BISSLER, JOHN J.

Chief, Division of Pediatric Nephrology, Le Bonheur Children's Hospital
Federal Express Chair of Excellence
Professor of Pediatrics, Depart of Pediatrics
Medical Director of Nephrology, St. Jude Children's Research Hospital

Office: 49 NORTH DUNLAP ST
ROOM 323
MEMPHIS TN 381632242
Tel: (901) 287-7477
jbissler@uthsc.edu

Publications

 1.     Siroky, B. J., Kleene, N. K., Kleene, S. J., Varnell, C. D., Comer, R. G., Liu, J., Bissler, J., Dixon, B. P. (2017). Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. American Journal of Physiology - Renal Physiology, (26), ajprenal.00465.2015. http://doi.org/10.1152/ajprenal.00465.2015

2.     Sun, P., Liu, J., Charles, H., Hulbert, J., & Bissler, J. (2017). Outcomes of angioembolization and nephrectomy for renal angiomyolipoma associated with tuberous sclerosis complex: a real-world US national study. Current Medical Research and Opinion, 33(5), 821–827. http://doi.org/10.1080/03007995.2017.1286307

3.     X. Song, Z. Liu, K. Cappell, C. Gregory, Q. Said, J. Prestifilippo, H. Charles, J. Hulbert, J. Bissler, Natural history of patients with tuberous sclerosis complex related renal angiomyolipoma, Curr. Med. Res. Opin. , 1–6 (2017).

4.     P. Sun, J. Liu, H. Charles, J. Hulbert, J. Bissler, Outcomes of angioembolization and nephrectomy for renal angiomyolipoma associated with tuberous sclerosis complex: a real-world US national study, Curr. Med. Res. Opin. 33, 821–827 (2017).

5.      J. J. Bissler, J. C. Kingswood, E. Radzikowska, B. A. Zonnenberg, E. Belousova, M. D. Frost, M. Sauter, S. Brakemeier, P. J. de Vries, N. Berkowitz, M. Voi, S. Peyrard, K. Budde, K. Eller, Ed. Everolimus long-term use in patients with tuberous sclerosis complex: Four-year update of the EXIST-2 study, PLoS One 12, e0180939 (2017).

6.     Bissler, J. J., Kingswood, J. C., Radzikowska, E. E. E., Zonnenberg, B. a., Frost, M., Belousova, E., … Budde, K. (2016). Everolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: Extension of a randomized controlled trial. Nephrology Dialysis Transplantation, 31(1), 111–9. http://doi.org/10.1093/ndt/gfv249

7.     Sahin, M., Henske, E. P., Manning, B. D., Ess, K. C., Bissler, J. J., Klann, E., … Rieff, H. (2016). Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations from the 2015 Strategic Planning Conference. Pediatric Neurology, 60, 1–12. http://doi.org/10.1016/j.pediatrneurol.2016.03.015

8.     Bissler, J., Cappell, K., Charles, H., Song, X., Liu, Z., Prestifilippo, J., … Hulbert, J. (2016). Long-term Clinical Morbidity in Patients With Renal Angiomyolipoma Associated With Tuberous Sclerosis Complex. Urology, 95, 80–7. http://doi.org/10.1016/j.urology.2016.04.027

9.     Bissler, John, J., & Kingswood, J. C. (2016). Optimal treatment of tuberous sclerosis complex associated renal angiomyolipomata : a systematic review. Therapeutic Advances Urology, 8(4), 1–12. http://doi.org/10.1177/1756287216641353

10.  Tipirneni-Sajja, A., Loeffler, R. B., Oesingmann, N., Bissler, J., Song, R., McCarville, B., … Hillenbrand, C. M. (2016). Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model. Physiological Reports, 4(7), e12755. http://doi.org/10.14814/phy2.12755

11.  Song, X., Liu, Z., Cappell, K., Gregory, C., Said, Q., Prestifilippo, J., … Bissler, J. (2016). Healthcare utilization and costs in patients with tuberous sclerosis complex-related renal angiomyolipoma. Journal of Medical Economics, 6998(January), 1–15. http://doi.org/10.1080/13696998.2016.1272461

12.  F. X. McCormack, N. Gupta, G. R. Finlay, L. R. Young, A. M. Taveira-DaSilva, C. G. Glasgow, W. K. Steagall, S. R. Johnson, S. A. Sahn, J. H. Ryu, C. Strange, K. Seyama, E. J. Sullivan, R. M. Kotloff, G. P. Downey, J. T. Chapman, M. K. Han, J. M. D’Armiento, Y. Inoue, E. P. Henske, J. J. Bissler, T. V Colby, B. W. Kinder, K. A. Wikenheiser-Brokamp, K. K. Brown, J. F. Cordier, C. Meyer, V. Cottin, J. L. Brozek, K. Smith, K. C. Wilson, J. Moss, ATS/JRS Committee on Lymphangioleiomyomatosis, Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management., Am. J. Respir. Crit. Care Med. 194, 748–61 (2016).

13.  J. C. Kingswood, J. J. Bissler, K. Budde, J. Hulbert, L. Guay-Woodford, J. R. Sampson, M. Sauter, J. Cox, U. Patel, F. Elmslie, C. Anderson, B. A. Zonnenberg, Review of the Tuberous Sclerosis Renal Guidelines from the 2012 Consensus Conference: Current Data and Future Study., Nephron 134, 51–58 (2016).

14.  A. Tipirneni-Sajja, R. B. Loeffler, N. Oesingmann, J. Bissler, R. Song, B. McCarville, D. P. Jones, M. Hudson, S. L. Spunt, C. M. Hillenbrand, Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model., Physiol. Rep. 4 (2016), doi:10.14814/phy2.12755.

15.  J. Bissler, K. Cappell, H. Charles, X. Song, Z. Liu, J. Prestifilippo, C. Gregory, J. Hulbert, Long-term Clinical Morbidity in Patients With Renal Angiomyolipoma Associated With Tuberous Sclerosis Complex., Urology 95, 80–7 (2016).

16.  K. Budde, B. A. Zonnenberg, M. Frost, W. Cheung, S. Urva, T. Brechenmacher, K. Stein, D. Chen, J. C. Kingswood, J. J. Bissler, Pharmacokinetics and pharmacodynamics of everolimus in patients with renal angiomyolipoma and tuberous sclerosis complex or lymphangioleiomyomatosis., Br. J. Clin. Pharmacol. 81, 958–70 (2016).

17.  M. Sahin, E. P. Henske, B. D. Manning, K. C. Ess, J. J. Bissler, E. Klann, D. J. Kwiatkowski, S. L. Roberds, A. J. Silva, C. S. Hillaire-Clarke, L. R. Young, M. Zervas, L. A. Mamounas, Tuberous Sclerosis Complex Working Group to Update the Research Plan, Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference., Pediatr. Neurol. 60, 1–12 (2016).

18.  J. J. Bissler, J. C. Kingswood, E. Radzikowska, B. A. Zonnenberg, M. Frost, E. Belousova, M. Sauter, N. Nonomura, S. Brakemeier, P. J. de Vries, N. Berkowitz, S. Miao, S. Segal, S. Peyrard, K. Budde, Everolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: extension of a randomized controlled trial., Nephrol. Dial. Transplant 31, 111–9 (2016).

19.  Kwiatkowski, D.J. et al., 2015. Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2. Eur J Hum Genet. Available at: http://www.ncbi.nlm.nih.gov/pubmed/25782670.

20.  Bissler, J.J. et al., 2015. Everolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: extension of a randomized controlled trial. Nephrology Dialysis Transplantation, p.gfv249. Available at: http://ndt.oxfordjournals.org/lookup/doi/10.1093/ndt/gfv249.http://doi.org/10.1681/ASN.2010050526

21.  Bissler, J. et al., 2015. Rates of interventional procedures in patients with tuberous sclerosis complex-related renal angiomyolipoma. Current Medical Research and Opinion, 31(8), pp.1501–1507. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26073843 [Accessed October 17, 2015].

22.  Cabrera-López, C. et al., 2015. Insight into response to mTOR inhibition when PKD1 and TSC2 are mutated. BMC Medical Genetics, 16(1), p.39. Available at: http://www.ncbi.nlm.nih.gov/pubmed/26077033 [Accessed October 17, 2015].

23.  Bissler, J. J. (2015). Therapies for polycystic kidney disease. Curr.Opin.Pediatr., 27(2), 227–232. http://doi.org/10.1097/MOP.0000000000000202

24.  Kwiatkowski1DJ, Palmer MR, Jozwiak s, Bissler JJ, Franz D, Segal S, Chen D and Sampson JR. Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2. (2015). Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2. European Journal of Human Genetics. http://doi.org/10.1038/ejhg.2015.47

25.  Guay-Woodford, L.M., Bissler, J.J., Braun, M.C., Bockenhauer, D., Cadnapaphornchai, M.A., Dell, K.M., Kerecuk, L., Liebau, M.C., Alonso-Peclet, M.H., Shneider, B., Emre, S., Heller, T., Kamath, B.M., Murray K.F., Moise, K., Eichenwald, E.E., Evans, J., Keller,. R.L., Wilkins-Haug, L., Bergmann, C., Gunay-Aygun, M., Hooper, S.R., Hardy, K.K., Hartung, E.A., Streisand, R., Perrone, R., and Moxey-Mims, M.  (2014) Consensus expert recommendations for diagnosis and management of autosomal recessive polycystic kidney disease:  report of an international conference.  J. Pediatr 165, 611-617.

Research Interests

 Tuberous sclerosis complex renal disease

Renal Cancers

Onconephrology

Polycystic kidney diseases

Publications

  1. Bissler, JJ, Franz, DN, Frost, MD, Belousova, E, Bebin, EM, Sparagana, S, Berkowitz, N, Ridolfi, A, Kingswood, JC. The effect of everolimus on renal angiomyolipoma in pediatric patients with tuberous sclerosis being treated for subependymal giant cell astrocytoma. Pediatr Nephrol, 33 (1), 101-109, 2018.
  2. Koh, KN, Sunkara, A, Kang, G, Sooter, A, Mulrooney, DA, Triplett, B, Onder, AM, Bissler, J, Cunningham, LC. Acute Kidney Injury in Pediatric Patients Receiving Allogeneic Hematopoietic Cell Transplantation: Incidence, Risk Factors, and Outcomes. Biol Blood Marrow Transplant, 2017.
  3. Song, X, Liu, Z, Cappell, K, Gregory, C, Said, Q, Prestifilippo, J, Charles, H, Hulbert, J, Bissler, J. Natural history of patients with tuberous sclerosis complex related renal angiomyolipoma. Curr Med Res Opin, 33 (7), 1277-1282, 2017.
  4. Sun, P, Liu, J, Charles, H, Hulbert, J, Bissler, J. Outcomes of angioembolization and nephrectomy for renal angiomyolipoma associated with tuberous sclerosis complex: a real-world US national study. Curr Med Res Opin, 33 (5), 821-827, 2017.
  5. Siroky, BJ, Kleene, NK, Kleene, SJ, Varnell, CD, Comer, RG, Liu, J, Lu, L, Pachciarz, NW, Bissler, JJ, Dixon, BP. Primary cilia regulate the osmotic stress response of renal epithelial cells through TRPM3. Am J Physiol Renal Physiol, 312 (4), F791-F805, 2017.
  6. Song, X, Liu, Z, Cappell, K, Gregory, C, Said, Q, Prestifilippo, J, Charles, H, Hulbert, J, Bissler, J. Healthcare utilization and costs in patients with tuberous sclerosiscomplex-related renal angiomyolipoma. J Med Econ, 20 (4), 388-394, 2017.
  7. Sparagana, S, Franz, DN, Krueger, DA, Bissler, JJ, Berkowitz, N, Burock, K, Kingswood, JC. Pooled analysis of menstrual irregularities from three major clinical studies evaluating everolimus for the treatment of tuberous sclerosis complex. PLoS One, 12 (10), e0186235, 2017.
  8. Bissler, JJ, Kingswood, JC, Radzikowska, E, Zonnenberg, BA, Belousova, E, Frost, MD, Sauter, M, Brakemeier, S, de Vries, PJ, Berkowitz, N, Voi, M, Peyrard, S, Budde, K. Everolimus long-term use in patients with tuberous sclerosis complex: Four-year update of the EXIST-2 study. PLoS One, 12 (8), e0180939, 2017.
  9. McCormack, FX, Gupta, N, Finlay, GR, Young, LR, Taveira-DaSilva, AM, Glasgow, CG, Steagall, WK, Johnson, SR, Sahn, SA, Ryu, JH, Strange, C, Seyama, K, Sullivan, EJ, Kotloff, RM, Downey, GP, Chapman, JT, Han, MK, D'Armiento, JM, Inoue, Y, Henske, EP, Bissler, JJ, Colby, TV, Kinder, BW, Wikenheiser-Brokamp, KA, Brown, KK, Cordier, JF, Meyer, C, Cottin, V, Brozek, JL, Smith, K, Wilson, KC, Moss, J, ,. Official American Thoracic Society/Japanese Respiratory Society Clinical Practice Guidelines: Lymphangioleiomyomatosis Diagnosis and Management. Am J Respir Crit Care Med, 194 (6), 748-61, 2016.
  10. Bissler, J, Cappell, K, Charles, H, Song, X, Liu, Z, Prestifilippo, J, Gregory, C, Hulbert, J. Long-term Clinical Morbidity in Patients With Renal Angiomyolipoma Associated With Tuberous Sclerosis Complex. Urology, 95, 80-7, 2016.
  11. Bissler, JJ, Kingswood, JC. Optimal treatment of tuberous sclerosis complex associated renal angiomyolipomata: a systematic review. Ther Adv Urol, 8 (4), 279-290, 2016.
  12. Sahin, M, Henske, EP, Manning, BD, Ess, KC, Bissler, JJ, Klann, E, Kwiatkowski, DJ, Roberds, SL, Silva, AJ, Hillaire-Clarke, CS, Young, LR, Zervas, M, Mamounas, LA, ,. Advances and Future Directions for Tuberous Sclerosis Complex Research: Recommendations From the 2015 Strategic Planning Conference. Pediatr Neurol, 60, 1-12, 2016.
  13. Budde, K, Zonnenberg, BA, Frost, M, Cheung, W, Urva, S, Brechenmacher, T, Stein, K, Chen, D, Kingswood, JC, Bissler, JJ. Pharmacokinetics and pharmacodynamics of everolimus in patients with renal angiomyolipoma and tuberous sclerosis complex or lymphangioleiomyomatosis. Br J Clin Pharmacol, 81 (5), 958-70, 2016.
  14. Tipirneni-Sajja, A, Loeffler, RB, Oesingmann, N, Bissler, J, Song, R, McCarville, B, Jones, DP, Hudson, M, Spunt, SL, Hillenbrand, CM. Measurement of glomerular filtration rate by dynamic contrast-enhanced magnetic resonance imaging using a subject-specific two-compartment model. Physiol Rep, 4 (7), 2016.
  15. Kingswood, JC, Bissler, JJ, Budde, K, Hulbert, J, Guay-Woodford, L, Sampson, JR, Sauter, M, Cox, J, Patel, U, Elmslie, F, Anderson, C, Zonnenberg, BA. Review of the Tuberous Sclerosis Renal Guidelines from the 2012 Consensus Conference: Current Data and Future Study. Nephron, 134 (2), 51-58, 2016.
  16. Bissler, JJ, Kingswood, JC, Radzikowska, E, Zonnenberg, BA, Frost, M, Belousova, E, Sauter, M, Nonomura, N, Brakemeier, S, de Vries, PJ, Berkowitz, N, Miao, S, Segal, S, Peyrard, S, Budde, K. Everolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: extension of a randomized controlled trial. Nephrol Dial Transplant, 31 (1), 111-9, 2016.
  17. Kwiatkowski, DJ, Palmer, MR, Jozwiak, S, Bissler, J, Franz, D, Segal, S, Chen, D, Sampson, JR. Response to everolimus is seen in TSC-associated SEGAs and angiomyolipomas independent of mutation type and site in TSC1 and TSC2. Eur J Hum Genet, 23 (12), 1665-72, 2015.
  18. Bissler, J, Cappell, K, Charles, H, Song, X, Liu, Z, Prestifilippo, J, Hulbert, J. Rates of interventional procedures in patients with tuberous sclerosis complex-related renal angiomyolipoma. Curr Med Res Opin, 31 (8), 1501-7, 2015.
  19. Sas, KM, Yin, H, Fitzgibbon, WR, Baicu, CF, Zile, MR, Steele, SL, Amria, M, Saigusa, T, Funk, J, Bunni, MA, Siegal, GP, Siroky, BJ, Bissler, JJ, Bell, PD. Hyperglycemia in the absence of cilia accelerates cystogenesis and induces renal damage. Am J Physiol Renal Physiol, 309 (1), F79-87, 2015.
  20. Cabrera-López, C, Bullich, G, Martí, T, Català, V, Ballarín, J, Bissler, JJ, Harris, PC, Ars, E, Torra, R. Insight into response to mTOR inhibition when PKD1 and TSC2 are mutated. BMC Med Genet, 16, 39, 2015.