KAUSHIK PARTHASARATHI, Ph.D.

Assistant Professor
Physiology
 
Assistant Professor
Medical Education

Office: 426 Nash Research Building
Tel: (901) 448-2682
kparthas@uthsc.edu

Education

  • Ph.D., Pennsylvania State University, University Park, PA, Bioengineering
  • M.S., Medical College of Virginia, Richmond VA, Biomedical Engineering
  • B.S.E., Bharathiar University, Coimbatore, India, Engineering

Publications

  1. Parthasarathi, K. Endothelial connexin43 mediates acid-induced increases in pulmonary microvascular permeability. Am J Physiol Lung Cell Mol Physiol, 303 (1), L33-42, 2012.
  2. Kandasamy, K, Sahu, G, Parthasarathi, K. Real-time imaging reveals endothelium-mediated leukocyte retention in LPS-treated lung microvessels. Microvasc Res, 83 (3), 323-31, 2012.
  3. Makena, PS, Gorantla, VK, Ghosh, MC, Bezawada, L, Kandasamy, K, Balazs, L, Luellen, CL, Thompson, KE, Parthasarathi, K, Ichijo, H, Waters, CM, Sinclair, SE. Deletion of apoptosis signal-regulating kinase-1 prevents ventilator-induced lung injury in mice. Am J Respir Cell Mol Biol, 46 (4), 461-9, 2012.
  4. Makena, PS, Gorantla, VK, Ghosh, MC, Bezawada, L, Balazs, L, Luellen, C, Parthasarathi, K, Waters, CM, Sinclair, SE. Lung injury caused by high tidal volume mechanical ventilation and hyperoxia is dependent on oxidant-mediated c-Jun NH2-terminal kinase activation. J Appl Physiol, 111 (5), 1467-76, 2011.
  5. Parthasarathi, K, Bhattacharya, J. Localized Acid Instillation by a Wedged-Catheter Method Reveals a Role for Vascular Gap Junctions in Spatial Expansion of Acid Injury. Anat Rec (Hoboken), 2011.
  6. Makena, PS, Luellen, CL, Balazs, L, Ghosh, MC, Parthasarathi, K, Waters, CM, Sinclair, SE. Preexposure to hyperoxia causes increased lung injury and epithelial apoptosis in mice ventilated with high tidal volumes. Am J Physiol Lung Cell Mol Physiol, 299 (5), L711-9, 2010.
  7. Kiefmann, R, Islam, MN, Lindert, J, Parthasarathi, K, Bhattacharya, J. Paracrine purinergic signaling determines lung endothelial nitric oxide production. Am J Physiol Lung Cell Mol Physiol, 296 (6), L901-10, 2009.
  8. Bertuglia, S, Ichimura, H, Fossati, G, Parthasarathi, K, Leoni, F, Modena, D, Cremonesi, P, Bhattacharya, J, Mascagni, P. ITF1697, a stable Lys-Pro-containing peptide, inhibits weibel-palade body exocytosis induced by ischemia/reperfusion and pressure elevation. Mol Med, 13 (11-12), 615-24, 2007.
  9. Lindert, J, Perlman, CE, Parthasarathi, K, Bhattacharya, J. Chloride-dependent secretion of alveolar wall liquid determined by optical-sectioning microscopy. Am J Respir Cell Mol Biol, 36 (6), 688-96, 2007.
  10. Kuebler, WM, Parthasarathi, K, Lindert, J, Bhattacharya, J. Real-time lung microscopy. J Appl Physiol, 102 (3), 1255-64, 2007.
  11. Ichimura, H, Parthasarathi, K, Lindert, J, Bhattacharya, J. Lung surfactant secretion by interalveolar Ca2+ signaling. Am J Physiol Lung Cell Mol Physiol, 291 (4), L596-601, 2006.
  12. Parthasarathi, K, Ichimura, H, Monma, E, Lindert, J, Quadri, S, Issekutz, A, Bhattacharya, J. Connexin 43 mediates spread of Ca2+-dependent proinflammatory responses in lung capillaries. J Clin Invest, 116 (8), 2193-200, 2006.
  13. Yiming, MT, Parthasarathi, K, Issekutz, AC, Bhattacharya, S. Sequence of endothelial signaling during lung expansion. Am J Respir Cell Mol Biol, 33 (6), 549-54, 2005.
  14. Ichimura, H, Parthasarathi, K, Issekutz, AC, Bhattacharya, J. Pressure-induced leukocyte margination in lung postcapillary venules. Am J Physiol Lung Cell Mol Physiol, 289 (3), L407-12, 2005.
  15. Padilla, J, Daley, E, Chow, A, Robinson, K, Parthasarathi, K, McKenzie, AN, Tschernig, T, Kurup, VP, Donaldson, DD, Grunig, G. IL-13 regulates the immune response to inhaled antigens. J Immunol, 174 (12), 8097-105, 2005.
  16. Quadri, SK, Bhattacharjee, M, Parthasarathi, K, Tanita, T, Bhattacharya, J. Endothelial barrier strengthening by activation of focal adhesion kinase. J Biol Chem, 278 (15), 13342-9, 2003.
  17. Ichimura, H, Parthasarathi, K, Quadri, S, Issekutz, AC, Bhattacharya, J. Mechano-oxidative coupling by mitochondria induces proinflammatory responses in lung venular capillaries. J Clin Invest, 111 (5), 691-9, 2003.
  18. Bhattacharya, S, Sen, N, Yiming, MT, Patel, R, Parthasarathi, K, Quadri, S, Issekutz, AC, Bhattacharya, J. High tidal volume ventilation induces proinflammatory signaling in rat lung endothelium. Am J Respir Cell Mol Biol, 28 (2), 218-24, 2003.
  19. Parthasarathi, K, Ichimura, H, Quadri, S, Issekutz, A, Bhattacharya, J. Mitochondrial reactive oxygen species regulate spatial profile of proinflammatory responses in lung venular capillaries. J Immunol, 169 (12), 7078-86, 2002.
  20. Bhattacharya, S, Patel, R, Sen, N, Quadri, S, Parthasarathi, K, Bhattacharya, J. Dual signaling by the alpha(v)beta(3)-integrin activates cytosolic PLA(2) in bovine pulmonary artery endothelial cells. Am J Physiol Lung Cell Mol Physiol, 280 (5), L1049-56, 2001.
  21. Kuebler, WM, Parthasarathi, K, Wang, PM, Bhattacharya, J. A novel signaling mechanism between gas and blood compartments of the lun. J Clin Invest, 106 (4), 607, 2000.
  22. Kuebler, WM, Parthasarathi, K, Wang, PM, Bhattacharya, J. A novel signaling mechanism between gas and blood compartments of the lung. J Clin Invest, 105 (7), 905-13, 2000.
  23. Parthasarathi, K, Lipowsky, HH. Capillary recruitment in response to tissue hypoxia and its dependence on red blood cell deformability. Am J Physiol, 277 (6 Pt 2), H2145-57, 1999.
  24. Parthasarathi, K, Pittman, RN. Measurements of hemoglobin concentration and oxygen saturation profiles in arterioles using intravital videomicroscopy and image analysis. Adv Exp Med Biol, 361, 249-60, 1994.