PETER J. MCKINNON, Ph.D., B.S.

Professor
Anatomy and Neurobiology

Office: ST JUDE CHILDREN'S RESEARCH HOSPITAL
332 NORTH LAUDERDALE STREET
MEMPHIS TN 381050000
Tel: (901) 495-2700
n/a

Publications

  1. Frappart, PO, McKinnon, PJ. Mouse models of DNA double-strand break repair and neurological disease. DNA Repair (Amst), 7 (7), 1051-60, 2008.
  2. Green, DR, McKinnon, PJ. A survivor hits the breaks. Mol Cell, 29 (4), 411-2, 2008.
  3. Katyal, S, McKinnon, PJ. DNA strand breaks, neurodegeneration and aging in the brain. Mech Ageing Dev, 129 (7-8), 483-91, 2008.
  4. Desmots, F, Russell, HR, Michel, D, McKinnon, PJ. Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis. J Biol Chem, 283 (6), 3264-71, 2008.
  5. Phillips, ER, McKinnon, PJ. DNA double-strand break repair and development. Oncogene, 26 (56), 7799-808, 2007.
  6. Katyal, S, el-Khamisy, SF, Russell, HR, Li, Y, Ju, L, Caldecott, KW, McKinnon, PJ. TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J, 26 (22), 4720-31, 2007.
  7. Frappart, PO, McKinnon, PJ. BRCA2 function and the central nervous system. Cell Cycle, 6 (20), 2453-7, 2007.
  8. Katyal, S, McKinnon, PJ. DNA repair deficiency and neurodegeneration. Cell Cycle, 6 (19), 2360-5, 2007.
  9. Lee, Y, Kawagoe, R, Sasai, K, Li, Y, Russell, HR, Curran, T, McKinnon, PJ. Loss of suppressor-of-fused function promotes tumorigenesis. Oncogene, 26 (44), 6442-7, 2007.
  10. McKinnon, PJ, Caldecott, KW. DNA strand break repair and human genetic disease. Annu Rev Genomics Hum Genet, 8, 37-55, 2007.
  11. Frappart, PO, Lee, Y, Lamont, J, McKinnon, PJ. BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J, 26 (11), 2732-42, 2007.
  12. Lee, Y, McKinnon, PJ. Responding to DNA double strand breaks in the nervous system. Neuroscience, 145 (4), 1365-74, 2007.
  13. Lee, Y, Miller, HL, Russell, HR, Boyd, K, Curran, T, McKinnon, PJ. Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res, 66 (14), 6964-71, 2006.
  14. Orii, KE, Lee, Y, Kondo, N, McKinnon, PJ. Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A, 103 (26), 10017-22, 2006.
  15. Sasai, K, Romer, JT, Lee, Y, Finkelstein, D, Fuller, C, McKinnon, PJ, Curran, T. Shh pathway activity is down-regulated in cultured medulloblastoma cells: implications for preclinical studies. Cancer Res, 66 (8), 4215-22, 2006.
  16. Frappart, PO, McKinnon, PJ. Ataxia-telangiectasia and related diseases. Neuromolecular Med, 8 (4), 495-511, 2006.
  17. Desmots, F, Russell, HR, Lee, Y, Boyd, K, McKinnon, PJ. The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol Cell Biol, 25 (23), 10329-37, 2005.
  18. Uziel, T, Zindy, F, Xie, S, Lee, Y, Forget, A, Magdaleno, S, Rehg, JE, Calabrese, C, Solecki, D, Eberhart, CG, Sherr, SE, Plimmer, S, Clifford, SC, Hatten, ME, McKinnon, PJ, Gilbertson, RJ, Curran, T, Sherr, CJ, Roussel, MF. The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev, 19 (22), 2656-67, 2005.
  19. McKinnon, PJ. ATM and ataxia telangiectasia. EMBO Rep, 5 (8), 772-6, 2004.
  20. Abner, CW, McKinnon, PJ. The DNA double-strand break response in the nervous system. DNA Repair (Amst), 3 (8-9), 1141-7, 2004.
  21. Schuendeln, MM, Piekorz, RP, Wichmann, C, Lee, Y, McKinnon, PJ, Boyd, K, Takahashi, Y, Ihle, JN. The centrosomal, putative tumor suppressor protein TACC2 is dispensable for normal development, and deficiency does not lead to cancer. Mol Cell Biol, 24 (14), 6403-9, 2004.
  22. Kitagawa, R, Bakkenist, CJ, McKinnon, PJ, Kastan, MB. Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev, 18 (12), 1423-38, 2004.
  23. Baker, SJ, McKinnon, PJ. Tumour-suppressor function in the nervous system. Nat Rev Cancer, 4 (3), 184-96, 2004.
  24. Gajjar, A, Hernan, R, Kocak, M, Fuller, C, Lee, Y, McKinnon, PJ, Wallace, D, Lau, C, Chintagumpala, M, Ashley, DM, Kellie, SJ, Kun, L, Gilbertson, RJ. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol, 22 (6), 984-93, 2004.
  25. Jeffers, JR, Parganas, E, Lee, Y, Yang, C, Wang, J, Brennan, J, MacLean, KH, Han, J, Chittenden, T, Ihle, JN, McKinnon, PJ, Cleveland, JL, Zambetti, GP. Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell, 4 (4), 321-8, 2003.
  26. Miller, HL, Lee, Y, Zhao, J, Chong, MJ, McKinnon, PJ. Atm and c-Abl cooperate in the response to genotoxic stress during nervous system development. Brain Res Dev Brain Res, 145 (1), 31-8, 2003.
  27. Lee, Y, Miller, HL, Jensen, P, Hernan, R, Connelly, M, Wetmore, C, Zindy, F, Roussel, MF, Curran, T, Gilbertson, RJ, McKinnon, PJ. A molecular fingerprint for medulloblastoma. Cancer Res, 63 (17), 5428-37, 2003.
  28. Lagutin, OV, Zhu, CC, Kobayashi, D, Topczewski, J, Shimamura, K, Puelles, L, Russell, HR, McKinnon, PJ, Solnica-Krezel, L, Oliver, G. Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev, 17 (3), 368-79, 2003.
  29. Lee, Y, McKinnon, PJ. DNA ligase IV suppresses medulloblastoma formation. Cancer Res, 62 (22), 6395-9, 2002.
  30. Inoue, A, Seidel, MG, Wu, W, Kamizono, S, Ferrando, AA, Bronson, RT, Iwasaki, H, Akashi, K, Morimoto, A, Hitzler, JK, Pestina, TI, Jackson, CW, Tanaka, R, Chong, MJ, McKinnon, PJ, Inukai, T, Grosveld, GC, Look, AT. Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell, 2 (4), 279-88, 2002.
  31. Russell, HR, Lee, Y, Miller, HL, Zhao, J, McKinnon, PJ. Murine ovarian development is not affected by inactivation of the bcl-2 family member diva. Mol Cell Biol, 22 (19), 6866-70, 2002.
  32. Lee, Y, Chong, MJ, McKinnon, PJ. Ataxia telangiectasia mutated-dependent apoptosis after genotoxic stress in the developing nervous system is determined by cellular differentiation status. J Neurosci, 21 (17), 6687-93, 2001.
  33. Lee, Y, McKinnon, PJ. ATM dependent apoptosis in the nervous system. Apoptosis, 5 (6), 523-9, 2000.
  34. Lee, Y, Barnes, DE, Lindahl, T, McKinnon, PJ. Defective neurogenesis resulting from DNA ligase IV deficiency requires Atm. Genes Dev, 14 (20), 2576-80, 2000.
  35. Rolig, RL, McKinnon, PJ. Linking DNA damage and neurodegeneration. Trends Neurosci, 23 (9), 417-24, 2000.
  36. Chong, MJ, Murray, MR, Gosink, EC, Russell, HR, Srinivasan, A, Kapsetaki, M, Korsmeyer, SJ, McKinnon, PJ. Atm and Bax cooperate in ionizing radiation-induced apoptosis in the central nervous system. Proc Natl Acad Sci U S A, 97 (2), 889-94, 2000.
  37. McKinnon, PJ, McLaughlin, SK, Kapsetaki, M, Margolskee, RF. Extracellular matrix-associated protein Sc1 is not essential for mouse development. Mol Cell Biol, 20 (2), 656-60, 2000.
  38. Gosink, EC, Chong, MJ, McKinnon, PJ. Ataxia telangiectasia mutated deficiency affects astrocyte growth but not radiosensitivity. Cancer Res, 59 (20), 5294-8, 1999.
  39. Kamijo, T, van de Kamp, E, Chong, MJ, Zindy, F, Diehl, JA, Sherr, CJ, McKinnon, PJ. Loss of the ARF tumor suppressor reverses premature replicative arrest but not radiation hypersensitivity arising from disabled atm function. Cancer Res, 59 (10), 2464-9, 1999.
  40. Soares, HD, Morgan, JI, McKinnon, PJ. Atm expression patterns suggest a contribution from the peripheral nervous system to the phenotype of ataxia-telangiectasia. Neuroscience, 86 (4), 1045-54, 1998.
  41. Herzog, KH, Chong, MJ, Kapsetaki, M, Morgan, JI, McKinnon, PJ. Requirement for Atm in ionizing radiation-induced cell death in the developing central nervous system. Science, 280 (5366), 1089-91, 1998.