LISA K. JENNINGS, Ph.D., M.S., B.A.

Prof & Director
Vascular Biology Center
Medicine-Internal Medicine

Prof
Molecular Sciences

Prof
Surgery-General

Prof
Biomedical Engineering
Joint Program UTHSC and Univ of Memphis

Office: H300 Coleman College Of Medicine Building
Tel: (901) 448-4350
ljennings@uthsc.edu

Education

  • Ph.D., University of Tennessee, Memphis, TN, Biochemistry
  • M.S., Memphis State University, Memphis, TN, Cell Biology
  • B.A., University of Tennessee, Knoxville, Botany

Publications

  1. Zhang, F, Kotha, J, Jennings, LK, Zhang, XA. Tetraspanins and vascular functions. Cardiovasc Res, 2009.
  2. Jennings, LK. Variability in platelet response to the antiplatelet agents aspirin and clopidogrel: mechanisms, measurement, and clinical relevance. Crit Pathw Cardiol, 8 (1), 20-8, 2009.
  3. Jennings, LK. Role of platelets in atherothrombosis. Am J Cardiol, 103 (3 Suppl), 4A-10A, 2009.
  4. Speich, HE, Grgurevich, S, Kueter, TJ, Earhart, AD, Slack, SM, Jennings, LK. Platelets undergo phosphorylation of Syk at Y525/526 and Y352 in response to pathophysiological shear stress. Am J Physiol Cell Physiol, 295 (4), C1045-54, 2008.
  5. Kotha, J, Zhang, C, Longhurst, CM, Lu, Y, Jacobs, J, Cheng, Y, Jennings, LK. Functional relevance of tetraspanin CD9 in vascular smooth muscle cell injury phenotypes: A novel target for the prevention of neointimal hyperplasia. Atherosclerosis, 2008.
  6. Jennings, LK, Saucedo, JF. Antiplatelet and anticoagulant agents: key differences in mechanisms of action, clinical application, and therapeutic benefit in patients with non-ST-segment-elevation acute coronary syndromes. Curr Opin Cardiol, 23 (4), 302-8, 2008.
  7. Kotha, J, Longhurst, C, Appling, W, Jennings, LK. Tetraspanin CD9 regulates beta1 integrin activation and enhances cell motility to fibronectin via a PI-3 kinase-dependent pathway. Exp Cell Res, 2008.
  8. Yang, J, Ji, R, Cheng, Y, Sun, JZ, Jennings, LK, Zhang, C. L-arginine chlorination results in the formation of a nonselective nitric-oxide synthase inhibitor. J Pharmacol Exp Ther, 318 (3), 1044-9, 2006.
  9. Jennings, LK. Current strategies with eptifibatide and other antiplatelet agents in percutaneous coronary intervention and acute coronary syndromes. Expert Opin Drug Metab Toxicol, 1 (4), 727-37, 2005.
  10. Cagiannos, C, Abul-Khoudoud, OR, DeRijk, W, Shell, DH, Jennings, LK, Tolley, EA, Handorf, CR, Fabian, TC. Rapamycin-coated expanded polytetrafluoroethylene bypass grafts exhibit decreased anastomotic neointimal hyperplasia in a porcine model. J Vasc Surg, 42 (5), 980-8, 2005.
  11. Liu, J, Jackson, CW, Gruppo, RA, Jennings, LK, Gartner, TK. The beta3 subunit of the integrin alphaIIbbeta3 regulates alphaIIb-mediated outside-in signaling. Blood, 105 (11), 4345-52, 2005.
  12. He, B, Liu, L, Cook, GA, Grgurevich, S, Jennings, LK, Zhang, XA. Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion. J Biol Chem, 280 (5), 3346-54, 2005.
  13. White, MM, Krishnan, R, Kueter, TJ, Jacoski, MV, Jennings, LK. The use of the point of care Helena ICHOR/Plateletworks and the Accumetrics Ultegra RPFA for assessment of platelet function with GPIIB-IIIa antagonists. J Thromb Thrombolysis, 18 (3), 163-9, 2004.
  14. Zhang, C, Yang, J, Jennings, LK. Leukocyte-derived myeloperoxidase amplifies high-glucose--induced endothelial dysfunction through interaction with high-glucose--stimulated, vascular non--leukocyte-derived reactive oxygen species. Diabetes, 53 (11), 2950-9, 2004.
  15. Zhang, C, Yang, J, Jennings, LK. Attenuation of neointima formation through the inhibition of DNA repair enzyme PARP-1 in balloon-injured rat carotid artery. Am J Physiol Heart Circ Physiol, 287 (2), H659-66, 2004.
  16. Zhang, C, Yang, J, Jacobs, JD, Jennings, LK. Interaction of myeloperoxidase with vascular NAD(P)H oxidase-derived reactive oxygen species in vasculature: implications for vascular diseases. Am J Physiol Heart Circ Physiol, 285 (6), H2563-72, 2003.
  17. Grgurevich, S, Krishnan, R, White, MM, Jennings, LK. Role of in vitro cholesterol depletion in mediating human platelet aggregation. J Thromb Haemost, 1 (3), 576-86, 2003.
  18. Haga, JH, Jennings, LK, Slack, SM. Inhibition of shear-stress-induced platelet aggregation and phosphotyrosine signaling by GPIIb-IIIa antagonists. Ann Biomed Eng, 30 (10), 1262-72, 2003.
  19. Bhanoori, M, Yellaturu, CR, Ghosh, SK, Hassid, A, Jennings, LK, Rao, GN. Thiol alkylation inhibits the mitogenic effects of platelet-derived growth factor and renders it proapoptotic via activation of STATs and p53 and induction of expression of caspase1 and p21(waf1/cip1). Oncogene, 22 (1), 117-30, 2003.
  20. Cook, GA, Longhurst, CM, Grgurevich, S, Cholera, S, Crossno, JT, Jennings, LK. Identification of CD9 extracellular domains important in regulation of CHO cell adhesion to fibronectin and fibronectin pericellular matrix assembly. Blood, 100 (13), 4502-11, 2002.
  21. Yellaturu, CR, Ghosh, SK, Rao, RK, Jennings, LK, Hassid, A, Rao, GN. A potential role for nuclear factor of activated T-cells in receptor tyrosine kinase and G-protein-coupled receptor agonist-induced cell proliferation. Biochem J, 368 (Pt 1), 183-90, 2002.
  22. Longhurst, CM, Jacobs, JD, White, MM, Crossno, JT, Fitzgerald, DA, Bao, J, Fitzgerald, TJ, Raghow, R, Jennings, LK. Chinese hamster ovary cell motility to fibronectin is modulated by the second extracellular loop of CD9. Identification of a putative fibronectin binding site. J Biol Chem, 277 (36), 32445-52, 2002.
  23. Zhang, C, Yang, J, Feng, J, Jennings, LK. Short-term administration of basic fibroblast growth factor enhances coronary collateral development without exacerbating atherosclerosis and balloon injury-induced vasoproliferation in atherosclerotic rabbits with acute myocardial infarction. J Lab Clin Med, 140 (2), 119-25, 2002.
  24. Jennings, LK, Jacoski, MV, White, MM. The pharmacodynamics of parenteral glycoprotein IIb/IIIa inhibitors. J Interv Cardiol, 15 (1), 45-60, 2002.
  25. Jennings, LK, Haga, JH, Slack, SM. Differential expression of a ligand induced binding site (LIBS) by GPIIb-IIIa ligand recognition peptides and parenteral antagonists. Thromb Haemost, 84 (6), 1095-102, 2000.
  26. Mondoro, TH, White, MM, Jennings, LK. Active GPIIb-IIIa conformations that link ligand interaction with cytoskeletal reorganization. Blood, 96 (7), 2487-95, 2000.
  27. Cook, GA, Wilkinson, DA, Crossno, JT, Raghow, R, Jennings, LK. The tetraspanin CD9 influences the adhesion, spreading, and pericellular fibronectin matrix assembly of Chinese hamster ovary cells on human plasma fibronectin. Exp Cell Res, 251 (2), 356-71, 1999.
  28. Longhurst, CM, White, MM, Wilkinson, DA, Jennings, LK. A CD9, alphaIIbbeta3, integrin-associated protein, and GPIb/V/IX complex on the surface of human platelets is influenced by alphaIIbbeta3 conformational states. Eur J Biochem, 263 (1), 104-11, 1999.
  29. Longhurst, CM, Jennings, LK. Integrin-mediated signal transduction. Cell Mol Life Sci, 54 (6), 514-26, 1998.
  30. Jennings, LK, White, MM. Expression of ligand-induced binding sites on glycoprotein IIb/IIIa complexes and the effect of various inhibitors. Am Heart J, 135 (5 Pt 2 Su), S179-83, 1998.
  31. Wall, CD, Conley, PB, Armendariz-Borunda, J, Sudarshan, C, Wagner, JE, Raghow, R, Jennings, LK. Expression of alpha IIb beta 3 integrin (GPIIb-IIIa) in myeloid cell lines and normal CD34+/CD33+ bone marrow cells. Blood Cells Mol Dis, 23 (3), 361-76, 1997.
  32. Jennings, LK, Slack, SM, Wall, CD, Mondoro, TH. Immunological comparisons of integrin alpha IIb beta 3 (GPIIb-IIIa) expressed on platelets and human erythroleukemia cells: evidence for cell specific differences. Blood Cells Mol Dis, 22 (1), 23-35, 1996.
  33. Jennings, LK, White, MM, Mandrell, TD. Interspecies comparison of platelet aggregation, LIBS expression and clot retraction: observed differences in GPIIb-IIIa functional activity. Thromb Haemost, 74 (6), 1551-6, 1995.
  34. Wall, JE, Buijs-Wilts, M, Arnold, JT, Wang, W, White, MM, Jennings, LK, Jackson, CW. A flow cytometric assay using mepacrine for study of uptake and release of platelet dense granule contents. Br J Haematol, 89 (2), 380-5, 1995.
  35. Slack, SM, Jennings, LK, Turitto, VT. Platelet size distribution measurements as indicators of shear stress-induced platelet aggregation. Ann Biomed Eng, 22 (6), 653-9, 1994.
  36. Heath, TL, Wall, CD, Jennings, LK. A GP IIIa ligand-induced binding site antibody detects multiple GP IIb-IIIa conformations, and its binding is modulated by various ligands. Ann N Y Acad Sci, 714, 300-2, 1994.
  37. Jennings, LK, Crossno, JT, Fox, CF, White, MM, Green, CA. Platelet p24/CD9, a member of the tetraspanin family of proteins. Ann N Y Acad Sci, 714, 175-84, 1994.
  38. Jennings, LK, White, MM, Sauer, CM, Mauer, AM, Robertson, JT. Cocaine-induced platelet defects. Stroke, 24 (9), 1352-9, 1993.
  39. White, MM, Foust, JT, Mauer, AM, Robertson, JT, Jennings, LK. Assessment of lumiaggregometry for research and clinical laboratories. Thromb Haemost, 67 (5), 572-7, 1992.
  40. Kouns, WC, Newman, PJ, Puckett, KJ, Miller, AA, Wall, CD, Fox, CF, Seyer, JM, Jennings, LK. Further characterization of the loop structure of platelet glycoprotein IIIa: partial mapping of functionally significant glycoprotein IIIa epitopes. Blood, 78 (12), 3215-23, 1991.
  41. Kouns, WC, Jennings, LK. Activation-independent exposure of the GPIIb-IIIa fibrinogen receptor. Thromb Res, 63 (3), 343-54, 1991.
  42. Kouns, WC, Fox, CF, Lamoreaux, WJ, Coons, LB, Jennings, LK. The effect of glycoprotein IIb-IIIa receptor occupancy on the cytoskeleton of resting and activated platelets. J Biol Chem, 266 (21), 13891-900, 1991.
  43. Jennings, LK, Wang, WC, Jackson, CW, Fox, CF, Bell, A. Hemostasis in Glanzmann's thrombasthenia (GT): GT platelets interfere with the aggregation of normal platelets. Am J Pediatr Hematol Oncol, 13 (1), 84-90, 1991.
  44. Kouns, WC, Wall, CD, White, MM, Fox, CF, Jennings, LK. A conformation-dependent epitope of human platelet glycoprotein IIIa. J Biol Chem, 265 (33), 20594-601, 1990.
  45. Jennings, LK, Fox, CF, Kouns, WC, McKay, CP, Ballou, LR, Schultz, HE. The activation of human platelets mediated by anti-human platelet p24/CD9 monoclonal antibodies. J Biol Chem, 265 (7), 3815-22, 1990.
  46. Jennings, LK, Dockter, ME, Wall, CD, Fox, CF, Kennedy, DM. Calcium mobilization in human platelets using indo-1 and flow cytometry. Blood, 74 (8), 2674-80, 1989.
  47. Jackson, CW, Jennings, LK. Heterogeneity of fibrinogen receptor expression on platelets activated in normal plasma with ADP: analysis by flow cytometry. Br J Haematol, 72 (3), 407-14, 1989.
  48. Jennings, LK, Jackson, CW. Heterogeneity of fibrinogen receptor expression on human platelets activated by ADP in native plasma. Prog Clin Biol Res, 283, 381-5, 1988.