RUSSELL W. CHESNEY, M.D., A.B.

Professor
Pediatrics
 
Professor
Physiology

Office: 471 Le Bonheur Research Center
Tel: (901) 287-6106
rchesney@uthsc.edu

Education

  • M.D., University of Rochester, Rochester, NY, Honors Seminars
  • , University of Rochester, Rochester, NY, Renal Physiology
  • , Harvard College, Cambridge, MA, Biology

Publications

  1. Han, X, Chesney, RW. TauT protects against cisplatin-induced acute kidney injury (AKI) established in a TauT transgenic mice model. Adv Exp Med Biol, 643, 113-22, 2009.
  2. Han, X, Chesney, RW. Mechanism of TauT in protecting against cisplatin-induced kidney injury (AKI). Adv Exp Med Biol, 643, 105-12, 2009.
  3. Chesney, RW, Carpenter, MA, Moxey-Mims, M, Nyberg, L, Greenfield, SP, Hoberman, A, Keren, R, Matthews, R, Matoo, TK, ,. Randomized Intervention for Children With Vesicoureteral Reflux (RIVUR): background commentary of RIVUR investigators. Pediatrics, 122 Suppl 5, S233-9, 2008.
  4. Chesney, RW. Rickets or abuse, or both. Pediatr Radiol, 38 (11), 1217-8, 2008.
  5. Han, X, Chesney, RW. Mechanisms of regulation of taurine transporter activity: a complex interplay of regulatory systems. Adv Exp Med Biol, 583, 79-90, 2006.
  6. Han, X, Chesney, RW. Is TauT an anti-apoptotic gene. Adv Exp Med Biol, 583, 59-67, 2006.
  7. Han, X, Patters, AB, Jones, DP, Zelikovic, I, Chesney, RW. The taurine transporter: mechanisms of regulation. Acta Physiol (Oxf), 187 (1-2), 61-73, 2006.
  8. Han, X, Chesney, RW. Regulation of TauT by cisplatin in LLC-PK1 renal cells. Pediatr Nephrol, 20 (8), 1067-72, 2005.
  9. Chesney, RW. The future of pediatric nephrology. Pediatr Nephrol, 20 (7), 867-71, 2005.
  10. Chesney, RW. Children as clinical research subjects. J Pediatr, 146 (5), 579-80, 2005.
  11. Chesney, RW. Primary hyperparathyroidism in pediatric patients: clear-cut differences from adult patients. Pediatrics, 115 (4), 1073, 2005.
  12. Hak, EB, Crill, CM, Bugnitz, MC, Mouser, JF, Chesney, RW. Increased parathyroid hormone and decreased calcitriol during neonatal extracorporeal membrane oxygenation. Intensive Care Med, 31 (2), 264-70, 2005.
  13. Chesney, RW. The pleasure of lifelong learning. Pharos Alpha Omega Alpha Honor Med Soc, 67 (4), 32, 2005.
  14. Chesney, RW. Bone mineral density in chronic renal insufficiency and end-stage renal disease: how to interpret the scans. J Pediatr Endocrinol Metab, 17 Suppl 4, 1327-32, 2004.
  15. Chesney, RW. American Pediatric Society Presidential Address 2003: the failure of Ockham's razor in 21st century pediatrics. Pediatr Res, 55 (6), 903-7, 2004.
  16. Chesney, RW, Chesney, PJ. Women pediatricians: can facts shed light on prejudices and myths. J Pediatr, 144 (4), 413-4, 2004.
  17. Chesney, RW, Christensen, ML. Changing requirements for evaluation of pharmacologic agents. Pediatrics, 113 (4 Suppl), 1128-32, 2004.
  18. Chesney, RW. Rickets: an old form for a new century. Pediatr Int, 45 (5), 509-11, 2003.
  19. Han, X, Patters, AB, Chesney, RW. Transactivation of TauT by p53 in MCF-7 cells: the role of estrogen receptors. Adv Exp Med Biol, 526, 139-47, 2003.
  20. Chesney, RW, Wyatt, RJ. Racial disparities in renal transplantation in children. Pediatrics, 112 (2), 409-11, 2003.
  21. Han, X, Patters, AB, Chesney, RW. Gating of taurine transport: role of the fourth segment of the taurine transporter. Adv Exp Med Biol, 526, 149-57, 2003.
  22. Han, X, Chesney, RW. Regulation of taurine transporter gene (TauT) by WT1. FEBS Lett, 540 (1-3), 71-6, 2003.
  23. Chesney, RW. Who was John Howland and why was an award named after him 50 years ago. Pediatr Res, 53 (3), 523-5, 2003.
  24. Chesney, RW. The development of pediatric nephrology. Pediatr Res, 52 (5), 770-8, 2002.
  25. Han, X, Patters, AB, Chesney, RW. Transcriptional repression of taurine transporter gene (TauT) by p53 in renal cells. J Biol Chem, 277 (42), 39266-73, 2002.
  26. Chesney, RW. Why physicians are certified by boards. J Pediatr, 141 (3), 299, 2002.
  27. Chesney, RW. Rickets: the third wave. Clin Pediatr (Phila), 41 (3), 137-9, 2002.
  28. Han, X, Budreau, AM, Chesney, RW. Cloning and characterization of the promoter region of the rat taurine transporter (TauT) gene. Adv Exp Med Biol, 483, 97-108, 2002.
  29. Han, X, Budreau, AM, Chesney, RW. Identification of promoter elements involved in adaptive regulation of the taurine transporter gene: role of cytosolic Ca2+ signaling. Adv Exp Med Biol, 483, 535-44, 2002.
  30. Han, X, Budreau, AM, Chesney, RW, Sturman, JA. Does the taurine transporter gene play a role in 3p-syndrome. Adv Exp Med Biol, 483, 613-9, 2002.
  31. Chesney, RW. The impact of medical school loans and the promise of loan repayment on entry into a pediatric academic career. Arch Pediatr Adolesc Med, 155 (12), 1296-7, 2001.
  32. Chesney, RW. Joseph W. St. Geme, Jr address 2001: can one have a successful academic career in 2001. Pediatrics, 108 (6), 1349-52, 2001.
  33. Chesney, RW. Privacy and its regulation: too much too soon, or too little too late. Pediatrics, 107 (6), 1423-4, 2001.
  34. Chesney, RW, McAnarney, E. AMSPDC: an overview of its history and evolving mission. J Pediatr, 138 (5), 615-6, 2001.
  35. Chesney, RW. Vitamin D deficiency and rickets. Rev Endocr Metab Disord, 2 (2), 145-51, 2001.
  36. Chesney, RW, Adamson, P, Wells, T, Wilson, JT, Walson, PD. The testing of antihypertensive medications in children: report of the Antihypertensive Agent Guidelines Subcommittee of the Pediatric Pharmacology Research Units. Pediatrics, 107 (3), 558-61, 2001.
  37. Han, X, Budreau, AM, Chesney, RW. The taurine transporter gene and its role in renal development. Amino Acids, 19 (3-4), 499-507, 2001.
  38. Han, X, Budreau, AM, Chesney, RW. Ser-322 is a critical site for PKC regulation of the MDCK cell taurine transporter (pNCT). J Am Soc Nephrol, 10 (9), 1874-9, 1999.
  39. Christensen, ML, Helms, RA, Chesney, RW. Is pediatric labeling really necessary. Pediatrics, 104 (3 Pt 2), 593-7, 1999.
  40. Thompson, JW, Chesney, RW, Stocks, RM, Shmerling, J, Herron, P. Pediatric hospitals' and physician strategies for the 21st century. Clin Pediatr (Phila), 38 (5), 259-63, 1999.
  41. Chesney, RW. The idiopathic nephrotic syndrome. Curr Opin Pediatr, 11 (2), 158-61, 1999.
  42. Helms, RA, Storm, MC, Christensen, ML, Hak, EB, Chesney, RW. Cysteine supplementation results in normalization of plasma taurine concentrations in children receiving home parenteral nutrition. J Pediatr, 134 (3), 358-61, 1999.
  43. Ilyas, M, Ammons, JD, Gaber, AO, Roy, S, Batisky, DL, Chesney, RW, Jones, DP, Wyatt, RJ. Comparable renal graft survival in African-American and Caucasian recipients. Pediatr Nephrol, 12 (7), 534-9, 1998.
  44. Chesney, RW, Helms, RA, Christensen, M, Budreau, AM, Han, X, Sturman, JA. An updated view of the value of taurine in infant nutrition. Adv Pediatr, 45, 179-200, 1998.
  45. Chesney, RW. The maintenance need for water in parenteral fluid therapy. Pediatrics, 102 (2 Pt 1), 399-400, 1998.
  46. Chesney, RW, Helms, RA, Christensen, M, Budreau, AM, Han, X, Sturman, JA. The role of taurine in infant nutrition. Adv Exp Med Biol, 442, 463-76, 1998.
  47. Han, X, Budreau, AM, Chesney, RW. Molecular cloning and functional expression of an LLC-PK1 cell taurine transporter that is adaptively regulated by taurine. Adv Exp Med Biol, 442, 261-8, 1998.
  48. Han, X, Budreau, AM, Chesney, RW. Functional expression of rat renal cortex taurine transporter in Xenopus laevis oocytes: adaptive regulation by dietary manipulation. Pediatr Res, 41 (5), 624-31, 1997.
  49. Han, X, Budreau, AM, Chesney, RW. Adaptive regulation of MDCK cell taurine transporter (pNCT) mRNA: transcription of pNCT gene is regulated by external taurine concentration. Biochim Biophys Acta, 1351 (3), 296-304, 1997.
  50. Han, X, Budreau, AM, Chesney, RW. Role of conserved peptide in taurine transporter inactivation modulated by protein kinase C. J Am Soc Nephrol, 7 (10), 2088-96, 1996.
  51. Koo, WW, Walters, J, Bush, AJ, Chesney, RW, Carlson, SE. Dual-energy X-ray absorptiometry studies of bone mineral status in newborn infants. J Bone Miner Res, 11 (7), 997-102, 1996.
  52. Han, X, Chesney, RW, Budreau, AM, Jones, DP. Regulation of expression of taurine transport in two continuous renal epithelial cell lines and inhibition of taurine transporter by a site-directed antibody. Adv Exp Med Biol, 403, 173-91, 1996.
  53. Helms, RA, Chesney, RW, Storm, MC. Sulfur amino acid metabolism in infants on parenteral nutrition. Clin Nutr, 14 (6), 381-7, 1995.
  54. Koo, WW, Chesney, RW, Mitchell, N. Case report: effect of pregnancy on idiopathic juvenile osteoporosis. Am J Med Sci, 309 (4), 223-5, 1995.
  55. Jones, DP, Mahmoud, H, Chesney, RW. Tumor lysis syndrome: pathogenesis and management. Pediatr Nephrol, 9 (2), 206-12, 1995.
  56. Jones, DP, Chesney, RW. Renal toxicity of cancer chemotherapeutic agents in children: ifosfamide and cisplatin. Curr Opin Pediatr, 7 (2), 208-13, 1995.
  57. Sehic, A, Chesney, RW. Acute renal failure: therapy. Pediatr Rev, 16 (4), 137-41, 1995.
  58. Sehic, A, Chesney, RW. Acute renal failure: diagnosis. Pediatr Rev, 16 (3), 101-6, 1995.
  59. Pivnick, EK, Kerr, NC, Kaufman, RA, Jones, DP, Chesney, RW. Rickets secondary to phosphate depletion. A sequela of antacid use in infancy. Clin Pediatr (Phila), 34 (2), 73-8, 1995.
  60. Jones, DP, Miller, LA, Chesney, RW. The relative roles of external taurine concentration and medium osmolality in the regulation of taurine transport in LLC-PK1 and MDCK cells. Pediatr Res, 37 (2), 227-32, 1995.
  61. Han, X, Chesney, RW. Expression of taurine transporter and its regulation by diet in Xenopus laevis oocytes following injection of rat kidney cortex mRNA. Adv Exp Med Biol, 359, 121-30, 1994.
  62. Jones, DP, Jiang, B, Chesney, RW. Regulation of taurine transport by external taurine concentration and medium osmolality in renal tubular cells in culture. Adv Exp Med Biol, 359, 131-8, 1994.
  63. Chesney, RW, Budreau, AM. Inhibitors of anion exchanger activity reduce sodium chloride-dependent taurine transport by brush border vesicles. Adv Exp Med Biol, 359, 111-20, 1994.
  64. Chesney, RW, Jones, D, Zelikovic, I. Renal amino acid transport: cellular and molecular events from clearance studies to frog eggs. Pediatr Nephrol, 7 (5), 574-84, 1993.
  65. Fitzwater, DS, Wyatt, RJ, Chesney, RW. Clinical quiz. Polyarteritis nodosa (PAN). Pediatr Nephrol, 7 (4), 501-2, 1993.
  66. Jones, DP, Miller, LA, Chesney, RW. Polarity of taurine transport in cultured renal epithelial cell lines: LLC-PK1 and MDCK. Am J Physiol, 265 (1 Pt 2), F137-45, 1993.
  67. Chesney, RW, Budreau, AM. Efflux of taurine from renal brush border membrane vesicles: is it adaptively regulated. Pediatr Nephrol, 7 (1), 35-40, 1993.
  68. Jones, DP, Chesney, RW. Development of tubular function. Clin Perinatol, 19 (1), 33-57, 1992.
  69. Jones, DP, Miller, LA, Budreau, A, Chesney, RW. Characteristics of taurine transport in cultured renal epithelial cell lines: asymmetric polarity of proximal and distal cell lines. Adv Exp Med Biol, 315, 405-11, 1992.
  70. Jones, DP, Miller, LA, Dowling, C, Chesney, RW. Regulation of taurine transporter activity in LLC-PK1 cells: role of protein synthesis and protein kinase C activation. J Am Soc Nephrol, 2 (5), 1021-9, 1991.
  71. Chesney, RW, Zelikovic, I, Budreau, A, Randle, D. Chloride and membrane potential dependence of sodium ion-proline symport. J Am Soc Nephrol, 2 (4), 885-93, 1991.
  72. Chesney, RW, Burstein, S. What investigations are appropriate in a teenage girl with chronic renal failure who has primary amenorrhea. Pediatr Nephrol, 5 (5), 586, 1991.
  73. Phelps, SJ, Evans, WE, Chesney, RW. Advances in pediatric pharmacokinetics and therapeutics. J Pediatr, 117 (6), 996-1001, 1990.
  74. Jones, DP, Miller, LA, Chesney, RW. Adaptive regulation of taurine transport in two continuous renal epithelial cell lines. Kidney Int, 38 (2), 219-26, 1990.
  75. Chesney, RW. Academic missions of division chiefs in pediatric departments. IV. The division chief as a developer of research programs in a pediatric division. Am J Dis Child, 144 (8), 895-7, 1990.
  76. Chesney, RW, Zelikovic, I, Jones, DP, Budreau, A, Jolly, K. The renal transport of taurine and the regulation of renal sodium-chloride-dependent transporter activity. Pediatr Nephrol, 4 (4), 399-407, 1990.
  77. Zelikovic, I, Chesney, RW, Friedman, AL, Ahlfors, CE. Taurine depletion in very low birth weight infants receiving prolonged total parenteral nutrition: role of renal immaturity. J Pediatr, 116 (2), 301-6, 1990.
  78. Chesney, RW. Requirements and upper limits of vitamin D intake in the term neonate, infant, and older child. J Pediatr, 116 (2), 159-66, 1990.
  79. Zelikovic, I, Budreau, A, Chesney, RW, Iwahashi, C, Lohstroh, P. Ionic and voltage requirements for tubular taurine transport. Prog Clin Biol Res, 351, 307-15, 1990.
  80. Chesney, RW. Vitamin D: can an upper limit be defined. J Nutr, 119 (12 Suppl), 1825-8, 1989.
  81. Chesney, RW, Kaufman, R, Stapleton, FB, Rivas, ML. Association of medullary sponge kidney and medullary dysplasia in Beckwith-Wiedemann syndrome. J Pediatr, 115 (5 Pt 1), 761-4, 1989.
  82. Zelikovic, I, Chesney, RW. Ionic requirements for amino acid transport. Am J Kidney Dis, 14 (4), 313-6, 1989.
  83. Zelikovic, I, Chesney, RW. Sodium-coupled amino acid transport in renal tubule. Kidney Int, 36 (3), 351-9, 1989.
  84. Zelikovic, I, Stejskal-Lorenz, E, Lohstroh, P, Budreau, A, Chesney, RW. Anion dependence of taurine transport by rat renal brush-border membrane vesicles. Am J Physiol, 256 (4 Pt 2), F646-55, 1989.
  85. Zelikovic, I, Chesney, RW. Development of renal amino acid transport systems. Semin Nephrol, 9 (1), 49-55, 1989.
  86. Chesney, PJ, Chesney, RW. Hemorrhagic shock and encephalopathy: reflections about a new devastating disorder that affects normal children. J Pediatr, 114 (2), 254-6, 1989.
  87. Chesney, RW. Current status and future needs of pediatric nephrology. Position paper from American Society of Pediatric Nephrology. Pediatr Res, 24 (6), 657-62, 1988.
  88. Chesney, RW, Zelikovic, I, Dabbagh, S, Friedman, A, Lippincott, S. Development of beta-amino acid transport in the kidney. J Exp Zool, 248 (1), 25-32, 1988.
  89. Feinstein, EI, Chesney, RW, Zelikovic, I. Peritonitis in childhood renal disease. Am J Nephrol, 8 (2), 147-65, 1988.