LAWRENCE M. PFEFFER, Ph.D., B.S.

Professor
Pathology
 
Professor
Urology

Office: 154 Cancer Research Building
Tel: (901) 448-7855
lpfeffer@uthsc.edu

Education

  • , Rockefeller University, New York, NY, Virology, Molecular Biology
  • Ph.D., Cornell U. Graduate School Med. Sci., NY, NY, Biochemistry
  • B.S., State University of New York at Albany, NY, Chemistry

Research interest/specialty

Dr. Pfeffer researches an anticancer drug called interferon, which is an important component of the host response to various insults. By understanding the way this compound works at the cellular and molecular level, he may be able to identify new strategies to enhance the drug''s effectiveness and/or diminishing undesirable side effects. He is also interested in identifying the role of cancer stem-like cells in the therapeutic resistance of cancer. His focus is on treating brain cancer, prostate cancer and melanoma. A specific area of interest is the  signal transduction pathways involving two transcription factors, STAT3 and NF-kB, and their role in the induction of interferon-induced protein encoding genes (ISGs) and small nonencoding genes (micro RNAs), and the role of these genes in cancer.

Research interest/specialty

Cellular signal transduction.

Publications

  1. Pfeffer, LM, Madey, MA, Riely, CA, Fleckenstein, JF. The Induction of Type I Interferon Production in Hepatitis C-Infected Patients. J Interferon Cytokine Res, 2009.
  2. Rosati, SF, Williams, RF, Nunnally, LC, McGee, MC, Sims, TL, Tracey, L, Zhou, J, Fan, M, Ng, CY, Nathwani, AC, Stewart, CF, Pfeffer, LM, Davidoff, AM. IFN-{beta} sensitizes neuroblastoma to the antitumor activity of temozolomide by modulating O6-methylguanine DNA methyltransferase expression. Mol Cancer Ther, 2008.
  3. Wei, L, Fan, M, Xu, L, Heinrich, K, Berry, MW, Homayouni, R, Pfeffer, LM. Bioinformatic analysis reveals cRel as a regulator of a subset of interferon-stimulated genes. J Interferon Cytokine Res, 28 (9), 541-51, 2008.
  4. Yang, CH, Murti, A, Pfeffer, SR, Fan, M, Du, Z, Pfeffer, LM. The role of TRAF2 binding to the type I interferon receptor in alternative NF kappaB activation and antiviral response. J Biol Chem, 283 (21), 14309-16, 2008.
  5. Du, Z, Wei, L, Murti, A, Pfeffer, SR, Fan, M, Yang, CH, Pfeffer, LM. Non-conventional signal transduction by type 1 interferons: the NF-kappaB pathway. J Cell Biochem, 102 (5), 1087-94, 2007.
  6. Gharavi, NM, Alva, JA, Mouillesseaux, KP, Lai, C, Yeh, M, Yeung, W, Johnson, J, Szeto, WL, Hong, L, Fishbein, M, Wei, L, Pfeffer, LM, Berliner, JA. Role of the Jak/STAT pathway in the regulation of interleukin-8 transcription by oxidized phospholipids in vitro and in atherosclerosis in vivo. J Biol Chem, 282 (43), 31460-8, 2007.
  7. Dickson, PV, Hamner, JB, Streck, CJ, Ng, CY, McCarville, MB, Calabrese, C, Gilbertson, RJ, Stewart, CF, Wilson, CM, Gaber, MW, Pfeffer, LM, Skapek, SX, Nathwani, AC, Davidoff, AM. Continuous delivery of IFN-beta promotes sustained maturation of intratumoral vasculature. Mol Cancer Res, 5 (6), 531-42, 2007.
  8. Yang, CH, Wei, L, Pfeffer, SR, Du, Z, Murti, A, Valentine, WJ, Zheng, Y, Pfeffer, LM. Identification of CXCL11 as a STAT3-dependent gene induced by IFN. J Immunol, 178 (2), 986-92, 2007.
  9. Zbytek, B, Pfeffer, LM, Slominski, AT. CRH inhibits NF-kappa B signaling in human melanocytes. Peptides, 27 (12), 3276-83, 2006.
  10. He, XS, Ji, X, Hale, MB, Cheung, R, Ahmed, A, Guo, Y, Nolan, GP, Pfeffer, LM, Wright, TL, Risch, N, Tibshirani, R, Greenberg, HB. Global transcriptional response to interferon is a determinant of HCV treatment outcome and is modified by race. Hepatology, 44 (2), 352-9, 2006.
  11. Bao, L, Wei, L, Peirce, JL, Homayouni, R, Li, H, Zhou, M, Chen, H, Lu, L, Williams, RW, Pfeffer, LM, Goldowitz, D, Cui, Y. Combining gene expression QTL mapping and phenotypic spectrum analysis to uncover gene regulatory relationships. Mamm Genome, 17 (6), 575-83, 2006.
  12. Wei, L, Sandbulte, MR, Thomas, PG, Webby, RJ, Homayouni, R, Pfeffer, LM. NFkappaB negatively regulates interferon-induced gene expression and anti-influenza activity. J Biol Chem, 281 (17), 11678-84, 2006.
  13. Yang, CH, Murti, A, Pfeffer, LM. Interferon induces NF-kappa B-inducing kinase/tumor necrosis factor receptor-associated factor-dependent NF-kappa B activation to promote cell survival. J Biol Chem, 280 (36), 31530-6, 2005.
  14. Yang, CH, Murti, A, Valentine, WJ, Du, Z, Pfeffer, LM. Interferon alpha activates NF-kappaB in JAK1-deficient cells through a TYK2-dependent pathway. J Biol Chem, 280 (27), 25849-53, 2005.
  15. Yang, CH, Murti, A, Baker, SJ, Frangou-Lazaridis, M, Vartapetian, AB, Murti, KG, Pfeffer, LM. Interferon induces the interaction of prothymosin-alpha with STAT3 and results in the nuclear translocation of the complex. Exp Cell Res, 298 (1), 197-206, 2004.
  16. Pfeffer, LM, Kim, JG, Pfeffer, SR, Carrigan, DJ, Baker, DP, Wei, L, Homayouni, R. Role of nuclear factor-kappaB in the antiviral action of interferon and interferon-regulated gene expression. J Biol Chem, 279 (30), 31304-11, 2004.
  17. Duntsch, CD, Zhou, Q, Jayakar, HR, Weimar, JD, Robertson, JH, Pfeffer, LM, Wang, L, Xiang, Z, Whitt, MA. Recombinant vesicular stomatitis virus vectors as oncolytic agents in the treatment of high-grade gliomas in an organotypic brain tissue slice-glioma coculture model. J Neurosurg, 100 (6), 1049-59, 2004.
  18. Zbytek, B, Pfeffer, LM, Slominski, AT. Corticotropin-releasing hormone stimulates NF-kappaB in human epidermal keratinocytes. J Endocrinol, 181 (3), R1-7, 2004.
  19. Miller, MA, Lavine, CL, Klas, SD, Pfeffer, LM, Whitt, MA. Recombinant replication-restricted VSV as an expression vector for murine cytokines. Protein Expr Purif, 33 (1), 92-103, 2004.
  20. Zbytek, B, Pfeffer, LM, Slominski, AT. Corticotropin-releasing hormone inhibits nuclear factor-kappaB pathway in human HaCaT keratinocytes. J Invest Dermatol, 121 (6), 1496-9, 2003.
  21. Pfeffer, LM, Yang, CH, Murti, A, McCormack, SA, Viar, MJ, Ray, RM, Johnson, LR. Polyamine depletion induces rapid NF-kappa B activation in IEC-6 cells. J Biol Chem, 276 (49), 45909-13, 2001.
  22. Pastore, RD, Pfeffer, LM, Nanus, DM. Renal cell carcinoma and interferon at the millennium. Cancer Invest, 19 (3), 281-91, 2001.
  23. Yang, CH, Murti, A, Pfeffer, SR, Kim, JG, Donner, DB, Pfeffer, LM. Interferon alpha /beta promotes cell survival by activating nuclear factor kappa B through phosphatidylinositol 3-kinase and Akt. J Biol Chem, 276 (17), 13756-61, 2001.
  24. Yang, CH, Murti, A, Pfeffer, SR, Basu, L, Kim, JG, Pfeffer, LM. IFNalpha/beta promotes cell survival by activating NF-kappa B. Proc Natl Acad Sci U S A, 97 (25), 13631-6, 2000.
  25. Pfeffer, LM. Conference report. International Society for Interferon and Cytokine Research. Cytokine Growth Factor Rev, 11 (3), 251-4, 2000.
  26. Nanus, DM, Geng, Y, Shen, R, Lai, HK, Pfeffer, SR, Pfeffer, LM. Interaction of retinoic acid and interferon in renal cancer cell lines. J Interferon Cytokine Res, 20 (9), 787-94, 2000.
  27. Pfeffer, LM, Yang, CH, Pfeffer, SR, Murti, A, McCormack, SA, Johnson, LR. Inhibition of ornithine decarboxylase induces STAT3 tyrosine phosphorylation and DNA binding in IEC-6 cells. Am J Physiol Cell Physiol, 278 (2), C331-5, 2000.
  28. Ozes, ON, Mayo, LD, Gustin, JA, Pfeffer, SR, Pfeffer, LM, Donner, DB. NF-kappaB activation by tumour necrosis factor requires the Akt serine-threonine kinase. Nature, 401 (6748), 82-5, 1999.
  29. Johnson, LR, McCormack, SA, Yang, CH, Pfeffer, SR, Pfeffer, LM. EGF induces nuclear translocation of STAT2 without tyrosine phosphorylation in intestinal epithelial cells. Am J Physiol, 276 (2 Pt 1), C419-25, 1999.
  30. Pfeffer, LM, Dinarello, CA, Herberman, RB, Williams, BR, Borden, EC, Bordens, R, Walter, MR, Nagabhushan, TL, Trotta, PP, Pestka, S. Biological properties of recombinant alpha-interferons: 40th anniversary of the discovery of interferons. Cancer Res, 58 (12), 2489-99, 1998.
  31. Walter, MR, Bordens, R, Nagabhushan, TL, Williams, BR, Herberman, RB, Dinarello, CA, Borden, EC, Trotta, PP, Pestka, S, Pfeffer, LM. Review of recent developments in the molecular characterization of recombinant alfa interferons on the 40th anniversary of the discovery of interferon. Cancer Biother Radiopharm, 13 (3), 143-54, 1998.
  32. Yang, CH, Murti, A, Pfeffer, LM. STAT3 complements defects in an interferon-resistant cell line: evidence for an essential role for STAT3 in interferon signaling and biological activities. Proc Natl Acad Sci U S A, 95 (10), 5568-72, 1998.
  33. Guo, D, Dunbar, JD, Yang, CH, Pfeffer, LM, Donner, DB. Induction of Jak/STAT signaling by activation of the type 1 TNF receptor. J Immunol, 160 (6), 2742-50, 1998.
  34. Basu, L, Yang, CH, Murti, A, Garcia, JV, Croze, E, Constantinescu, SN, Mullersman, JE, Pfeffer, LM. The antiviral action of interferon is potentiated by removal of the conserved IRTAM domain of the IFNAR1 chain of the interferon alpha/beta receptor: effects on JAK-STAT activation and receptor down-regulation. Virology, 242 (1), 14-21, 1998.
  35. Holland, KA, Owczarek, CM, Hwang, SY, Tymms, MJ, Constantinescu, SN, Pfeffer, LM, Kola, I, Hertzog, PJ. A type I interferon signaling factor, ISF21, encoded on chromosome 21 is distinct from receptor components and their down-regulation and Is necessary for transcriptional activation of interferon-regulated genes. J Biol Chem, 272 (34), 21045-51, 1997.
  36. Pfeffer, LM. Biologic activities of natural and synthetic type I interferons. Semin Oncol, 24 (3 Suppl 9), S9-63-S9-69, 1997.
  37. Pfeffer, LM, Mullersman, JE, Pfeffer, SR, Murti, A, Shi, W, Yang, CH. STAT3 as an adapter to couple phosphatidylinositol 3-kinase to the IFNAR1 chain of the type I interferon receptor. Science, 276 (5317), 1418-20, 1997.
  38. Pfeffer, LM, Basu, L, Pfeffer, SR, Yang, CH, Murti, A, Russell-Harde, D, Croze, E. The short form of the interferon alpha/beta receptor chain 2 acts as a dominant negative for type I interferon action. J Biol Chem, 272 (17), 11002-5, 1997.
  39. Croze, E, Russell-Harde, D, Wagner, TC, Pu, H, Pfeffer, LM, Perez, HD. The human type I interferon receptor. Identification of the interferon beta-specific receptor-associated phosphoprotein. J Biol Chem, 271 (52), 33165-8, 1996.
  40. Pfeffer, LM, Wang, C, Constantinescu, SN, Croze, E, Blatt, LM, Albino, AP, Nanus, DM. Human renal cancers resistant to IFN's antiproliferative action exhibit sensitivity to IFN's gene-inducing and antiviral actions. J Urol, 156 (5), 1867-71, 1996.
  41. Pfeffer, LM. Interferons in 1995. Cytokine Growth Factor Rev, 7 (1), 107-11, 1996.
  42. Yang, CH, Shi, W, Basu, L, Murti, A, Constantinescu, SN, Blatt, L, Croze, E, Mullersman, JE, Pfeffer, LM. Direct association of STAT3 with the IFNAR-1 chain of the human type I interferon receptor. J Biol Chem, 271 (14), 8057-61, 1996.
  43. Constantinescu, SN, Croze, E, Murti, A, Wang, C, Basu, L, Hollander, D, Russell-Harde, D, Betts, M, Garcia-Martinez, V, Mullersman, JE, Pfeffer, LM. Expression and signaling specificity of the IFNAR chain of the type I interferon receptor complex. Proc Natl Acad Sci U S A, 92 (23), 10487-91, 1995.
  44. Mullersman, JE, Pfeffer, LM. An Alu cassette in the cytoplasmic domain of an interferon receptor subunit. J Interferon Cytokine Res, 15 (9), 815-7, 1995.
  45. Mullersman, JE, Pfeffer, LM. A novel cytoplasmic homology domain in interferon receptors. Trends Biochem Sci, 20 (2), 55-6, 1995.
  46. Tamm, I, Kikuchi, T, Kreutter, D, Pledger, WJ, Pfeffer, LM. Selective interferon-alpha/beta effects on platelet-derived growth factor-stimulated processes in quiescent BALB/c-3T3 fibroblasts. J Interferon Res, 14 (5), 265-73, 1994.
  47. Constantinescu, SN, Croze, E, Wang, C, Murti, A, Basu, L, Mullersman, JE, Pfeffer, LM. Role of interferon alpha/beta receptor chain 1 in the structure and transmembrane signaling of the interferon alpha/beta receptor complex. Proc Natl Acad Sci U S A, 91 (20), 9602-6, 1994.
  48. Colamonici, OR, Porterfield, B, Domanski, P, Constantinescu, S, Pfeffer, LM. Complementation of the interferon alpha response in resistant cells by expression of the cloned subunit of the interferon alpha receptor. A central role of this subunit in interferon alpha signaling. J Biol Chem, 269 (13), 9598-602, 1994.
  49. Colamonici, OR, Domanski, P, Krolewski, JJ, Fu, XY, Reich, NC, Pfeffer, LM, Sweet, ME, Platanias, LC. Interferon alpha (IFN alpha) signaling in cells expressing the variant form of the type I IFN receptor. J Biol Chem, 269 (8), 5660-5, 1994.
  50. Pfeffer, LM, Constantinescu, SN, Wang, C. Transmembrane signaling by IFN-alpha. Prog Mol Subcell Biol, 14, 242-59, 1994.
  51. Wang, C, Constantinescu, SN, MacEwan, DJ, Strulovici, B, Dekker, LV, Parker, PJ, Pfeffer, LM. Interferon alpha induces protein kinase C-epsilon (PKC-epsilon) gene expression and a 4.7-kb PKC-epsilon-related transcript. Proc Natl Acad Sci U S A, 90 (15), 6944-8, 1993.
  52. Platanias, LC, Pfeffer, LM, Cruciani, R, Colamonici, OR. Characterization of the alpha subunit of the IFN-alpha receptor. Evidence of N- and O-linked glycosylation and association with other surface proteins. J Immunol, 150 (8 Pt 1), 3382-8, 1993.
  53. Platanias, LC, Pfeffer, LM, Barton, KP, Vardiman, JW, Golomb, HM, Colamonici, OR. Expression of the IFN alpha receptor in hairy cell leukaemia. Br J Haematol, 82 (3), 541-6, 1992.
  54. Colamonici, OR, Pfeffer, LM, D'Alessandro, F, Platanias, LC, Gregory, SA, Rosolen, A, Nordan, R, Cruciani, RA, Diaz, MO. Multichain structure of the IFN-alpha receptor on hematopoietic cells. J Immunol, 148 (7), 2126-32, 1992.
  55. Improta, T, Pine, R, Pfeffer, LM. Interferon-gamma potentiates the antiviral activity and the expression of interferon-stimulated genes induced by interferon-alpha in U937 cells. J Interferon Res, 12 (2), 87-94, 1992.
  56. Rosolen, A, Colamonici, OR, Pfeffer, LM, Whitesell, L, Nordan, R, Neckers, LM. Detection of functional interferon alpha receptors in human neuroendocrine tumor cell lines using a new monoclonal antibody. Eur Cytokine Netw, 3 (2), 81-8, 1992.
  57. Colamonici, OR, Pfeffer, LM. Structure of the human interferon alpha receptor. Pharmacol Ther, 52 (2), 227-33, 1991.
  58. Pfeffer, LM, Colamonici, OR. Transmembrane signalling by interferon-alpha. Pharmacol Ther, 52 (2), 149-57, 1991.
  59. Eisenkraft, BL, Nanus, DM, Albino, AP, Pfeffer, LM. alpha-Interferon down-regulates epidermal growth factor receptors on renal carcinoma cells: relation to cellular responsiveness to the antiproliferative action of alpha-interferon. Cancer Res, 51 (21), 5881-7, 1991.
  60. Song, JG, Pfeffer, LM, Foster, DA. v-Src increases diacylglycerol levels via a type D phospholipase-mediated hydrolysis of phosphatidylcholine. Mol Cell Biol, 11 (10), 4903-8, 1991.
  61. Pfeffer, LM, Tan, YH. Do second messengers play a role in interferon signal transduction. Trends Biochem Sci, 16 (9), 321-3, 1991.
  62. Pfeffer, LM, Eisenkraft, BL, Reich, NC, Improta, T, Baxter, G, Daniel-Issakani, S, Strulovici, B. Transmembrane signaling by interferon alpha involves diacylglycerol production and activation of the epsilon isoform of protein kinase C in Daudi cells. Proc Natl Acad Sci U S A, 88 (18), 7988-92, 1991.
  63. Marino, MW, Feld, LJ, Jaffe, EA, Pfeffer, LM, Han, HM, Donner, DB. Phosphorylation of the proto-oncogene product eukaryotic initiation factor 4E is a common cellular response to tumor necrosis factor. J Biol Chem, 266 (5), 2685-8, 1991.
  64. Reich, NC, Pfeffer, LM. Evidence for involvement of protein kinase C in the cellular response to interferon alpha. Proc Natl Acad Sci U S A, 87 (22), 8761-5, 1990.
  65. Pfeffer, LM, Strulovici, B, Saltiel, AR. Interferon-alpha selectively activates the beta isoform of protein kinase C through phosphatidylcholine hydrolysis. Proc Natl Acad Sci U S A, 87 (17), 6537-41, 1990.
  66. Nanus, DM, Pfeffer, LM, Bander, NH, Bahri, S, Albino, AP. Antiproliferative and antitumor effects of alpha-interferon in renal cell carcinomas: correlation with the expression of a kidney-associated differentiation glycoprotein. Cancer Res, 50 (14), 4190-4, 1990.
  67. Pfeffer, LM, Donner, DB. The down-regulation of alpha-interferon receptors in human lymphoblastoid cells: relation to cellular responsiveness to the antiproliferative action of alpha-interferon. Cancer Res, 50 (9), 2654-7, 1990.
  68. Pfeffer, LM, Landsberger, FR. Interferon-alpha modulates the plasma membrane-cytoskeletal complex of human lymphoblastoid cells sensitive to the antiproliferative action of interferon-alpha. J Interferon Res, 10 (1), 91-7, 1990.
  69. Schwab, R, Pfeffer, LM, Szabo, P, Gamble, D, Schnurr, CM, Weksler, ME. Defective expression of high affinity IL-2 receptors on activated T cells from aged humans. Int Immunol, 2 (3), 239-46, 1990.
  70. Marino, MW, Pfeffer, LM, Guidon, PT, Donner, DB. Tumor necrosis factor induces phosphorylation of a 28-kDa mRNA cap-binding protein in human cervical carcinoma cells. Proc Natl Acad Sci U S A, 86 (21), 8417-21, 1989.
  71. Nanus, DM, Ebrahim, SA, Bander, NH, Real, FX, Pfeffer, LM, Shapiro, JR, Albino, AP. Transformation of human kidney proximal tubule cells by ras-containing retroviruses. Implications for tumor progression. J Exp Med, 169 (3), 953-72, 1989.
  72. Vanden Broecke, C, Pfeffer, LM. Characterization of interferon-alpha binding sites on human cell lines. J Interferon Res, 8 (6), 803-11, 1988.
  73. Kessler, DS, Pine, R, Pfeffer, LM, Levy, DE, Darnell, JE. Cells resistant to interferon are defective in activation of a promoter-binding factor. EMBO J, 7 (12), 3779-83, 1988.
  74. Pfeffer, LM, Stebbing, N, Donner, DB. Cytoskeletal association of human alpha-interferon-receptor complexes in interferon-sensitive and -resistant lymphoblastoid cells. Proc Natl Acad Sci U S A, 84 (10), 3249-53, 1987.
  75. Pfeffer, LM, Donner, DB, Tamm, I. Interferon-alpha down-regulates insulin receptors in lymphoblastoid (Daudi) cells. Relationship to inhibition of cell proliferation. J Biol Chem, 262 (8), 3665-70, 1987.
  76. Tamm, I, Lin, SL, Pfeffer, LM, Sehgal, PB. Interferons alpha and beta as cellular regulatory molecules. Interferon, 9, 13-74, 1987.
  77. Nachshen, DA, Pfeffer, LM, Tamm, I. Effect of anti-Ig on cytosolic Ca2+ in Daudi lymphoblastoid cells. J Biol Chem, 261 (32), 15134-9, 1986.
  78. Pfeffer, LM, Tamm, I. Interferon-beta inhibition of concanavalin A-stimulated calcium uptake and exchange in HeLa cells. J Interferon Res, 6 (5), 551-6, 1986.
  79. Pfeffer, LM, Kwok, BC, Landsberger, FR, Tamm, I. Interferon stimulates cholesterol and phosphatidylcholine synthesis but inhibits cholesterol ester synthesis in HeLa-S3 cells. Proc Natl Acad Sci U S A, 82 (8), 2417-21, 1985.
  80. Pfeffer, LM, Tamm, I. Interferon inhibition of thymidine incorporation into DNA through effects on thymidine transport and uptake. J Cell Physiol, 121 (2), 431-6, 1984.
  81. Jasny, BR, Pfeffer, LM, Tamm, I. Effects of beta interferon on human fibroblasts at different population doubling levels. Proliferation, cell volume, thymidine uptake, and DNA synthesis. J Exp Med, 159 (6), 1741-9, 1984.
  82. Tamm, I, Kikuchi, T, Wang, E, Pfeffer, LM. Growth rate of control and beta-interferon-treated human fibroblast populations over the course of their in vitro life span. Cancer Res, 44 (6), 2291-6, 1984.
  83. Wang, E, Michl, J, Pfeffer, LM, Silverstein, SC, Tamm, I. Interferon suppresses pinocytosis but stimulates phagocytosis in mouse peritoneal macrophages: related changes in cytoskeletal organization. J Cell Biol, 98 (4), 1328-41, 1984.
  84. Pfeffer, LM, Tamm, I. Comparison of the effects of alpha and beta interferons on the proliferation and volume of human tumor cells (HeLa-S3, Daudi, P3HR-1). J Interferon Res, 3 (4), 395-408, 1983.
  85. Pfeffer, LM, Tamm, I. Effects of beta interferon on concanavalin A binding and size of HeLa cells. J Interferon Res, 2 (3), 431-40, 1982.
  86. Wang, E, Pfeffer, LM, Tamm, I. Interferon increases the abundance of submembranous microfilaments in HeLa-S3 cells in suspension culture. Proc Natl Acad Sci U S A, 78 (10), 6281-5, 1981.
  87. Pfeffer, LM, Landsberger, FR, Tamm, I. Beta-interferon-induced time-dependent changes in the plasma membrane lipid bilayer of cultured cells. J Interferon Res, 1 (4), 613-20, 1981.
  88. Pfeffer, LM, Wang, E, Landsberger, FR, Tamm, I. Assays to measure plasma membrane and cytoskeletal changes in interferon-treated cells. Methods Enzymol, 79 (Pt B), 461-73, 1981.
  89. Tamm, I, Pfeffer, LM, Murphy, JS. Assay of the inhibitory activities of human interferons on the proliferation and locomotion of fibroblasts. Methods Enzymol, 79 (Pt B), 404-13, 1981.
  90. Pfeffer, LM, Wang, E, Tamm, I. Interferon inhibits the redistribution of cell surface components. J Exp Med, 152 (2), 469-74, 1980.
  91. Pfeffer, LM, Wang, E, Tamm, I. Interferon effects on microfilament organization, cellular fibronectin distribution, and cell motility in human fibroblasts. J Cell Biol, 85 (1), 9-17, 1980.
  92. Pfeffer, LM, Murphy, JS, Tamm, I. Interferon effects on the growth and division of human fibroblasts. Exp Cell Res, 121 (1), 111-20, 1979.
  93. Kopelovich, L, Pfeffer, LM, Bias, N. Growth characteristics of human skin fibroblasts in vitro: a simple experimental approach for the identification of hereditary adenomatosis of the colon and rectum. Cancer, 43 (1), 218-23, 1979.
  94. Pfeffer, LM, Kopelovich, L. Differential genetic susceptibility of cultured human skin fibroblasts to transformation by Kirsten murine sarcoma virus. Cell, 10 (2), 313-20, 1977.