MEHMET KOCAK, Ph.D.

Assistant Professor
Preventive Medicine

Office: 633 Doctors Office Building
Tel: (901) 448-5900
mkocak1@uthsc.edu
https://academic.uthsc.edu/docs/fac_port_cv/Mehmet_Kocak_CV_2012_04_02.pdf

Education

  • Ph.D., University of Memphis, Applied Statistics
  • M.S., Michigan State University, Applied Statistics
  • B.S., Hacettepe University, Ankara, Turkey, Statistics

Publications

  1. Blaney, SM, Kocak, M, Gajjar, A, Chintagumpala, M, Merchant, T, Kieran, M, Pollack, IF, Gururangan, S, Geyer, R, Phillips, P, McLendon, RE, Packer, R, Goldman, S, Banerjee, A, Heideman, R, Boyett, JM, Kun, L. Pilot study of systemic and intrathecal mafosfamide followed by conformal radiation for infants with intracranial central nervous system tumors: a pediatric brain tumor consortium study (PBTC-001). J Neurooncol, 2012.
  2. Qaddoumi, I, Sane, M, Li, S, Kocak, M, Pai-Panandiker, A, Harreld, J, Klimo, P, Wright, K, Broniscer, A, Gajjar, A. Diagnostic utility and correlation of tumor markers in the serum and cerebrospinal fluid of children with intracranial germ cell tumors. Childs Nerv Syst, 28 (7), 1017-24, 2012.
  3. Pui, CH, Pei, D, Pappo, AS, Howard, SC, Cheng, C, Sandlund, JT, Furman, WL, Ribeiro, RC, Spunt, SL, Rubnitz, JE, Jeha, S, Hudson, MM, Kun, LE, Merchant, TE, Kocak, M, Broniscer, A, Metzger, ML, Downing, JR, Leung, W, Evans, WE, Gajjar, A. Treatment Outcomes in Black and White Children With Cancer: Results From the SEER Database and St Jude Children's Research Hospital, 1992 Through 2007. J Clin Oncol, 30 (16), 2005-12, 2012.
  4. Godfraind, C, Kaczmarska, JM, Kocak, M, Dalton, J, Wright, KD, Sanford, RA, Boop, FA, Gajjar, A, Merchant, TE, Ellison, DW. Distinct disease-risk groups in pediatric supratentorial and posterior fossa ependymomas. Acta Neuropathol, 2012.
  5. Jakacki, RI, Burger, PC, Zhou, T, Holmes, EJ, Kocak, M, Onar, A, Goldwein, J, Mehta, M, Packer, RJ, Tarbell, N, Fitz, C, Vezina, G, Hilden, J, Pollack, IF. Outcome of Children With Metastatic Medulloblastoma Treated With Carboplatin During Craniospinal Radiotherapy: A Children's Oncology Group Phase I/II Study. Journal of Clinical Oncology, 2012.
  6. Fouladi, M, Stewart, CF, Olson, J, Wagner, LM, Onar-Thomas, A, Kocak, M, Packer, RJ, Goldman, S, Gururangan, S, Gajjar, A, Demuth, T, Kun, LE, Boyett, JM, Gilbertson, RJ. Phase I trial of MK-0752 in children with refractory CNS malignancies: a pediatric brain tumor consortium study. J Clin Oncol, 29 (26), 3529-34, 2011.
  7. McLendon, RE, Adekunle, A, Rajaram, V, Koçak, M, Blaney, SM. Embryonal central nervous system neoplasms arising in infants and young children: a pediatric brain tumor consortium study. Arch Pathol Lab Med, 135 (8), 984-93, 2011.
  8. Ellison, DW, Kocak, M, Figarella-Branger, D, Felice, G, Catherine, G, Pietsch, T, Frappaz, D, Massimino, M, Grill, J, Boyett, JM, Grundy, RG. Histopathological grading of pediatric ependymoma: reproducibility and clinical relevance in European trial cohorts. J Negat Results Biomed, 10, 7, 2011.
  9. Poussaint, TY, Kocak, M, Vajapeyam, S, Packer, RI, Robertson, RL, Geyer, R, Haas-Kogan, D, Pollack, IF, Vezina, G, Zimmerman, R, Cha, S, Patay, Z, Boyett, JM, Kun, LE. MRI as a central component of clinical trials analysis in brainstem glioma: a report from the Pediatric Brain Tumor Consortium (PBTC). Neuro Oncol, 13 (4), 417-27, 2011.
  10. Ellison, DW, Kocak, M, Dalton, J, Megahed, H, Lusher, ME, Ryan, SL, Zhao, W, Nicholson, SL, Taylor, RE, Bailey, S, Clifford, SC. Definition of disease-risk stratification groups in childhood medulloblastoma using combined clinical, pathologic, and molecular variables. J Clin Oncol, 29 (11), 1400-7, 2011.
  11. Haas-Kogan, DA, Banerjee, A, Poussaint, TY, Kocak, M, Prados, MD, Geyer, JR, Fouladi, M, Broniscer, A, Minturn, JE, Pollack, IF, Packer, RJ, Boyett, JM, Kun, LE. Phase II trial of tipifarnib and radiation in children with newly diagnosed diffuse intrinsic pontine gliomas. Neuro Oncol, 13 (3), 298-306, 2011.
  12. Ellison, DW, Dalton, J, Kocak, M, Nicholson, SL, Fraga, C, Neale, G, Kenney, AM, Brat, DJ, Perry, A, Yong, WH, Taylor, RE, Bailey, S, Clifford, SC, Gilbertson, RJ. Medulloblastoma: clinicopathological correlates of SHH, WNT, and non-SHH/WNT molecular subgroups. Acta Neuropathol, 121 (3), 381-96, 2011.
  13. Pollack, IF, Stewart, CF, Kocak, M, Poussaint, TY, Broniscer, A, Banerjee, A, Douglas, JG, Kun, LE, Boyett, JM, Geyer, JR. A phase II study of gefitinib and irradiation in children with newly diagnosed brainstem gliomas: a report from the Pediatric Brain Tumor Consortium. Neuro Oncol, 13 (3), 290-7, 2011.
  14. Zukotynski, KA, Fahey, FH, Kocak, M, Alavi, A, Wong, TZ, Treves, ST, Shulkin, BL, Haas-Kogan, DA, Geyer, JR, Vajapeyam, S, Boyett, JM, Kun, LE, Poussaint, TY. Evaluation of 18F-FDG PET and MRI associations in pediatric diffuse intrinsic brain stem glioma: a report from the Pediatric Brain Tumor Consortium. J Nucl Med, 52 (2), 188-95, 2011.
  15. Löbel, U, Sedlacik, J, Reddick, WE, Kocak, M, Ji, Q, Broniscer, A, Hillenbrand, CM, Patay, Z. Quantitative diffusion-weighted and dynamic susceptibility-weighted contrast-enhanced perfusion MR imaging analysis of T2 hypointense lesion components in pediatric diffuse intrinsic pontine glioma. AJNR Am J Neuroradiol, 32 (2), 315-22, 2011.
  16. Löbel, U, Sedlacik, J, Sabin, ND, Kocak, M, Broniscer, A, Hillenbrand, CM, Patay, Z. Three-dimensional susceptibility-weighted imaging and two-dimensional T2*-weighted gradient-echo imaging of intratumoral hemorrhages in pediatric diffuse intrinsic pontine glioma. Neuroradiology, 52 (12), 1167-77, 2010.
  17. Geyer, JR, Stewart, CF, Kocak, M, Broniscer, A, Phillips, P, Douglas, JG, Blaney, SM, Packer, RJ, Gururangan, S, Banerjee, A, Kieran, MW, Kun, LE, Gilbertson, RJ, Boyett, JM. A phase I and biology study of gefitinib and radiation in children with newly diagnosed brain stem gliomas or supratentorial malignant gliomas. Eur J Cancer, 46 (18), 3287-93, 2010.
  18. Zhao, W, Boyett, JM, Kocak, M, Ellison, DW, Wu, Y. Maximum likelihood estimation of reviewers' acumen in central review setting: categorical data. Theor Biol Med Model, 8, 3, 2010.
  19. Broniscer, A, Baker, JN, Tagen, M, Onar-Thomas, A, Gilbertson, RJ, Davidoff, AM, Pai Panandiker, AS, Panandiker, AP, Leung, W, Chin, TK, Stewart, CF, Kocak, M, Rowland, C, Merchant, TE, Kaste, SC, Gajjar, A. Phase I study of vandetanib during and after radiotherapy in children with diffuse intrinsic pontine glioma. J Clin Oncol, 28 (31), 4762-8, 2010.
  20. Fahey, FH, Kinahan, PE, Doot, RK, Kocak, M, Thurston, H, Poussaint, TY. Variability in PET quantitation within a multicenter consortium. Med Phys, 37 (7), 3660-6, 2010.
  21. Sedlacik, J, Löbel, U, Kocak, M, Loeffler, RB, Reichenbach, JR, Broniscer, A, Patay, Z, Hillenbrand, CM. Attenuation of cerebral venous contrast in susceptibility-weighted imaging of spontaneously breathing pediatric patients sedated with propofol. AJNR Am J Neuroradiol, 31 (5), 901-6, 2010.
  22. Miller, NG, Reddick, WE, Kocak, M, Glass, JO, Löbel, U, Morris, B, Gajjar, A, Patay, Z. Cerebellocerebral diaschisis is the likely mechanism of postsurgical posterior fossa syndrome in pediatric patients with midline cerebellar tumors. AJNR Am J Neuroradiol, 31 (2), 288-94, 2010.
  23. Mehmet Kocak, Gaolin Zheng, Giri Narasimhan, E. Olusegun George, Saumyadipta Pyne. Differential meta-analysis for testing the relative importance of two competing null hypotheses over multiple experiments. Special Issue on Statistical Genomics in Journal of Indian Society of Agricultural Statistics, 1 (64), 1-10, 2010.
  24. Onar, A, Kocak, M, Boyett, JM. Continual reassessment method vs. traditional empirically based design: modifications motivated by Phase I trials in pediatric oncology by the Pediatric Brain Tumor Consortium. J Biopharm Stat, 19 (3), 437-55, 2009.
  25. Broniscer, A, Baker, SJ, Stewart, CF, Merchant, TE, Laningham, FH, Schaiquevich, P, Kocak, M, Morris, EB, Endersby, R, Ellison, DW, Gajjar, A. Phase I and pharmacokinetic studies of erlotinib administered concurrently with radiotherapy for children, adolescents, and young adults with high-grade glioma. Clin Cancer Res, 15 (2), 701-7, 2009.
  26. Williams, G, Fahey, FH, Treves, ST, Kocak, M, Pollack, IF, Boyett, JM, Kun, LE, Poussaint, TY. Exploratory evaluation of two-dimensional and three-dimensional methods of FDG PET quantification in pediatric anaplastic astrocytoma: a report from the Pediatric Brain Tumor Consortium (PBTC). Eur J Nucl Med Mol Imaging, 35 (9), 1651-8, 2008.
  27. Haas-Kogan, DA, Banerjee, A, Kocak, M, Prados, MD, Geyer, JR, Fouladi, M, McKnight, T, Poussaint, TY, Broniscer, A, Blaney, SM, Boyett, JM, Kun, LE. Phase I trial of tipifarnib in children with newly diagnosed intrinsic diffuse brainstem glioma. Neuro Oncol, 10 (3), 341-7, 2008.
  28. Joshi, BH, Puri, RA, Leland, P, Varricchio, F, Gupta, G, Kocak, M, Gilbertson, RJ, Puri, RK, ,. Identification of interleukin-13 receptor alpha2 chain overexpression in situ in high-grade diffusely infiltrative pediatric brainstem glioma. Neuro Oncol, 10 (3), 265-74, 2008.
  29. Loyer, P, Trembley, JH, Grenet, JA, Busson, A, Corlu, A, Zhao, W, Kocak, M, Kidd, VJ, Lahti, JM. Characterization of cyclin L1 and L2 interactions with CDK11 and splicing factors: influence of cyclin L isoforms on splice site selection. J Biol Chem, 283 (12), 7721-32, 2008.
  30. Gururangan, S, Turner, CD, Stewart, CF, O'Shaughnessy, M, Kocak, M, Poussaint, TY, Phillips, PC, Goldman, S, Packer, R, Pollack, IF, Blaney, SM, Karsten, V, Gerson, SL, Boyett, JM, Friedman, HS, Kun, LE. Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study. Clin Cancer Res, 14 (4), 1124-30, 2008.
  31. MacDonald, TJ, Stewart, CF, Kocak, M, Goldman, S, Ellenbogen, RG, Phillips, P, Lafond, D, Poussaint, TY, Kieran, MW, Boyett, JM, Kun, LE. Phase I clinical trial of cilengitide in children with refractory brain tumors: Pediatric Brain Tumor Consortium Study PBTC-012. J Clin Oncol, 26 (6), 919-24, 2008.
  32. Sanders, RP, Kocak, M, Burger, PC, Merchant, TE, Gajjar, A, Broniscer, A. High-grade astrocytoma in very young children. Pediatr Blood Cancer, 49 (7), 888-93, 2007.
  33. Broniscer, A, Baker, SJ, West, AN, Fraser, MM, Proko, E, Kocak, M, Dalton, J, Zambetti, GP, Ellison, DW, Kun, LE, Gajjar, A, Gilbertson, RJ, Fuller, CE. Clinical and molecular characteristics of malignant transformation of low-grade glioma in children. J Clin Oncol, 25 (6), 682-9, 2007.
  34. Calabrese, C, Poppleton, H, Kocak, M, Hogg, TL, Fuller, C, Hamner, B, Oh, EY, Gaber, MW, Finklestein, D, Allen, M, Frank, A, Bayazitov, IT, Zakharenko, SS, Gajjar, A, Davidoff, A, Gilbertson, RJ. A perivascular niche for brain tumor stem cells. Cancer Cell, 11 (1), 69-82, 2007.
  35. Broniscer, A, Laningham, FH, Kocak, M, Krasin, MJ, Fouladi, M, Merchant, TE, Kun, LE, Boyett, JM, Gajjar, A. Intratumoral hemorrhage among children with newly diagnosed, diffuse brainstem glioma. Cancer, 106 (6), 1364-71, 2006.
  36. Broniscer, A, Chintagumpala, M, Fouladi, M, Krasin, MJ, Kocak, M, Bowers, DC, Iacono, LC, Merchant, TE, Stewart, CF, Houghton, PJ, Kun, LE, Ledet, D, Gajjar, A. Temozolomide after radiotherapy for newly diagnosed high-grade glioma and unfavorable low-grade glioma in children. J Neurooncol, 76 (3), 313-9, 2006.
  37. Fouladi, M, Gilger, E, Kocak, M, Wallace, D, Buchanan, G, Reeves, C, Robbins, N, Merchant, T, Kun, LE, Khan, R, Gajjar, A, Mulhern, R. Intellectual and functional outcome of children 3 years old or younger who have CNS malignancies. J Clin Oncol, 23 (28), 7152-60, 2005.
  38. Howard, V, Greene, JM, Pahwa, S, Winkelstein, JA, Boyle, JM, Kocak, M, Conley, ME. The health status and quality of life of adults with X-linked agammaglobulinemia. Clin Immunol, 118 (2-3), 201-8, 2005.
  39. Mulhern, RK, Palmer, SL, Merchant, TE, Wallace, D, Kocak, M, Brouwers, P, Krull, K, Chintagumpala, M, Stargatt, R, Ashley, DM, Tyc, VL, Kun, L, Boyett, J, Gajjar, A. Neurocognitive consequences of risk-adapted therapy for childhood medulloblastoma. J Clin Oncol, 23 (24), 5511-9, 2005.
  40. Fouladi, M, Chintagumpala, M, Laningham, FH, Ashley, D, Kellie, SJ, Langston, JW, McCluggage, CW, Woo, S, Kocak, M, Krull, K, Kun, LE, Mulhern, RK, Gajjar, A. White matter lesions detected by magnetic resonance imaging after radiotherapy and high-dose chemotherapy in children with medulloblastoma or primitive neuroectodermal tumor. J Clin Oncol, 22 (22), 4551-60, 2004.
  41. Gajjar, A, Hernan, R, Kocak, M, Fuller, C, Lee, Y, McKinnon, PJ, Wallace, D, Lau, C, Chintagumpala, M, Ashley, DM, Kellie, SJ, Kun, L, Gilbertson, RJ. Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol, 22 (6), 984-93, 2004.
  42. Gilbertson, RJ, Hill, DA, Hernan, R, Kocak, M, Geyer, R, Olson, J, Gajjar, A, Rush, L, Hamilton, RL, Finkelstein, SD, Pollack, IF. ERBB1 is amplified and overexpressed in high-grade diffusely infiltrative pediatric brain stem glioma. Clin Cancer Res, 9 (10 Pt 1), 3620-4, 2003.