Assistant Professor
Pharmaceutical Sciences

MEMPHIS TN 381632198
Tel: (901) 448-1536


  • Postdoc/Staff Scientist, Sanford Research/USD, Nanoparticles and Drug Delivery
  • PostDoc, Cleveland Clinic, Nanoparticles and Drug Delivery
  • PostDoc, University of Nebraska Medical Center, Nanoparticles and Drug Delivery
  • PostDoc, Gwangju Institute of Science & Technology, South Korea, Materials Science, Hydrogels and Nanoparticles
  • Ph.D., Sri Krishnadevarya University, Polymer Science

Research Description

My research goal is primarily to study the fate of drug nanoformulations that leads to novel insights of various biological factors and properties responsible for effective and targeted delivery. At the translational front, my work focuses on identification of novel therapeutic treatment strategies including development of targeted delivery systems for therapeutic macromolecules; designing of anti-tumor drug formulations for improving target-ability and efficiency; developing novel multi-functional self-assembling polymer materials; and novel applications of these materials for photodynamic, hyperthermia and imaging in cancer therapeutics. The overall goal of my research is to use these studied materials to devise advanced delivery systems that can be tailored to meet the needs of individual cancer patient. Despite recent advances in diagnostic techniques and treatment modalities, cancer remains the second leading cause of mortality in the United States. Development of resistance to therapeutic drugs is a major obstacle in clinical outcome. Thus, developing novel therapeutic strategies are required in overcoming the heterogeneous functions of tumor drug resistance. Therefore, my research interest is to investigate improved therapeutic potential of clinical drug(s) using nanotechnology. Nanoparticle (nanotechnology) drug delivery systems could prove to be a promising adjunct to improve the therapeutic effect by maximizing the permeability and retention of drugs in solid tumors and thus can reduce non-specific toxicity. Additionally, drug nanoformulations also reduce the chemotherapeutic dose required for therapy due to improved targeting of drug, increased intracellular accumulation and sustained release for superior pharmacological actions. These characteristics significantly reduce the chemotherapy related adverse effects and relapse. All these prompted us to put forward more interest to generate safe and effective drug nanoformulations for cancer therapy. I have recently developed and patented a unique magnetic nanoparticle for drug delivery application which hold great potential to improve the therapeutic efficacy of existing natural and chemotherapeutic drugs. Some of my published and un-published data on this nanoformulation exhibits improved drug accumulation in target tissues.

Research Interest/Specialty

I am interested in developing my investigating skills by evaluating key opportunities in utilizing novel nanotechnology such as multi-functional therapeutics, molecular imaging, in vivo imaging, early detection, prevention, and control. My objective is to translate my basic nanotechnology research results into improved patient care, i.e., a Cancer Nanotechnology Plan (CNPlan). Toward this end, I have obtained a foundation in cancer biology and common skills to test efficacy of various anti-cancer agent nanoformulation and imaging capabilities through in vitro experiments.

Research Keywords

Nanoparticles, Nanogels, Multi-functional Nanoformulations, Drug Delivery, Imaging, Targeted Therapies, Novel Drug Treatment Modalities


  1. Chowdhury, P, Nagesh, PKB, Hatami, E, Wagh, S, Dan, N, Tripathi, MK, Khan, S, Hafeez, BB, Meibohm, B, Chauhan, SC, Jaggi, M, Yallapu, MM. Tannic acid-inspired paclitaxel nanoparticles for enhanced anticancer effects in breast cancer cells. J Colloid Interface Sci, 535, 133-148, 2018.
  2. Tripathi, MK, Zacheaus, C, Doxtater, K, Keramatnia, F, Gao, C, Yallapu, MM, Jaggi, M, Chauhan, SC. Z Probe, An Efficient Tool for Characterizing Long Non-Coding RNA in FFPE Tissues. Noncoding RNA, 4 (3), 2018.
  3. Hatami, E, Nagesh, PKB, Chowdhury, P, Chauhan, SC, Jaggi, M, Samarasinghe, AE, Yallapu, MM. Tannic Acid-Lung Fluid Assemblies Promote Interaction and Delivery of Drugs to Lung Cancer Cells. Pharmaceutics, 10 (3), 2018.
  4. Nagesh, PKB, Chowdhury, P, Hatami, E, Boya, VKN, Kashyap, VK, Khan, S, Hafeez, BB, Chauhan, SC, Jaggi, M, Yallapu, MM. miRNA-205 Nanoformulation Sensitizes Prostate Cancer Cells to Chemotherapy. Cancers (Basel), 10 (9), 2018.
  5. Chowdhury, P, Nagesh, PKB, Khan, S, Hafeez, BB, Chauhan, SC, Jaggi, M, Yallapu, MM. Development of polyvinylpyrrolidone/paclitaxel self-assemblies for breast cancer. Acta Pharm Sin B, 8 (4), 602-614, 2018.
  6. Almabadi, HM, Nagesh, PKB, Sahay, P, Bhandari, S, Eckstein, EC, Jaggi, M, Chauhan, SC, Yallapu, MM, Pradhan, P. Optical study of chemotherapy efficiency in cancer treatment via intracellular structural disorder analysis using partial wave spectroscopy. J Biophotonics, e201800056, 2018.
  7. Varaprasad, K, Nunez, D, Yallapu, MM, Jayaramudu, T, Elgueta, E, Oyarzun, P. Nano-hydroxyapatite polymeric hydrogels for dye removal. RSC Adv, 8 (32), 18118-18127, 2018.
  8. Kumar, BNP, Puvvada, N, Rajput, S, Sarkar, S, Mahto, MK, Yallapu, MM, Pathak, A, Emdad, L, Das, SK, Reis, RL, Kundu, SC, Fisher, PB, Mandal, M. Targeting of EGFR, VEGFR2, and Akt by Engineered Dual Drug Encapsulated Mesoporous Silica-Gold Nanoclusters Sensitizes Tamoxifen-Resistant Breast Cancer. Mol Pharm, 2018.
  9. Sahay, P, Ganju, A, Almabadi, HM, Ghimire, HM, Yallapu, MM, Skalli, O, Jaggi, M, Chauhan, SC, Pradhan, P. Quantification of photonic localization properties of targeted nuclear mass density variations: Application in cancer-stage detection. J Biophotonics, 11 (5), e201700257, 2018.
  10. Tripathi, MK, Doxtater, K, Keramatnia, F, Zacheaus, C, Yallapu, MM, Jaggi, M, Chauhan, SC. Role of lncRNAs in ovarian cancer: defining new biomarkers for therapeutic purposes. Drug Discov Today, 2018.
  11. Dan, N, Setua, S, Kashyap, VK, Khan, S, Jaggi, M, Yallapu, MM, Chauhan, SC. Antibody-Drug Conjugates for Cancer Therapy: Chemistry to Clinical Implications. Pharmaceuticals (Basel), 11 (2), 2018.
  12. Nagesh, PKB, Hatami, E, Chowdhury, P, Kashyap, VK, Khan, S, Hafeez, BB, Chauhan, SC, Jaggi, M, Yallapu, MM. Tannic Acid Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Prostate Cancer. Cancers (Basel), 10 (3), 2018.
  13. Ganju, A, Chauhan, SC, Hafeez, BB, Doxtater, K, Tripathi, MK, Zafar, N, Yallapu, MM, Kumar, R, Jaggi, M. Protein kinase D1 regulates subcellular localisation and metastatic function of metastasis-associated protein 1. Br J Cancer, 118 (4), 587-599, 2018.
  14. Kumari, S, Khan, S, Gupta, SC, Kashyap, VK, Yallapu, MM, Chauhan, SC, Jaggi, M. MUC13 contributes to rewiring of glucose metabolism in pancreatic cancer. Oncogenesis, 7 (2), 19, 2018.
  15. Khan, S, Zafar, N, Khan, SS, Setua, S, Behrman, SW, Stiles, ZE, Yallapu, MM, Sahay, P, Ghimire, H, Ise, T, Nagata, S, Wang, L, Wan, JY, Pradhan, P, Jaggi, M, Chauhan, SC. Clinical significance of MUC13 in pancreatic ductal adenocarcinoma. HPB (Oxford), 2018.
  16. Gong, Y, Chowdhury, P, Midde, NM, Rahman, MA, Yallapu, MM, Kumar, S. Novel elvitegravir nanoformulation approach to suppress the viral load in HIV-infected macrophages. Biochem Biophys Rep, 12, 214-219, 2017.
  17. Varaprasad, K, Raghavendra, GM, Jayaramudu, T, Yallapu, MM, Sadiku, R. A mini review on hydrogels classification and recent developments in miscellaneous applications. Mater Sci Eng C Mater Biol Appl, 79, 958-971, 2017.
  18. Kumar, S, Sinha, N, Gerth, KA, Rahman, MA, Yallapu, MM, Midde, NM. Specific packaging and circulation of cytochromes P450, especially 2E1 isozyme, in human plasma exosomes and their implications in cellular communications. Biochem Biophys Res Commun, 2017.
  19. Hafeez, BB, Ganju, A, Sikander, M, Kashyap, VK, Hafeez, ZB, Chauhan, N, Malik, S, Massey, AE, Tripathi, MK, Halaweish, FT, Zafar, N, Singh, MM, Yallapu, MM, Jaggi, M, Chauhan, SC. Ormeloxifene suppresses prostate tumor growth and metastatic phenotypes via inhibition of oncogenic β-catenin signaling and EMT progression. Mol Cancer Ther, 2017.
  20. Karuri, AR, Kashyap, VK, Yallapu, MM, Zafar, N, Kedia, SK, Jaggi, M, Chauhan, SC. Disparity in rates of HPV infection and cervical cancer in underserved US populations. Front Biosci (Schol Ed), 9, 254-269, 2017.
  21. Chowdhury, P, Roberts, AM, Khan, S, Hafeez, BB, Chauhan, SC, Jaggi, M, Yallapu, MM. Magnetic nanoformulations for prostate cancer. Drug Discov Today, 2017.
  22. Setua, S, Khan, S, Doxtater, K, Yallapu, MM, Jaggi, M, Chauhan, SC. miR-145: Revival of a Dragon in Pancreatic Cancer. J Nat Sci, 3 (3), 2017.
  23. Sikander, M, Hafeez, BB, Malik, S, Alsayari, A, Halaweish, FT, Yallapu, MM, Chauhan, SC, Jaggi, M. Cucurbitacin D exhibits potent anti-cancer activity in cervical cancer. Sci Rep, 6, 36594, 2016.
  24. Boya, VN, Lovett, R, Setua, S, Gandhi, V, Nagesh, PK, Khan, S, Jaggi, M, Yallapu, MM, Chauhan, SC. Probing mucin interaction behavior of magnetic nanoparticles. J Colloid Interface Sci, 488, 258-268, 2016.
  25. Ganju, A, Khan, S, Hafeez, BB, Behrman, SW, Yallapu, MM, Chauhan, SC, Jaggi, M. miRNA nanotherapeutics for cancer. Drug Discov Today, 2016.
  26. Setua, S, Khan, S, Yallapu, MM, Behrman, SW, Sikander, M, Khan, SS, Jaggi, M, Chauhan, SC. Restitution of Tumor Suppressor MicroRNA-145 Using Magnetic Nanoformulation for Pancreatic Cancer Therapy. J Gastrointest Surg, 2016.
  27. Khan, S, Sikander, M, Ebeling, MC, Ganju, A, Kumari, S, Yallapu, MM, Hafeez, BB, Ise, T, Nagata, S, Zafar, N, Behrman, SW, Wan, JY, Ghimire, HM, Sahay, P, Pradhan, P, Chauhan, SC, Jaggi, M. MUC13 interaction with receptor tyrosine kinase HER2 drives pancreatic ductal adenocarcinoma progression. Oncogene, 2016.
  28. Nagesh, PK, Johnson, NR, Boya, VK, Chowdhury, P, Othman, SF, Khalilzad-Sharghi, V, Hafeez, BB, Ganju, A, Khan, S, Behrman, SW, Zafar, N, Chauhan, SC, Jaggi, M, Yallapu, MM. PSMA targeted docetaxel-loaded superparamagnetic iron oxide nanoparticles for prostate cancer. Colloids Surf B Biointerfaces, 144, 8-20, 2016.
  29. Zaman, MS, Chauhan, N, Yallapu, MM, Gara, RK, Maher, DM, Kumari, S, Sikander, M, Khan, S, Zafar, N, Jaggi, M, Chauhan, SC. Curcumin Nanoformulation for Cervical Cancer Treatment. Sci Rep, 6, 20051, 2015.
  30. Yallapu, MM, Nagesh, PK, Jaggi, M, Chauhan, SC. Therapeutic Applications of Curcumin Nanoformulations. AAPS J, 2015.
  31. Rao, P, Yallapu, MM, Sari, Y, Fisher, PB, Kumar, S. Designing Novel Nanoformulations Targeting Glutamate Transporter Excitatory Amino Acid Transporter 2: Implications in Treating Drug Addiction. J Pers Nanomed, 1 (1), 3-9, 2015.
  32. Khan, S, Chauhan, N, Yallapu, MM, Ebeling, MC, Balakrishna, S, Ellis, RT, Thompson, PA, Balabathula, P, Behrman, SW, Zafar, N, Singh, MM, Halaweish, FT, Jaggi, M, Chauhan, SC. Nanoparticle formulation of ormeloxifene for pancreatic cancer. Biomaterials, 53, 731-43, 2015.
  33. Khan, S, Ebeling, MC, Chauhan, N, Thompson, PA, Gara, RK, Ganju, A, Yallapu, MM, Behrman, SW, Zhao, H, Zafar, N, Singh, MM, Jaggi, M, Chauhan, SC. Ormeloxifene Suppresses Desmoplasia and Enhances Sensitivity of Gemcitabine in Pancreatic Cancer. Cancer Res, 2015.
  34. Yallapu, MM, Chauhan, N, Othman, SF, Khalilzad-Sharghi, V, Ebeling, MC, Khan, S, Jaggi, M, Chauhan, SC. Implications of protein corona on physico-chemical and biological properties of magnetic nanoparticles. Biomaterials, 46, 1-12, 2015.
  35. PSS Rao, Murali M. Yallapu, Youssef Sari, Paul B. Fisher, and Santosh Kumar. Designing Novel Nanoformulations Targeting Glutamate Transporter 1/Excitatory Amino Acid Transporter 2: Implications in Treating Drug Addiction. J Personali NanoMed, 1 (1), 2-7, 2015.
  36. Gara, RK, Kumari, S, Ganju, A, Yallapu, MM, Jaggi, M, Chauhan, SC. Slit/Robo pathway: a promising therapeutic target for cancer. Drug Discov Today, 2014.
  37. Khan, S, Ebeling, MC, Zaman, MS, Sikander, M, Yallapu, MM, Chauhan, N, Yacoubian, AM, Behrman, SW, Zafar, N, Kumar, D, Thompson, PA, Jaggi, M, Chauhan, SC. MicroRNA-145 targets MUC13 and suppresses growth and invasion of pancreatic cancer. Oncotarget, 5 (17), 7599-609, 2014.
  38. Yallapu, MM, Katti, KS, Katti, DR, Mishra, SR, Khan, S, Jaggi, M, Chauhan, SC. The Roles of Cellular Nanomechanics in Cancer. Med Res Rev, 2014.
  39. Yallapu, MM, Khan, S, Maher, DM, Ebeling, MC, Sundram, V, Chauhan, N, Ganju, A, Balakrishna, S, Gupta, BK, Zafar, N, Jaggi, M, Chauhan, SC. Anti-cancer activity of curcumin loaded nanoparticles in prostate cancer. Biomaterials, 2014.
  40. Bajpai, SK, Pathak, V, Soni, B, Mohan, YM. CNWs loaded poly(SA) hydrogels: Effect of high concentration of CNWs on water uptake and mechanical properties. Carbohydr Polym, 106, 351-8, 2014.
  41. Ganju, A, Yallapu, MM, Khan, S, Behrman, SW, Chauhan, SC, Jaggi, M. Nanoways to overcome docetaxel resistance in prostate cancer. Drug Resist Updat, 2014.
  42. Yallapu, MM, Ebeling, MC, Khan, S, Sundram, V, Chauhan, N, Gupta, BK, Puumala, SE, Jaggi, M, Chauhan, SC. Novel curcumin-loaded magnetic nanoparticles for pancreatic cancer treatment. Mol Cancer Ther, 12 (8), 1471-80, 2013.
  43. Yallapu, MM, Ebeling, MC, Jaggi, M, Chauhan, SC. Plasma proteins interaction with curcumin nanoparticles: implications in cancer therapeutics. Curr Drug Metab, 14 (4), 504-15, 2013.
  44. Yallapu, MM, Jaggi, M, Chauhan, SC. Curcumin nanomedicine: a road to cancer therapeutics. Curr Pharm Des, 19 (11), 1994-2010, 2012.
  45. Yallapu, MM, Othman, SF, Curtis, ET, Bauer, NA, Chauhan, N, Kumar, D, Jaggi, M, Chauhan, SC. Curcumin-loaded magnetic nanoparticles for breast cancer therapeutics and imaging applications. Int J Nanomedicine, 7, 1761-79, 2012.
  46. Yallapu, MM, Jaggi, M, Chauhan, SC. Curcumin nanoformulations: a future nanomedicine for cancer. Drug Discov Today, 17 (1-2), 71-80, 2012.
  47. Yallapu, MM, Dobberpuhl, MR, Maher, DM, Jaggi, M, Chauhan, SC. Design of curcumin loaded cellulose nanoparticles for prostate cancer. Curr Drug Metab, 13 (1), 120-8, 2012.
  48. Yallapu, MM, Ebeling, MC, Chauhan, N, Jaggi, M, Chauhan, SC. Interaction of curcumin nanoformulations with human plasma proteins and erythrocytes. Int J Nanomedicine, 6, 2779-90, 2011.
  49. Yallapu, MM, Jaggi, M, Chauhan, SC. Design and engineering of nanogels for cancer treatment. Drug Discov Today, 16 (9-10), 457-63, 2011.
  50. Yallapu, MM, Othman, SF, Curtis, ET, Gupta, BK, Jaggi, M, Chauhan, SC. Multi-functional magnetic nanoparticles for magnetic resonance imaging and cancer therapy. Biomaterials, 32 (7), 1890-905, 2011.
  51. Yallapu, MM, Gupta, BK, Jaggi, M, Chauhan, SC. Fabrication of curcumin encapsulated PLGA nanoparticles for improved therapeutic effects in metastatic cancer cells. J Colloid Interface Sci, 351 (1), 19-29, 2010.
  52. Yallapu, MM, Foy, SP, Jain, TK, Labhasetwar, V. PEG-functionalized magnetic nanoparticles for drug delivery and magnetic resonance imaging applications. Pharm Res, 27 (11), 2283-95, 2010.
  53. Yallapu, MM, Jaggi, M, Chauhan, SC. Poly(β-cyclodextrin)/curcumin self-assembly: a novel approach to improve curcumin delivery and its therapeutic efficacy in prostate cancer cells. Macromol Biosci, 10 (10), 1141-51, 2010.
  54. Yallapu, MM, Jaggi, M, Chauhan, SC. beta-Cyclodextrin-curcumin self-assembly enhances curcumin delivery in prostate cancer cells. Colloids Surf B Biointerfaces, 79 (1), 113-25, 2010.
  55. Yallapu, MM, Jaggi, M, Chauhan, SC. Scope of nanotechnology in ovarian cancer therapeutics. J Ovarian Res, 3, 19, 2010.
  56. Vimala, K, Mohan, YM, Sivudu, KS, Varaprasad, K, Ravindra, S, Reddy, NN, Padma, Y, Sreedhar, B, MohanaRaju, K. Fabrication of porous chitosan films impregnated with silver nanoparticles: a facile approach for superior antibacterial application. Colloids Surf B Biointerfaces, 76 (1), 248-58, 2010.
  57. Yallapu, MM, Maher, DM, Sundram, V, Bell, MC, Jaggi, M, Chauhan, SC. Curcumin induces chemo/radio-sensitization in ovarian cancer cells and curcumin nanoparticles inhibit ovarian cancer cell growth. J Ovarian Res, 3, 11, 2010.
  58. Thomas, V, Yallapu, MM, Sreedhar, B, Bajpai, SK. Fabrication, characterization of chitosan/nanosilver film and its potential antibacterial application. J Biomater Sci Polym Ed, 20 (14), 2129-44, 2009.
  59. Reddy, MK, Vasir, JK, Sahoo, SK, Jain, TK, Yallapu, MM, Labhasetwar, V. Inhibition of apoptosis through localized delivery of rapamycin-loaded nanoparticles prevented neointimal hyperplasia and reendothelialized injured artery. Circ Cardiovasc Interv, 1 (3), 209-16, 2008.
  60. Namdeo, M, Saxena, S, Tankhiwale, R, Bajpai, M, Mohan, YM, Bajpai, SK. Magnetic nanoparticles for drug delivery applications. J Nanosci Nanotechnol, 8 (7), 3247-71, 2008.
  61. Thomas, V, Yallapu, MM, Sreedhar, B, Bajpai, SK. A versatile strategy to fabricate hydrogel-silver nanocomposites and investigation of their antimicrobial activity. J Colloid Interface Sci, 315 (1), 389-95, 2007.
  62. Bajpai, SK, Mohan, YM, Bajpai, M, Tankhiwale, R, Thomas, V. Synthesis of polymer stabilized silver and gold nanostructures. J Nanosci Nanotechnol, 7 (9), 2994-3010, 2007.