LESTER VANMIDDLESWORTH, Ph.D., M.D., M.S., M.S.

Distinguished Professor
Physiology

Office: 510 NASH RESEARCH BUILDING
894 UNION AVENUE
MEMPHIS TN 381630000
Tel: (901) 448-5837
lvanmidd@uthsc.edu

Education

  • M.D., University of Tennessee Medical Units, Memphis, Medicine
  • M.D., University of Tennessee Medical Units, Memphis, Medicine
  • Ph.D., University of California, Berkeley , Physiology
  • Ph.D., University of California, Berkeley, Physiology
  • M.S., University of Virginia, Charlottesville, Physiology
  • M.S., University of Virginia, Charlottesville, Physiology
  • M.S., University of Virginia, Charlottesville, Chemistry
  • M.S., University of Virginia, Charlottesville, Chemistry
  • B.S., University of Virginia, Charlottesville, Chemistry
  • B.S., University of Virginia, Charlottesville, Chemistry

Research description

Studies have included iodine deficiency and environmental contamination by radioactive isotopes. Recent clinical studies suggested that medication used to treat overactive thyroids reduced the biological response to radioiodine. Current investigations involve radiobiology of thyroid cell cultures.

Research interest/specialty

this laboratory has been evaluating physiology and pathology of the thyroid gland.

Research keywords

iodine deficiency, radioactive isotopes, radiobiology, thyroid cell cultures, gamma radiation spectral analysis, tissue culture.

Research interest/specialty

this laboratory has been evaluating physiology and pathology of the thyroid gland.

Research keywords

iodine deficiency, radioactive isotopes, radiobiology, thyroid cell cultures, gamma radiation spectral analysis, tissue culture.

Research description

Studies have included iodine deficiency and environmental contamination by radioactive isotopes. Recent clinical studies suggested that medication used to treat overactive thyroids reduced the biological response to radioiodine. Current investigations involve radiobiology of thyroid cell cultures.

Publications

  1. Deng, W, Shuyu, E, Tsukahara, R, Valentine, WJ, Durgam, G, Gududuru, V, Balazs, L, Manickam, V, Arsura, M, VanMiddlesworth, L, Johnson, LR, Parrill, AL, Miller, DD, Tigyi, G. The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology, 132 (5), 1834-51, 2007.
  2. Wilson, T, Chen, Q, Zagzebski, JA, Varghese, T, VanMiddlesworth, L. Initial clinical experience imaging scatterer size and strain in thyroid nodules. J Ultrasound Med, 25 (8), 1021-9, 2006.
  3. Imseis, RE, Vanmiddlesworth, L, Massie, JD, Bush, AJ, Vanmiddlesworth, NR. Pretreatment with propylthiouracil but not methimazole reduces the therapeutic efficacy of iodine-131 in hyperthyroidism. J Clin Endocrinol Metab, 83 (2), 685-7, 1998.
  4. VanMiddlesworth, L, Handl, J. 129I, 131I and 127I in animal thyroids after the Chernobyl nuclear accident. Health Phys, 73 (4), 647-50, 1997.
  5. Kuefer, MU, Moinuddin, M, Heideman, RL, Lustig, RH, Rose, SR, Burstein, S, VanMiddlesworth, L, Fleming, I, Jenkins, JJ, Shearer, PD. Papillary thyroid carcinoma: demographics, treatment, and outcome in eleven pediatric patients treated at a single institution. Med Pediatr Oncol, 28 (6), 433-40, 1997.