KAZUKO SAKATA, Ph.D.

Assistant Professor
Pharmacology
 
Assistant Professor
Psychiatry

Office: 430 Crowe Research Building
Tel: (901) 448-2662
ksakata@uthsc.edu

Education

  • PostDoc, National Institute of Health, Neural Development and Plasticity
  • Ph.D., Osaka University, Japan, Medical Science
  • M.S., Osaka University, Japan, Medical Science
  • B.S., Osaka University, Japan, Pharmacology

Research interest/specialty

Current projects focus on studying the roles of activity-dependent expression of BDNF (Brain Derived Neurotrophic Factor) in depression and anxiety, using genetically modified mice. We study from gene to behavior, using molecular and biochemical, electrophysiological, and behavioral techniques.

Publications

  1. Chen, Y, Wang, B, Liu, D, Li, JJ, Xue, Y, Sakata, K, Zhu, LQ, Heldt, SA, Xu, H, Liao, FF. Hsp90 Chaperone Inhibitor 17-AAG Attenuates Aβ-Induced Synaptic Toxicity and Memory Impairment. J Neurosci, 34 (7), 2464-70, 2014.
  2. Sakata, K.*. Brain-derived neurotrophic factor for depression therapeutics. Austin Journal of Pharmacology and Therapeutics (Accepted), 2014.
  3. Sakata, K* and Duke, SM.. Lack of BDNF expression through promoter IV disturbs expression of monoamine genes in the frontal cortex and hippocampus. Neuroscience, 28 (260), 260-75, 2014.
  4. Sakata K., Martinowich K., Woo N.H., Schloesser R.J., Jimenez D.V., Ji Y., Shen L., Lu B.. Role of activity-dependent BDNF expression in hippocampal-prefrontal cortical regulation of behavioral perseverance. Proc Natl Acad Sci U S A., 110 (37), 15103-1510, 2013.
  5. Sakata K*, Mastin JR, Duke SM, Vail MG, Overacre AE, Dong BE, Jha S. Effects of antidepressant treatment on mice lacking BDNF expression through promoter IV. European J. of Neuroscience, 37 (11), 1863-74, 2013.
  6. Reiner A, Wang HB, Del Mar N, Sakata K, Yoo W, Deng YP.. BDNF may play a differential role in the protective effect of the mGluR2/3 agonist LY379268 on striatal projection neurons in R6/2 Huntington's disease mice.. Brain Res., 1473 (14), 161-72, 2012.
  7. Jiao, Y, Zhang, Z, Zhang, C, Wang, X, Sakata, K, Lu, B, Sun, QQ. A key mechanism underlying sensory experience-dependent maturation of neocortical GABAergic circuits in vivo. Proc Natl Acad Sci U S A, 108 (29), 12131-6, 2011.
  8. Jha S., Dong B, Sakata K*. Enriched environment treatment reverses depression-like behavior and restores reduced hippocampal neurogenesis and protein levels of brain-derived neurotrophic factor in mice lacking its expression through promoter IV. Translational Psychiatry. (1), e40, 2011.
  9. Sakata K.*. Brain-Derived Neurotrophic Factor and Major Depression. Neurobiology of Depression, Frontiers in Neuroscience Book Series, 391-417, 2011.
  10. Sakata K*, Jin L, Jha S.. Lack of promoter IV-driven BDNF transcription results in depression- like behavior.. Genes Brain Behav., 7 (9), 712-721, 2010.
  11. Sakata K, Woo NH, Martinowich K, Greene JS, Schloesser RJ, Shen L, Lu B.. Critical role of promoter IV-driven BDNF transcription in GABAergic transmission and synaptic plasticity in the prefrontal cortex.. Proc Natl Acad Sci U S A., 106 (14), 5942-7, 2009.
  12. Shimazu K, Zhao M, Sakata K, Akbarian S, Bates B, Jaenisch R, Lu B. NT-3 facilitates hippocampal plasticity and learning and memory by regulating neurogenesis.. Epub, 3 (13), 307-315, 2006.
  13. Genoud C., Knott GW., Sakata K., Lu B., Welker E.. Altered synapse formation in the adult somatosensory cortex of brain-derived neurotrophic factor heterozygote mice.. J Neuroscience, (10) (24), 2394-400, 2004.
  14. Pang PT., Teng HK., Zaitsev E., Woo NT., Sakata K., Zhen S., Teng KK., Yung WH., Hempstead BL., Lu B.. Cleavage of proBDNF by tPA/plasmin is essential for long-term hippocampal plasticity.. Science, (5695) (306), 487-91, 2004.
  15. Zhou YX., Zhao M., Li D., Shimazu K., Sakata K., Deng CX., Lu B.. Cerebellar deficits and hyperactivity in mice lacking Smad4.. J Biol Chem., (43) (278), 42313-20, 2003.
  16. Sakata K. (corresponding author), Yamashita T., Maeda M., Y.Moriyama Y. and Tohyama M.. Cloning of a lymphatic peptide/histidine transporter.. Biochemical J. (356), 53-60, 2001.
  17. Mitsuda N., Ohkubo N., Tamatani M., Lee Y., Taniguchi M., Namikawa K., Kiyama H., Yamaguchi A., Sato N., Sakata K., Ogihara T., Vitek MP., Tohyama M.. Activated CREB Regulates Neuronal Expression of Presenilin-1.. J. Biol. Chem., (13) (276), 9688-98, 2001.
  18. Sakata K. (corresponding author), Shimada S., Yamashita T., KInoue K. and Tohyama M.. Cloning of a bovine orphan transporter and its short splicing variant. PM. FEBS Lett. (443), 267-270, 1999.
  19. Sakata K., Sato K., Schloss P., Betz H., Shimada S. and Tohyama M.. Characterization of glycine release mediated by glycine transporter 1 stably expressed in HEK-293 cells.. Mol. Brain Res. (49), 89-94, 1997.
  20. Kitanaka J., Hashimoto H., Gotoh M., Kondo K., Sakata K., Hirasawa Y., Sawada M., Marunouti T., Matsuda T., Baba A.. Expression pattern of messenger RNAs for prostanoid receptors in glial cell cultures.. Brain Res. (707), 282-287, 1996.
  21. Kondo K., Hashimoto H., Sakata K., Saga H., Kitanaka J., Baba A.. Stimulation of cyclic AMP formation by adenylate cyclase-activating polypeptide is attenuated by glutamate in rat brain slices.. (67), 399-401, 1995.