DALE PARKER SUTTLE, Ph.D., B.S.

Associate Professor
Pharmacology

Office: 201a Crowe Research Building
Tel: (901) 448-7810
psuttle@uthsc.edu

Publications

  1. Joshi, AA, Wu, Z, Reed, RF, Suttle, DP. Nuclear factor-Y binding to the topoisomerase IIalpha promoter is inhibited by both the p53 tumor suppressor and anticancer drugs. Mol Pharmacol, 63 (2), 359-67, 2003.
  2. Joshi, AA, Wang, Q, Suttle, DP. p53 modulation of DNA topoisomerase IIalpha gene expression. Cell Biochem Biophys, 33 (2), 209-16, 2001.
  3. Lothstein, L, Suttle, DP, Roaten, JB, Koseki, Y, Israel, M, Sweatman, TW. Catalytic inhibition of DNA topoisomerase II by N-benzyladriamycin (AD 288). Biochem Pharmacol, 60 (11), 1621-8, 2000.
  4. Wang, Q, Zambetti, GP, Suttle, DP. Inhibition of DNA topoisomerase II alpha gene expression by the p53 tumor suppressor. Mol Cell Biol, 17 (1), 389-97, 1997.
  5. Lin, T, Suttle, DP. UMP synthase activity expressed in deficient hamster cells by separate transferase and decarboxylase proteins or by linker-deleted bifunctional protein. Somat Cell Mol Genet, 21 (3), 161-75, 1995.
  6. Beck, WT, Danks, MK, Wolverton, JS, Chen, M, Granzen, B, Kim, R, Suttle, DP. Resistance of mammalian tumor cells to inhibitors of DNA topoisomerase II. Adv Pharmacol, 29B, 145-69, 1994.
  7. Danks, MK, Warmoth, MR, Friche, E, Granzen, B, Bugg, BY, Harker, WG, Zwelling, LA, Futscher, BW, Suttle, DP, Beck, WT. Single-strand conformational polymorphism analysis of the M(r) 170,000 isozyme of DNA topoisomerase II in human tumor cells. Cancer Res, 53 (6), 1373-9, 1993.
  8. Lin, T, Suttle, DP. Expression of catalytic domains of human UMP synthase in uridine auxotrophic bacteria. Somat Cell Mol Genet, 19 (2), 193-202, 1993.
  9. Beck, WT, Danks, MK, Wolverton, JS, Granzen, B, Chen, M, Schmidt, CA, Bugg, BY, Friche, E, Suttle, DP. Altered DNA topoisomerase II in multidrug resistance. Cytotechnology, 11 (2), 115-9, 1993.
  10. Bugg, BY, Danks, MK, Beck, WT, Suttle, DP. Expression of a mutant DNA topoisomerase II in CCRF-CEM human leukemic cells selected for resistance to teniposide. Proc Natl Acad Sci U S A, 88 (17), 7654-8, 1991.
  11. Qumsiyeh, MB, Suttle, DP. Localization of the adenosine deaminase, transferrin, and UMP synthetase genes on Chinese hamster chromosomes 4 and 6 by in situ hybridization. J Hered, 81 (2), 111-6, 1990.
  12. Qumsiyeh, MB, Suttle, DP. Cytogenetic analysis of amplification and deamplification of UMP synthase genes in Chinese hamster cells. Somat Cell Mol Genet, 15 (6), 503-12, 1989.
  13. Suttle, DP. A reversible selection system for UMP synthase gene amplification and deamplification. Somat Cell Mol Genet, 15 (5), 435-43, 1989.
  14. Qumsiyeh, MB, Valentine, MB, Suttle, DP. Localization of the gene for uridine monophosphate synthase to human chromosome region 3q13 by in situ hybridization. Genomics, 5 (1), 160-2, 1989.
  15. Danks, MK, Schmidt, CA, Cirtain, MC, Suttle, DP, Beck, WT. Altered catalytic activity of and DNA cleavage by DNA topoisomerase II from human leukemic cells selected for resistance to VM-26. Biochemistry, 27 (24), 8861-9, 1988.
  16. Winkler, JK, Suttle, DP. Analysis of UMP synthase gene and mRNA structure in hereditary orotic aciduria fibroblasts. Am J Hum Genet, 43 (1), 86-94, 1988.
  17. Suttle, DP, Bugg, BY, Winkler, JK, Kanalas, JJ. Molecular cloning and nucleotide sequence for the complete coding region of human UMP synthase. Proc Natl Acad Sci U S A, 85 (6), 1754-8, 1988.
  18. Beck, WT, Cirtain, MC, Danks, MK, Felsted, RL, Safa, AR, Wolverton, JS, Suttle, DP, Trent, JM. Pharmacological, molecular, and cytogenetic analysis of "atypical" multidrug-resistant human leukemic cells. Cancer Res, 47 (20), 5455-60, 1987.