RICHARD JOHN WEBBY, Ph.D.

Professor
Dept of Micr, Immun, & Biochem

Office: 332 N. LAUDERALE ROOM E9056 MEMPHIS TN 38105
Tel: (901) 495-3014
rwebby@uthsc.edu

Publications

  1. Yen, HL, Aldridge, JR, Boon, AC, Ilyushina, NA, Salomon, R, Hulse-Post, DJ, Marjuki, H, Franks, J, Boltz, DA, Bush, D, Lipatov, AS, Webby, RJ, Rehg, JE, Webster, RG. Changes in H5N1 influenza virus hemagglutinin receptor binding domain affect systemic spread. Proc Natl Acad Sci U S A, 106 (1), 286-91, 2009.
  2. Sandbulte, MR, Boon, AC, Webby, RJ, Riberdy, JM. Analysis of cytokine secretion from human plasmacytoid dendritic cells infected with H5N1 or low-pathogenicity influenza viruses. Virology, 381 (1), 22-8, 2008.
  3. Ducatez, MF, Webster, RG, Webby, RJ. Animal influenza epidemiology. Vaccine, 26 Suppl 4, D67-9, 2008.
  4. Webby, RJ, Sandbulte, MR. Influenza vaccines. Front Biosci, 13, 4912-24, 2008.
  5. Boon, AC, Sandbulte, MR, Seiler, P, Webby, RJ, Songserm, T, Guan, Y, Webster, RG. Role of terrestrial wild birds in ecology of influenza A virus (H5N1). Emerg Infect Dis, 13 (11), 1720-4, 2007.
  6. Krauss, S, Obert, CA, Franks, J, Walker, D, Jones, K, Seiler, P, Niles, L, Pryor, SP, Obenauer, JC, Naeve, CW, Widjaja, L, Webby, RJ, Webster, RG. Influenza in migratory birds and evidence of limited intercontinental virus exchange. PLoS Pathog, 3 (11), e167, 2007.
  7. Webby, RJ, Webster, RG, Richt, JA. Influenza viruses in animal wildlife populations. Curr Top Microbiol Immunol, 315, 67-83, 2007.
  8. Hulse-Post, DJ, Franks, J, Boyd, K, Salomon, R, Hoffmann, E, Yen, HL, Webby, RJ, Walker, D, Nguyen, TD, Webster, RG. Molecular changes in the polymerase genes (PA and PB1) associated with high pathogenicity of H5N1 influenza virus in mallard ducks. J Virol, 81 (16), 8515-24, 2007.
  9. Thomas, PG, Brown, SA, Keating, R, Yue, W, Morris, MY, So, J, Webby, RJ, Doherty, PC. Hidden epitopes emerge in secondary influenza virus-specific CD8+ T cell responses. J Immunol, 178 (5), 3091-8, 2007.
  10. Sandbulte, MR, Jimenez, GS, Boon, AC, Smith, LR, Treanor, JJ, Webby, RJ. Cross-reactive neuraminidase antibodies afford partial protection against H5N1 in mice and are present in unexposed humans. PLoS Med, 4 (2), e59, 2007.
  11. Webster, RG, Webby, RJ, Hoffmann, E, Rodenberg, J, Kumar, M, Chu, HJ, Seiler, P, Krauss, S, Songserm, T. The immunogenicity and efficacy against H5N1 challenge of reverse genetics-derived H5N3 influenza vaccine in ducks and chickens. Virology, 351 (2), 303-11, 2006.
  12. Govorkova, EA, Webby, RJ, Humberd, J, Seiler, JP, Webster, RG. Immunization with reverse-genetics-produced H5N1 influenza vaccine protects ferrets against homologous and heterologous challenge. J Infect Dis, 194 (2), 159-67, 2006.
  13. Widjaja, L, Ilyushina, N, Webster, RG, Webby, RJ. Molecular changes associated with adaptation of human influenza A virus in embryonated chicken eggs. Virology, 350 (1), 137-45, 2006.
  14. Wei, L, Sandbulte, MR, Thomas, PG, Webby, RJ, Homayouni, R, Pfeffer, LM. NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity. J Biol Chem, 281 (17), 11678-84, 2006.
  15. Salomon, R, Franks, J, Govorkova, EA, Ilyushina, NA, Yen, HL, Hulse-Post, DJ, Humberd, J, Trichet, M, Rehg, JE, Webby, RJ, Webster, RG, Hoffmann, E. The polymerase complex genes contribute to the high virulence of the human H5N1 influenza virus isolate A/Vietnam/1203/04. J Exp Med, 203 (3), 689-97, 2006.
  16. Thomas, PG, Brown, SA, Yue, W, So, J, Webby, RJ, Doherty, PC. An unexpected antibody response to an engineered influenza virus modifies CD8+ T cell responses. Proc Natl Acad Sci U S A, 103 (8), 2764-9, 2006.
  17. Avadhanula, V, Rodriguez, CA, Devincenzo, JP, Wang, Y, Webby, RJ, Ulett, GC, Adderson, EE. Respiratory viruses augment the adhesion of bacterial pathogens to respiratory epithelium in a viral species- and cell type-dependent manner. J Virol, 80 (4), 1629-36, 2006.
  18. Hoffmann, E, Lipatov, AS, Webby, RJ, Govorkova, EA, Webster, RG. Role of specific hemagglutinin amino acids in the immunogenicity and protection of H5N1 influenza virus vaccines. Proc Natl Acad Sci U S A, 102 (36), 12915-20, 2005.
  19. Choi, YK, Nguyen, TD, Ozaki, H, Webby, RJ, Puthavathana, P, Buranathal, C, Chaisingh, A, Auewarakul, P, Hanh, NT, Ma, SK, Hui, PY, Guan, Y, Peiris, JS, Webster, RG. Studies of H5N1 influenza virus infection of pigs by using viruses isolated in Vietnam and Thailand in 2004. J Virol, 79 (16), 10821-5, 2005.
  20. Lipatov, AS, Andreansky, S, Webby, RJ, Hulse, DJ, Rehg, JE, Krauss, S, Perez, DR, Doherty, PC, Webster, RG, Sangster, MY. Pathogenesis of Hong Kong H5N1 influenza virus NS gene reassortants in mice: the role of cytokines and B- and T-cell responses. J Gen Virol, 86 (Pt 4), 1121-30, 2005.
  21. Lipatov, AS, Webby, RJ, Govorkova, EA, Krauss, S, Webster, RG. Efficacy of H5 influenza vaccines produced by reverse genetics in a lethal mouse model. J Infect Dis, 191 (8), 1216-20, 2005.
  22. Andreansky, SS, Stambas, J, Thomas, PG, Xie, W, Webby, RJ, Doherty, PC. Consequences of immunodominant epitope deletion for minor influenza virus-specific CD8+-T-cell responses. J Virol, 79 (7), 4329-39, 2005.
  23. Choi, YK, Seo, SH, Kim, JA, Webby, RJ, Webster, RG. Avian influenza viruses in Korean live poultry markets and their pathogenic potential. Virology, 332 (2), 529-37, 2005.
  24. Lipatov, AS, Govorkova, EA, Webby, RJ, Ozaki, H, Peiris, M, Guan, Y, Poon, L, Webster, RG. Influenza: emergence and control. J Virol, 78 (17), 8951-9, 2004.
  25. Widjaja, L, Krauss, SL, Webby, RJ, Xie, T, Webster, RG. Matrix gene of influenza a viruses isolated from wild aquatic birds: ecology and emergence of influenza a viruses. J Virol, 78 (16), 8771-9, 2004.
  26. Choi, YK, Ozaki, H, Webby, RJ, Webster, RG, Peiris, JS, Poon, L, Butt, C, Leung, YH, Guan, Y. Continuing evolution of H9N2 influenza viruses in Southeastern China. J Virol, 78 (16), 8609-14, 2004.
  27. Webby, RJ, Rossow, K, Erickson, G, Sims, Y, Webster, R. Multiple lineages of antigenically and genetically diverse influenza A virus co-circulate in the United States swine population. Virus Res, 103 (1-2), 67-73, 2004.
  28. Webby, RJ, Perez, DR, Coleman, JS, Guan, Y, Knight, JH, Govorkova, EA, McClain-Moss, LR, Peiris, JS, Rehg, JE, Tuomanen, EI, Webster, RG. Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines. Lancet, 363 (9415), 1099-103, 2004.
  29. Ozaki, H, Govorkova, EA, Li, C, Xiong, X, Webster, RG, Webby, RJ. Generation of high-yielding influenza A viruses in African green monkey kidney (Vero) cells by reverse genetics. J Virol, 78 (4), 1851-7, 2004.
  30. Webby, RJ, Webster, RG. Are we ready for pandemic influenza. Science, 302 (5650), 1519-22, 2003.
  31. Liu, M, Guan, Y, Peiris, M, He, S, Webby, RJ, Perez, D, Webster, RG. The quest of influenza A viruses for new hosts. Avian Dis, 47 (3 Suppl), 849-56, 2003.
  32. Webby, RJ, Woolcock, PR, Krauss, SL, Walker, DB, Chin, PS, Shortridge, KF, Webster, RG. Multiple genotypes of nonpathogenic H6N2 influenza viruses isolated from chickens in California. Avian Dis, 47 (3 Suppl), 905-10, 2003.
  33. Perez, DR, Webby, RJ, Hoffmann, E, Webster, RG. Land-based birds as potential disseminators of avian mammalian reassortant influenza A viruses. Avian Dis, 47 (3 Suppl), 1114-7, 2003.
  34. Webby, RJ, Andreansky, S, Stambas, J, Rehg, JE, Webster, RG, Doherty, PC, Turner, SJ. Protection and compensation in the influenza virus-specific CD8+ T cell response. Proc Natl Acad Sci U S A, 100 (12), 7235-40, 2003.
  35. Liu, M, He, S, Walker, D, Zhou, N, Perez, DR, Mo, B, Li, F, Huang, X, Webster, RG, Webby, RJ. The influenza virus gene pool in a poultry market in South central china. Virology, 305 (2), 267-75, 2003.
  36. Webby, RJ, Woolcock, PR, Krauss, SL, Webster, RG. Reassortment and interspecies transmission of North American H6N2 influenza viruses. Virology, 295 (1), 44-53, 2002.
  37. Webby, RJ, Webster, RG. Emergence of influenza A viruses. Philos Trans R Soc Lond B Biol Sci, 356 (1416), 1817-28, 2001.
  38. Webby, RJ, Swenson, SL, Krauss, SL, Gerrish, PJ, Goyal, SM, Webster, RG. Evolution of swine H3N2 influenza viruses in the United States. J Virol, 74 (18), 8243-51, 2000.