MEIYUN FAN, M.D., Ph.D.

Assistant Professor
Pathology

Office: 122 Cancer Research Building
Tel: (901) 448-4192
MFan2@uthsc.edu

Research interest/specialty

Breast cancer cell biology and antiestrogen resistance; regualtion of gene transcription

Research interest/specialty

Breast cancer cell biology and antiestrogen resistance; regualtion of gene transcription

Publications

  1. Xin, F, Li, M, Balch, C, Thomson, M, Fan, M, Liu, Y, Hammond, SM, Kim, S, Nephew, KP. Computational analysis of microRNA profiles and their target genes suggests significant involvement in breast cancer antiestrogen resistance. Bioinformatics, 25 (4), 430-4, 2009.
  2. Rosati, SF, Williams, RF, Nunnally, LC, McGee, MC, Sims, TL, Tracey, L, Zhou, J, Fan, M, Ng, CY, Nathwani, AC, Stewart, CF, Pfeffer, LM, Davidoff, AM. IFN-beta sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression. Mol Cancer Ther, 7 (12), 3852-8, 2008.
  3. Wei, L, Fan, M, Xu, L, Heinrich, K, Berry, MW, Homayouni, R, Pfeffer, LM. Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes. J Interferon Cytokine Res, 28 (9), 541-51, 2008.
  4. Long, X, Fan, M, Bigsby, RM, Nephew, KP. Apigenin inhibits antiestrogen-resistant breast cancer cell growth through estrogen receptor-alpha-dependent and estrogen receptor-alpha-independent mechanisms. Mol Cancer Ther, 7 (7), 2096-108, 2008.
  5. Berry, NB, Fan, M, Nephew, KP. Estrogen receptor-alpha hinge-region lysines 302 and 303 regulate receptor degradation by the proteasome. Mol Endocrinol, 22 (7), 1535-51, 2008.
  6. Yang, CH, Murti, A, Pfeffer, SR, Fan, M, Du, Z, Pfeffer, LM. The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response. J Biol Chem, 283 (21), 14309-16, 2008.
  7. Du, Z, Wei, L, Murti, A, Pfeffer, SR, Fan, M, Yang, CH, Pfeffer, LM. Non-conventional signal transduction by type 1 interferons: the NF-kappaB pathway. J Cell Biochem, 102 (5), 1087-94, 2007.
  8. Fan, M, Rickert, EL, Chen, L, Aftab, SA, Nephew, KP, Weatherman, RV. Characterization of molecular and structural determinants of selective estrogen receptor downregulators. Breast Cancer Res Treat, 103 (1), 37-44, 2007.
  9. Fan, M, Yan, PS, Hartman-Frey, C, Chen, L, Paik, H, Oyer, SL, Salisbury, JD, Cheng, AS, Li, L, Abbosh, PH, Huang, TH, Nephew, KP. Diverse gene expression and DNA methylation profiles correlate with differential adaptation of breast cancer cells to the antiestrogens tamoxifen and fulvestrant. Cancer Res, 66 (24), 11954-66, 2006.
  10. Li, L, Cheng, AS, Jin, VX, Paik, HH, Fan, M, Li, X, Zhang, W, Robarge, J, Balch, C, Davuluri, RV, Kim, S, Huang, TH, Nephew, KP. A mixture model-based discriminate analysis for identifying ordered transcription factor binding site pairs in gene promoters directly regulated by estrogen receptor-alpha. Bioinformatics, 22 (18), 2210-6, 2006.
  11. Cheng, AS, Jin, VX, Fan, M, Smith, LT, Liyanarachchi, S, Yan, PS, Leu, YW, Chan, MW, Plass, C, Nephew, KP, Davuluri, RV, Huang, TH. Combinatorial analysis of transcription factor partners reveals recruitment of c-MYC to estrogen receptor-alpha responsive promoters. Mol Cell, 21 (3), 393-404, 2006.
  12. Fan, M, Park, A, Nephew, KP. CHIP (carboxyl terminus of Hsc70-interacting protein) promotes basal and geldanamycin-induced degradation of estrogen receptor-alpha. Mol Endocrinol, 19 (12), 2901-14, 2005.
  13. Jin, VX, Leu, YW, Liyanarachchi, S, Sun, H, Fan, M, Nephew, KP, Huang, TH, Davuluri, RV. Identifying estrogen receptor alpha target genes using integrated computational genomics and chromatin immunoprecipitation microarray. Nucleic Acids Res, 32 (22), 6627-35, 2004.
  14. Leu, YW, Yan, PS, Fan, M, Jin, VX, Liu, JC, Curran, EM, Welshons, WV, Wei, SH, Davuluri, RV, Plass, C, Nephew, KP, Huang, TH. Loss of estrogen receptor signaling triggers epigenetic silencing of downstream targets in breast cancer. Cancer Res, 64 (22), 8184-92, 2004.
  15. Fan, M, Nakshatri, H, Nephew, KP. Inhibiting proteasomal proteolysis sustains estrogen receptor-alpha activation. Mol Endocrinol, 18 (11), 2603-15, 2004.
  16. Fan, M, Bigsby, RM, Nephew, KP. The NEDD8 pathway is required for proteasome-mediated degradation of human estrogen receptor (ER)-alpha and essential for the antiproliferative activity of ICI 182,780 in ERalpha-positive breast cancer cells. Mol Endocrinol, 17 (3), 356-65, 2003.
  17. Fan, M, Long, X, Bailey, JA, Reed, CA, Osborne, E, Gize, EA, Kirk, EA, Bigsby, RM, Nephew, KP. The activating enzyme of NEDD8 inhibits steroid receptor function. Mol Endocrinol, 16 (2), 315-30, 2002.