SUZANNE J. BAKER, Ph.D., B.S.

Professor
Pathology

Office: D2006 ST JUDE CHILDREN'S RESEARCH HOSPITAL
332 NORTH LAUDERDALE STREET
MEMPHIS TN 381050000
Tel: (901) 495-2254
sbaker6@uthsc.edu

Publications

  1. Frappart, PO, Lee, Y, Russell, HR, Chalhoub, N, Wang, YD, Orii, KE, Zhao, J, Kondo, N, Baker, SJ, McKinnon, PJ. Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A, 106 (6), 1880-5, 2009.
  2. Broniscer, A, Baker, SJ, Stewart, CF, Merchant, TE, Laningham, FH, Schaiquevich, P, Kocak, M, Morris, EB, Endersby, R, Ellison, DW, Gajjar, A. Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma. Clin Cancer Res, 15 (2), 701-7, 2009.
  3. Chow, LM, Zhang, J, Baker, SJ. Inducible Cre recombinase activity in mouse mature astrocytes and adult neural precursor cells. Transgenic Res, 17 (5), 919-28, 2008.
  4. Endersby, R, Baker, SJ. PTEN signaling in brain: neuropathology and tumorigenesis. Oncogene, 27 (41), 5416-30, 2008.
  5. Chalhoub, N, Baker, SJ. PTEN and the PI3-Kinase Pathway in Cancer. Annu Rev Pathol, 2008.
  6. Fraser, MM, Bayazitov, IT, Zakharenko, SS, Baker, SJ. Phosphatase and tensin homolog, deleted on chromosome 10 deficiency in brain causes defects in synaptic structure, transmission and plasticity, and myelination abnormalities. Neuroscience, 151 (2), 476-88, 2008.
  7. Weber, T, Corbett, MK, Chow, LM, Valentine, MB, Baker, SJ, Zuo, J. Rapid cell-cycle reentry and cell death after acute inactivation of the retinoblastoma gene product in postnatal cochlear hair cells. Proc Natl Acad Sci U S A, 105 (2), 781-5, 2008.
  8. Torchia, EC, Boyd, K, Rehg, JE, Qu, C, Baker, SJ. EWS/FLI-1 induces rapid onset of myeloid/erythroid leukemia in mice. Mol Cell Biol, 27 (22), 7918-34, 2007.
  9. Broniscer, A, Baker, SJ, West, AN, Fraser, MM, Proko, E, Kocak, M, Dalton, J, Zambetti, GP, Ellison, DW, Kun, LE, Gajjar, A, Gilbertson, RJ, Fuller, CE. Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol, 25 (6), 682-9, 2007.
  10. Baker, SJ. PTEN enters the nuclear age. Cell, 128 (1), 25-8, 2007.
  11. Chow, LM, Tian, Y, Weber, T, Corbett, M, Zuo, J, Baker, SJ. Inducible Cre recombinase activity in mouse cerebellar granule cell precursors and inner ear hair cells. Dev Dyn, 235 (11), 2991-8, 2006.
  12. Chow, LM, Baker, SJ. PTEN function in normal and neoplastic growth. Cancer Lett, 241 (2), 184-96, 2006.
  13. Chalhoub, N, Kozma, SC, Baker, SJ. S6k1 is not required for Pten-deficient neuronal hypertrophy. Brain Res, 1100 (1), 32-41, 2006.
  14. Fraser, MM, Zhu, X, Kwon, CH, Uhlmann, EJ, Gutmann, DH, Baker, SJ. Pten loss causes hypertrophy and increased proliferation of astrocytes in vivo. Cancer Res, 64 (21), 7773-9, 2004.
  15. Yang, CH, Murti, A, Baker, SJ, Frangou-Lazaridis, M, Vartapetian, AB, Murti, KG, Pfeffer, LM. Interferon induces the interaction of prothymosin-alpha with STAT3 and results in the nuclear translocation of the complex. Exp Cell Res, 298 (1), 197-206, 2004.
  16. Baker, SJ, McKinnon, PJ. Tumour-suppressor function in the nervous system. Nat Rev Cancer, 4 (3), 184-96, 2004.
  17. Baker, SJ, Kinzler, KW, Vogelstein, B. Knudson's hypothesis and the TP53 revolution. Genes Chromosomes Cancer, 38 (4), 329, 2003.
  18. Kwon, CH, Zhu, X, Zhang, J, Baker, SJ. mTor is required for hypertrophy of Pten-deficient neuronal soma in vivo. Proc Natl Acad Sci U S A, 100 (22), 12923-8, 2003.
  19. Torchia, EC, Jaishankar, S, Baker, SJ. Ewing tumor fusion proteins block the differentiation of pluripotent marrow stromal cells. Cancer Res, 63 (13), 3464-8, 2003.
  20. Baker, SJ. Redefining p53--entering the tumor suppressor era. Cell Cycle, 2 (1), 7-8, 2003.
  21. Kwon, CH, Zhu, X, Zhang, J, Knoop, LL, Tharp, R, Smeyne, RJ, Eberhart, CG, Burger, PC, Baker, SJ. Pten regulates neuronal soma size: a mouse model of Lhermitte-Duclos disease. Nat Genet, 29 (4), 404-11, 2001.
  22. Zhu, X, Kwon, CH, Schlosshauer, PW, Ellenson, LH, Baker, SJ. PTEN induces G(1) cell cycle arrest and decreases cyclin D3 levels in endometrial carcinoma cells. Cancer Res, 61 (11), 4569-75, 2001.
  23. Knoop, LL, Baker, SJ. EWS/FLI alters 5'-splice site selection. J Biol Chem, 276 (25), 22317-22, 2001.
  24. Knoop, LL, Baker, SJ. The splicing factor U1C represses EWS/FLI-mediated transactivation. J Biol Chem, 275 (32), 24865-71, 2000.
  25. Jaishankar, S, Zhang, J, Roussel, MF, Baker, SJ. Transforming activity of EWS/FLI is not strictly dependent upon DNA-binding activity. Oncogene, 18 (40), 5592-7, 1999.