ROBERT J. WYATT, M.D., B.A.

Professor, Department of Pediatrics

Office: 301 Wpt Le Bonheur Children
Tel: (901) 287-5376
rwyatt@uthsc.edu

Education

  • M.S., University of Tennessee Health Science Center, Memphis, TN, Epidemiology
  • M.D., Medical College of Georgia, Medicine
  • B.A., Vanderbilt University, Nashville, TN, General Biology

Research interest/specialty

Pediatric Nephrology
Epidemiology

Research keywords

IgA nephropathy
Complement

Research interest/specialty

Pediatric Nephrology Epidemiology

Research keywords

IgA nephropathy Complement

Publications

  1. Eison, TM, Hastings, MC, Moldoveanu, Z, Sanders, JT, Gaber, L, Walker, PD, Lau, KK, Julian, BA, Novak, J, Wyatt, RJ. Association of IgG co-deposition with serum levels of galactose-deficient IgA1 in pediatric IgA nephropathy. Clin Nephrol, 78 (6), 465-9, 2012.
  2. Spencer, JD, Hastings, MC, Wyatt, RJ, Ault, BH. Has the incidence of childhood steroid sensitive nephrotic syndrome changed. Clin Nephrol, 78 (2), 112-5, 2012.
  3. Hastings, MC, Afshan, S, Sanders, JT, Kane, O, Eison, TM, Lau, KK, Moldoveanu, Z, Julian, BA, Novak, J, Wyatt, RJ. Serum galactose-deficient IgA1 level is not associated with proteinuria in children with IgA nephropathy. Int J Nephrol, 2012, 315467, 2012.
  4. Papeta, N, Kiryluk, K, Patel, A, Sterken, R, Kacak, N, Snyder, HJ, Imus, PH, Mhatre, AN, Lawani, AK, Julian, BA, Wyatt, RJ, Novak, J, Wyatt, CM, Ross, MJ, Winston, JA, Klotman, ME, Cohen, DJ, Appel, GB, D'Agati, VD, Klotman, PE, Gharavi, AG. APOL1 variants increase risk for FSGS and HIVAN but not IgA nephropathy. J Am Soc Nephrol, 22 (11), 1991-6, 2011.
  5. Novak, J, Raskova Kafkova, L, Suzuki, H, Tomana, M, Matousovic, K, Brown, R, Hall, S, Sanders, JT, Eison, TM, Moldoveanu, Z, Novak, L, Novak, Z, Mayne, R, Julian, BA, Mestecky, J, Wyatt, RJ. IgA1 immune complexes from pediatric patients with IgA nephropathy activate cultured human mesangial cells. Nephrol Dial Transplant, 26 (11), 3451-7, 2011.
  6. Suzuki, H, Kiryluk, K, Novak, J, Moldoveanu, Z, Herr, AB, Renfrow, MB, Wyatt, RJ, Scolari, F, Mestecky, J, Gharavi, AG, Julian, BA. The pathophysiology of IgA nephropathy. J Am Soc Nephrol, 22 (10), 1795-803, 2011.
  7. Novak, J, Moldoveanu, Z, Julian, BA, Raska, M, Wyatt, RJ, Suzuki, Y, Tomino, Y, Gharavi, AG, Mestecky, J, Suzuki, H. Aberrant glycosylation of IgA1 and anti-glycan antibodies in IgA nephropathy: role of mucosal immune system. Adv Otorhinolaryngol, 72, 60-3, 2011.
  8. Kiryluk, K, Moldoveanu, Z, Sanders, JT, Eison, TM, Suzuki, H, Julian, BA, Novak, J, Gharavi, AG, Wyatt, RJ. Aberrant glycosylation of IgA1 is inherited in both pediatric IgA nephropathy and Henoch-Schönlein purpura nephritis. Kidney Int, 80 (1), 79-87, 2011.
  9. Kiryluk, K, Julian, BA, Wyatt, RJ, Scolari, F, Zhang, H, Novak, J, Gharavi, AG. Genetic studies of IgA nephropathy: past, present, and future. Pediatr Nephrol, 25 (11), 2257-68, 2010.
  10. Hastings, MC, Moldoveanu, Z, Julian, BA, Novak, J, Sanders, JT, McGlothan, KR, Gharavi, AG, Wyatt, RJ. Galactose-Deficient IgA1 in African Americans with IgA Nephropathy: Serum Levels and Heritability. Clin J Am Soc Nephrol, 2010.
  11. Eison, TM, Ault, BH, Jones, DP, Chesney, RW, Wyatt, RJ. Post-streptococcal acute glomerulonephritis in children: clinical features and pathogenesis. Pediatr Nephrol, 2010.
  12. Lavigne, KA, Woodford, SY, Barker, CV, Julian, BA, Novak, J, Moldoveanu, Z, Gharavi, AG, Wyatt, RJ, ,. Familial IgA nephropathy in southeastern Kentucky. Clin Nephrol, 73 (2), 115-121, 2010.
  13. Lau, KK, Suzuki, H, Novak, J, Wyatt, RJ. Pathogenesis of Henoch-Schönlein purpura nephritis. Pediatr Nephrol, 25 (1), 19-26, 2010.
  14. Suzuki, H, Fan, R, Zhang, Z, Brown, R, Hall, S, Julian, BA, Chatham, WW, Suzuki, Y, Wyatt, RJ, Moldoveanu, Z, Lee, JY, Robinson, J, Tomana, M, Tomino, Y, Mestecky, J, Novak, J. Aberrantly glycosylated IgA1 in IgA nephropathy patients is recognized by IgG antibodies with restricted heterogeneity. J Clin Invest, 119 (6), 1668-77, 2009.
  15. Lau, KK, Yang, Y, Cook, GA, Wyatt, RJ, Nishimura, H. Control of aquaporin 2 expression in collecting ducts of quail kidneys. Gen Comp Endocrinol, 160 (3), 288-94, 2009.
  16. Sanders, JT, Wyatt, RJ. IgA nephropathy and Henoch-Schönlein purpura nephritis. Curr Opin Pediatr, 20 (2), 163-170, 2008.
  17. Suzuki, H, Moldoveanu, Z, Hall, S, Brown, R, Vu, HL, Novak, L, Julian, BA, Tomana, M, Wyatt, RJ, Edberg, JC, Alarcón, GS, Kimberly, RP, Tomino, Y, Mestecky, J, Novak, J. IgA1-secreting cell lines from patients with IgA nephropathy produce aberrantly glycosylated IgA1. J Clin Invest, 118 (2), 629-39, 2008.
  18. Gharavi, AG, Moldoveanu, Z, Wyatt, RJ, Barker, CV, Woodford, SY, Lifton, RP, Mestecky, J, Novak, J, Julian, BA. Aberrant IgA1 Glycosylation Is Inherited in Familial and Sporadic IgA Nephropathy. J Am Soc Nephrol, 2008.
  19. Lau, KK, Wyatt, RJ, Moldoveanu, Z, Tomana, M, Julian, BA, Hogg, RJ, Lee, JY, Huang, WQ, Mestecky, J, Novak, J. Serum levels of galactose-deficient IgA in children with IgA nephropathy and Henoch-Schönlein purpura. Pediatr Nephrol, 22 (12), 2067-72, 2007.
  20. Julian, BA, Wittke, S, Novak, J, Good, DM, Coon, JJ, Kellmann, M, Zürbig, P, Schiffer, E, Haubitz, M, Moldoveanu, Z, Calcatera, SM, Wyatt, RJ, Sýkora, J, Sládková, E, Hes, O, Mischak, H, McGuire, BM. Electrophoretic methods for analysis of urinary polypeptides in IgA-associated renal diseases. Electrophoresis, 28 (23), 4469-83, 2007.
  21. Julian, BA, Wittke, S, Haubitz, M, Zürbig, P, Schiffer, E, McGuire, BM, Wyatt, RJ, Novak, J. Urinary biomarkers of IgA nephropathy and other IgA-associated renal diseases. World J Urol, 25 (5), 467-76, 2007.
  22. Mestecky, J, Tomana, M, Moldoveanu, Z, Julian, BA, Suzuki, H, Matousovic, K, Renfrow, MB, Novak, L, Wyatt, RJ, Novak, J. Role of aberrant glycosylation of IgA1 molecules in the pathogenesis of IgA nephropathy. Kidney Blood Press Res, 31 (1), 29-37, 2007.
  23. Beerman, I, Novak, J, Wyatt, RJ, Julian, BA, Gharavi, AG. The genetics of IgA nephropathy. Nat Clin Pract Nephrol, 3 (6), 325-38, 2007.
  24. Moldoveanu, Z, Wyatt, RJ, Lee, JY, Tomana, M, Julian, BA, Mestecky, J, Huang, WQ, Anreddy, SR, Hall, S, Hastings, MC, Lau, KK, Cook, WJ, Novak, J. Patients with IgA nephropathy have increased serum galactose-deficient IgA1 levels. Kidney Int, 71 (11), 1148-54, 2007.
  25. Raska, M, Moldoveanu, Z, Suzuki, H, Brown, R, Kulhavy, R, Andrasi, J, Hall, S, Vu, HL, Carlsson, F, Lindahl, G, Tomana, M, Julian, BA, Wyatt, RJ, Mestecky, J, Novak, J. Identification and characterization of CMP-NeuAc:GalNAc-IgA1 alpha2,6-sialyltransferase in IgA1-producing cells. J Mol Biol, 369 (1), 69-78, 2007.
  26. Novak, J, Moldoveanu, Z, Renfrow, MB, Yanagihara, T, Suzuki, H, Raska, M, Hall, S, Brown, R, Huang, WQ, Goepfert, A, Kilian, M, Poulsen, K, Tomana, M, Wyatt, RJ, Julian, BA, Mestecky, J. IgA nephropathy and Henoch-Schoenlein purpura nephritis: aberrant glycosylation of IgA1, formation of IgA1-containing immune complexes, and activation of mesangial cells. Contrib Nephrol, 157, 134-8, 2007.
  27. Suzuki, H, Moldoveanu, Z, Hall, S, Brown, R, Julian, BA, Wyatt, RJ, Tomana, M, Tomino, Y, Novak, J, Mestecky, J. IgA nephropathy: characterization of IgG antibodies specific for galactose-deficient IgA1. Contrib Nephrol, 157, 129-33, 2007.
  28. Julian, BA, Wyatt, RJ, Matousovic, K, Moldoveanu, Z, Mestecky, J, Novak, J. IgA nephropathy: a clinical overview. Contrib Nephrol, 157, 19-26, 2007.
  29. Hastings, MC, Wyatt, RJ, Ault, BH, Jones, DP, Lau, KK, Gaber, AO, Gaber, LW. Diagnosis of de novo localized thrombotic microangiopathy by surveillance biopsy. Pediatr Nephrol, 22 (5), 742-6, 2007.
  30. Hastings, MC, Delos Santos, NM, Wyatt, RJ. Renal survival in pediatric patients with IgA nephropathy. Pediatr Nephrol, 22 (2), 317-8, 2007.
  31. Colleen Hastings, M, Wyatt, RJ, Lau, KK, Jones, DP, Powell, SL, Hays, DW, Gaber, LW, Osama Gaber, A, Ault, BH. Five years' experience with thymoglobulin induction in a pediatric renal transplant population. Pediatr Transplant, 10 (7), 805-10, 2006.
  32. McGlothan, KR, Wyatt, RJ, Ault, BH, Hastings, MC, Rogers, T, DiSessa, T, Jones, DP. Predominance of nocturnal hypertension in pediatric renal allograft recipients. Pediatr Transplant, 10 (5), 558-64, 2006.
  33. Hogg, RJ, Lee, J, Nardelli, N, Julian, BA, Cattran, D, Waldo, B, Wyatt, R, Jennette, JC, Sibley, R, Hyland, K, Fitzgibbons, L, Hirschman, G, Donadio, JV, Holub, BJ, ,. Clinical trial to evaluate omega-3 fatty acids and alternate day prednisone in patients with IgA nephropathy: report from the Southwest Pediatric Nephrology Study Group. Clin J Am Soc Nephrol, 1 (3), 467-74, 2006.
  34. Lau, KK, Wyatt, RJ, Gaber, LW. Purpura followed by proteinuria in a 7-year-old girl. Am J Kidney Dis, 46 (6), 1140-4, 2005.
  35. Lau, KK, Gaber, LW, Delos Santos, NM, Wyatt, RJ. C1q nephropathy: features at presentation and outcome. Pediatr Nephrol, 20 (6), 744-9, 2005.
  36. Lau, KK, Wyatt, RJ. Glomerulonephritis. Adolesc Med Clin, 16 (1), 67-85, 2005.
  37. Novak, J, Tomana, M, Matousovic, K, Brown, R, Hall, S, Novak, L, Julian, BA, Wyatt, RJ, Mestecky, J. IgA1-containing immune complexes in IgA nephropathy differentially affect proliferation of mesangial cells. Kidney Int, 67 (2), 504-13, 2005.
  38. Lau, KK, Gaber, LW, Delos Santos, NM, Fisher, KA, Grimes, SJ, Wyatt, RJ. Pediatric IgA nephropathy: clinical features at presentation and outcome for African-Americans and Caucasians. Clin Nephrol, 62 (3), 167-72, 2004.
  39. Delos Santos, NM, Wyatt, RJ. Pediatric IgA nephropathies: clinical aspects and therapeutic approaches. Semin Nephrol, 24 (3), 269-86, 2004.
  40. Hogg, RJ, Wyatt, RJ, ,. A randomized controlled trial of mycophenolate mofetil in patients with IgA nephropathy [ISRCTN62574616]. BMC Nephrol, 5, 3, 2004.
  41. Chesney, RW, Wyatt, RJ. Racial disparities in renal transplantation in children. Pediatrics, 112 (2), 409-11, 2003.
  42. Ault, BH, Honaker, MR, Osama Gaber, A, Jones, DP, Duhart Jr, BT, Powell, SL, Hays, DW, Wyatt, RJ. Short-term outcomes of Thymoglobulin induction in pediatric renal transplant recipients. Pediatr Nephrol, 17 (10), 815-8, 2002.
  43. Santos, NM, Ault, BH, Gharavi, AG, Kritchevsky, SB, Quasney, MW, Jackson, EC, Fisher, KA, Woodford, SY, Mitchell, BL, Gaber, LW, Arheart, KL, Wyatt, RJ. Angiotensin-converting enzyme genotype and outcome in pediatric IgA nephropathy. Pediatr Nephrol, 17 (7), 496-502, 2002.
  44. Wyatt, RJ, Hogg, RJ. Evidence-based assessment of treatment options for children with IgA nephropathies. Pediatr Nephrol, 16 (2), 156-67, 2001.
  45. Canon, HL, Buckingham, SC, Wyatt, RJ, Jones, DP. Fungal peritonitis caused by Curvularia species in a child undergoing peritoneal dialysis. Pediatr Nephrol, 16 (1), 35-7, 2001.
  46. Gharavi, AG, Yan, Y, Scolari, F, Schena, FP, Frasca, GM, Ghiggeri, GM, Cooper, K, Amoroso, A, Viola, BF, Battini, G, Caridi, G, Canova, C, Farhi, A, Subramanian, V, Nelson-Williams, C, Woodford, S, Julian, BA, Wyatt, RJ, Lifton, RP. IgA nephropathy, the most common cause of glomerulonephritis, is linked to 6q22-23. Nat Genet, 26 (3), 354-7, 2000.
  47. Ilyas, M, Ammons, JD, Gaber, AO, Roy, S, Batisky, DL, Chesney, RW, Jones, DP, Wyatt, RJ. Comparable renal graft survival in African-American and Caucasian recipients. Pediatr Nephrol, 12 (7), 534-9, 1998.
  48. Waldo, FB, Wyatt, RJ, Hogg, RJ, Andreoli, SP, Milliner, DS. Current concepts and controversies in IgA nephropathy. Pediatr Nephrol, 12 (6), 498-504, 1998.
  49. Wyatt, RJ, Julian, BA, Baehler, RW, Stafford, CC, McMorrow, RG, Ferguson, T, Jackson, E, Woodford, SY, Miller, PM, Kritchevsky, S. Epidemiology of IgA nephropathy in central and eastern Kentucky for the period 1975 through 1994. Central Kentucky Region of the Southeastern United States IgA Nephropathy DATABANK Project. J Am Soc Nephrol, 9 (5), 853-8, 1998.
  50. Sehic, AM, Gaber, LW, Roy, S, Miller, PM, Kritchevsky, SB, Wyatt, RJ. Increased recognition of IgA nephropathy in African-American children. Pediatr Nephrol, 11 (4), 435-7, 1997.
  51. Wyatt, RJ, Emancipator, SN, Kon, V, Waldo, FB, Donadio, J, Grande, JP, Andreoli, SP, Glassock, RJ. IgA nephropathy databank: development of a system for management of renal biopsy acquired data. Am J Kidney Dis, 29 (6), 817-28, 1997.
  52. Ilyas, M, Roy, S, Abbasi, S, Leggiadro, RJ, English, BK, Wyatt, RJ. Serious infections due to penicillin-resistant Streptococcus peneumoniae in two children with nephrotic syndrome. Pediatr Nephrol, 10 (5), 639-41, 1996.
  53. Wyatt, RJ, Kagy, L, Kritchevsky, SB. Epidemiology of pediatric kidney diseases. Pediatr Ann, 25 (5), 288-96, 1996.
  54. Wyatt, RJ, Kritchevsky, SB, Woodford, SY, Miller, PM, Roy, S, Holland, NH, Jackson, E, Bishof, NA. IgA nephropathy: long-term prognosis for pediatric patients. J Pediatr, 127 (6), 913-9, 1995.
  55. Vogt, BA, Wyatt, RJ, Burke, BA, Simonton, SC, Kashtan, CE. Inherited factor H deficiency and collagen type III glomerulopathy. Pediatr Nephrol, 9 (1), 11-5, 1995.
  56. Matsell, DG, Wyatt, RJ, Gaber, LW. Terminal complement complexes in acute poststreptococcal glomerulonephritis. Pediatr Nephrol, 8 (6), 671-6, 1994.
  57. McLean, RH, Niblack, G, Julian, B, Wang, T, Wyatt, R, Phillips, JA, Collins, TS, Winkelstein, J, Valle, D. Hemolytically inactive C4B complement allotype caused by a proline to leucine mutation in the C5-binding site. J Biol Chem, 269 (44), 27727-31, 1994.
  58. Fitzwater, DS, Wyatt, RJ. Hematuria. Pediatr Rev, 15 (3), 102-8; quiz 109, 1994.
  59. Hogg, RJ, Silva, FG, Wyatt, RJ, Reisch, JS, Argyle, JC, Savino, DA. Prognostic indicators in children with IgA nephropathy--report of the Southwest Pediatric Nephrology Study Group. Pediatr Nephrol, 8 (1), 15-20, 1994.
  60. Batisky, DL, Wyatt, RJ, Fitzwater, DS, Gaber, AO, Roy, S. Pediatric renal transplant experience in Memphis, Tennessee. Transplant Proc, 26 (1), 54-6, 1994.
  61. Waldo, FB, Wyatt, RJ, Kelly, DR, Herrera, GA, Benfield, MR, Kohaut, EC. Treatment of IgA nephropathy in children: efficacy of alternate-day oral prednisone. Pediatr Nephrol, 7 (5), 529-32, 1993.
  62. Fitzwater, DS, Wyatt, RJ, Chesney, RW. Clinical quiz. Polyarteritis nodosa (PAN). Pediatr Nephrol, 7 (4), 501-2, 1993.
  63. Matsell, DG, Wyatt, RJ. The role of I and B in peritonitis associated with the nephrotic syndrome of childhood. Pediatr Res, 34 (1), 84-8, 1993.
  64. Baldree, LA, Wyatt, RJ, Julian, BA, Falk, RJ, Jennette, JC. Immunoglobulin A-fibronectin aggregate levels in children and adults with immunoglobulin A nephropathy. Am J Kidney Dis, 22 (1), 1-4, 1993.
  65. Wyatt, RJ. The complement system in IgA nephropathy and Henoch-Schönlein purpura: functional and genetic aspects. Contrib Nephrol, 104, 82-91, 1993.
  66. Noe, HN, Wyatt, RJ, Peeden, JN, Rivas, ML. The transmission of vesicoureteral reflux from parent to child. J Urol, 148 (6), 1869-71, 1992.
  67. Pratt, CB, Meyer, WH, Jenkins, JJ, Avery, L, McKay, CP, Wyatt, RJ, Hancock, ML. Ifosfamide, Fanconi's syndrome, and rickets. J Clin Oncol, 9 (8), 1495-9, 1991.
  68. Wyatt, RJ, Julian, BA, Woodford, SY, Wang, C, Roberts, J, Thompson, JS, Christenson, MJ, McLean, RH. C4A deficiency and poor prognosis in patients with IgA nephropathy. Clin Nephrol, 36 (1), 1-5, 1991.
  69. Crowley-Nowick, PA, Julian, BA, Wyatt, RJ, Galla, JH, Wall, BM, Warnock, DG, Mestecky, J, Jackson, S. IgA nephropathy in blacks: studies of IgA2 allotypes and clinical course. Kidney Int, 39 (6), 1218-24, 1991.
  70. Matsell, DG, Roy, S, Tamerius, JD, Morrow, PR, Kolb, WP, Wyatt, RJ. Plasma terminal complement complexes in acute poststreptococcal glomerulonephritis. Am J Kidney Dis, 17 (3), 311-6, 1991.
  71. Wyatt, RJ, Julian, BA, Rivas, ML. Role for specific complement phenotypes and deficiencies in the clinical expression of IgA nephropathy. Am J Med Sci, 301 (2), 115-23, 1991.
  72. Ault, BH, Stapleton, FB, Rivas, ML, Waldo, FB, Roy, S, McLean, RH, Bin, JA, Wyatt, RJ. Association of Henoch-Schönlein purpura glomerulonephritis with C4B deficiency. J Pediatr, 117 (5), 753-5, 1990.
  73. Matsell, DG, Roy, S, Bin, JA, Wyatt, RJ. Nephrosis, peritonitis and complement deficiency. Pediatr Nephrol, 4 (5), 575, 1990.
  74. Wyatt, RJ, Rivas, ML, Schena, FP, Bin, JA, Julian, BA. Regional variation in C4 phenotype in patients with IgA nephropathy. J Pediatr, 116 (5), S72-7, 1990.
  75. Rosenberg, EW, Noah, PW, Wyatt, RJ, Jones, RM, Kolb, WP. Complement activation in psoriasis. Clin Exp Dermatol, 15 (1), 16-20, 1990.
  76. Wyatt, RJ, Schneider, PD, Alpers, CE, Hudson, EC, Julian, BA. C4B deficiency in two siblings with IgA nephropathy. Am J Kidney Dis, 15 (1), 66-71, 1990.
  77. Wang, C, Rivas, ML, Burghen, GA, Hudson, EC, Wyatt, RJ. C4 and Bf phenotypes in black and Caucasian patients with childhood onset insulin dependent diabetes mellitus. J Clin Lab Immunol, 30 (4), 183-90, 1989.
  78. Wyatt, RJ. Can one predict the prognosis in patients with IgA nephropathy from the analysis of serum complement. Pediatr Nephrol, 3 (4), 467, 1989.
  79. McLean, RH, Porter, CC, Wyatt, RJ. Molecular studies of the fourth component of complement (C4) in glomerulonephritis. Semin Nephrol, 9 (1), 102-6, 1989.
  80. Waldo, FB, Alexander, R, Wyatt, RJ, Kohaut, EC. Alternate-day prednisone therapy in children with IgA-associated nephritis. Am J Kidney Dis, 13 (1), 55-60, 1989.
  81. Wyatt, RJ, Wang, C, Hudson, EC, Jones, RM, Noah, PW, Rosenberg, EW. Bf and C4 phenotypes in patients with psoriasis. Acta Derm Venereol Suppl (Stockh), 146, 211-3, 1989.
  82. Wyatt, RJ, Wang, C, Hudson, EC, Jones, RM, Noah, PW, Rosenberg, EW. Complement phenotypes in patients with psoriasis. Hum Hered, 39 (6), 327-32, 1989.
  83. Stapleton, FB, Strother, DR, Roy, S, Wyatt, RJ, McKay, CP, Murphy, SB. Acute renal failure at onset of therapy for advanced stage Burkitt lymphoma and B cell acute lymphoblastic lymphoma. Pediatrics, 82 (6), 863-9, 1988.
  84. Wyatt, RJ, Julian, BA. Activation of complement in IgA nephropathy. Am J Kidney Dis, 12 (5), 437-42, 1988.
  85. Julian, BA, Woodford, SY, Baehler, RW, McMorrow, RG, Wyatt, RJ. Familial clustering and immunogenetic aspects of IgA nephropathy. Am J Kidney Dis, 12 (5), 366-70, 1988.
  86. Imai, H, Chen, A, Wyatt, RJ, Rifai, A. Lack of complement activation by human IgA immune complexes. Clin Exp Immunol, 73 (3), 479-83, 1988.
  87. Wang, WC, Herrod, HG, Valenski, WR, Wyatt, RJ. Lymphocyte and complement abnormalities in splenectomized patients with hematologic disorders. Am J Hematol, 28 (4), 239-45, 1988.
  88. Jones, DP, Stapleton, FB, Roy, S, Wyatt, RJ. Beneficial effect of second courses of cytotoxic therapy in children with minimal change nephrotic syndrome. Pediatr Nephrol, 2 (3), 291-5, 1988.
  89. Wyatt, RJ, Forristal, J, West, CD, Sugimoto, S, Curd, JG. Complement profiles in acute post-streptococcal glomerulonephritis. Pediatr Nephrol, 2 (2), 219-23, 1988.
  90. Wyatt, RJ, Valenski, WR, Stapleton, FB, Roy, S, Woolridge, TD, Trouy, RL, Herrod, HG. Immunoregulatory studies in patients with IgA nephropathy. J Clin Lab Immunol, 25 (3), 109-14, 1988.
  91. Wyatt, RJ, Julian, BA, Woodford, SY, McLean, RH, Thompson, JS. Immunogenetic markers as prognostic features in patients from Kentucky with IgA nephropathy. Semin Nephrol, 7 (4), 389-92, 1987.
  92. Julian, BA, Phillips, JA, Orlando, PJ, Wyatt, RJ, Butler, MG. Analysis of immunoglobulin heavy chain restriction fragment length polymorphisms in IgA nephropathy. Semin Nephrol, 7 (4), 306-10, 1987.
  93. Imai, H, Chen, A, Wyatt, RJ, Rifai, A. Composition of IgA immune complexes precipitated with polyethylene glycol. A model for isolation and analysis of immune complexes. J Immunol Methods, 103 (2), 239-45, 1987.
  94. Asamoah, A, Wyatt, RJ, Julian, BA, Quiggins, PA, Wilson, AF, Elston, RC. A major gene model for the familial aggregation of plasma IgA concentration. Am J Med Genet, 27 (4), 857-66, 1987.
  95. Wyatt, RJ, Rivas, ML, Julian, BA, Quiggins, PA, Woodford, SY, McMorrow, RG, Baehler, RW. Regionalization in hereditary IgA nephropathy. Am J Hum Genet, 41 (1), 36-50, 1987.
  96. Wyatt, RJ, Kanayama, Y, Julian, BA, Negoro, N, Sugimoto, S, Hudson, EC, Curd, JG. Complement activation in IgA nephropathy. Kidney Int, 31 (4), 1019-23, 1987.
  97. Tucker, WS, Niblack, GD, McLean, RH, Alspaugh, MA, Wyatt, RJ, Jordan, SC, Bright, GM, Pincus, T. Serositis with autoimmune endocrinopathy: clinical and immunogenetic features. Medicine (Baltimore), 66 (2), 138-47, 1987.
  98. Wyatt, RJ, Julian, BA, Waldo, FB, McLean, RH. Complement phenotypes (C3 and C4) in IgA nephropathy. Adv Exp Med Biol, 216B, 1569-75, 1987.
  99. Julian, BA, Wyatt, RJ, Waldo, FB, Koopman, WJ, Jackson, S, Schrohenloher, RE, Galla, JH, Mestecky, J, Czerkinsky, C. Immunological studies of IgA nephropathy: familial and racial aspects. Adv Exp Med Biol, 216B, 1489-98, 1987.
  100. Egido, J, Julian, BA, Wyatt, RJ. Genetic factors in primary IgA nephropathy. Nephrol Dial Transplant, 2 (3), 134-42, 1987.
  101. Bridges, RB, Wyatt, RJ, Rehm, SR. Effects of smoking on inflammatory mediators and their relationship to pulmonary dysfunction. Eur J Respir Dis Suppl, 146, 145-52, 1986.
  102. Wyatt, RJ. Deficiencies in regulator proteins. 3. Properdin. Prog Allergy, 39, 339-43, 1986.
  103. Wyatt, RJ, Jones, D, Stapleton, FB, Roy, S, Odom, TW, McLean, RH. Recurrent hemolytic-uremic syndrome with the hypomorphic fast allele of the third component of complement. J Pediatr, 107 (4), 564-6, 1985.
  104. Bridges, RB, Rehm, SR, Wyatt, RJ. Increased plasma concentrations of C9, C1-inhibitor and alpha 1-protease inhibitor associated with cigarette smoking. Life Sci, 36 (10), 955-63, 1985.
  105. Julian, BA, Quiggins, PA, Thompson, JS, Woodford, SY, Gleason, K, Wyatt, RJ. Familial IgA nephropathy. Evidence of an inherited mechanism of disease. N Engl J Med, 312 (4), 202-8, 1985.
  106. McLean, RH, Wyatt, RJ, Julian, BA. Complement phenotypes in glomerulonephritis: increased frequency of homozygous null C4 phenotypes in IgA nephropathy and Henoch-Schönlein purpura. Kidney Int, 26 (6), 855-60, 1984.
  107. Wyatt, RJ, Julian, BA, Bhathena, DB, Mitchell, BL, Holland, NH, Malluche, HH. Iga nephropathy: presentation, clinical course, and prognosis in children and adults. Am J Kidney Dis, 4 (2), 192-200, 1984.
  108. Roberts, JL, Wyatt, RJ, Schwartz, MM, Lewis, EJ. Differential characteristics of immune-bound antibodies in diffuse proliferative and membranous forms of lupus glomerulonephritis. Clin Immunol Immunopathol, 29 (2), 223-41, 1983.
  109. Julian, BA, Wyatt, RJ, McMorrow, RG, Galla, JH. Serum complement proteins in IgA nephropathy. Clin Nephrol, 20 (5), 251-8, 1983.
  110. Wyatt, RJ, Farrell, M, Berry, PL, Forristal, J, Maloney, MJ, West, CD. Reduced alternative complement pathway control protein levels in anorexia nervosa: response to parenteral alimentation. Am J Clin Nutr, 35 (5), 973-80, 1982.
  111. Wyatt, RJ, Julian, BA, Weinstein, A, Rothfield, NF, McLean, RH. Partial H (beta 1H) deficiency and glomerulonephritis in two families. J Clin Immunol, 2 (2), 110-7, 1982.
  112. Wyatt, RJ, Julian, BA, Galla, JH. Properdin deficiency with IgA nephropathy. N Engl J Med, 305 (18), 1097, 1981.
  113. Wyatt, RJ, Bridges, RB, Halatek, DG. Complement levels in cigarette smokers: elevation of serum concentrations of C5, C9, and C1-inhibitor. J Clin Lab Immunol, 6 (2), 131-5, 1981.
  114. Wyatt, RJ, Walsh, JW, Holland, NH. Shunt nephritis. Role of the complement system in its pathogenesis and management. J Neurosurg, 55 (1), 99-107, 1981.
  115. Wyatt, RJ, Forristal, J, Davis, CA, Coleman, TH, West, CD. Control of serum C3 levels by beta 1H and C3b inactivator. J Lab Clin Med, 95 (6), 905-17, 1980.
  116. Wyatt, RJ, McAdams, AJ, Forristal, J, Snyder, J, West, CD. Glomerular deposition of complement-control proteins in acute and chronic glomerulonephritis. Kidney Int, 16 (4), 505-12, 1979.
  117. Davis, CA, McAdams, AJ, Wyatt, RJ, Forristal, J, McEnery, PT, West, CD. Idiopathic rapidly progressive glomerulonephritis with C3 nephritic factor and hypocomplementemia. J Pediatr, 94 (4), 559-63, 1979.
  118. Curtis, JJ, Wyatt, RJ, Bhathena, D, Lucas, BA, Holland, NH, Luke, RG. Renal transplantation for patients with type I and type II membranoproliferative glomerulonephritis: serial complement and nephritic factor measurements and the problem of recurrence of disease. Am J Med, 66 (2), 216-25, 1979.
  119. Pitts, JS, Donaldson, VH, Forristal, J, Wyatt, RJ. Remissions induced in hereditary angioneurotic edema with an attenuated androgen (danazol): correlation between concentrations of C1-inhibitor and the forth and second components of complement. J Lab Clin Med, 92 (4), 501-7, 1978.
  120. Wyatt, RJ, McRoberts, JW, Holland, NH. Hematuria in childhood: significance and management. J Urol, 117 (3), 366-8, 1977.