L Darryl Quarles, MD

Professor/Division Chief
Associate Dean
Exe Dean-Coll of Medicine

MEMPHIS TN 381632116
Tel: (901) 448-5385

Research Interest/Specialty

Bone and Mineral Metabolism





  1. Lu, JL, Kalantar-Zadeh, K, Ma, JZ, Quarles, LD, Kovesdy, CP. Association of Body Mass Index with Outcomes in Patients with CKD. J Am Soc Nephrol, 2014.
  2. Molnar, MZ, Kalantar-Zadeh, K, Lott, EH, Lu, JL, Malakauskas, SM, Ma, JZ, Quarles, DL, Kovesdy, CP. Angiotensin-converting enzyme inhibitor, angiotensin receptor blocker use, and mortality in patients with chronic kidney disease. J Am Coll Cardiol, 63 (7), 650-8, 2014.
  3. Pi, M, Quarles, LD. Novel bone endocrine networks integrating mineral and energy metabolism. Curr Osteoporos Rep, 11 (4), 391-9, 2013.
  4. David, V, Dai, B, Martin, A, Huang, J, Han, X, Quarles, LD. Calcium regulates FGF-23 expression in bone. Endocrinology, 154 (12), 4469-82, 2013.
  5. Kovesdy, CP, Quarles, LD. Fibroblast growth factor-23: what we know, what we don't know, and what we need to know. Nephrol Dial Transplant, 28 (9), 2228-36, 2013.
  6. Yang, W, Guo, D, Harris, MA, Cui, Y, Gluhak-Heinrich, J, Wu, J, Chen, XD, Skinner, C, Nyman, JS, Edwards, JR, Mundy, GR, Lichtler, A, Kream, BE, Rowe, DW, Kalajzic, I, David, V, Quarles, DL, Villareal, D, Scott, G, Ray, M, Liu, S, Martin, JF, Mishina, Y, Harris, SE. Bmp2 in osteoblasts of periosteum and trabecular bone links bone formation to vascularization and mesenchymal stem cells. J Cell Sci, 126 (Pt 18), 4085-98, 2013.
  7. Kovesdy, CP, Bleyer, AJ, Molnar, MZ, Ma, JZ, Sim, JJ, Cushman, WC, Quarles, LD, Kalantar-Zadeh, K. Blood pressure and mortality in U.S. veterans with chronic kidney disease: a cohort study. Ann Intern Med, 159 (4), 233-42, 2013.
  8. Kovesdy, CP, Quarles, LD, Lott, EH, Lu, JL, Ma, JZ, Molnar, MZ, Kalantar-Zadeh, K. Survival advantage in black versus white men with CKD: effect of estimated GFR and case mix. Am J Kidney Dis, 62 (2), 228-35, 2013.
  9. Kovesdy, CP, Quarles, LD. The role of fibroblast growth factor-23 in cardiorenal syndrome. Nephron Clin Pract, 123 (3-4), 194-201, 2013.
  10. Alshayeb, HM, Wall, BM, Showkat, A, Mangold, T, Quarles, LD. Chronic kidney disease and diabetes mellitus predict resistance to vitamin D replacement therapy. Am J Med Sci, 345 (4), 314-20, 2013.
  11. Quarles, LD. A systems biology preview of the relationships between mineral and metabolic complications in chronic kidney disease. Semin Nephrol, 33 (2), 130-42, 2013.
  12. Quarles, LD. Reducing cardiovascular mortality in chronic kidney disease: something borrowed, something new. J Clin Invest, 123 (2), 542-3, 2013.
  13. Martin, A, David, V, Li, H, Dai, B, Feng, JQ, Quarles, LD. Overexpression of the DMP1 C-terminal fragment stimulates FGF23 and exacerbates the hypophosphatemic rickets phenotype in Hyp mice. Mol Endocrinol, 26 (11), 1883-95, 2012.
  14. Dai, B, David, V, Alshayeb, HM, Showkat, A, Gyamlani, G, Horst, RL, Wall, BM, Quarles, LD. Assessment of 24,25(OH)2D levels does not support FGF23-mediated catabolism of vitamin D metabolites. Kidney Int, 82 (10), 1061-70, 2012.
  15. Pi, M, Wu, Y, Lenchik, NI, Gerling, I, Quarles, LD. GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets. Endocrinology, 153 (10), 4608-15, 2012.
  16. Dreaden, EC, Gryder, BE, Austin, LA, Tene Defo, BA, Hayden, SC, Pi, M, Quarles, LD, Oyelere, AK, El-Sayed, MA. Antiandrogen gold nanoparticles dual-target and overcome treatment resistance in hormone-insensitive prostate cancer cells. Bioconjug Chem, 23 (8), 1507-12, 2012.
  17. Qiu, N, Xiao, Z, Cao, L, David, V, Quarles, LD. Conditional mesenchymal disruption of pkd1 results in osteopenia and polycystic kidney disease. PLoS One, 7 (9), e46038, 2012.
  18. Quarles, LD. Role of FGF23 in vitamin D and phosphate metabolism: implications in chronic kidney disease. Exp Cell Res, 318 (9), 1040-8, 2012.
  19. Pi, M, Quarles, LD. Multiligand specificity and wide tissue expression of GPRC6A reveals new endocrine networks. Endocrinology, 153 (5), 2062-9, 2012.
  20. Qiu, N, Xiao, Z, Cao, L, Buechel, MM, David, V, Roan, E, Quarles, LD. Disruption of Kif3a in osteoblasts results in defective bone formation and osteopenia. J Cell Sci, 125 (Pt 8), 1945-57, 2012.
  21. Dai, B, David, V, Martin, A, Huang, J, Li, H, Jiao, Y, Gu, W, Quarles, LD. A comparative transcriptome analysis identifying FGF23 regulated genes in the kidney of a mouse CKD model. PLoS One, 7 (9), e44161, 2012.
  22. Martin, A, Quarles, LD. Evidence for FGF23 involvement in a bone-kidney axis regulating bone mineralization and systemic phosphate and vitamin D homeostasis. Adv Exp Med Biol, 728, 65-83, 2012.