MICHAEL LLOYD CHRISTENSEN, Pharm.D., B.S., A.S.

Professor
Dept of Clinical Pharmacy

Office: P420 Le Bonheur Outpatient Center
Tel: (901) 448-7144
mchristensen@uthsc.edu

Education

  • Board Cert., Board of Pharmacuetical Specialists, Nutrition Support Pharmacist
  • PostDoc, St. Jude Children's Research Hosp, Pharmacokinetics/Pharmacodynamics
  • PostDoc, UT/LeBonheur Children's Med Ctr, Pediatric Pharmacy
  • Pharm.D., University of Tennessee, Memphis, Pharmacy
  • B.S., North Dakota State University, Fargo, Pharmacy
  • Other, North Dakota State College of Science, Whapeton, Pre-Pharmacy

Clinical Care Specialty/Interest

 Pediatric Parenteral Nutrition

Pediatric Clinical Pharmacology

Clinical care specialist/interest

Pharmacokinetics Service, Le Bonheur Children''s Medical Center

Parenteral Nutrition Support Service, Le Bonheur Children''s Medical Center

Area of teaching/subject

Top 200 Drugs (Pharmacy)

Pharmacy Math (Pharmacy)

Research keywords

pediatric Clinical pharmacology

Publications

  1. Elabiad, MT, Christensen, M. Changes in Premature Infant Mercury and Lead Blood Levels after Blood Transfusions. Am J Perinatol, 2013.
  2. Chhim, RF, Shelton, CM, Christensen, ML. Recent new drug approvals, part 2: drugs undergoing active clinical studies in children. J Pediatr Pharmacol Ther, 18 (1), 14-38, 2013.
  3. Shelton, CM, Chhim, RF, Christensen, ML. Recent new drug approvals. Part 1: drugs with pediatric indications. J Pediatr Pharmacol Ther, 17 (4), 329-39, 2012.
  4. Hicks, JK, Shelton, CM, Sahni, JK, Christensen, ML. Retrospective evaluation of enoxaparin dosing in patients 48 weeks' postmenstrual age or younger in a neonatal intensive care unit. Ann Pharmacother, 46 (7-8), 943-51, 2012.
  5. Christensen, ML. Best pharmaceuticals for children act and pediatric research equity act: time for permanent status. J Pediatr Pharmacol Ther, 17 (2), 140-1, 2012.
  6. Tillman, EM, Crill, CM, Black, DD, Hak, EB, Lazar, LF, Christensen, ML, Huang, EY, Helms, RA. Enteral fish oil for treatment of parenteral nutrition-associated liver disease in six infants with short-bowel syndrome. Pharmacotherapy, 31 (5), 503-9, 2011.
  7. Zhang, Y, Mehrotra, N, Budha, NR, Christensen, ML, Meibohm, B. A tandem mass spectrometry assay for the simultaneous determination of acetaminophen, caffeine, phenytoin, ranitidine, and theophylline in small volume pediatric plasma specimens. Clin Chim Acta, 398 (1-2), 105-12, 2008.
  8. Howard-Thompson, A, Christensen, ML. Elevated tobramycin concentrations following endotracheal administration in a premature infant. J Pediatr Pharmacol Ther, 13 (2), 88-92, 2008.
  9. Blake, MJ, Gaedigk, A, Pearce, RE, Bomgaars, LR, Christensen, ML, Stowe, C, James, LP, Wilson, JT, Kearns, GL, Leeder, JS. Ontogeny of dextromethorphan O- and N-demethylation in the first year of life. Clin Pharmacol Ther, 81 (4), 510-6, 2007.
  10. Crill, CM, Storm, MC, Christensen, ML, Hankins, CT, Bruce Jenkins, M, Helms, RA. Carnitine supplementation in premature neonates: effect on plasma and red blood cell total carnitine concentrations, nutrition parameters and morbidity. Clin Nutr, 25 (6), 886-96, 2006.
  11. Crill, CM, Christensen, ML, Storm, MC, Helms, RA. Relative bioavailability of carnitine supplementation in premature neonates. JPEN J Parenter Enteral Nutr, 30 (5), 421-5, 2006.
  12. Lustig, RH, Mietus-Snyder, ML, Bacchetti, P, Lazar, AA, Velasquez-Mieyer, PA, Christensen, ML. Insulin dynamics predict body mass index and z-score response to insulin suppression or sensitization pharmacotherapy in obese children. J Pediatr, 148 (1), 23-9, 2006.
  13. Elbahlawan, L, Binaei, S, Christensen, ML, Zhang, Q, Quasney, MW, Dahmer, MK. Beta2-adrenergic receptor polymorphisms in African American children with status asthmaticus. Pediatr Crit Care Med, 7 (1), 15-8, 2006.
  14. Christensen, ML, Meibohm, B, Capparelli, EV, Velasquez-Mieyer, P, Burghen, GA, Tamborlane, WV. Single- and multiple-dose pharmacokinetics of pioglitazone in adolescents with type 2 diabetes. J Clin Pharmacol, 45 (10), 1137-44, 2005.
  15. Whitworth, J, Christensen, ML. Clinical management of infants and children with gastroesophageal reflux disease. J Pediatr Pharmacol Ther, 9 (4), 243-53, 2004.
  16. Chesney, RW, Christensen, ML. Changing requirements for evaluation of pharmacologic agents. Pediatrics, 113 (4 Suppl), 1128-32, 2004.
  17. Christensen, ML, Mottern, RK, Jabbour, JT, Fuseau, E. Pharmacokinetics of sumatriptan nasal spray in children. J Clin Pharmacol, 44 (4), 359-67, 2004.
  18. Velasquez-Mieyer, PA, Umpierrez, GE, Lustig, RH, Cashion, AK, Cowan, PA, Christensen, M, Spencer, KA, Burghen, GA. Race affects insulin and GLP-1 secretion and response to a long-acting somatostatin analogue in obese adults. Int J Obes Relat Metab Disord, 28 (2), 330-3, 2004.
  19. Christensen, ML, Rashed, SM, Sinclair, J, Cowan, PA, Velasquez-Mieyer, P, Burghen, GA. Type 2 diabetes mellitus in children and adolescents: the new challenge. J Pediatr Pharmacol Ther, 9 (1), 15-26, 2004.
  20. Al-Jeraisy, M, Phelps, SJ, Christensen, ML, Einhaus, S. Intraventricular vancomycin in pediatric patients with cerebrospinal fluid shunt infections. J Pediatr Pharmacol Ther, 9 (1), 36-42, 2004.
  21. Christensen, ML, Mottern, RK, Jabbour, JT, Fuseau, E. Pharmacokinetics of sumatriptan nasal spray in adolescents. J Clin Pharmacol, 43 (7), 721-6, 2003.
  22. Christensen, ML, Chesney, RW. Has the 'therapeutic orphan' finally been adopted. J Pediatr Pharmacol Ther, 8 (3), 175-6, 2003.
  23. El Bahlawan, L, Christensen, M, Binaei, S, Murphy, C, Zhang, Q, Quasney, M. Lack of association between the tumor necrosis factor-alpha regulatory region genetic polymorphisms associated with elevated tumor necrosis factor-alpha levels and children with asthma. Chest, 123 (3 Suppl), 374S-5S, 2003.
  24. Binaei, S, Christensen, M, Murphy, C, Zhang, Q, Quasney, M. Beta2-adrenergic receptor polymorphisms in children with status asthmaticus. Chest, 123 (3 Suppl), 375S, 2003.
  25. Binaei, S, Rashed, SM, Christensen, ML. β2-Adrenoreceptor Polymorphisms in Asthmatic Patients. J Pediatr Pharmacol Ther, 8 (1), 22-8, 2003.
  26. Christensen, ML, Eades, SK, Fuseau, E, Kempsford, RD, Phelps, SJ, Hak, LJ. Pharmacokinetics of naratriptan in adolescent subjects with a history of migraine. J Clin Pharmacol, 41 (2), 170-5, 2001.
  27. Edick, CM, Parnell, D, Christensen, ML, Hak, LJ. Falsely elevated systolic blood pressure with patient-operated blood pressure measuring devices. J Am Pharm Assoc (Wash), 40 (5), 670-2, 2000.
  28. Eades, SK, Boineau, FG, Christensen, ML. Increased tacrolimus levels in a pediatric renal transplant patient attributed to chronic diarrhea. Pediatr Transplant, 4 (1), 63-6, 2000.
  29. Mouser, JF, Hak, EB, Helms, RA, Christensen, ML, Storm, MC. Chromium and zinc concentrations in pediatric patients receiving long-term parenteral nutrition. Am J Health Syst Pharm, 56 (19), 1950-6, 1999.
  30. Christensen, ML, Helms, RA, Chesney, RW. Is pediatric labeling really necessary. Pediatrics, 104 (3 Pt 2), 593-7, 1999.
  31. Helms, RA, Storm, MC, Christensen, ML, Hak, EB, Chesney, RW. Cysteine supplementation results in normalization of plasma taurine concentrations in children receiving home parenteral nutrition. J Pediatr, 134 (3), 358-61, 1999.
  32. Chesney, RW, Helms, RA, Christensen, M, Budreau, AM, Han, X, Sturman, JA. An updated view of the value of taurine in infant nutrition. Adv Pediatr, 45, 179-200, 1998.
  33. Eades, SK, Christensen, ML. The clinical pharmacology of loop diuretics in the pediatric patient. Pediatr Nephrol, 12 (7), 603-16, 1998.
  34. Chesney, RW, Helms, RA, Christensen, M, Budreau, AM, Han, X, Sturman, JA. The role of taurine in infant nutrition. Adv Exp Med Biol, 442, 463-76, 1998.
  35. Christensen, ML, Wang, WC, Harris, S, Eades, SK, Wilimas, JA. Transdermal fentanyl administration in children and adolescents with sickle cell pain crisis. J Pediatr Hematol Oncol, 18 (4), 372-6, 1996.
  36. Christensen, ML. Effect of abrupt discontinuation of high glucose infusion rates during parenteral nutrition. JPEN J Parenter Enteral Nutr, 20 (4), 309-10, 1996.
  37. Christensen, ML. The effect of dietary protein depletion on hepatic 5-fluorouracil metabolism. JPEN J Parenter Enteral Nutr, 19 (1), 88-9, 1995.
  38. Crom, WR, de Graaf, SS, Synold, T, Uges, DR, Bloemhof, H, Rivera, G, Christensen, ML, Mahmoud, H, Evans, WE. Pharmacokinetics of vincristine in children and adolescents with acute lymphocytic leukemia. J Pediatr, 125 (4), 642-9, 1994.
  39. Christensen, ML, Hancock, ML, Gattuso, J, Hurwitz, CA, Smith, C, McCormick, J, Mirro, J. Parenteral nutrition associated with increased infection rate in children with cancer. Cancer, 72 (9), 2732-8, 1993.
  40. Christensen, ML, Helms, RA, Veal, DF, Boehm, KA, Storm, MC. Clearance of N-acetyl-L-tyrosine in infants receiving a pediatric amino acid solution. Clin Pharm, 12 (8), 606-9, 1993.
  41. Christensen, ML, Burgess, J, Helms, RA, Mirro, J, Kalwinsky, DK, Storm, MC. Plasma amino acids in patients with acute nonlymphocytic leukemia receiving parenteral nutrition. Ann Pharmacother, 27 (2), 146-50, 1993.
  42. Helms, RA, Mowatt-Larssen, CA, Boehm, KA, Christensen, ML, Hughes, MA, Fernandes, ET, Storm, MC. Urinary nitrogen constituents in the postsurgical preterm neonate receiving parenteral nutrition. JPEN J Parenter Enteral Nutr, 17 (1), 68-72, 1993.
  43. Baker, DK, Relling, MV, Pui, CH, Christensen, ML, Evans, WE, Rodman, JH. Increased teniposide clearance with concomitant anticonvulsant therapy. J Clin Oncol, 10 (2), 311-5, 1992.
  44. Petros, WP, Rodman, JH, Relling, MV, Christensen, M, Pui, CH, Rivera, GK, Evans, WE. Variability in teniposide plasma protein binding is correlated with serum albumin concentrations. Pharmacotherapy, 12 (4), 273-7, 1992.
  45. Crom, WR, Relling, MV, Christensen, ML, Rivera, GK, Evans, WE. Age-related differences in hepatic drug clearance in children: studies with lorazepam and antipyrine. Clin Pharmacol Ther, 50 (2), 132-40, 1991.
  46. Phelps, SJ, Brown, RO, Helms, RA, Christensen, ML, Kudsk, K, Cochran, EB. Toxicities of parenteral nutrition in the critically ill patient. Crit Care Clin, 7 (3), 725-53, 1991.
  47. Helms, RA, Mauer, EC, Hay, WW, Christensen, ML, Storm, MC. Effect of intravenous L-carnitine on growth parameters and fat metabolism during parenteral nutrition in neonates. JPEN J Parenter Enteral Nutr, 14 (5), 448-53, 1990.
  48. Christensen, ML, Helms, RA, Mauer, EC, Storm, MC. Plasma carnitine concentration and lipid metabolism in infants receiving parenteral nutrition. J Pediatr, 115 (5 Pt 1), 794-8, 1989.
  49. Christensen, ML, Stewart, CF, Crom, WR. Evaluation of aminoglycoside disposition in patients previously treated with cisplatin. Ther Drug Monit, 11 (6), 631-6, 1989.
  50. Evans, WE, Relling, MV, de Graaf, S, Rodman, JH, Pieper, JA, Christensen, ML, Crom, WR. Hepatic drug clearance in children: studies with indocyanine green as a model substrate. J Pharm Sci, 78 (6), 452-6, 1989.
  51. Christensen, ML, Rivera, GK, Crom, WR, Hancock, ML, Evans, WE. Effect of hydration on methotrexate plasma concentrations in children with acute lymphocytic leukemia. J Clin Oncol, 6 (5), 797-801, 1988.
  52. Horowitz, ME, Etcubanas, E, Christensen, ML, Houghton, JA, George, SL, Green, AA, Houghton, PJ. Phase II testing of melphalan in children with newly diagnosed rhabdomyosarcoma: a model for anticancer drug development. J Clin Oncol, 6 (2), 308-14, 1988.
  53. Stewart, CF, Christensen, ML, Evens, RP, Cremer, M, Evans, WE. Influence of concomitant aspirin or prednisone on methotrexate synovial fluid concentration. J Pharmacol Exp Ther, 243 (1), 131-7, 1987.
  54. Helms, RA, Christensen, ML, Mauer, EC, Storm, MC. Comparison of a pediatric versus standard amino acid formulation in preterm neonates requiring parenteral nutrition. J Pediatr, 110 (3), 466-70, 1987.
  55. Crom, WR, Glynn-Barnhart, AM, Rodman, JH, Teresi, ME, Kavanagh, RE, Christensen, ML, Relling, MV, Evans, WE. Pharmacokinetics of anticancer drugs in children. Clin Pharmacokinet, 12 (3), 168-213, 1987.
  56. Helms, RA, Whitington, PF, Mauer, EC, Catarau, EM, Christensen, ML, Borum, PR. Enhanced lipid utilization in infants receiving oral L-carnitine during long-term parenteral nutrition. J Pediatr, 109 (6), 984-8, 1986.
  57. Helms, RA, Dickerson, RN, Ebbert, ML, Christensen, ML, Herrod, HG. Retinol-binding protein and prealbumin: useful measures of protein repletion in critically ill, malnourished infants. J Pediatr Gastroenterol Nutr, 5 (4), 586-92, 1986.
  58. Evans, WE, Christensen, ML. Drug interactions with methotrexate. J Rheumatol Suppl, 12 Suppl 12, 15-20, 1985.
  59. Helms, RA, Herrod, HG, Burckart, GJ, Christensen, ML. E-rosette formation, total T-cells, and lymphocyte transformation in infants receiving intravenous safflower oil emulsion. JPEN J Parenter Enteral Nutr, 7 (6), 541-5, 1983.