Associate Professor

MEMPHIS TN 381033403
Tel: (901) 448-4192

Research Description

Research Keywords

Breast cancer

Drug resistance



racial disparity

Research Interest/Specialty

Molecular mechanisms of drug resistance and metastasis

Regulation of HIF1A and TGFB/EMT signaling pathways by miRNAs encoded by MIR17HG

Contribution of population-specific SNPs to racial disparity of breast cancer

Research interest/specialty

Breast cancer cell biology and antiestrogen resistance; regualtion of gene transcription


  1. Brown, M, Fan, M. Detection of miRNA in Cultured Cells or Xenograft Tissues of Breast Cancer. Methods Mol Biol, 1406, 81-8, 2016.
  2. Pfeffer, SR, Grossmann, KF, Cassidy, PB, Yang, CH, Fan, M, Kopelovich, L, Leachman, SA, Pfeffer, LM. Detection of Exosomal miRNAs in the Plasma of Melanoma Patients. J Clin Med, 4 (12), 2012-27, 2015.
  3. Brooks, DL, Schwab, LP, Krutilina, R, Parke, DN, Sethuraman, A, Hoogewijs, D, Schörg, A, Gotwald, L, Fan, M, Wenger, RH, Seagroves, TN. ITGA6 is directly regulated by hypoxia-inducible factors and enriches for cancer stem cell activity and invasion in metastatic breast cancer models. Mol Cancer, 15, 26, 2015.
  4. Pfeffer, LM, Li, K, Fleckenstein, JF, Marion, TN, Diament, J, Yang, CH, Pfeffer, SR, Fan, M, Handorf, E, Handorf, CR. An interferon response gene signature is associated with the therapeutic response of hepatitis C patients. PLoS One, 9 (8), e104202, 2014.
  5. Yang, CH, Yue, J, Pfeffer, SR, Fan, M, Paulus, E, Hosni-Ahmed, A, Sims, M, Qayyum, S, Davidoff, AM, Handorf, CR, Pfeffer, LM. MicroRNA-21 promotes glioblastoma tumorigenesis by down-regulating insulin-like growth factor-binding protein-3 (IGFBP3). J Biol Chem, 289 (36), 25079-87, 2014.
  6. Fan, M, Sethuraman, A, Brown, M, Sun, W, Pfeffer, LM. Systematic analysis of metastasis-associated genes identifies miR-17-5p as a metastatic suppressor of basal-like breast cancer. Breast Cancer Res Treat, 146 (3), 487-502, 2014.
  7. Garner, JM, Fan, M, Yang, CH, Du, Z, Sims, M, Davidoff, AM, Pfeffer, LM. Constitutive activation of signal transducer and activator of transcription 3 (STAT3) and nuclear factor κB signaling in glioblastoma cancer stem cells regulates the Notch pathway. J Biol Chem, 288 (36), 26167-76, 2013.
  8. Krutilina, R, Sun, W, Sethuraman, A, Brown, M, Seagroves, TN, Pfeffer, LM, Ignatova, T, Fan, M. MicroRNA-18a inhibits hypoxia-inducible factor 1α activity and lung metastasis in basal breast cancers. Breast Cancer Res, 16 (4), R78, 2013.
  9. Fan, M, Krutilina, R, Sun, J, Sethuraman, A, Yang, CH, Wu, ZH, Yue, J, Pfeffer, LM. Comprehensive analysis of microRNA (miRNA) targets in breast cancer cells. J Biol Chem, 288 (38), 27480-93, 2013.
  10. Wang, C, Schwab, LP, Fan, M, Seagroves, TN, Buolamwini, JK. Chemoprevention activity of dipyridamole in the MMTV-PyMT transgenic mouse model of breast cancer. Cancer Prev Res (Phila), 6 (5), 437-47, 2013.
  11. Fan, M, Pfeffer, SR, Lynch, HT, Cassidy, P, Leachman, S, Pfeffer, LM, Kopelovich, L. Altered transcriptome signature of phenotypically normal skin fibroblasts heterozygous for CDKN2A in familial melanoma: relevance to early intervention. Oncotarget, 4 (1), 128-41, 2013.
  12. Chen, H, Fan, M, Pfeffer, LM, Laribee, RN. The histone H3 lysine 56 acetylation pathway is regulated by target of rapamycin (TOR) signaling and functions directly in ribosomal RNA biogenesis. Nucleic Acids Res, 40 (14), 6534-46, 2012.
  13. Niu, J, Shi, Y, Tan, G, Yang, CH, Fan, M, Pfeffer, LM, Wu, ZH. DNA damage induces NF-κB-dependent microRNA-21 up-regulation and promotes breast cancer cell invasion. J Biol Chem, 287 (26), 21783-95, 2012.
  14. Li, K, Li, NL, Wei, D, Pfeffer, SR, Fan, M, Pfeffer, LM. Activation of chemokine and inflammatory cytokine response in hepatitis C virus-infected hepatocytes depends on Toll-like receptor 3 sensing of hepatitis C virus double-stranded RNA intermediates. Hepatology, 55 (3), 666-75, 2012.
  15. Rao, SK, Pavicevic, Z, Du, Z, Kim, JG, Fan, M, Jiao, Y, Rosebush, M, Samant, S, Gu, W, Pfeffer, LM, Nosrat, CA. Pro-inflammatory genes as biomarkers and therapeutic targets in oral squamous cell carcinoma. J Biol Chem, 285 (42), 32512-21, 2010.
  16. Yang, CH, Yue, J, Fan, M, Pfeffer, LM. IFN induces miR-21 through a signal transducer and activator of transcription 3-dependent pathway as a suppressive negative feedback on IFN-induced apoptosis. Cancer Res, 70 (20), 8108-16, 2010.
  17. Wang, N, Dong, Q, Li, J, Jangra, RK, Fan, M, Brasier, AR, Lemon, SM, Pfeffer, LM, Li, K. Viral induction of the zinc finger antiviral protein is IRF3-dependent but NF-kappaB-independent. J Biol Chem, 285 (9), 6080-90, 2010.
  18. Yang, CH, Fan, M, Slominski, AT, Yue, J, Pfeffer, LM. The role of constitutively activated STAT3 in B16 melanoma cells. Int J Interferon Cytokine Mediat Res, 2010 (2), 1-7, 2010.
  19. Du, Z, Fan, M, Kim, JG, Eckerle, D, Lothstein, L, Wei, L, Pfeffer, LM. Interferon-resistant Daudi cell line with a Stat2 defect is resistant to apoptosis induced by chemotherapeutic agents. J Biol Chem, 284 (41), 27808-15, 2009.
  20. Xin, F, Li, M, Balch, C, Thomson, M, Fan, M, Liu, Y, Hammond, SM, Kim, S, Nephew, KP. Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance. Bioinformatics, 25 (4), 430-4, 2009.
  21. Rosati, SF, Williams, RF, Nunnally, LC, McGee, MC, Sims, TL, Tracey, L, Zhou, J, Fan, M, Ng, CY, Nathwani, AC, Stewart, CF, Pfeffer, LM, Davidoff, AM. IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression. Mol Cancer Ther, 7 (12), 3852-8, 2008.
  22. Wei, L, Fan, M, Xu, L, Heinrich, K, Berry, MW, Homayouni, R, Pfeffer, LM. Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes. J Interferon Cytokine Res, 28 (9), 541-51, 2008.
  23. Berry, NB, Fan, M, Nephew, KP. Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. Mol Endocrinol, 22 (7), 1535-51, 2008.
  24. Long, X, Fan, M, Bigsby, RM, Nephew, KP. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms. Mol Cancer Ther, 7 (7), 2096-108, 2008.
  25. Yang, CH, Murti, A, Pfeffer, SR, Fan, M, Du, Z, Pfeffer, LM. The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response. J Biol Chem, 283 (21), 14309-16, 2008.
  26. Du, Z, Wei, L, Murti, A, Pfeffer, SR, Fan, M, Yang, CH, Pfeffer, LM. Non-conventional signal transduction by type 1 interferons: the NF-kappaB pathway. J Cell Biochem, 102 (5), 1087-94, 2007.
  27. Fan, M, Rickert, EL, Chen, L, Aftab, SA, Nephew, KP, Weatherman, RV. Characterization of molecular and structural determinants of selective estrogen receptor downregulators. Breast Cancer Res Treat, 103 (1), 37-44, 2007.
  28. Fan, M, Yan, PS, Hartman-Frey, C, Chen, L, Paik, H, Oyer, SL, Salisbury, JD, Cheng, AS, Li, L, Abbosh, PH, Huang, TH, Nephew, KP. Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Res, 66 (24), 11954-66, 2006.
  29. Li, L, Cheng, AS, Jin, VX, Paik, HH, Fan, M, Li, X, Zhang, W, Robarge, J, Balch, C, Davuluri, RV, Kim, S, Huang, TH, Nephew, KP. A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-alpha. Bioinformatics, 22 (18), 2210-6, 2006.
  30. Cheng, AS, Jin, VX, Fan, M, Smith, LT, Liyanarachchi, S, Yan, PS, Leu, YW, Chan, MW, Plass, C, Nephew, KP, Davuluri, RV, Huang, TH. Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Mol Cell, 21 (3), 393-404, 2006.
  31. Fan, M, Park, A, Nephew, KP. CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. Mol Endocrinol, 19 (12), 2901-14, 2005.
  32. Jin, VX, Leu, YW, Liyanarachchi, S, Sun, H, Fan, M, Nephew, KP, Huang, TH, Davuluri, RV. Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray. Nucleic Acids Res, 32 (22), 6627-35, 2004.
  33. Leu, YW, Yan, PS, Fan, M, Jin, VX, Liu, JC, Curran, EM, Welshons, WV, Wei, SH, Davuluri, RV, Plass, C, Nephew, KP, Huang, TH. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Res, 64 (22), 8184-92, 2004.
  34. Fan, M, Nakshatri, H, Nephew, KP. Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation. Mol Endocrinol, 18 (11), 2603-15, 2004.
  35. Fan, M, Bigsby, RM, Nephew, KP. The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells. Mol Endocrinol, 17 (3), 356-65, 2003.
  36. Fan, M, Long, X, Bailey, JA, Reed, CA, Osborne, E, Gize, EA, Kirk, EA, Bigsby, RM, Nephew, KP. The activating enzyme of NEDD8 inhibits steroid receptor function. Mol Endocrinol, 16 (2), 315-30, 2002.