Karl T. Weber, MD

Neuton Stern Professor of Cardiovascular Medicine

Office: A312 Coleman College Of Medicine Building
Tel: (901) 448-5750
ktweber@uthsc.edu

Education

  • M.A., University of Pennsylvania, Philadelphia, PA, Honors Seminars
  • M.D., Temple Univ. School Medicine, Philadelphia, PA, Medicine
  • B.S., Moravian College, Bethlehem, PA, Biology

Clinical/Research Interests

Congestive heart failure (CHF): its pathogenesis and pathophysiologic expressions.  Basic science studies focus on the neuroendocrine-immune interface gone awry, where secondary hyperparathyroidism (SHPT) in rats with aldosteronism accounts for intracellular calcium overloading and oxidative stress of diverse tissues.  In the case of circulating immune cells, a resultant immunostimulatory state includes a proinflammatory phenotype with oxi/nitrosative stress, vascular invasion and wasting of soft tissue and bone.  In the case of cardiac myocytes and mitochondria, oxidative stress leads to mitochondrial transition pore opening resulting in cell death.  Translational studies in human CHF focus on Ca2+, Mg2+ and Zn2+ homeostasis, SHPT, hypovitaminosis D and bone health.

Biographical Information

Dr. Weber is the Neuton Stern Professor of Cardiovascular Medicine and Director of the Division of Cardiovascular Diseases at the University of Tennessee Health Science Center.  He received his undergraduate degree from Moravian College and his medical degree from Temple University School of Medicine, where he also completed his internship.  After a 2-year stay at the National Institutes of Health’s Artificial Heart Program, he served his residency in internal medicine and fellowship in cardiology at the University of Alabama College of Medicine at Birmingham.  Dr. Weber joined the Department of Medicine, Cardiovascular-Pulmonary Division, at the University of Pennsylvania as Assistant Professor in 1974, later becoming tenured Associate Professor of Medicine and Director of the Cardio-Pulmonary Research Laboratories.  In 1983 Dr. Weber was appointed Director of the Cardiology Division and Cardiovascular Institute of the Michael Reese Hospital and Medical Center and Harold H. Hines, Jr. Professor of Medicine at the University of Chicago.  He joined the University of Missouri Health Sciences Center in 1990 serving as Chairman of the Department of Internal Medicine and Director of the Division of Cardiology through 1997.

Dr. Weber’s research interests (NIH-funded since 1974 and through 2014) have focused on heart failure, its pathogenic origins, and its pathophysiologic expressions.  Among his many scientific contributions that have advanced the practice of medicine is his pioneering work into the importance of the heart’s extracellular matrix and mechanisms responsible for cardiac fibrosis and the dyshomeostasis of macro- and micronutrients in congestive heart failure.  Dr. Weber is a prolific author with over 550 publications.  He serves on US and international editorial boards and has been elected president of the Central Society for Clinical Research (1995–96), International Society for Heart Research, North American Section (1997–2000), International Academy of Cardiovascular Sciences/North America (IACS/NA) (2005–09) and President-Elect of the Southern Society for Clinical Investigation (2010-11).  Dr. Weber is the recipient of Moravian College (1987) and Temple University School of Medicine (1998) Alumni Achievement Awards.  In 2005 he was selected recipient of the Makato Nagano Award for Distinguished Achievements in Cardiovascular Research presented by the IACS.  Always eager to take the path less well traveled, his current basic and translational research interests focus on congestive heart failure as a systemic illness with wasting, the role of macro- and micronutrients, and its expression and management in African-Americans.

See below for recent publications.

Publications

  1. Gandhi, MS, Kamalov, G, Shahbaz, AU, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Cellular and molecular pathways to myocardial necrosis and replacement fibrosis. Heart Fail Rev, 2010.
  2. Kamalov, G, Ahokas, RA, Zhao, W, Zhao, T, Shahbaz, AU, Johnson, PL, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Uncoupling the coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria seen in aldosteronism. J Cardiovasc Pharmacol, 55 (3), 248-54, 2010.
  3. Kamalov, G, Ahokas, RA, Zhao, W, Shahbaz, AU, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. Am J Physiol Heart Circ Physiol, 298 (2), H385-94, 2010.
  4. Battin, DL, Ali, S, Shahbaz, AU, Massie, JD, Munir, A, Davis, RC, Newman, KP, Weber, KT. Hypoalbuminemia and lymphocytopenia in patients with decompensated biventricular failure. Am J Med Sci, 339 (1), 31-5, 2010.
  5. Shook, MS, Zafarullah, H, Nelson, MD, Bhattacharya, SK, Davis, RC, Newman, KP, Weber, KT. Normoglycemia in nondiabetic African Americans hospitalized with heart failure. Am J Med Sci, 338 (4), 255-8, 2009.
  6. Kamalov, G, Holewinski, JP, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Nutrient dyshomeostasis in congestive heart failure. Am J Med Sci, 338 (1), 28-33, 2009.
  7. Kamalov, G, Deshmukh, PA, Baburyan, NY, Gandhi, MS, Johnson, PL, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. J Cardiovasc Pharmacol, 53 (5), 414-23, 2009.
  8. Dishmon, DA, Dotson, JL, Munir, A, Nelson, MD, Bhattacharya, SK, D Cruz, IA, Davis, RC, Weber, KT. Hypovitaminosis D and valvular calcification in patients with dilated cardiomyopathy. Am J Med Sci, 337 (5), 312-6, 2009.
  9. Ali, S, Shahbaz, AU, Nelson, MD, Shirwany, A, Munir, A, D'cruz, IC, Weber, KT. Reduced relative lymphocyte count in african-americans with decompensated heart failure. Am J Med Sci, 337 (3), 156-60, 2009.
  10. Bhattacharya, SK, Gandhi, MS, Kamalov, G, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Myocardial remodeling in low-renin hypertension: molecular pathways to cellular injury in relative aldosteronism. Curr Hypertens Rep, 11 (6), 412-20, 2009.
  11. Paulus, BM, Ali, S, Zia, AA, Munir, A, Davis, RC, Mansbach, CM, Smith, WC, Weber, KT. Causes and consequences of systemic venous hypertension. Am J Med Sci, 336 (6), 489-97, 2008.
  12. Zafarullah, H, Shahbaz, AU, Alturkmani, R, Laguardia, SP, Paulus, BM, Battin, DL, Afzal, MO, Davis, RC, Smith, JL, Weber, KT. Elevated serum cobalamin in patients with decompensated biventricular failure. Am J Med Sci, 336 (5), 383-8, 2008.
  13. Gandhi, MS, Deshmukh, PA, Kamalov, G, Zhao, T, Zhao, W, Whaley, JT, Tichy, JR, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism. J Cardiovasc Pharmacol, 52 (3), 245-52, 2008.
  14. Carbone, LD, Cross, JD, Raza, SH, Bush, AJ, Sepanski, RJ, Dhawan, S, Khan, BQ, Gupta, M, Ahmad, K, Khouzam, RN, Dishmon, DA, Nesheiwat, JP, Hajjar, MA, Chishti, WA, Nasser, W, Khan, M, Womack, CR, Cho, T, Haskin, AR, Weber, KT. Fracture risk in men with congestive heart failure risk reduction with spironolactone. J Am Coll Cardiol, 52 (2), 135-8, 2008.
  15. Ahmad, K, Gandhi, MS, Smith, WC, Weber, KT. Bilateral pleural effusions in congestive heart failure. Am J Med Sci, 335 (6), 484-8, 2008.
  16. Carbone, LD, Rosenberg, EW, Tolley, EA, Holick, MF, Hughes, TA, Watsky, MA, Barrow, KD, Chen, TC, Wilkin, NK, Bhattacharya, SK, Dowdy, JC, Sayre, RM, Weber, KT. 25-Hydroxyvitamin D, cholesterol, and ultraviolet irradiation. Metabolism, 57 (6), 741-8, 2008.
  17. Alsafwah, S, Laguardia, SP, Nelson, MD, Battin, DL, Newman, KP, Carbone, LD, Weber, KT. Hypovitaminosis D in African Americans residing in Memphis, Tennessee with and without heart failure. Am J Med Sci, 335 (4), 292-7, 2008.
  18. Selektor, Y, Parker, RB, Sun, Y, Zhao, W, Bhattacharya, SK, Weber, KT. Tissue 65Zinc translocation in a rat model of chronic aldosteronism. J Cardiovasc Pharmacol, 51 (4), 359-64, 2008.
  19. Selektor, Y, Weber, KT. The salt-avid state of congestive heart failure revisited. Am J Med Sci, 335 (3), 209-18, 2008.
  20. Selektor, Y, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism. Am J Med Sci, 335 (2), 105-10, 2008.
  21. Thomas, M, Vidal, A, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone. Am J Physiol Heart Circ Physiol, 293 (4), H2361-6, 2007.
  22. Arroyo, M, Laguardia, SP, Bhattacharya, SK, Nelson, MD, Johnson, PL, Carbone, LD, Newman, KP, Weber, KT. Micronutrients in African-Americans with decompensated and compensated heart failure. Transl Res, 148 (6), 301-8, 2006.
  23. Laguardia, SP, Dockery, BK, Bhattacharya, SK, Nelson, MD, Carbone, LD, Weber, KT. Secondary hyperparathyroidism and hypovitaminosis D in African-Americans with decompensated heart failure. Am J Med Sci, 332 (3), 112-8, 2006.
  24. Goodwin, KD, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements. Am J Med Sci, 332 (2), 73-8, 2006.
  25. Zhao, W, Ahokas, RA, Weber, KT, Sun, Y. ANG II-induced cardiac molecular and cellular events: role of aldosterone. Am J Physiol Heart Circ Physiol, 291 (1), H336-43, 2006.
  26. Sun, Y, Ahokas, RA, Bhattacharya, SK, Gerling, IC, Carbone, LD, Weber, KT. Oxidative stress in aldosteronism. Cardiovasc Res, 71 (2), 300-9, 2006.
  27. Khouzam, RN, Nelson, MD, Klemis, JE, Wall, BM, Mangold, TA, Weber, KT. Effect of timed semirecumbency and furosemide dosing on urinary sodium excretion in patients with compensated heart failure. Am J Med Sci, 332 (1), 1-5, 2006.
  28. Bhattacharya, SK, Ahokas, RA, Carbone, LD, Newman, KP, Gerling, IC, Sun, Y, Weber, KT. Macro- and micronutrients in African-Americans with heart failure. Heart Fail Rev, 11 (1), 45-55, 2006.
  29. Parker, RB, Yates, CR, Laizure, SC, Weber, KT. P-glycoprotein modulates aldosterone plasma disposition and tissue uptake. J Cardiovasc Pharmacol, 47 (1), 55-9, 2006.
  30. Khouzam, RN, Dishmon, DA, Farah, V, Flax, SD, Carbone, LD, Weber, KT. Secondary hyperparathyroidism in patients with untreated and treated congestive heart failure. Am J Med Sci, 331 (1), 30-4, 2006.
  31. Vidal, A, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, Weber, KT. Calcium paradox of aldosteronism and the role of the parathyroid glands. Am J Physiol Heart Circ Physiol, 290 (1), H286-94, 2006.
  32. Weber, KT. Are myocardial fibrosis and diastolic dysfunction reversible in hypertensive heart disease. Congest Heart Fail, 11 (6), 322-4; quiz 325, 2005.
  33. Weber, KT. The proinflammatory heart failure phenotype: a case of integrative physiology. Am J Med Sci, 330 (5), 219-26, 2005.
  34. Sun, Y, Weber, KT. Animal models of cardiac fibrosis. Methods Mol Med, 117, 273-90, 2005.
  35. Kamalov, G, Varma, BR, Lu, L, Sun, Y, Weber, KT, Guntaka, RV. Expression of the multifunctional Y-box protein, YB-1, in myofibroblasts of the infarcted rat heart. Biochem Biophys Res Commun, 334 (1), 239-44, 2005.
  36. Runyan, AL, Sun, Y, Bhattacharya, SK, Ahokas, RA, Chhokar, VS, Gerling, IC, Weber, KT. Responses in extracellular and intracellular calcium and magnesium in aldosteronism. J Lab Clin Med, 146 (2), 76-84, 2005.
  37. Runyan, AL, Chhokar, VS, Sun, Y, Bhattacharya, SK, Runyan, JW, Weber, KT. Bone loss in rats with aldosteronism. Am J Med Sci, 330 (1), 1-7, 2005.
  38. Law, PH, Sun, Y, Bhattacharya, SK, Chhokar, VS, Weber, KT. Diuretics and bone loss in rats with aldosteronism. J Am Coll Cardiol, 46 (1), 142-6, 2005.
  39. Campos, PC, D'Cruz, IA, Johnson, LS, Malhotra, A, Ramanathan, KB, Weber, KT. Functional valvular incompetence in decompensated heart failure: noninvasive monitoring and response to medical management. Am J Med Sci, 329 (5), 217-21, 2005.
  40. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation, 111 (7), 871-8, 2005.
  41. Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cells. Circulation, 111 (1), 51-7, 2005.
  42. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Loss of bone minerals and strength in rats with aldosteronism. Am J Physiol Heart Circ Physiol, 287 (5), H2023-6, 2004.
  43. Weber, KT. Efficacy of aldosterone receptor antagonism in heart failure: potential mechanisms. Curr Heart Fail Rep, 1 (2), 51-6, 2004.
  44. Sun, Y, Zhang, J, Lu, L, Bedigian, MP, Robinson, AD, Weber, KT. Tissue angiotensin II in the regulation of inflammatory and fibrogenic components of repair in the rat heart. J Lab Clin Med, 143 (1), 41-51, 2004.
  45. Weber, KT. A neuroendocrine-immune interface. The immunostimulatory state of aldosteronism. Herz, 28 (8), 692-701, 2003.
  46. Ahokas, RA, Warrington, KJ, Gerling, IC, Sun, Y, Wodi, LA, Herring, PA, Lu, L, Bhattacharya, SK, Postlethwaite, AE, Weber, KT. Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface. Circ Res, 93 (10), e124-35, 2003.
  47. Weber, KT, Sun, Y, Wodi, LA, Munir, A, Jahangir, E, Ahokas, RA, Gerling, IC, Postlethwaite, AE, Warrington, KJ. Toward a broader understanding of aldosterone in congestive heart failure. J Renin Angiotensin Aldosterone Syst, 4 (3), 155-63, 2003.
  48. Gerling, IC, Sun, Y, Ahokas, RA, Wodi, LA, Bhattacharya, SK, Warrington, KJ, Postlethwaite, AE, Weber, KT. Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotype. Am J Physiol Heart Circ Physiol, 285 (2), H813-21, 2003.
  49. Weber, KT, Gerling, IC, Kiani, MF, Guntaka, RV, Sun, Y, Ahokas, RA, Postlethwaite, AE, Warrington, KJ. Aldosteronism in heart failure: a proinflammatory/fibrogenic cardiac phenotype. Search for biomarkers and potential drug targets. Curr Drug Targets, 4 (6), 505-16, 2003.
  50. Sun, Y, Weber, KT. RAS and connective tissue in the heart. Int J Biochem Cell Biol, 35 (6), 919-31, 2003.
  51. Guntaka, RV, Varma, BR, Weber, KT. Triplex-forming oligonucleotides as modulators of gene expression. Int J Biochem Cell Biol, 35 (1), 22-31, 2003.