JOHN M. STUART, M.D.

Professor
Medicine-Rheumatology

Office: 151 Research, Veterans Affairs Medical Center
Tel: (901) 577-7266
jstuart@uthsc.edu

Publications

  1. Xiong, Q, Jiao, Y, Hasty, KA, Canale, ST, Stuart, JM, Beamer, WG, Deng, HW, Baylink, D, Gu, W. Quantitative trait loci, genes, and polymorphisms that regulate bone mineral density in mouse. Genomics, 2009.
  2. Xiong, Q, Jiao, Y, Hasty, KA, Stuart, JM, Postlethwaite, A, Kang, AH, Gu, W. Genetic and molecular basis of quantitative trait loci of arthritis in rat: genes and polymorphisms. J Immunol, 181 (2), 859-64, 2008.
  3. Myers, LK, Tang, B, Rosioniec, EF, Stuart, JM, Kang, AH. An altered peptide ligand of type II collagen suppresses autoimmune arthritis. Crit Rev Immunol, 27 (4), 345-56, 2008.
  4. Sakurai, Y, Brand, DD, Tang, B, Rosloniec, EF, Stuart, JM, Kang, AH, Myers, LK. Analog peptides of type II collagen can suppress arthritis in HLA-DR4 (DRB1*0401) transgenic mice. Arthritis Res Ther, 8 (5), R150, 2006.
  5. Sakurai, Y, Tang, B, Rosloniec, EF, Stuart, JM, Kang, AH, Myers, LK. Molecular characterization of an arthritogenic collagen peptide interacting with I-Ar. Immunology, 117 (1), 136-42, 2006.
  6. Lee, SM, Morcos, Y, Jang, H, Stuart, JM, Levin, MC. HTLV-1 induced molecular mimicry in neurological disease. Curr Top Microbiol Immunol, 296, 125-36, 2005.
  7. Zhou, F, He, X, Iwakura, Y, Horai, R, Stuart, JM. Arthritis in mice that are deficient in interleukin-1 receptor antagonist is dependent on genetic background. Arthritis Rheum, 52 (12), 3731-8, 2005.
  8. Tang, B, Brand, DD, Ma, Z, Stuart, JM, Myers, LK, Kang, AH. Pathogenesis of collagen-induced arthritis: modulation of disease by arthritogenic T-cell epitope location. Immunology, 113 (3), 384-91, 2004.
  9. Myers, LK, Tang, B, Brand, DD, Rosloniec, EF, Stuart, JM, Kang, AH. Efficacy of modified recombinant type II collagen in modulating autoimmune arthritis. Arthritis Rheum, 50 (9), 3004-11, 2004.
  10. He, X, Rosloniec, EF, Myers, LK, McColgan, WL, Gumanovskaya, M, Kang, AH, Stuart, JM. T cell receptors recognizing type II collagen in HLA-DR-transgenic mice characterized by highly restricted V beta usage. Arthritis Rheum, 50 (6), 1996-2004, 2004.
  11. Rosloniec, EF, Whittington, KB, He, X, Stuart, JM, Kang, AH. Collagen-induced arthritis mediated by HLA-DR1 (*0101) and HLA-DR4 (*0401). Am J Med Sci, 327 (4), 169-79, 2004.
  12. Myers, LK, Sakurai, Y, Rosloniec, EF, Stuart, JM, Kang, AH. An analog peptide that suppresses collagen-induced arthritis. Am J Med Sci, 327 (4), 212-6, 2004.
  13. Myers, LK, Myllyharju, J, Nokelainen, M, Brand, DD, Cremer, MA, Stuart, JM, Bodo, M, Kivirikko, KI, Kang, AH. Relevance of posttranslational modifications for the arthritogenicity of type II collagen. J Immunol, 172 (5), 2970-5, 2004.
  14. Myers, LK, Sakurai, Y, Tang, B, He, X, Rosloniec, EF, Stuart, JM, Kang, AH. Peptide-induced suppression of collagen-induced arthritis in HLA-DR1 transgenic mice. Arthritis Rheum, 46 (12), 3369-77, 2002.
  15. Levin, MC, Lee, SM, Kalume, F, Morcos, Y, Dohan, FC, Hasty, KA, Callaway, JC, Zunt, J, Desiderio, D, Stuart, JM. Autoimmunity due to molecular mimicry as a cause of neurological disease. Nat Med, 8 (5), 509-13, 2002.
  16. Myers, LK, Tang, B, Stuart, JM, Kang, AH. The role of IL-4 in regulation of murine collagen-induced arthritis. Clin Immunol, 102 (2), 185-91, 2002.
  17. Brand, DD, Myers, LK, Whittington, KB, Latham, KA, Stuart, JM, Kang, AH, Rosloniec, EF. Detection of early changes in autoimmune T cell phenotype and function following intravenous administration of type II collagen in a TCR-transgenic model. J Immunol, 168 (1), 490-8, 2002.
  18. He, X, Weyand, CM, Goronzy, JJ, Zhong, W, Stuart, JM. Bi-directional modulation of T cell-dependent antibody production by prostaglandin E(2). Int Immunol, 14 (1), 69-77, 2002.
  19. He, X, Kang, AH, Stuart, JM. Anti-Human type II collagen CD19+ B cells are present in patients with rheumatoid arthritis and healthy individuals. J Rheumatol, 28 (10), 2168-75, 2001.
  20. Shlopov, BV, Stuart, JM, Gumanovskaya, ML, Hasty, KA. Regulation of cartilage collagenase by doxycycline. J Rheumatol, 28 (4), 835-42, 2001.
  21. He, X, Kang, AH, Stuart, JM. Accumulation of T cells reactive to type II collagen in synovial fluid of patients with rheumatoid arthritis. J Rheumatol, 27 (3), 589-93, 2000.
  22. Tang, B, Brand, DD, Chiang, TM, Stuart, JM, Kang, AH, Myers, LK. Immunogenicity and arthritogenicity of recombinant CB10 in B10.RIII mice. J Immunol, 164 (1), 481-7, 2000.
  23. He, X, Stuart, JM. Prostaglandin E2 selectively inhibits human CD4+ T cells secreting low amounts of both IL-2 and IL-4. J Immunol, 163 (11), 6173-9, 1999.
  24. Tang, B, Chiang, TM, Brand, DD, Gumanovskaya, ML, Stuart, JM, Kang, AH, Myers, LK. Molecular definition and characterization of recombinant bovine CB8 and CB10: immunogenicity and arthritogenicity. Clin Immunol, 92 (3), 256-64, 1999.
  25. Gumanovskaya, ML, Myers, LK, Rosloniec, EF, Stuart, JM, Kang, AH. Intravenous tolerization with type II collagen induces interleukin-4-and interleukin-10-producing CD4+ T cells. Immunology, 97 (3), 466-73, 1999.
  26. Myers, LK, Brand, DD, Ye, XJ, Cremer, MA, Rosloniec, EF, Bodo, M, Myllyharju, J, Helaakoski, T, Nokelainen, M, Pihlajaniemi, T, Kivirikko, K, Yang, CL, Ala-Kokko, L, Prockop, DJ, Notbohm, H, Fietzek, P, Stuart, JM, Kang, AH. Characterization of recombinant type II collagen: arthritogenicity and tolerogenicity in DBA/1 mice. Immunology, 95 (4), 631-9, 1998.
  27. Myers, LK, Tang, B, Rosloniec, EF, Stuart, JM, Chiang, TM, Kang, AH. Characterization of a peptide analog of a determinant of type II collagen that suppresses collagen-induced arthritis. J Immunol, 161 (7), 3589-95, 1998.
  28. Tang, B, Myers, LK, Rosloniec, EF, Whittington, KB, Stuart, JM, Kang, AH. Characterization of signal transduction through the TCR-zeta chain following T cell stimulation with analogue peptides of type II collagen 260-267. J Immunol, 160 (7), 3135-42, 1998.
  29. Kawamura, S, Miyahara, H, Esaki, Y, Myers, LK, Rosloniec, EF, Stuart, JM, Kang, AH. Restricted TCR V alpha repertoire in the T cell response to a tolerogenic determinant of type II collagen. J Immunol, 158 (12), 6013-8, 1997.
  30. Myers, LK, Seyer, JM, Stuart, JM, Kang, AH. Suppression of murine collagen-induced arthritis by nasal administration of collagen. Immunology, 90 (2), 161-4, 1997.
  31. Brand, DD, Marion, TN, Myers, LK, Rosloniec, EF, Watson, WC, Stuart, JM, Kang, AH. Autoantibodies to murine type II collagen in collagen-induced arthritis: a comparison of susceptible and nonsusceptible strains. J Immunol, 157 (11), 5178-84, 1996.
  32. Rosloniec, EF, Whittington, KB, Brand, DD, Myers, LK, Stuart, JM. Identification of MHC class II and TCR binding residues in the type II collagen immunodominant determinant mediating collagen-induced arthritis. Cell Immunol, 172 (1), 21-8, 1996.
  33. Rosloniec, EF, Brand, DD, Whittington, KB, Stuart, JM, Ciubotaru, M, Ward, ES. Vaccination with a recombinant V alpha domain of a TCR prevents the development of collagen-induced arthritis. J Immunol, 155 (9), 4504-11, 1995.
  34. Miyahara, H, Myers, LK, Rosloniec, EF, Brand, DD, Seyer, JM, Stuart, JM, Kang, AH. Identification and characterization of a major tolerogenic T-cell epitope of type II collagen that suppresses arthritis in B10.RIII mice. Immunology, 86 (1), 110-5, 1995.
  35. Myers, LK, Miyahara, H, Terato, K, Seyer, JM, Stuart, JM, Kang, AH. Collagen-induced arthritis in B10.RIII mice (H-2r): identification of an arthritogenic T-cell determinant. Immunology, 84 (4), 509-13, 1995.
  36. Myers, LK, Cooper, SW, Terato, K, Seyer, JM, Stuart, JM, Kang, AH. Identification and characterization of a tolerogenic T cell determinant within residues 181-209 of chick type II collagen. Clin Immunol Immunopathol, 75 (1), 33-8, 1995.
  37. Brand, DD, Myers, LK, Terato, K, Whittington, KB, Stuart, JM, Kang, AH, Rosloniec, EF. Characterization of the T cell determinants in the induction of autoimmune arthritis by bovine alpha 1(II)-CB11 in H-2q mice. J Immunol, 152 (6), 3088-97, 1994.
  38. Myers, LK, Seyer, JM, Stuart, JM, Terato, K, David, CS, Kang, AH. T cell epitopes of type II collagen that regulate murine collagen-induced arthritis. J Immunol, 151 (1), 500-5, 1993.
  39. Myers, LK, Rosloniec, EF, Seyer, JM, Stuart, JM, Kang, AH. A synthetic peptide analogue of a determinant of type II collagen prevents the onset of collagen-induced arthritis. J Immunol, 150 (10), 4652-8, 1993.
  40. Myers, LK, Terato, K, Seyer, JM, Stuart, JM, Kang, AH. Characterization of a tolerogenic T cell epitope of type II collagen and its relevance to collagen-induced arthritis. J Immunol, 149 (4), 1439-43, 1992.
  41. Terato, K, Hasty, KA, Reife, RA, Cremer, MA, Kang, AH, Stuart, JM. Induction of arthritis with monoclonal antibodies to collagen. J Immunol, 148 (7), 2103-8, 1992.
  42. Reife, RA, Hasty, KA, Mainardi, CL, Stuart, JM. Immunolocalization of metalloproteinases in collagen autoimmune arthritis. Matrix Suppl, 1, 397, 1992.
  43. Reife, RA, Loutis, N, Watson, WC, Hasty, KA, Stuart, JM. SWR mice are resistant to collagen-induced arthritis but produce potentially arthritogenic antibodies. Arthritis Rheum, 34 (6), 776-81, 1991.
  44. Spinella, DG, Jeffers, JR, Reife, RA, Stuart, JM. The role of C5 and T-cell receptor Vb genes in susceptibility to collagen-induced arthritis. Immunogenetics, 34 (1), 23-7, 1991.
  45. Myers, LK, Stuart, JM, Seyer, JM, Kang, AH. Identification of an immunosuppressive epitope of type II collagen that confers protection against collagen-induced arthritis. J Exp Med, 170 (6), 1999-2010, 1989.
  46. Myers, LK, Stuart, JM, Kang, AH. A CD4 cell is capable of transferring suppression of collagen-induced arthritis. J Immunol, 143 (12), 3976-80, 1989.
  47. Stuart, JM, Watson, WC, Kang, AH. Collagen autoimmunity and arthritis. FASEB J, 2 (14), 2950-6, 1988.
  48. Yoo, TJ, Kim, SY, Stuart, JM, Floyd, RA, Olson, GA, Cremer, MA, Kang, AH. Induction of arthritis in monkeys by immunization with type II collagen. J Exp Med, 168 (2), 777-82, 1988.
  49. Hernandez, AD, Cremer, MA, Townes, AS, Stuart, JM, Kang, AH. The immune response of guinea-pigs to type II collagen: poor cross-reactivity with homologous type II collagen accounts for resistance to collagen-induced arthritis. Immunology, 63 (4), 619-24, 1988.