Assistant Professor

Tel: (901) 448-1796


  • PostDoc, University of Chicago, Gastroenterology, Hepatology, and Nutrition
  • Ph.D., University of Wisconsin, Nutritional Sciences
  • B.S., University of Wisconsin, Natural Science

My Current Curriculum Vitae

Research Interest/Specialty

As an experimental biologist I am fascinated by the interaction of diet, intestinal microorganisms and their metabolites, and the neuro-immune compartments in regulating intestinal and peripheral homeostasis. I employ novel in vitro and in vivo models to address translational science questions in metabolism.

Research Description

The Vision of our laboratory is to improve human health by harnessing underlying intestinal mechanisms that regulate metabolism. 

Our Mission is discovery. We pursue novel questions with translational relevance through experimental excellence, strong teamwork, and mutually beneficial collaborations. Through careful experimentation, we rigorously test hypotheses that elevate our understanding of intestinal physiology and microbial function that influence metabolism. Our goal is to apply our discoveries into treatments that target the underlying mechanisms of metabolic dysfunction and ultimately improve human health.  


Our Gnotobiotic Facility maintains mice under sterile (germ-free) and defined (associated) microbial states to explore the causal relationship microbial organisms confer upon their mammalian hosts. The use of this technology enhances our ability to test important hypotheses of microbial involvement in the regulation of metabolic disease.  

Lab Members


Kent A. Willis, MD, Neonatology Fellow

E. Richard Moran III, Summer Medical Student

Neena A. Johns, Summer Medical Student

Tahiyah Mimts, Undergraduate Volunteer (Rhodes College)


Charles Klazer Gomes, PhD, Senior Research Specialist

Research Keywords

 Gastrointestinal Physiology, Enteral Nutrition, Parenteral Nutrition, Microbiome, Microbiota, Bariatric Surgery


  1. Pierre JF, Li Y, Gomes CK, Rao P, Chang EB, Yin DP. Bile Diversion Improves Metabolic Phenotype Dependent on Farnesoid X Receptor (FXR). Obesity. In Press, 2019.
  2. Martinez-Guryn K, Leone V, Pierre JF. Nutritional modulation of the gut microbiome in gastrointestinal and metabolic diseases. J of Nutritional Biochemistry, Special Issue (Edited), 2019.
  3. Sean C. McConnell, Erica L. Westerman, Joseph F. Pierre, Erin J Heckler, Nancy B. Schwartz. Career Choice, Gender, and Mentor Impact: Results of the U.S. National Postdoc Survey. BioRxIV (PrePrint), 2018.
  4. Wang X, Wang H, Pierre JF, Wang S, Huang H, Zhang J, Liang S, Zeng Q, Zhang C, Huang M, Ruan C, Lin J, Li H. Marine microalgae bioengineered Schizochytrium sp. meal hydrolysates inhibits acute inflammation.. Scientific Reports, 1 (8), 2018.
  5. Johnson CD, Barlow AJ, Pierre JF, Erickson CS, Epstein ML, Gosain A. Deletion of Choline Acetyltransferase in enteric neurons results in intestinal dysmotility and dysbiosis. FASEB (March 23), 2018.
  6. McAllan L, Maynard KR, Kardian AS, Stayton AS, Fox LS, Stephenson EJ, Alshibli NK, Gomes CK, Pierre JF, Puchowicz MA, Gavrilova O, Bridges D, Martinowich K, Han JC. Disruption of BDNF production from individual exon promoters generates distinct body composition phenotypes in mice.. Am J Physiology – Endo and Metabolism, 2018.
  7. Pierre JF, Hinterleitner R, Bouziat R, Hubert N, Leone V, Miyoshi J, Jabri B, Chang EB. Data on Changes to Mucosal Inflammation and the Intestinal Microbiota following Dietary Micronutrients in Genetically Susceptible Hosts. Data in Brief (In Press), 2018.
  8. Sean C McConnell, Erica L Westerman, Joseph F Pierre, Erin J Heckler, Nancy B Schwartz. United States National Postdoc Survey results and the interaction of gender, career choice and mentor impact. eLIFE (7), 2018.
  9. Meisel M, Hinterleitner R, Pacis A, Chen L, Earley Z, Mayassi T, Pierre JF, Ernest J, Galipeau H, Thuille N, Bouziat, Buscarlet M, Ringus DL, Wang Y, Li Y, Dinh V, Kim S, McDonald B, Zurenski MA, Musch M, Furtado GC, Lira S, Baier G, Chang EB, Erin A, Weber C, Busque L, Godley L, Verdu E, Barrerio LB, Jabri B. Bacterial translocation is required for pre-leukemic myeloproliferation in Tet2 deficient mice. Nature, 2018.
  10. Martinez-Guryn K, Frazier K, Hubert N, Urlass S, Musch MA, Ojeda P, Pierre JF, Sontag T, Reardon C, Leone V, Chang EB. Essential role of small bowel microbiota in regulating host digestive and absorptive adaptive responses to dietary lipids. Cell Host & Microbe, 4 (23), 458-469, 2018.
  11. Miyoshi J, Sofia MA, Pierre JF. The Evidence for Fungus in Crohn's Disease Pathogenesis. Clinical Journal of Gastroenterology (Epub ahead), 2018.
  12. Wun K, Theriault B, Pierre JF, Chen EB, Leone V, Harris KG, Chen E, Xiong L, Jiang T, Spedale M, Eskandari, Chang EB, Ho KJ.. Microbiota control acute arterial inflammation and neointimal hyperplasia development after arterial injury.. PLoS One, 2018.
  13. Pierre, JF. Gastrointestinal immune and microbiome changes during parenteral nutrition. Am J Physiol Gastrointest Liver Physiol, 312 (3), G246-G256, 2017.
  14. Pierre JF, Hinterleitner R, Bouziat R, Hubert N, Leone V, Miyoshi J, Jabri B, Chang EB. Antioxidant Micronutrients Alter Mucosal Inflammatory Risk in a Murine Model of Genetic and Microbial Susceptibility. Journal of Nutritional Biochemistry, 54, 95-104, 2017.
  15. Martinez, KB, Pierre, JF, Chang, EB. The Gut Microbiota: The Gateway to Improved Metabolism. Gastroenterol Clin North Am, 45 (4), 601-614, 2016.
  16. Busch, RA, Heneghan, AF, Pierre, JF, Neuman, JC, Reimer, CA, Wang, X, Kimple, ME, Kudsk, KA. Bombesin Preserves Goblet Cell Resistin-Like Molecule β During Parenteral Nutrition but Not Other Goblet Cell Products. JPEN J Parenter Enteral Nutr, 40 (7), 1042-9, 2016.
  17. Pierre, JF, Martinez, KB, Ye, H, Nadimpalli, A, Morton, TC, Yang, J, Wang, Q, Patno, N, Chang, EB, Yin, DP. Activation of bile acid signaling improves metabolic phenotypes in high-fat diet-induced obese mice. Am J Physiol Gastrointest Liver Physiol, 311 (2), G286-304, 2016.
  18. Ward, MA, Pierre, JF, Leal, RF, Huang, Y, Shogan, B, Dalal, SR, Weber, CR, Leone, VA, Musch, MW, An, GC, Rao, MC, Rubin, DT, Raffals, LE, Antonopoulos, DA, Sogin, ML, Hyman, NH, Alverdy, JC, Chang, EB. Insights into the pathogenesis of ulcerative colitis from a murine model of stasis-induced dysbiosis, colonic metaplasia, and genetic susceptibility. Am J Physiol Gastrointest Liver Physiol, 310 (11), G973-88, 2016.
  19. Pierre, JF. Young Investigator Perspectives. Rethinking the biomedical postdoc: but first let's get the data. Am J Physiol Gastrointest Liver Physiol, 310 (11), G885-6, 2016.
  20. Busch, RA, Jonker, MA, Pierre, JF, Heneghan, AF, Kudsk, KA. Innate Mucosal Immune System Response of BALB/c vs C57BL/6 Mice to Injury in the Setting of Enteral and Parenteral Feeding. JPEN J Parenter Enteral Nutr, 40 (2), 256-63, 2016.
  21. Pierre, JF, Busch, RA, Kudsk, KA. The gastrointestinal immune system: Implications for the surgical patient. Curr Probl Surg, 53 (1), 11-47, 2016.
  22. Dolan KT, Pierre JF, Heckler EJ.. Revitalizing Biomedical Research: Recommendations from the Future of Research Chicago Symposium.. F1000 RESEARCH, 1548 (5), 2016.
  23. Pierre, JF, Neuman, JC, Brill, AL, Brar, HK, Thompson, MF, Cadena, MT, Connors, KM, Busch, RA, Heneghan, AF, Cham, CM, Jones, EK, Kibbe, CR, Davis, DB, Groblewski, GE, Kudsk, KA, Kimple, ME. The gastrin-releasing peptide analog bombesin preserves exocrine and endocrine pancreas morphology and function during parenteral nutrition. Am J Physiol Gastrointest Liver Physiol, 309 (6), G431-42, 2015.
  24. Wang, X, Pierre, JF, Heneghan, AF, Busch, RA, Kudsk, KA. Glutamine Improves Innate Immunity and Prevents Bacterial Enteroinvasion During Parenteral Nutrition. JPEN J Parenter Enteral Nutr, 39 (6), 688-97, 2015.
  25. Jonker, MA, Heneghan, AF, Fechner, JH, Pierre, JF, Sano, Y, Lan, J, Kudsk, KA. Gut Lymphocyte Phenotype Changes After Parenteral Nutrition and Neuropeptide Administration. Ann Surg, 262 (1), 194-201, 2015.
  26. Leone, V, Gibbons, SM, Martinez, K, Hutchison, AL, Huang, EY, Cham, CM, Pierre, JF, Heneghan, AF, Nadimpalli, A, Hubert, N, Zale, E, Wang, Y, Huang, Y, Theriault, B, Dinner, AR, Musch, MW, Kudsk, KA, Prendergast, BJ, Gilbert, JA, Chang, EB. Effects of diurnal variation of gut microbes and high-fat feeding on host circadian clock function and metabolism. Cell Host Microbe, 17 (5), 681-9, 2015.
  27. Pierre, JF, Heneghan, AF, Wang, X, Roenneburg, DA, Groblewski, GE, Kudsk, KA. Bombesin improves adaptive immunity of the salivary gland during parenteral nutrition. JPEN J Parenter Enteral Nutr, 39 (2), 190-9, 2015.
  28. Wang X, Pierre JF, Kudsk KA.. Parenteral nutrition, critical illness, Paneth cell function and the innate immune response in Diet and Nutrition in Critical Care,. Victor Preedy PhD ed. - Springer Publishing, 2015.
  29. Gosain, A, Barlow-Anacker, AJ, Erickson, CS, Pierre, JF, Heneghan, AF, Epstein, ML, Kudsk, KA. Impaired Cellular Immunity in the Murine Neural Crest Conditional Deletion of Endothelin Receptor-B Model of Hirschsprung's Disease. PLoS One, 10 (6), e0128822, 2014.
  30. Heneghan, AF, Pierre, JF, Tandee, K, Shanmuganayagam, D, Wang, X, Reed, JD, Steele, JL, Kudsk, KA. Parenteral nutrition decreases paneth cell function and intestinal bactericidal activity while increasing susceptibility to bacterial enteroinvasion. JPEN J Parenter Enteral Nutr, 38 (7), 817-24, 2014.
  31. Busch, RA, Heneghan, AF, Pierre, JF, Wang, X, Kudsk, KA. The enteric nervous system neuropeptide, bombesin, reverses innate immune impairments during parenteral nutrition. Ann Surg, 260 (3), 432-43; discussion 443-4, 2014.
  32. Pierre, JF, Barlow-Anacker, AJ, Erickson, CS, Heneghan, AF, Leverson, GE, Dowd, SE, Epstein, ML, Kudsk, KA, Gosain, A. Intestinal dysbiosis and bacterial enteroinvasion in a murine model of Hirschsprung's disease. J Pediatr Surg, 49 (8), 1242-51, 2014.
  33. Heneghan AF1, Pierre JF, Gosain A, Kudsk KA.. IL-25 improves luminal innate immunity and barrier function during parenteral nutrition.. Ann Surg., 2 (259), 394-400, 2014.
  34. Kudsk KA & Pierre JF.. Nutrition and Immunity of the Gut.. Metabolic Medicine and Surgery. edited by Michael M. Rothkopf and Michael J. Nusbaum. CRC Press., 2014.
  35. Pierre JF, Heneghan AF, Feliciano RP, Shanmuganayagam D, Krueger CG, Reed JD, Kudsk KA.. Cranberry proanthocyanidins improve intestinal sIgA during elemental enteral nutrition.. JPEN J Parenter Enteral Nutr., 1 (38), 107-14, 2014.
  36. Heneghan, AF, Pierre, JF, Kudsk, KA. JAK-STAT and intestinal mucosal immunology. JAKSTAT, 2 (4), e25530, 2013.
  37. Pierre, JF, Heneghan, AF, Lawson, CM, Wischmeyer, PE, Kozar, RA, Kudsk, KA. Pharmaconutrition review: physiological mechanisms. JPEN J Parenter Enteral Nutr, 37 (5 Suppl), 51S-65S, 2013.
  38. Erickson, CS, Barlow, AJ, Pierre, JF, Heneghan, AF, Epstein, ML, Kudsk, KA, Gosain, A. Colonic enteric nervous system analysis during parenteral nutrition. J Surg Res, 184 (1), 132-7, 2013.
  39. Heneghan AF, Pierre JF, Kudsk KA.. IL-25 improves IgA levels during parenteral nutrition through the JAK-STAT pathway.. Ann Surg., 6 (258), 1065-71, 2013.
  40. Omata J, Pierre JF, Heneghan AF, Tsao FH, Sano Y, Jonker MA, Kudsk KA.. Parenteral nutrition suppresses the bactericidal response of the small intestine.. Surgery., 1 (153), 17-24, 2013.
  41. Pierre JF, Heneghan AF, Feliciano RP, Shanmuganayagam D, Roenneburg DA, Krueger CG, Reed JD, Kudsk KA.. Cranberry proanthocyanidins improve the gut mucous layer morphology and function in mice receiving elemental enteral nutrition.. JPEN J Parenter Enteral Nutr., 3 (37), 401-9, 2013.
  42. Pierre JF, Heneghan AF, Shea MP, Meudt J, Reed JD, Kudsk KA, Shanmuganayagam D.. Parenteral Nutrition Increases Susceptibility of Ileum to Invasion by E. coli.. J Surg Res., 2 (183), 583-91, 2013.
  43. Zaitoun I, Erickson CS, Barlow AJ, Klein TR, Heneghan AF, Pierre JF, Epstein ML, Gosain A.. Altered neuronal density and neurotransmitter expression in the ganglionated region of Ednrb null mice: implications for Hirschsprung's disease.. Neurogastroenterol Motil., 3 (25), 233-44, 2013.
  44. Tsao FH, Culver BJ, Pierre JF, Shanmuganayagam D, Patten CC Jr, Meyer KC.. Effect of prophylactic supplementation with grape polyphenolics on endotoxin-induced serum secretory phospholipase A2 activity in rats.. Comp Med., 4 (62), 271-8, 2012.
  45. Lan J, Heneghan AF, Sano Y, Jonker MA, Omata J, Xu W, Pierre JF, Kudsk KA.. Parenteral nutrition impairs lymphotoxin β receptor signaling via NF-κB.. Ann Surg., 5 (253), 996-1003, 2011.
  46. Pierre JF, Heneghan AF, Tsao FH, Sano Y, Jonker MA, Omata J, Lan J, Kudsk KA.. Route and type of nutrition and surgical stress influence secretory phospholipase A2 secretion of the murine small intestine.. JPEN J Parenter Enteral Nutr., 6 (35), 748-56, 2011.