JUNAITH S. MOHAMED

Assistant Professor
Clinical Lab Sciences

Office: 660 930 MADISON BUILDING
930 MADISON AVENUE
MEMPHIS TN 381632243
Tel: (901) 448-8560
jmohamed@uthsc.edu

Research

Our research has focused on functional genomics and bioinformatics approaches to study the epigenetic signaling mechanisms that regulate skeletal muscle mass and function for the purposes of understanding how aging and neuromuscular disorders induce muscle atrophy and weakness as well as to develop appropriate therapies that will prevent, retard, or reverse muscle atrophy and weakness.  To address his research questions, we use several state-of-the-art genetic, cell and molecular biology techniques, bioinformatics tools, in vitro and in vivo experiments, and mouse models of human diseases. We also uses microarray and next-generation sequencing technologies to explore how genome-wide chromatin and transcriptome changes affect skeletal muscle mass and function.

Research Interests

  • Aging 
  • Stroke
  • Atrophy
  • Growth
  • Regeneration
  • Metabolism
  • Genomics
  • Proteomics
  • Metabolomics
  • Bioinformatics

Publications

  • Oliveira JRS, Mohamed JS, Myers MJ, Brooks MJ, Alway SE. 2018. Effects of hindlimb suspension and reloading on gastrocnemius and soleus muscle mass and function in geriatric mice. Exp. Gerontol. 115:19-31. PMID: 30448397
  • Brooks MJ, Hajira A, Mohamed JS, Alway SE. 2018. Voluntary wheel running increases satellite cell abundance and improves recovery from disuse in gastrocnemius muscles from mice. J. Appl. Physiol. 124(6):1616-1628. PMID: 29470148
  • Haramizu S, Asano S, Butler DC, Stanton DA, Hajira A, Mohamed JS, Alway SE. 2017. Dietary resveratrol confers apoptotic resistance to oxidative stress in myoblasts. J. Nutr. Biochem. 50:103-115. PMID: 29053994 
  • Alway SE, McCrory JL, Kearcher K, Vickers A, Frear B, Gilleland DL, Bonner DE, Thomas JM, Donley DA, Lively MW, Mohamed JS. 2017. Resveratrol Enhances Exercise-Induced Cellular and Functional Adaptations of Skeletal Muscle in Older Men and Women. J. Gerontol. A. Biol. Sci. Med. Sci. 72(12):1595-1606. PMID: 28505227 
  • Pardo PS, Hajira A, Boriek AM, Mohamed JS. 2017. MicroRNA-434-3p regulates age-related apoptosis through eIF5A1 in the skeletal muscle. Aging (Albany NY). 9(3):1012-1029. PMID: 28331100 
  • Alway SE, Mohamed JS, Myers MJ. 2017. Mitochondria Initiate and Regulate Sarcopenia. Exerc. Sport Sci. Rev. 45(2):58-69. PMID: 28098577 
  • Mohamed JS, Hajira A, Lopez MA, Boriek AM. 2015. Genome-wide Mechanosensitive MicroRNA (MechanomiR) Screen Uncovers Dysregulation of Their Regulatory Networks in the mdm Mouse Model of Muscular Dystrophy. J Biol Chem. 2015 290(41):24986-5011. PMID: 26272747 
  • Mohamed JS, Wilson JC, Myers MJ, Sisson KJ, Alway SE. 2014. Dysregulation of SIRT-1 in aging mice increases skeletal muscle fatigue by a PARP-1-dependent mechanism. Aging (Albany NY). 6(10):820-34. PMID: 25361036 
  • Mohamed JS, Hajira A, Pardo PS, Boriek AM. 2014. MicroRNA-149 inhibits PARP-2 and promotes mitochondrial biogenesis via SIRT-1/PGC-1α network in skeletal muscle. Diabetes. 63(5):1546-59. PMID: 24757201 

PubMed – NCBI