CESAR A. MIGLIORATI, DDS, MS, PhD

D.D.S., M.S., Ph.D.
Chair
Professor of Oral Medicine
Department of Diagnostic Sciences and Oral Medicine

Office: N231 Dunn Dental Building
Tel: (901) 448-2613
migliorati@uthsc.edu

Education

  • Ph.D., USP School of Dentistry Sao Paulo Brazil, Stomatology/HIV/AIDS
  • M.S., UC San Francisco, Oral Biology
  • M.S., USP School of Dentistry Sao Paulo Brazil, Dentistry/Dental Clinics/Stomatology
  • D.D.S., USP School of Dentistry Sao Paulo Brazil, Dentistry

Research interest/specialty

Areas of interest include oral complications of cancer therapies in adults and pediatric oncology. Particular interest involves studies with oral osteonecrosis in individuals using medications like the bisphosphonates, bevacizumab, denosumab, etc.

I have clinical specialty in Oral Medicine, more specifically the diagnosis and mangement of oral mucosal and bony lesions. In terest is focused on patients with chronic inflammatory diseases (lichen planus, pemphigoid, pemphigus, erytema multiforme), infections, cancer and HIV infection.

Research interest/specialty

Areas of interest include oral complications of cancer therapies in adults and pediatric oncology. Particular interest involves studies with oral osteonecrosis in individuals using medications like the bisphosphonates, bevacizumab, denosumab, etc. I have clinical specialty in Oral Medicine, more specifically the diagnosis and mangement of oral mucosal disease, oral complications of cancer therapy, and premalignant and malignant oral disease. Interest is focused on patients with cancer and HIV infection.

Publications

  1. Martins, MA, Martins, MD, Lascala, CA, Curi, MM, Migliorati, CA, Tenis, CA, Marques, MM. Association of laser phototherapy with PRP improves healing of bisphosphonate-related osteonecrosis of the jaws in cancer patients: A preliminary study. Oral Oncol, 48 (1), 79-84, 2012.
  2. Hellstein, JW, Adler, RA, Edwards, B, Jacobsen, PL, Kalmar, JR, Koka, S, Migliorati, CA, Ristic, H, ,. Managing the care of patients receiving antiresorptive therapy for prevention and treatment of osteoporosis: executive summary of recommendations from the American Dental Association Council on Scientific Affairs. J Am Dent Assoc, 142 (11), 1243-51, 2011.
  3. Nicolatou-Galitis, O, Papadopoulou, E, Sarri, T, Boziari, P, Karayianni, A, Kyrtsonis, MC, Repousis, P, Barbounis, V, Migliorati, CA. Osteonecrosis of the jaw in oncology patients treated with bisphosphonates: prospective experience of a dental oncology referral center. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 112 (2), 195-202, 2011.
  4. Migliorati, CA, Epstein, JB, Abt, E, Berenson, JR. Osteonecrosis of the jaw and bisphosphonates in cancer: a narrative review. Nat Rev Endocrinol, 7 (1), 34-42, 2011.
  5. Migliorati, CA, Woo, SB, Hewson, I, Barasch, A, Elting, LS, Spijkervet, FK, Brennan, MT, ,. A systematic review of bisphosphonate osteonecrosis (BON) in cancer. Support Care Cancer, 18 (8), 1099-106, 2010.
  6. Migliorati, CA, Mattos, K, Palazzolo, MJ. How patients' lack of knowledge about oral bisphosphonates can interfere with medical and dental care. J Am Dent Assoc, 141 (5), 562-6, 2010.
  7. Migliorati, CA. Commentary: Massive osteolysis or Gorham-Stout disease. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 109 (2), 242-3, 2010.
  8. Migliorati, CA, Covington, JS. New oncology drugs and osteonecrosis of the jaw (ONJ). J Tenn Dent Assoc, 89 (4), 36-8; quiz 38-9, 2010.
  9. Yarom, N, Elad, S, Madrid, C, Migliorati, CA. Osteonecrosis of the jaws induced by drugs other than bisphosphonates - a call to update terminology in light of new data. Oral Oncol, 46 (1), e1, 2010.
  10. Cummings, SR, San Martin, J, McClung, MR, Siris, ES, Eastell, R, Reid, IR, Delmas, P, Zoog, HB, Austin, M, Wang, A, Kutilek, S, Adami, S, Zanchetta, J, Libanati, C, Siddhanti, S, Christiansen, C, ,. Denosumab for prevention of fractures in postmenopausal women with osteoporosis. N Engl J Med, 361 (8), 756-65, 2009.
  11. Migliorati, CA, Schubert, MM, Peterson, DE. Bisphosphonate osteonecrosis (BON): unanswered questions and research possibilities. Rev Recent Clin Trials, 4 (2), 99-109, 2009.
  12. Migliorati, CA. Low incidence of osteonecrosis of the jaw in postmenopausal women with osteoporosis taking zoledronic acid once yearly. J Evid Based Dent Pract, 9 (1), 13-5, 2009.
  13. Edwards, BJ, Hellstein, JW, Jacobsen, PL, Kaltman, S, Mariotti, A, Migliorati, CA, ,. Updated recommendations for managing the care of patients receiving oral bisphosphonate therapy: an advisory statement from the American Dental Association Council on Scientific Affairs. J Am Dent Assoc, 139 (12), 1674-7, 2008.
  14. Edwards, BJ, Gounder, M, McKoy, JM, Boyd, I, Farrugia, M, Migliorati, C, Marx, R, Ruggiero, S, Dimopoulos, M, Raisch, DW, Singhal, S, Carson, K, Obadina, E, Trifilio, S, West, D, Mehta, J, Bennett, CL. Pharmacovigilance and reporting oversight in US FDA fast-track process: bisphosphonates and osteonecrosis of the jaw. Lancet Oncol, 9 (12), 1166-72, 2008.
  15. Migliorati, CA, Hsu, CJ, Chopra, S, Kaltman, SS. Dental management of patients with a history of bisphosphonate therapy: clinical dilemma. J Calif Dent Assoc, 36 (10), 769-74, 2008.
  16. Migliorati, CA, Armonis, BN, Nicolatou-Galitis, O. Oral osteonecrosis associated with the use of ibandronate: report of a case and clinical implications. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 106 (1), e18-21, 2008.
  17. Migliorati, CA. Intravenous bisphosphonate therapy may lead to osteonecrosis of the jaw in multiple myeloma, breast, and prostate cancer patients. J Evid Based Dent Pract, 8 (2), 93-4, 2008.
  18. Migliorati, CA. Periodontal diseases and cancer. Lancet Oncol, 9 (6), 510-2, 2008.
  19. Edwards, BJ, Migliorati, CA. Osteoporosis and its implications for dental patients. J Am Dent Assoc, 139 (5), 545-52; quiz 625-6, 2008.
  20. Diel, IJ, Fogelman, I, Al-Nawas, B, Hoffmeister, B, Migliorati, C, Gligorov, J, Väänänen, K, Pylkkänen, L, Pecherstorfer, M, Aapro, MS. Pathophysiology, risk factors and management of bisphosphonate-associated osteonecrosis of the jaw: Is there a diverse relationship of amino- and non-aminobisphosphonates. Crit Rev Oncol Hematol, 64 (3), 198-207, 2007.
  21. Migliorati, CA, Madrid, C. The interface between oral and systemic health: the need for more collaboration. Clin Microbiol Infect, 13 Suppl 4, 11-6, 2007.
  22. Siegel, MA, Migliorati, CA, Velez, I, Forrest, M. Exposed bone in the palate. J Am Dent Assoc, 138 (10), 1341-3, 2007.
  23. Schubert, MM, Eduardo, FP, Guthrie, KA, Franquin, JC, Bensadoun, RJ, Migliorati, CA, Lloid, CM, Eduardo, CP, Walter, NF, Marques, MM, Hamdi, M. A phase III randomized double-blind placebo-controlled clinical trial to determine the efficacy of low level laser therapy for the prevention of oral mucositis in patients undergoing hematopoietic cell transplantation. Support Care Cancer, 15 (10), 1145-54, 2007.
  24. Migliorati, CA, Hujoel, P. Osteonecrosis of the jaw may not be a common acute side-effect of oral bisphosphonates. J Evid Based Dent Pract, 7 (2), 77-8, 2007.
  25. Stewart, C, Cohen, D, Bhattacharyya, I, Scheitler, L, Riley, S, Calamia, K, Migliorati, C, Baughman, R, Langford, P, Katz, J. Oral manifestations of Wegener's granulomatosis: a report of three cases and a literature review. J Am Dent Assoc, 138 (3), 338-48; quiz 396, 398, 2007.
  26. Al-Hashimi, I, Schifter, M, Lockhart, PB, Wray, D, Brennan, M, Migliorati, CA, Axéll, T, Bruce, AJ, Carpenter, W, Eisenberg, E, Epstein, JB, Holmstrup, P, Jontell, M, Lozada-Nur, F, Nair, R, Silverman, B, Thongprasom, K, Thornhill, M, Warnakulasuriya, S, van der Waal, I. Oral lichen planus and oral lichenoid lesions: diagnostic and therapeutic considerations. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 103 Suppl, S25.e1-12, 2007.
  27. Brennan, M, Migliorati, CA, Lockhart, PB, Wray, D, Al-Hashimi, I, Axéll, T, Bruce, AJ, Carpenter, W, Eisenberg, E, Epstein, JB, Holmstrup, P, Jontell, M, Nair, R, Sasser, H, Schifter, M, Silverman, B, Thongprasom, K, Thornhill, M, Warnakulasuriya, S, van der Waal, I. Management of oral epithelial dysplasia: a review. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 103 Suppl, S19.e1-12, 2007.
  28. Keefe, DM, Schubert, MM, Elting, LS, Sonis, ST, Epstein, JB, Raber-Durlacher, JE, Migliorati, CA, McGuire, DB, Hutchins, RD, Peterson, DE, ,. Updated clinical practice guidelines for the prevention and treatment of mucositis. Cancer, 109 (5), 820-31, 2007.
  29. Migliorati, CA. Bisphosphonates are associated with the development of exposed bone (osteonecrosis/osteopetrosis) in the oral cavity. J Evid Based Dent Pract, 6 (4), 283-4, 2006.
  30. Migliorati, CA, Oberle-Edwards, L, Schubert, M. The role of alternative and natural agents, cryotherapy, and/or laser for management of alimentary mucositis. Support Care Cancer, 14 (6), 533-40, 2006.
  31. McGuire, DB, Johnson, J, Migliorati, C. Promulgation of guidelines for mucositis management: educating health care professionals and patients. Support Care Cancer, 14 (6), 548-57, 2006.
  32. Migliorati, CA, Siegel, MA, Elting, LS. Bisphosphonate-associated osteonecrosis: a long-term complication of bisphosphonate treatment. Lancet Oncol, 7 (6), 508-14, 2006.
  33. Migliorati, CA, Casiglia, J, Epstein, J, Jacobsen, PL, Siegel, MA, Woo, SB. Managing the care of patients with bisphosphonate-associated osteonecrosis: an American Academy of Oral Medicine position paper. J Am Dent Assoc, 136 (12), 1658-68, 2005.
  34. Migliorati, CA, Schubert, MM, Peterson, DE, Seneda, LM. Bisphosphonate-associated osteonecrosis of mandibular and maxillary bone: an emerging oral complication of supportive cancer therapy. Cancer, 104 (1), 83-93, 2005.
  35. Migliorati, CA. Bisphosphonate-associated oral osteonecrosis. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 99 (2), 135, 2005.
  36. Migliorati, CA, Birman, EG, Cury, AE. Oropharyngeal candidiasis in HIV-infected patients under treatment with protease inhibitors. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 98 (3), 301-10, 2004.
  37. Migliorati, CA. Bisphosphanates and oral cavity avascular bone necrosis. J Clin Oncol, 21 (22), 4253-4, 2003.
  38. Migliorati, CA, Migliorati, EK. Oral lesions and HIV. An approach to the diagnosis of oral mucosal lesions for the dentist in private practice. Schweiz Monatsschr Zahnmed, 107 (10), 860-71, 1997.
  39. Solèr, RA, Migliorati, C, van Waes, H, Nadal, D. Thalidomide treatment of mucosal ulcerations in HIV infection. Arch Dis Child, 74 (1), 64-5, 1996.
  40. Chinn, H, Chernoff, DN, Migliorati, CA, Silverman, S, Green, TL. Oral histoplasmosis in HIV-infected patients. A report of two cases. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 79 (6), 710-4, 1995.
  41. Jones, AC, Migliorati, CA, Stewart, CM. Oral cytology: indications, contraindications, and technique. Gen Dent, 43 (1), 74-7; quiz 79-80, 1995.
  42. Stewart, CM, Jones, AC, Bates, RE, Boeff, D, Migliorati, C, Bentrup, K. Percutaneous and mucous membrane exposure protocol in a southeastern dental school. Oral Surg Oral Med Oral Pathol, 78 (3), 401-7, 1994.
  43. Jones, AC, Pink, FE, Sandow, PL, Stewart, CM, Migliorati, CA, Baughman, RA. The Cytobrush Plus cell collector in oral cytology. Oral Surg Oral Med Oral Pathol, 77 (1), 95-9, 1994.
  44. Migliorati, CA, Koller, MM. HIV disease: medical and dental aspects and trends for the future. A literature review. Schweiz Monatsschr Zahnmed, 104 (5), 565-77, 1994.
  45. Migliorati, CA, Jones, AC, Baughman, PA. Use of exfoliative cytology in the diagnosis of oral hairy leukoplakia. Oral Surg Oral Med Oral Pathol, 76 (6), 704-10, 1993.
  46. Migliorati, CA, Ranken, R, Kaplan, MJ, Silverman, S. Reactivity of monoclonal antibodies 17.13 and 63.12 with 141 oral mucosal lesions. J Oral Pathol Med, 21 (9), 412-7, 1992.
  47. Jones, AC, Migliorati, CA, Baughman, RA. The simultaneous occurrence of oral herpes simplex virus, cytomegalovirus, and histoplasmosis in an HIV-infected patient. Oral Surg Oral Med Oral Pathol, 74 (3), 334-9, 1992.
  48. Silverman, S, Migliorati, C. Toluidine blue staining and early detection of oral precancerous and malignant lesions. Iowa Dent J, 78 (2), 15-6, 1992.
  49. May, R, Migliorati, CA. Oral manifestations of AIDS: Part 3. Dent Manage, 31 (6), 33-7, 1991.
  50. Migliorati, CA, Ranken, R, Kaplan, M, Silverman, S. Use of monoclonal antibody 17.13 in the diagnosis of human oral squamous cell carcinoma. J Oral Pathol Med, 19 (9), 414-8, 1990.
  51. Luangjamekorn, L, Silverman, S, Gallo, J, McKnight, M, Migliorati, C. Findings in 50 AIDS virus-infected patients with positive oral Candida cultures. J Dent Assoc Thai, 40 (4), 157-64, 1990.
  52. Silverman, S, McKnight, ML, Migliorati, C, Luangjarmekorn, L, Sererat, T, Taniguchi, K, Gallo, J. Chemotherapeutic mouthrinses in immunocompromised patients. Am J Dent, 2 Spec No, 303-7, 1989.
  53. Ficarra, G, Berson, AM, Silverman, S, Quivey, JM, Lozada-Nur, F, Sooy, DD, Migliorati, CA. Kaposi's sarcoma of the oral cavity: a study of 134 patients with a review of the pathogenesis, epidemiology, clinical aspects, and treatment. Oral Surg Oral Med Oral Pathol, 66 (5), 543-50, 1988.
  54. Migliorati, CA, Migliorati, EK, Silverman, S, Greenspan, D, Greenspan, JS. Phenotypic identification of mononuclear cells in oral premalignant lesions and cancer by monoclonal antibodies. J Oral Pathol, 15 (6), 352-8, 1986.
  55. Silverman, S, Migliorati, CA, Lozada-Nur, F, Greenspan, D, Conant, MA. Oral findings in people with or at high risk for AIDS: a study of 375 homosexual males. J Am Dent Assoc, 112 (2), 187-92, 1986.
  56. Silverman, S, Lozada-Nur, F, Migliorati, C. Clinical efficacy of prednisone in the treatment of patients with oral inflammatory ulcerative diseases: a study of fifty-five patients. Oral Surg Oral Med Oral Pathol, 59 (4), 360-3, 1985.
  57. Meyer, JR, Migliorati, CA, Daniels, TE, Greenspan, JS. Localization of basement membrane components in mucous membrane pemphigoid. J Invest Dermatol, 84 (2), 105-7, 1985.
  58. Migliorati, CA, Migliorati, EK, Silverman Junior, S, Lozada, F, Greenspan, JS. [Acquired immune deficiency syndrome (AIDS). Rev Assoc Paul Cir Dent, 38 (5), 351-2, 355-7, 1984.
  59. Lozada, F, Silverman, S, Migliorati, C. Adverse side effects associated with prednisone in the treatment of patients with oral inflammatory ulcerative diseases. J Am Dent Assoc, 109 (2), 269-70, 1984.
  60. Lozada-Nur, F, Silverman, S, Migliorati, C, Conant, M, Abrams, D, Volverding, PA, Greenspan, D. The diagnosis of AIDS and AIDS related complex in the dental office: findings in 171 homosexual males. CDA J, 12 (6), 21-5, 1984.
  61. Silverman, S, Migliorati, C, Barbosa, J. Toluidine blue staining in the detection of oral precancerous and malignant lesions. Oral Surg Oral Med Oral Pathol, 57 (4), 379-82, 1984.
  62. Lozada, F, Silverman, S, Migliorati, CA, Conant, MA, Volberding, PA. Oral manifestations of tumor and opportunistic infections in the acquired immunodeficiency syndrome (AIDS): findings in 53 homosexual men with Kaposi's sarcoma. Oral Surg Oral Med Oral Pathol, 56 (5), 491-4, 1983.
  63. Silverman, S, Lozada, F, Migliorati, C, Conant, M. Current assessment; dental risks and guidelines in the AIDS epidemic. CDA J, 11 (10), 7-10, 1983.
  64. Migliorati, CA, de Oliveira, MA, Migliorati, EK. [Immunology and periodontal disease. Rev Assoc Paul Cir Dent, 34 (3), 236-46, 1980.