James Carson

Senior Associate Dean for Research and Graduate Studies
College of Health Professions

Professor, Department of Physical Therapy

Office: RM 633 930 MADISON BUILDING
930 MADISON AVENUE
MEMPHIS TN 381632243
Tel: (901) 448-5588
jcarso16@uthsc.edu
https://scholar.google.com/citations?user=9oLoP7UAAAAJ

Research

My "Integrative Muscle Biology Laboratory" employs molecular biology techniques with in vivo and in vitro models to examine the regulation of skeletal muscle anabolic and metabolic plasticity. A major focus of my research seeks to improve our understanding of the cellular signaling that integrates muscle mechanical signaling with alterations in systemic inflammation and sex hormone signaling. To this end, I have employed in vivoparadigms of hindlimb disuse, treadmill exercise, muscle stretch, compensatory overload, stimulated concentric contractions, and stimulated eccentric contractions. I have investigated muscle responses to the previously mentioned treatments with physiological systemic disruptions related to aging, ovariectomy, orchiectomy, cancer, and high fat, diet-induced obesity. These in vivoparadigms have been complemented with in vitroexamination of cultured myotube responses to stretch, hormone administration, and inflammatory stimuli.My lab also has years of experience quantifying mouse muscle molecular signaling, phenotype, and morphology after either exercise or disease treatments.  We are currently examining if IL-6 directly or indirectly represses protein synthesis and creates anabolic resistance in cachectic muscle. My research encompasses over 115-refereed publications in journals, such as J Biol Chem, American Physiological Society Journals, Skeletal Muscle, and FASEB Journal.

JA Carson PubMed Link

https://www.ncbi.nlm.nih.gov/myncbi/browse/collection/47977065/?sort=date&direction=descending