Co-Director Biomedical Informatics Unit, CTSI
Adjunct Associate Professor, Department of Neurology

Office: 3774 WALKER AVE
MEMPHIS TN 381520000
Tel: (901) 678-1670


  • Ph.D., University of Houston, Houston, TX, Biochemistry
  • B.S., University of Houston, Houston, TX, Biology

Research interest/specialty

* Neurobiology
* DNA Microarray Analysis
* Gene Regulatory Networks
* Text-mining
* Automated Gene Annotation and Function

Research interest/specialty

* Neurobiology * DNA Microarray Analysis * Gene Regulatory Networks * Text-mining * Automated Gene Annotation and Function

Research keywords

bioinformatics, alzheimer's disease, neurodevelopment

Research description

My research interests are in three broad areas: 1) Mechanisms underlying neurodegeneration and Alzheimer’s Disease; 2) Mechanisms of mammalian brain development; 3) Genomics and Bioinformatics. Current research projects in my lab are summarized below.


  1. Wei, L, Fan, M, Xu, L, Heinrich, K, Berry, MW, Homayouni, R, Pfeffer, LM. Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes. J Interferon Cytokine Res, 28 (9), 541-51, 2008.
  2. Barker, KS, Park, H, Phan, QT, Xu, L, Homayouni, R, Rogers, PD, Filler, SG. Transcriptome profile of the vascular endothelial cell response to Candida albicans. J Infect Dis, 198 (2), 193-202, 2008.
  3. Liu, TT, Znaidi, S, Barker, KS, Xu, L, Homayouni, R, Saidane, S, Morschhäuser, J, Nantel, A, Raymond, M, Rogers, PD. Genome-wide expression and location analyses of the Candida albicans Tac1p regulon. Eukaryot Cell, 6 (11), 2122-38, 2007.
  4. Driscoll, CJ, Cashion, AK, Hathaway, DK, Thompson, C, Conley, Y, Riely, C, Xu, L, Homayouni, R. Blood gene expression profiling in liver transplant recipients with hepatitis C virus and posttransplantation diabetes mellitus. Transplant Proc, 38 (10), 3646-8, 2006.
  5. LeDoux, MS, Xu, L, Xiao, J, Ferrell, B, Menkes, DL, Homayouni, R. Murine central and peripheral nervous system transcriptomes: comparative gene expression. Brain Res, 1107 (1), 24-41, 2006.
  6. Bao, L, Wei, L, Peirce, JL, Homayouni, R, Li, H, Zhou, M, Chen, H, Lu, L, Williams, RW, Pfeffer, LM, Goldowitz, D, Cui, Y. Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships. Mamm Genome, 17 (6), 575-83, 2006.
  7. Wei, L, Sandbulte, MR, Thomas, PG, Webby, RJ, Homayouni, R, Pfeffer, LM. NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity. J Biol Chem, 281 (17), 11678-84, 2006.
  8. Li, X, Bürklen, T, Yuan, X, Schlattner, U, Desiderio, DM, Wallimann, T, Homayouni, R. Stabilization of ubiquitous mitochondrial creatine kinase preprotein by APP family proteins. Mol Cell Neurosci, 31 (2), 263-72, 2006.
  9. Liu, TT, Lee, RE, Barker, KS, Lee, RE, Wei, L, Homayouni, R, Rogers, PD. Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrob Agents Chemother, 49 (6), 2226-36, 2005.
  10. Homayouni, R, Heinrich, K, Wei, L, Berry, MW. Gene clustering by latent semantic indexing of MEDLINE abstracts. Bioinformatics, 21 (1), 104-15, 2005.
  11. Pfeffer, LM, Kim, JG, Pfeffer, SR, Carrigan, DJ, Baker, DP, Wei, L, Homayouni, R. Role of nuclear factor-kappaB in the antiviral action of interferon and interferon-regulated gene expression. J Biol Chem, 279 (30), 31304-11, 2004.
  12. Homayouni, R, Magdaleno, S, Keshvara, L, Rice, DS, Curran, T. Interaction of Disabled-1 and the GTPase activating protein Dab2IP in mouse brain. Brain Res Mol Brain Res, 115 (2), 121-9, 2003.
  13. Homayouni, R, Rice, DS, Curran, T. Disabled-1 interacts with a novel developmentally regulated protocadherin. Biochem Biophys Res Commun, 289 (2), 539-47, 2001.
  14. Homayouni, R, Curran, T. Cortical development: Cdk5 gets into sticky situations. Curr Biol, 10 (9), R331-4, 2000.
  15. D'Arcangelo, G, Homayouni, R, Keshvara, L, Rice, DS, Sheldon, M, Curran, T. Reelin is a ligand for lipoprotein receptors. Neuron, 24 (2), 471-9, 1999.
  16. Homayouni, R, Rice, DS, Sheldon, M, Curran, T. Disabled-1 binds to the cytoplasmic domain of amyloid precursor-like protein 1. J Neurosci, 19 (17), 7507-15, 1999.