RICHARD E. LEE, Ph.D., B.Sc.

Professor
Pharmaceutical Sciences
 
Professor
Micro Immuno & Bioch

Office: 327B ST JUDE CHILDREN'S RESEARCH HOSPITAL
332 NORTH LAUDERDALE STREET
MEMPHIS TN 381052794
Tel: (901) 595-6617
rlee@uthsc.edu

Education

  • Ph.D., University of Newcastle-upon-Tyne, U.K., Organic Chemistry
  • B.S., Director, MidSouth Center for Biodefense and Security (MSCBS), Chemistry

Research interest/specialty

Develop a novel set of nitrofurans and other agents to treat tuberculosis.

Research interest/specialty

Develop a novel set of nitrofurans and other agents to treat tuberculosis.

Publications

  1. Rakesh, , Sun, D, Lee, RB, Tangallapally, RP, Lee, RE. Synthesis, optimization and structure-activity relationships of 3,5-disubstituted isoxazolines as new anti-tuberculosis agents. Eur J Med Chem, 44 (2), 460-72, 2009.
  2. Hevener, KE, Zhao, W, Ball, DM, Babaoglu, K, Qi, J, White, SW, Lee, RE. Validation of Molecular Docking Programs for Virtual Screening against Dihydropteroate Synthase. J Chem Inf Model, 2009.
  3. Grimes, KD, Lu, YJ, Zhang, YM, Luna, VA, Hurdle, JG, Carson, EI, Qi, J, Kudrimoti, S, Rock, CO, Lee, RE. Novel acyl phosphate mimics that target PlsY, an essential acyltransferase in gram-positive bacteria. ChemMedChem, 3 (12), 1936-45, 2008.
  4. Hurdle, JG, Lee, RB, Budha, NR, Carson, EI, Qi, J, Scherman, MS, Cho, SH, McNeil, MR, Lenaerts, AJ, Franzblau, SG, Meibohm, B, Lee, RE. A microbiological assessment of novel nitrofuranylamides as anti-tuberculosis agents. J Antimicrob Chemother, 62 (5), 1037-45, 2008.
  5. Hevener, KE, Ball, DM, Buolamwini, JK, Lee, RE. Quantitative structure-activity relationship studies on nitrofuranyl anti-tubercular agents. Bioorg Med Chem, 16 (17), 8042-53, 2008.
  6. Budha, NR, Lee, RE, Meibohm, B. Biopharmaceutics, pharmacokinetics and pharmacodynamics of antituberculosis drugs. Curr Med Chem, 15 (8), 809-25, 2008.
  7. Yendapally, R, Hurdle, JG, Carson, EI, Lee, RB, Lee, RE. N-substituted 3-acetyltetramic acid derivatives as antibacterial agents. J Med Chem, 51 (5), 1487-91, 2008.
  8. Yendapally, R, Lee, RE. Design, synthesis, and evaluation of novel ethambutol analogues. Bioorg Med Chem Lett, 18 (5), 1607-11, 2008.
  9. Mahrous, EA, Lee, RB, Lee, RE. A rapid approach to lipid profiling of mycobacteria using 2D HSQC NMR maps. J Lipid Res, 49 (2), 455-63, 2008.
  10. Tangallapally, RP, Sun, D, Rakesh, , Budha, N, Lee, RE, Lenaerts, AJ, Meibohm, B, Lee, RE. Discovery of novel isoxazolines as anti-tuberculosis agents. Bioorg Med Chem Lett, 17 (23), 6638-42, 2007.
  11. Budha, NR, Mehrotra, N, Tangallapally, R, Rakesh, , Qi, J, Daniels, AJ, Lee, RE, Meibohm, B. Pharmacokinetically-guided lead optimization of nitrofuranylamide anti-tuberculosis agents. AAPS J, 10 (1), 157-65, 2007.
  12. Sun, D, Jones, V, Carson, EI, Lee, RE, Scherman, MS, McNeil, MR, Lee, RE. Solid-phase synthesis and biological evaluation of a uridinyl branched peptide urea library. Bioorg Med Chem Lett, 17 (24), 6899-904, 2007.
  13. Lu, YJ, Zhang, F, Grimes, KD, Lee, RE, Rock, CO. Topology and active site of PlsY: the bacterial acylphosphate:glycerol-3-phosphate acyltransferase. J Biol Chem, 282 (15), 11339-46, 2007.
  14. Sun, D, Lee, RE. Solid-phase synthesis of a thymidinyl dipeptide urea library. J Comb Chem, 9 (3), 370-85, 2007.
  15. Tangallapally, RP, Yendapally, R, Daniels, AJ, Lee, RE, Lee, RE. Nitrofurans as novel anti-tuberculosis agents: identification, development and evaluation. Curr Top Med Chem, 7 (5), 509-26, 2007.
  16. Zhang, YM, Chohnan, S, Virga, KG, Stevens, RD, Ilkayeva, OR, Wenner, BR, Bain, JR, Newgard, CB, Lee, RE, Rock, CO, Jackowski, S. Chemical knockout of pantothenate kinase reveals the metabolic and genetic program responsible for hepatic coenzyme A homeostasis. Chem Biol, 14 (3), 291-302, 2007.
  17. Lu, YJ, Zhang, YM, Grimes, KD, Qi, J, Lee, RE, Rock, CO. Acyl-phosphates initiate membrane phospholipid synthesis in Gram-positive pathogens. Mol Cell, 23 (5), 765-72, 2006.
  18. Yoon, KJ, Qi, J, Remack, JS, Virga, KG, Hatfield, MJ, Potter, PM, Lee, RE, Danks, MK. Development of an etoposide prodrug for dual prodrug-enzyme antitumor therapy. Mol Cancer Ther, 5 (6), 1577-84, 2006.
  19. Tangallapally, RP, Lee, RE, Lenaerts, AJ, Lee, RE. Synthesis of new and potent analogues of anti-tuberculosis agent 5-nitro-furan-2-carboxylic acid 4-(4-benzyl-piperazin-1-yl)-benzylamide with improved bioavailability. Bioorg Med Chem Lett, 16 (10), 2584-9, 2006.
  20. Virga, KG, Zhang, YM, Leonardi, R, Ivey, RA, Hevener, K, Park, HW, Jackowski, S, Rock, CO, Lee, RE. Structure-activity relationships and enzyme inhibition of pantothenamide-type pantothenate kinase inhibitors. Bioorg Med Chem, 14 (4), 1007-20, 2006.
  21. Tangallapally, RP, Yendapally, R, Lee, RE, Lenaerts, AJ, Lee, RE. Synthesis and evaluation of cyclic secondary amine substituted phenyl and benzyl nitrofuranyl amides as novel antituberculosis agents. J Med Chem, 48 (26), 8261-9, 2005.
  22. Li, W, Lee, RE, Lee, RE, Li, J. Methods for acquisition and assignment of multidimensional high-resolution magic angle spinning NMR of whole cell bacteria. Anal Chem, 77 (18), 5785-92, 2005.
  23. Liu, TT, Lee, RE, Barker, KS, Lee, RE, Wei, L, Homayouni, R, Rogers, PD. Genome-wide expression profiling of the response to azole, polyene, echinocandin, and pyrimidine antifungal agents in Candida albicans. Antimicrob Agents Chemother, 49 (6), 2226-36, 2005.
  24. Lee, RE, Liu, TT, Barker, KS, Lee, RE, Rogers, PD. Genome-wide expression profiling of the response to ciclopirox olamine in Candida albicans. J Antimicrob Chemother, 55 (5), 655-62, 2005.
  25. Lee, RE, Li, W, Chatterjee, D, Lee, RE. Rapid structural characterization of the arabinogalactan and lipoarabinomannan in live mycobacterial cells using 2D and 3D HR-MAS NMR: structural changes in the arabinan due to ethambutol treatment and gene mutation are observed. Glycobiology, 15 (2), 139-51, 2005.
  26. Leonardi, R, Chohnan, S, Zhang, YM, Virga, KG, Lee, RE, Rock, CO, Jackowski, S. A pantothenate kinase from Staphylococcus aureus refractory to feedback regulation by coenzyme A. J Biol Chem, 280 (5), 3314-22, 2005.
  27. Zhang, YM, Frank, MW, Virga, KG, Lee, RE, Rock, CO, Jackowski, S. Acyl carrier protein is a cellular target for the antibacterial action of the pantothenamide class of pantothenate antimetabolites. J Biol Chem, 279 (49), 50969-75, 2004.
  28. Tangallapally, RP, Yendapally, R, Lee, RE, Hevener, K, Jones, VC, Lenaerts, AJ, McNeil, MR, Wang, Y, Franzblau, S, Lee, RE. Synthesis and evaluation of nitrofuranylamides as novel antituberculosis agents. J Med Chem, 47 (21), 5276-83, 2004.
  29. Babaoglu, K, Qi, J, Lee, RE, White, SW. Crystal structure of 7,8-dihydropteroate synthase from Bacillus anthracis: mechanism and novel inhibitor design. Structure, 12 (9), 1705-17, 2004.
  30. Yoon, KJ, Hyatt, JL, Morton, CL, Lee, RE, Potter, PM, Danks, MK. Characterization of inhibitors of specific carboxylesterases: development of carboxylesterase inhibitors for translational application. Mol Cancer Ther, 3 (8), 903-9, 2004.
  31. Ivey, RA, Zhang, YM, Virga, KG, Hevener, K, Lee, RE, Rock, CO, Jackowski, S, Park, HW. The structure of the pantothenate kinase.ADP.pantothenate ternary complex reveals the relationship between the binding sites for substrate, allosteric regulator, and antimetabolites. J Biol Chem, 279 (34), 35622-9, 2004.
  32. Yoon, KJ, Krull, EJ, Morton, CL, Bornmann, WG, Lee, RE, Potter, PM, Danks, MK. Activation of a camptothecin prodrug by specific carboxylesterases as predicted by quantitative structure-activity relationship and molecular docking studies. Mol Cancer Ther, 2 (11), 1171-81, 2003.
  33. Babaoglu, K, Page, MA, Jones, VC, McNeil, MR, Dong, C, Naismith, JH, Lee, RE. Novel inhibitors of an emerging target in Mycobacterium tuberculosis; substituted thiazolidinones as inhibitors of dTDP-rhamnose synthesis. Bioorg Med Chem Lett, 13 (19), 3227-30, 2003.
  34. Yoon, KJ, Morton, CL, Potter, PM, Danks, MK, Lee, RE. Synthesis and evaluation of esters and carbamates to identify critical functional groups for esterase-specific metabolism. Bioorg Med Chem, 11 (15), 3237-44, 2003.