  9. Nookala, S, Gandrakota, R, Wohabrebbi, A, Wang, X, Howell, D, Giorgianni, F, Beranova-Giorgianni, S, Desiderio, DM, Jablonski, MM. In search of the identity of the XAP-1 antigen: a protein localized to cone outer segments. Invest Ophthalmol Vis Sci, 51 (5), 2736-43, 2010.
  10. Chen, L, Giorgianni, F, Beranova-Giorgianni, S. Characterization of the phosphoproteome in LNCaP prostate cancer cells by in-gel isoelectric focusing and tandem mass spectrometry. J Proteome Res, 9 (1), 174-8, 2010.
  11. Beranova-Giorgianni, S, Desiderio, DM, Giorgianni, F. Phosphoproteome analysis by in-gel isoelectric focusing and tandem mass spectrometry. Methods Mol Biol, 519, 383-96, 2009.
  12. Wang, X, Nookala, S, Narayanan, C, Giorgianni, F, Beranova-Giorgianni, S, McCollum, G, Gerling, I, Penn, JS, Jablonski, MM. Proteomic analysis of the retina: removal of RPE alters outer segment assembly and retinal protein expression. Glia, 57 (4), 380-92, 2009.
  13. Pabst, MJ, Pabst, KM, Handsman, DB, Beranova-Giorgianni, S, Giorgianni, F. Proteome of monocyte priming by lipopolysaccharide, including changes in interleukin-1beta and leukocyte elastase inhibitor. Proteome Sci, 6, 13, 2007.
  14. Giorgianni, F, Zhao, Y, Desiderio, DM, Beranova-Giorgianni, S. Toward a global characterization of the phosphoproteome in prostate cancer cells: identification of phosphoproteins in the LNCaP cell line. Electrophoresis, 28 (12), 2027-34, 2007.
  15. Beranova-Giorgianni, S, Zhao, Y, Desiderio, DM, Giorgianni, F. Phosphoproteomic analysis of the human pituitary. Pituitary, 9 (2), 109-20, 2006.
  16. Zhao, Y, Giorgianni, F, Desiderio, DM, Fang, B, Beranova-Giorgianni, S. Toward a global analysis of the human pituitary proteome by multiple gel-based technology. Anal Chem, 77 (16), 5324-31, 2005.
  17. Giorgianni, F, Cappiello, A, Beranova-Giorgianni, S, Palma, P, Trufelli, H, Desiderio, DM. LC-MS/MS analysis of peptides with methanol as organic modifier: improved limits of detection. Anal Chem, 76 (23), 7028-38, 2004.
  18. Giorgianni, F, Beranova-Giorgianni, S, Desiderio, DM. Identification and characterization of phosphorylated proteins in the human pituitary. Proteomics, 4 (3), 587-98, 2004.
  19. Gadgil, HS, Pabst, KM, Giorgianni, F, Umstot, ES, Desiderio, DM, Beranova-Giorgianni, S, Gerling, IC, Pabst, MJ. Proteome of monocytes primed with lipopolysaccharide: analysis of the abundant proteins. Proteomics, 3 (9), 1767-80, 2003.
  20. Giorgianni, F, Desiderio, DM, Beranova-Giorgianni, S. Proteome analysis using isoelectric focusing in immobilized pH gradient gels followed by mass spectrometry. Electrophoresis, 24 (1-2), 253-9, 2003.
  21. Beranova-Giorgianni, S, Giorgianni, F, Desiderio, DM. Analysis of the proteome in the human pituitary. Proteomics, 2 (5), 534-42, 2002.