MARK S. LEDOUX, M.D.

LeDoux, Mark S., M.D., Ph.D.
Professor, Neurology
Professor, Anatomy & Neurobiology

Office: 415 LINK BUILDING
855 MONROE AVENUE
MEMPHIS TN 381630000
Tel: (901) 448-1662
mledoux@uthsc.edu

Education

  • Ph.D., University of Alabama at Birmingham, Birmingham, AL, Neuroscience
  • M.D., LSU School of Medicine, New Orleans, LA, Medicine
  • B.S., Univ. of Louisiana; Lafayette, Lafayette, LA, Chemistry

Research interest/specialty

Genetics and Molecular Biology of Dystonia

Mechanisms of Neurodegeneration in Parkinson Disease

Cell-Type Specificity of Gene Expression in the Nervous System

Treatment of Huntington Disease, Restless Legs Syndrome, Dystonia, Tourette Syndrome, Essential Tremor and Parkinson Disease

Research interest/specialty

Genetics and Molecular Biology of Dystonia Mechanisms of Neurodegeneration in Parkinson Disease Cell-Type Specificity of Gene Expression in the Nervous System Treatment of Huntington Disease, Restless Legs Syndrome, Dystonia, Tourette Syndrome, Essential Tremor and Parkinson Disease

Publications

  1. Schilling, BK, Karlage, RE, Ledoux, MS, Pfeiffer, RF, Weiss, LW, Falvo, MJ. Impaired leg extensor strength in individuals with Parkinson disease and relatedness to functional mobility. Parkinsonism Relat Disord, 2009.
  2. Ledoux, MS. Meige syndrome: What's in a name. Parkinsonism Relat Disord, 2009.
  3. ,. Randomized controlled trial of ethyl-eicosapentaenoic acid in Huntington disease: the TREND-HD study. Arch Neurol, 65 (12), 1582-9, 2008.
  4. Dorsey, ER, Beck, CA, Adams, M, Chadwick, G, de Blieck, EA, McCallum, C, Briner, L, Deuel, L, Clarke, A, Stewart, R, Shoulson, I, ,. Communicating clinical trial results to research participants. Arch Neurol, 65 (12), 1590-5, 2008.
  5. DeCuypere, M, Lu, Y, Miller, DD, LeDoux, MS. Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and Parkinson's disease brain. J Neurochem, 107 (5), 1398-413, 2008.
  6. Xiao, J, Bastian, RW, Perlmutter, JS, Racette, BA, Tabbal, SD, Karimi, M, Paniello, RC, Blitzer, A, Batish, SD, Wszolek, ZK, Uitti, RJ, Hedera, P, Simon, DK, Tarsy, D, Truong, DD, Frei, KP, Pfeiffer, RF, Gong, S, Zhao, Y, LeDoux, MS. High-throughput mutational analysis of TOR1A in primary dystonia. BMC Med Genet, 10, 24, 2008.
  7. Bloomer, RJ, Schilling, BK, Karlage, RE, Ledoux, MS, Pfeiffer, RF, Callegari, J. Effect of resistance training on blood oxidative stress in Parkinson disease. Med Sci Sports Exerc, 40 (8), 1385-9, 2008.
  8. Zhao, Y, Xiao, J, Ueda, M, Wang, Y, Hines, M, Nowak, TS, LeDoux, MS. Glial elements contribute to stress-induced torsinA expression in the CNS and peripheral nervous system. Neuroscience, 155 (2), 439-53, 2008.
  9. Zhao, Y, Decuypere, M, Ledoux, MS. Abnormal motor function and dopamine neurotransmission in DYT1 DeltaGAG transgenic mice. Exp Neurol, 210 (2), 719-730, 2008.
  10. Decuypere, M, Kalabokis, VN, Hao, R, Schroeder, D, Miller, DD, Ledoux, MS. Localization of N-methyl-norsalsolinol within rodent and human brain. J Neurosci Res, 2008.
  11. Heck, D, Zhao, Y, Roy, S, Ledoux, MS, Reiter, LT. Analysis of Cerebellar Function in Ube3a Deficient Mice Reveals Novel Genotype Specific Behaviors. Hum Mol Genet, 2008.
  12. Devanagondi, R, Egami, K, LeDoux, MS, Hess, EJ, Jinnah, HA. Neuroanatomical substrates for paroxysmal dyskinesia in lethargic mice. Neurobiol Dis, 27 (3), 249-57, 2007.
  13. Yan, J, Jiao, Y, Jiao, F, Stuart, J, Donahue, LR, Beamer, WG, Li, X, Roe, BA, LeDoux, MS, Gu, W. Effects of carbonic anhydrase VIII deficiency on cerebellar gene expression profiles in the wdl mouse. Neurosci Lett, 413 (3), 196-201, 2007.
  14. Xiao, J, Gong, S, Ledoux, MS. Caytaxin deficiency disrupts signaling pathways in cerebellar cortex. Neuroscience, 144 (2), 439-61, 2007.
  15. Zhou, FW, Xu, JJ, Zhao, Y, LeDoux, MS, Zhou, FM. Opposite functions of histamine H1 and H2 receptors and H3 receptor in substantia nigra pars reticulata. J Neurophysiol, 96 (3), 1581-91, 2006.
  16. LeDoux, MS, Xu, L, Xiao, J, Ferrell, B, Menkes, DL, Homayouni, R. Murine central and peripheral nervous system transcriptomes: comparative gene expression. Brain Res, 1107 (1), 24-41, 2006.
  17. Weller, RE, LeDoux, MS, Toll, LM, Gould, MK, Hicks, RA, Cox, JE. Subdivisions of inferior temporal cortex in squirrel monkeys make dissociable contributions to visual learning and memory. Behav Neurosci, 120 (2), 423-46, 2006.
  18. Xiao, J, Ledoux, MS. Caytaxin deficiency causes generalized dystonia in rats. Brain Res Mol Brain Res, 141 (2), 181-92, 2005.
  19. Jiao, Y, Yan, J, Zhao, Y, Donahue, LR, Beamer, WG, Li, X, Roe, BA, Ledoux, MS, Gu, W. Carbonic anhydrase-related protein VIII deficiency is associated with a distinctive lifelong gait disorder in waddles mice. Genetics, 171 (3), 1239-46, 2005.
  20. Gong, S, DeCuypere, M, Zhao, Y, LeDoux, MS. Cerebral cortical control of orbicularis oculi motoneurons. Brain Res, 1047 (2), 177-93, 2005.
  21. Jinnah, HA, Hess, EJ, Ledoux, MS, Sharma, N, Baxter, MG, Delong, MR. Rodent models for dystonia research: characteristics, evaluation, and utility. Mov Disord, 20 (3), 283-92, 2005.
  22. Xiao, J, Gong, S, Zhao, Y, LeDoux, MS. Developmental expression of rat torsinA transcript and protein. Brain Res Dev Brain Res, 152 (1), 47-60, 2004.
  23. Rahim, F, Gupta, D, Bertorini, TE, Ledoux, MS. Dropped head presentation of mitochondrial myopathy. J Clin Neuromuscul Dis, 5 (2), 108-14, 2003.
  24. Xiao, J, LeDoux, MS. Cloning, developmental regulation and neural localization of rat epsilon-sarcoglycan. Brain Res Mol Brain Res, 119 (2), 132-43, 2003.
  25. Gong, S, Zhou, Q, LeDoux, MS. Blink-related sensorimotor anatomy in the rat. Anat Embryol (Berl), 207 (3), 193-208, 2003.
  26. Cuthbertson, S, LeDoux, MS, Jones, S, Jones, J, Zhou, Q, Gong, S, Ryan, P, Reiner, A. Localization of preganglionic neurons that innervate choroidal neurons of pterygopalatine ganglion. Invest Ophthalmol Vis Sci, 44 (9), 3713-24, 2003.
  27. Gong, S, LeDoux, MS. Immunohistochemical detection of wheat germ agglutinin-horseradish peroxidase (WGA-HRP). J Neurosci Methods, 126 (1), 25-34, 2003.
  28. LeDoux, MS, Brady, KA. Secondary cervical dystonia associated with structural lesions of the central nervous system. Mov Disord, 18 (1), 60-9, 2003.
  29. Al-Hayk, K, LeDoux, MS. Epilepsia partialis continua mistaken for Parkinson's disease. Mov Disord, 18 (1), 107, 2003.
  30. LeDoux, MS, Lorden, JF. Abnormal spontaneous and harmaline-stimulated Purkinje cell activity in the awake genetically dystonic rat. Exp Brain Res, 145 (4), 457-67, 2002.
  31. Ziefer, P, Leung, J, Razzano, T, Shalish, C, LeDoux, MS, Lorden, JF, Ozelius, L, Breakefield, XO, Standaert, DG, Augood, SJ. Molecular cloning and expression of rat torsinA in the normal and genetically dystonic (dt) rat. Brain Res Mol Brain Res, 101 (1-2), 132-5, 2002.
  32. LeDoux, MS, Zhou, Q, Murphy, RB, Greene, ML, Ryan, P. Parasympathetic innervation of the meibomian glands in rats. Invest Ophthalmol Vis Sci, 42 (11), 2434-41, 2001.
  33. Kim, HS, Hong, SJ, LeDoux, MS, Kim, KS. Regulation of the tyrosine hydroxylase and dopamine beta-hydroxylase genes by the transcription factor AP-2. J Neurochem, 76 (1), 280-94, 2001.
  34. LeDoux, MS. Tularemia presenting with ataxia. Clin Infect Dis, 30 (1), 211-2, 2000.
  35. LeDoux, MS, Lorden, JF. Abnormal cerebellar output in the genetically dystonic rat. Adv Neurol, 78, 63-78, 1998.
  36. LeDoux, MS, Hurst, DC, Lorden, JF. Single-unit activity of cerebellar nuclear cells in the awake genetically dystonic rat. Neuroscience, 86 (2), 533-45, 1998.
  37. LeDoux, MS, Lorden, JF, Smith, JM, Mays, LE. Serotonergic modulation of eye blinks in cat and monkey. Neurosci Lett, 253 (1), 61-4, 1998.
  38. LeDoux, MS, McGill, LJ, Pulsinelli, WA, Pfeiffer, RF, Deuschl, G, Siderowf, A, Kurlan, R, Sethi, K. Severe bilateral tremor in a liver transplant recipient taking cyclosporine. Mov Disord, 13 (3), 589-96, 1998.
  39. LeDoux, MS. Paroxysmal kinesigenic dystonia associated with a medullary hemorrhage. Mov Disord, 12 (5), 819, 1997.
  40. LeDoux, MS, Lorden, JF, Weir, AD, Smith, JM. Blink reflex to supraorbital nerve stimulation in the cat. Exp Brain Res, 116 (1), 104-12, 1997.
  41. LeDoux, MS, Lorden, JF, Meinzen-Derr, J. Selective elimination of cerebellar output in the genetically dystonic rat. Brain Res, 697 (1-2), 91-103, 1995.
  42. LeDoux, MS, Rutledge, SL, Mountz, JM, Darji, JT. SPECT abnormalities in generalized dystonia. Pediatr Neurol, 13 (1), 5-10, 1995.
  43. Ledoux, MS, Lorden, JF, Ervin, JM. Inferior olive serotonin and norepinephrine levels during development in the genetically dystonic rat. Brain Res Bull, 33 (3), 299-305, 1994.
  44. LeDoux, MS, Lorden, JF. Focal dystonia secondary to cavernous angioma of the basal ganglia: case report and review of the literature. Neurosurgery, 32 (6), 1056, 1993.
  45. LeDoux, MS, Faye-Petersen, OM, Aronin, PA, Vaid, YN, Pitts, RM. Lumbosacral neurenteric cyst in an infant. Case report. J Neurosurg, 78 (5), 821-5, 1993.
  46. LeDoux, MS, Lorden, JF, Ervin, JM. Cerebellectomy eliminates the motor syndrome of the genetically dystonic rat. Exp Neurol, 120 (2), 302-10, 1993.
  47. LeDoux, MS, Langford, KH. Spinal cord stimulation for the failed back syndrome. Spine, 18 (2), 191-4, 1993.
  48. Whitworth, RH, LeDoux, MS, Gould, HJ. Topographic distribution of connections from the primary motor cortex to the corpus striatum in Aotus trivirgatus. J Comp Neurol, 307 (2), 177-88, 1991.
  49. LeDoux, MS, Aronin, PA, Odrezin, GT. Surgically treated cavernous angiomas of the brain stem: report of two cases and review of the literature. Surg Neurol, 35 (5), 395-9, 1991.
  50. LeDoux, MS, Naftalis, RC, Aronin, PA. Stabilization of the cervical spine in spondyloepiphyseal dysplasia congenita. Neurosurgery, 28 (4), 580-3, 1991.
  51. LeDoux, MS, Sillers, MJ, Atkins, CP. Spontaneous rupture of the stomach in an adult. South Med J, 84 (3), 399-401, 1991.
  52. Gould, HJ, Whitworth, RH, LeDoux, MS. Thalamic and extrathalamic connections of the dysgranular unresponsive zone in the grey squirrel (Sciurus carolinensis). J Comp Neurol, 287 (1), 38-63, 1989.
  53. Ledoux, MS, Whitworth, RH, Gould, HJ. Interhemispheric connections of the somatosensory cortex in the rabbit. J Comp Neurol, 258 (1), 145-57, 1987.