JONATHAN H. JAGGAR, Ph.D.

Maury W. Bronstein Professor of Physiology

Office: 507 LINK BUILDING
855 MONROE AVENUE
MEMPHIS TN 381632194
Tel: (901) 448-1208
jjaggar@uthsc.edu

Education

  • PostDoc, University of Vermont, Burlington, VT, Vascular Physiology
  • Ph.D., University of Sheffield, UK
  • Ph.D., University of Sheffield, Sheffield, UK, Physiology
  • B.S., Coventry University, Coventry, UK, Applied Biology

Research interest/specialty

The focus of the laboratory is to study mechanisms that regulate the diameter of small arteries and arterioles that modulate systemic blood pressure and organ blood flow. Smooth muscle cells within the vascular wall determine arterial diameter. Thus, our major focus is to investigate the functional significance of arterial smooth muscle cell plasma membrane and intracellular ion channels and local and global calcium signals in regulating arterial smooth muscle cell contractility. Research in

Research interest/specialty

The focus of the laboratory is to study mechanisms that regulate the diameter of small arteries and arterioles that modulate systemic blood pressure and organ blood flow. Smooth muscle cells within the vascular wall determine arterial diameter. Thus, our major focus is to investigate the functional significance of arterial smooth muscle cell plasma membrane and intracellular ion channels and local and global calcium signals in regulating arterial smooth muscle cell contractility. Research in

Publications

  1. Narayanan, D, Bulley, S, Leo, MD, Burris, SK, Gabrick, KS, Boop, FA, Jaggar, JH. Smooth Muscle Cell Transient Receptor Potential Polycystin (TRPP)2 Channels Contribute To The Myogenic Response In Cerebral Arteries. J Physiol, 2013.
  2. Bannister, JP, Leo, MD, Narayanan, D, Jangsangthong, W, Nair, A, Evanson, KW, Pachuau, J, Gabrick, KS, Boop, FA, Jaggar, JH. The voltage-dependent L-type Ca2+ (CaV1.2) channel C-terminus fragment is a bi-modal vasodilator. J Physiol, 591 (Pt 12), 2987-98, 2013.
  3. Schwingshackl, A, Teng, B, Ghosh, M, Lim, KG, Tigyi, G, Narayanan, D, Jaggar, JH, Waters, CM. Regulation of interleukin-6 secretion by the two-pore-domain potassium channel Trek-1 in alveolar epithelial cells. Am J Physiol Lung Cell Mol Physiol, 304 (4), L276-86, 2013.
  4. Adebiyi, A, Thomas-Gatewood, CM, Leo, MD, Kidd, MW, Neeb, ZP, Jaggar, JH. An elevation in physical coupling of type 1 inositol 1,4,5-trisphosphate (IP3) receptors to transient receptor potential 3 (TRPC3) channels constricts mesenteric arteries in genetic hypertension. Hypertension, 60 (5), 1213-9, 2012.
  5. Bannister, JP, Bulley, S, Narayanan, D, Thomas-Gatewood, C, Luzny, P, Pachuau, J, Jaggar, JH. Transcriptional upregulation of α2δ-1 elevates arterial smooth muscle cell voltage-dependent Ca2+ channel surface expression and cerebrovascular constriction in genetic hypertension. Hypertension, 60 (4), 1006-15, 2012.
  6. Bulley, S, Neeb, ZP, Burris, SK, Bannister, JP, Thomas-Gatewood, CM, Jangsangthong, W, Jaggar, JH. TMEM16A/ANO1 channels contribute to the myogenic response in cerebral arteries. Circ Res, 111 (8), 1027-36, 2012.
  7. Narayanan, D, Adebiyi, A, Jaggar, JH. Inositol trisphosphate receptors in smooth muscle cells. Am J Physiol Heart Circ Physiol, 302 (11), H2190-210, 2012.
  8. Liang, GH, Xi, Q, Leffler, CW, Jaggar, JH. Hydrogen sulfide activates Ca²⁺ sparks to induce cerebral arteriole dilatation. J Physiol, 590 (Pt 11), 2709-20, 2012.
  9. Thomas-Gatewood, C, Neeb, ZP, Bulley, S, Adebiyi, A, Bannister, JP, Leo, MD, Jaggar, JH. TMEM16A channels generate Ca²⁺-activated Cl⁻ currents in cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol, 301 (5), H1819-27, 2011.
  10. Adebiyi, A, McNally, EM, Jaggar, JH. Vasodilation induced by oxygen/glucose deprivation is attenuated in cerebral arteries of SUR2 null mice. Am J Physiol Heart Circ Physiol, 301 (4), H1360-8, 2011.
  11. Samak, G, Narayanan, D, Jaggar, JH, Rao, R. CaV1.3 channels and intracellular calcium mediate osmotic stress-induced N-terminal c-Jun kinase activation and disruption of tight junctions in Caco-2 CELL MONOLAYERS. J Biol Chem, 286 (34), 30232-43, 2011.
  12. Xi, Q, Tcheranova, D, Basuroy, S, Parfenova, H, Jaggar, JH, Leffler, CW. Glutamate-induced calcium signals stimulate CO production in piglet astrocytes. Am J Physiol Heart Circ Physiol, 301 (2), H428-33, 2011.
  13. Leffler, CW, Parfenova, H, Jaggar, JH. Carbon monoxide as an endogenous vascular modulator. Am J Physiol Heart Circ Physiol, 301 (1), H1-H11, 2011.
  14. Liang, GH, Adebiyi, A, Leo, MD, McNally, EM, Leffler, CW, Jaggar, JH. Hydrogen sulfide dilates cerebral arterioles by activating smooth muscle cell plasma membrane KATP channels. Am J Physiol Heart Circ Physiol, 300 (6), H2088-95, 2011.
  15. Bannister, JP, Thomas-Gatewood, CM, Neeb, ZP, Adebiyi, A, Cheng, X, Jaggar, JH. Ca(V)1.2 channel N-terminal splice variants modulate functional surface expression in resistance size artery smooth muscle cells. J Biol Chem, 286 (17), 15058-66, 2011.
  16. Leffler, CW, Parfenova, H, Basuroy, S, Jaggar, JH, Umstot, ES, Fedinec, AL. Hydrogen sulfide and cerebral microvascular tone in newborn pigs. Am J Physiol Heart Circ Physiol, 300 (2), H440-7, 2011.
  17. Adebiyi, A, Narayanan, D, Jaggar, JH. Caveolin-1 assembles type 1 inositol 1,4,5-trisphosphate receptors and canonical transient receptor potential 3 channels into a functional signaling complex in arterial smooth muscle cells. J Biol Chem, 286 (6), 4341-8, 2011.
  18. Zhao, G, Neeb, ZP, Leo, MD, Pachuau, J, Adebiyi, A, Ouyang, K, Chen, J, Jaggar, JH. Type 1 IP3 receptors activate BKCa channels via local molecular coupling in arterial smooth muscle cells. J Gen Physiol, 136 (3), 283-91, 2010.
  19. Narayanan, D, Xi, Q, Pfeffer, LM, Jaggar, JH. Mitochondria control functional CaV1.2 expression in smooth muscle cells of cerebral arteries. Circ Res, 107 (5), 631-41, 2010.
  20. Crnich, R, Amberg, GC, Leo, MD, Gonzales, AL, Tamkun, MM, Jaggar, JH, Earley, S. Vasoconstriction resulting from dynamic membrane trafficking of TRPM4 in vascular smooth muscle cells. Am J Physiol Cell Physiol, 299 (3), C682-94, 2010.
  21. Xi, Q., Narayanan, D., Leffler, C.W., Jaggar, J.H.. Glutamate regulates Ca2+ signals in smooth muscle cells of newborn piglet brain slice arterioles through astrocyte- and heme oxygenase-dependent mechanisms. Am J Physiol (298), H562-h569, 2010.
  22. Bannister, J.P., Adebiyi, A., Zhao, G., Narayanan, N., Thomas, C.M., Feng, J.Y., Jaggar, J.H.. Smooth muscle cell α2δ-1 subunits are essential for vasoregulation by CaV1.2 channels. Circ. Res. (105), 948-955, 2009.
  23. Cheng X., Pachuau J., Blaskova E., Asuncion-Chin M., Liu J., Dopico A.M., Jaggar J.H.. Alternative splicing of CaV1.2 channel exons in smooth muscle cells of resistance-size arteries generates currents with unique electrophysiological properties. Am. J. Physiol. (297), H680-H688, 2009.
  24. Zhao, G, Adebiyi, A, Blaskova, E, Xi, Q, Jaggar, JH. Type 1 inositol 1,4,5-trisphosphate receptors mediate UTP-induced cation currents, Ca2+ signals, and vasoconstriction in cerebral arteries. Am J Physiol Cell Physiol, 295 (5), C1376-84, 2008.
  25. Adebiyi, A, McNally, EM, Jaggar, JH. Sulfonylurea receptor-dependent and -independent pathways mediate vasodilation induced by ATP-sensitive K+ channel openers. Mol Pharmacol, 74 (3), 736-43, 2008.
  26. Xi, Q, Adebiyi, A, Zhao, G, Chapman, KE, Waters, CM, Hassid, A, Jaggar, JH. IP3 constricts cerebral arteries via IP3 receptor-mediated TRPC3 channel activation and independently of sarcoplasmic reticulum Ca2+ release. Circ Res, 102 (9), 1118-26, 2008.
  27. Li, A, Xi, Q, Umstot, ES, Bellner, L, Schwartzman, ML, Jaggar, JH, Leffler, CW. Astrocyte-derived CO is a diffusible messenger that mediates glutamate-induced cerebral arteriolar dilation by activating smooth muscle Cell KCa channels. Circ Res, 102 (2), 234-41, 2008.
  28. Cheng, X, Liu, J, Asuncion-Chin, M, Blaskova, E, Bannister, JP, Dopico, AM, Jaggar, JH. A novel Ca(V)1.2 N terminus expressed in smooth muscle cells of resistance size arteries modifies channel regulation by auxiliary subunits. J Biol Chem, 282 (40), 29211-21, 2007.
  29. Zhao, G, Adebiyi, A, Xi, Q, Jaggar, JH. Hypoxia reduces KCa channel activity by inducing Ca2+ spark uncoupling in cerebral artery smooth muscle cells. Am J Physiol Cell Physiol, 292 (6), C2122-8, 2007.
  30. Adebiyi, A, Zhao, G, Cheranov, SY, Ahmed, A, Jaggar, JH. Caveolin-1 abolishment attenuates the myogenic response in murine cerebral arteries. Am J Physiol Heart Circ Physiol, 292 (3), H1584-92, 2007.
  31. Li, A, Adebiyi, A, Leffler, CW, Jaggar, JH. KCa channel insensitivity to Ca2+ sparks underlies fractional uncoupling in newborn cerebral artery smooth muscle cells. Am J Physiol Heart Circ Physiol, 291 (3), H1118-25, 2006.
  32. Cheng, X, Jaggar, JH. Genetic ablation of caveolin-1 modifies Ca2+ spark coupling in murine arterial smooth muscle cells. Am J Physiol Heart Circ Physiol, 290 (6), H2309-19, 2006.
  33. Cheranov, SY, Jaggar, JH. TNF-alpha dilates cerebral arteries via NAD(P)H oxidase-dependent Ca2+ spark activation. Am J Physiol Cell Physiol, 290 (4), C964-71, 2006.
  34. Leffler, CW, Parfenova, H, Jaggar, JH, Wang, R. Carbon monoxide and hydrogen sulfide: gaseous messengers in cerebrovascular circulation. J Appl Physiol, 100 (3), 1065-76, 2006.
  35. Jaggar, JH, Li, A, Parfenova, H, Liu, J, Umstot, ES, Dopico, AM, Leffler, CW. Heme is a carbon monoxide receptor for large-conductance Ca2+-activated K+ channels. Circ Res, 97 (8), 805-12, 2005.
  36. Xi, Q, Cheranov, SY, Jaggar, JH. Mitochondria-derived reactive oxygen species dilate cerebral arteries by activating Ca2+ sparks. Circ Res, 97 (4), 354-62, 2005.
  37. Leffler, CW, Fedinec, AL, Parfenova, H, Jaggar, JH. Permissive contributions of NO and prostacyclin in CO-induced cerebrovascular dilation in piglets. Am J Physiol Heart Circ Physiol, 289 (1), H432-8, 2005.
  38. Liu, P, Xi, Q, Ahmed, A, Jaggar, JH, Dopico, AM. Essential role for smooth muscle BK channels in alcohol-induced cerebrovascular constriction. Proc Natl Acad Sci U S A, 101 (52), 18217-22, 2004.
  39. Ahmed, A, Waters, CM, Leffler, CW, Jaggar, JH. Ionic mechanisms mediating the myogenic response in newborn porcine cerebral arteries. Am J Physiol Heart Circ Physiol, 287 (5), H2061-9, 2004.
  40. Barkoudah, E, Jaggar, JH, Leffler, CW. The permissive role of endothelial NO in CO-induced cerebrovascular dilation. Am J Physiol Heart Circ Physiol, 287 (4), H1459-65, 2004.
  41. Cheranov, SY, Jaggar, JH. Mitochondrial modulation of Ca2+ sparks and transient KCa currents in smooth muscle cells of rat cerebral arteries. J Physiol, 556 (Pt 3), 755-71, 2004.
  42. Xi, Q, Tcheranova, D, Parfenova, H, Horowitz, B, Leffler, CW, Jaggar, JH. Carbon monoxide activates KCa channels in newborn arteriole smooth muscle cells by increasing apparent Ca2+ sensitivity of alpha-subunits. Am J Physiol Heart Circ Physiol, 286 (2), H610-8, 2004.
  43. Fiumana, E, Parfenova, H, Jaggar, JH, Leffler, CW. Carbon monoxide mediates vasodilator effects of glutamate in isolated pressurized cerebral arterioles of newborn pigs. Am J Physiol Heart Circ Physiol, 284 (4), H1073-9, 2003.
  44. Wang, DA, Du, H, Jaggar, JH, Brindley, DN, Tigyi, GJ, Watsky, MA. Injury-elicited differential transcriptional regulation of phospholipid growth factor receptors in the cornea. Am J Physiol Cell Physiol, 283 (6), C1646-54, 2002.
  45. Cheranov, SY, Jaggar, JH. Sarcoplasmic reticulum calcium load regulates rat arterial smooth muscle calcium sparks and transient K(Ca) currents. J Physiol, 544 (Pt 1), 71-84, 2002.
  46. Jaggar, JH, Leffler, CW, Cheranov, SY, Tcheranova, D, E, S, Cheng, X. Carbon monoxide dilates cerebral arterioles by enhancing the coupling of Ca2+ sparks to Ca2+-activated K+ channels. Circ Res, 91 (7), 610-7, 2002.
  47. Jaggar, JH. Intravascular pressure regulates local and global Ca(2+) signaling in cerebral artery smooth muscle cells. Am J Physiol Cell Physiol, 281 (2), C439-48, 2001.