JAMES B. DALE, M.D., B.A.

Professor
Medicine-Infectious Disease
 
Professor
Micro Immuno & Bioch

Office: E332 COLEMAN BUILDING
956 COURT AVENUE
MEMPHIS TN 381630000
Tel: (901) 448-2101
jbdale@uthsc.edu

Education

  • M.D., University of Tennessee, Memphis, TN, Medicine
  • B.A., University of Tennessee, Knoxville, TN, Zoology

Research interest/specialty

* Experimental Biology
* Infectious Disease
* Medical Research

Research keywords

Experimental Biology, Infectious Disease, Medical Research

Research interest/specialty

* Experimental Biology * Infectious Disease * Medical Research

Research keywords

Experimental Biology, Infectious Disease, Medical Research

Publications

  1. Steer, AC, Carapetis, JR, Dale, JB, Fraser, JD, Good, MF, Guilherme, L, Moreland, NJ, Mulholland, EK, Schodel, F, Smeesters, PR. Status of research and development of vaccines for Streptococcus pyogenes. Vaccine, 34 (26), 2953-8, 2016.
  2. Fischetti, VA, Dale, JB. One More Disguise in the Stealth Behavior of Streptococcus pyogenes. MBio, 7 (3), 2016.
  3. Tapia, MD, Sow, SO, Tamboura, B, Keita, MM, Berthe, A, Samake, M, Nataro, JP, Onwuchekwa, UO, Penfound, TA, Blackwelder, W, Dale, JB, Kotloff, KL. Streptococcal pharyngitis in schoolchildren in Bamako, Mali. Pediatr Infect Dis J, 34 (5), 463-8, 2015.
  4. Dale, JB, Niedermeyer, SE, Agbaosi, T, Hysmith, ND, Penfound, TA, Hohn, CM, Pullen, M, Bright, MI, Murrell, DS, Shenep, LE, Courtney, HS. Protective immunogenicity of group A streptococcal M-related proteins. Clin Vaccine Immunol, 22 (3), 344-50, 2015.
  5. Dale, JB, Bisno, AL. In memoriam: Gene H. Stollerman. Clin Infect Dis, 59 (12), 1805-6, 2014.
  6. Shulman, ST, Tanz, RR, Dale, JB, Steer, AC, Smeesters, PR. Added value of the emm-cluster typing system to analyze group A Streptococcus epidemiology in high-income settings. Clin Infect Dis, 59 (11), 1651-2, 2014.
  7. Sanderson-Smith, M, De Oliveira, DM, Guglielmini, J, McMillan, DJ, Vu, T, Holien, JK, Henningham, A, Steer, AC, Bessen, DE, Dale, JB, Curtis, N, Beall, BW, Walker, MJ, Parker, MW, Carapetis, JR, Van Melderen, L, Sriprakash, KS, Smeesters, PR, ,. A systematic and functional classification of Streptococcus pyogenes that serves as a new tool for molecular typing and vaccine development. J Infect Dis, 210 (8), 1325-38, 2014.
  8. Niedermeyer, SE, Penfound, TA, Hohn, C, Li, Y, Homayouni, R, Zhao, J, Dale, JB. Group A streptococcus expresses a trio of surface proteins containing protective epitopes. Clin Vaccine Immunol, 21 (10), 1421-5, 2014.
  9. Wozniak, A, García, P, Geoffroy, EA, Aguirre, DB, González, SA, Sarno, VA, Dale, JB, Salazar-Echegarai, FJ, Vera, A, Bueno, SM, Kalergis, AM. A novel live vector group A streptococcal emm type 9 vaccine delivered intranasally protects mice against challenge infection with emm type 9 group A streptococci. Clin Vaccine Immunol, 21 (9), 1343-9, 2014.
  10. Klonoski, JM, Hurtig, HR, Juber, BA, Schuneman, MJ, Bickett, TE, Svendsen, JM, Burum, B, Penfound, TA, Sereda, G, Dale, JB, Chaussee, MS, Huber, VC. Vaccination against the M protein of Streptococcus pyogenes prevents death after influenza virus: S. pyogenes super-infection. Vaccine, 32 (40), 5241-9, 2014.
  11. Engel, ME, Muhamed, B, Whitelaw, AC, Musvosvi, M, Mayosi, BM, Dale, JB. Group A streptococcal emm type prevalence among symptomatic children in Cape Town and potential vaccine coverage. Pediatr Infect Dis J, 33 (2), 208-10, 2014.
  12. Dale, JB, Fischetti, VA, Carapetis, JR, Steer, AC, Sow, S, Kumar, R, Mayosi, BM, Rubin, FA, Mulholland, K, Hombach, JM, Schödel, F, Henao-Restrepo, AM. Group A streptococcal vaccines: paving a path for accelerated development. Vaccine, 31 Suppl 2, B216-22, 2013.
  13. Dale, JB, Penfound, TA, Tamboura, B, Sow, SO, Nataro, JP, Tapia, M, Kotloff, KL. Potential coverage of a multivalent M protein-based group A streptococcal vaccine. Vaccine, 31 (12), 1576-81, 2013.
  14. Dale, JB, Penfound, TA, Chiang, EY, Walton, WJ. New 30-valent M protein-based vaccine evokes cross-opsonic antibodies against non-vaccine serotypes of group A streptococci. Vaccine, 29 (46), 8175-8, 2011.
  15. Bronze, MS, Dale, JB. Progress in the Development of Effective Vaccines to Prevent Selected Gram-Positive Bacterial Infections. Am J Med Sci, 2010.
  16. Penfound, TA, Chiang, EY, Ahmed, EA, Dale, JB. Protective efficacy of group A streptococcal vaccines containing type-specific and conserved M protein epitopes. Vaccine, 28 (31), 5017-22, 2010.
  17. Penfound, TA, Ofek, I, Courtney, HS, Hasty, DL, Dale, JB. The NH(2)-terminal region of Streptococcus pyogenes M5 protein confers protection against degradation by proteases and enhances mucosal colonization of mice. J Infect Dis, 201 (10), 1580-8, 2010.
  18. Ahmed, EA, Penfound, TA, Brewer, SC, Tennant, PA, Chiang, EY, Dale, JB. Streptococcal protective antigens (Spa): a new family of type-specific proteins of group A streptococci. Eur J Clin Microbiol Infect Dis, 2009.
  19. Shulman, ST, Tanz, RR, Dale, JB, Beall, B, Kabat, W, Kabat, K, Cederlund, E, Patel, D, Rippe, J, Li, Z, Sakota, V, ,. Seven-year surveillance of north american pediatric group a streptococcal pharyngitis isolates. Clin Infect Dis, 49 (1), 78-84, 2009.
  20. Jaggi, P, Dale, JB, Chiang, E, Beniwal, P, Kabat, W, Shulman, ST. Age-associated differences in prevalence of group A streptococcal type-specific M antibodies in children. Eur J Pediatr, 168 (6), 679-83, 2009.
  21. Cox, KH, Ruiz-Bustos, E, Courtney, HS, Dale, JB, Pence, MA, Nizet, V, Aziz, RK, Gerling, I, Price, SM, Hasty, DL. Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes. PLoS ONE, 4 (4), e5366, 2009.
  22. Courtney, HS, Ofek, I, Penfound, T, Nizet, V, Pence, MA, Kreikemeyer, B, Podbielski, A, Podbielbski, A, Hasty, DL, Dale, JB. Relationship between expression of the family of M proteins and lipoteichoic acid to hydrophobicity and biofilm formation in Streptococcus pyogenes. PLoS ONE, 4 (1), e4166, 2008.
  23. Stollerman, GH, Dale, JB. The importance of the group a streptococcus capsule in the pathogenesis of human infections: a historical perspective. Clin Infect Dis, 46 (7), 1038-45, 2008.
  24. Dale, JB. Current status of group A streptococcal vaccine development. Adv Exp Med Biol, 609, 53-63, 2008.
  25. Shulman, ST, Stollerman, G, Beall, B, Dale, JB, Tanz, RR. Temporal changes in streptococcal M protein types and the near-disappearance of acute rheumatic fever in the United States. Clin Infect Dis, 42 (4), 441-7, 2006.
  26. Courtney, HS, Hasty, DL, Dale, JB. Anti-phagocytic mechanisms of Streptococcus pyogenes: binding of fibrinogen to M-related protein. Mol Microbiol, 59 (3), 936-47, 2006.
  27. Bisno, AL, Rubin, FA, Cleary, PP, Dale, JB, ,. Prospects for a group A streptococcal vaccine: rationale, feasibility, and obstacles--report of a National Institute of Allergy and Infectious Diseases workshop. Clin Infect Dis, 41 (8), 1150-6, 2005.
  28. McNeil, SA, Halperin, SA, Langley, JM, Smith, B, Warren, A, Sharratt, GP, Baxendale, DM, Reddish, MA, Hu, MC, Stroop, SD, Linden, J, Fries, LF, Vink, PE, Dale, JB. Safety and immunogenicity of 26-valent group a streptococcus vaccine in healthy adult volunteers. Clin Infect Dis, 41 (8), 1114-22, 2005.
  29. Dale, JB, Penfound, T, Chiang, EY, Long, V, Shulman, ST, Beall, B. Multivalent group A streptococcal vaccine elicits bactericidal antibodies against variant M subtypes. Clin Diagn Lab Immunol, 12 (7), 833-6, 2005.
  30. Kotloff, KL, Corretti, M, Palmer, K, Campbell, JD, Reddish, MA, Hu, MC, Wasserman, SS, Dale, JB. Safety and immunogenicity of a recombinant multivalent group a streptococcal vaccine in healthy adults: phase 1 trial. JAMA, 292 (6), 709-15, 2004.
  31. Kotloff, KL, Dale, JB. Progress in group A streptococcal vaccine development. Pediatr Infect Dis J, 23 (8), 765-6, 2004.
  32. Shulman, ST, Tanz, RR, Kabat, W, Kabat, K, Cederlund, E, Patel, D, Li, Z, Sakota, V, Dale, JB, Beall, B, ,. Group A streptococcal pharyngitis serotype surveillance in North America, 2000-2002. Clin Infect Dis, 39 (3), 325-32, 2004.
  33. Hall, MA, Stroop, SD, Hu, MC, Walls, MA, Reddish, MA, Burt, DS, Lowell, GH, Dale, JB. Intranasal immunization with multivalent group A streptococcal vaccines protects mice against intranasal challenge infections. Infect Immun, 72 (5), 2507-12, 2004.
  34. Courtney, HS, Hasty, DL, Dale, JB. Serum opacity factor (SOF) of Streptococcus pyogenes evokes antibodies that opsonize homologous and heterologous SOF-positive serotypes of group A streptococci. Infect Immun, 71 (9), 5097-103, 2003.
  35. Kang, AH. Presentation of the Southern Society for Clinical Investigation 2002 Founders' Medal to Dr. James B. Dale. Am J Med Sci, 324 (2), 57-60, 2002.
  36. Dale, JB. Southern Society for Clinical Investigation Founders' Medal recipient's address. Am J Med Sci, 324 (2), 61-6, 2002.
  37. Courtney, HS, Hasty, DL, Dale, JB. Molecular mechanisms of adhesion, colonization, and invasion of group A streptococci. Ann Med, 34 (2), 77-87, 2002.
  38. Hu, MC, Walls, MA, Stroop, SD, Reddish, MA, Beall, B, Dale, JB. Immunogenicity of a 26-valent group A streptococcal vaccine. Infect Immun, 70 (4), 2171-7, 2002.
  39. Courtney, HS, Dale, JB, Hasty, DL. Mapping the fibrinogen-binding domain of serum opacity factor of group a streptococci. Curr Microbiol, 44 (4), 236-40, 2002.
  40. Dale, JB, Chiang, EY, Hasty, DL, Courtney, HS. Antibodies against a synthetic peptide of SagA neutralize the cytolytic activity of streptolysin S from group A streptococci. Infect Immun, 70 (4), 2166-70, 2002.
  41. McLellan, DG, Chiang, EY, Courtney, HS, Hasty, DL, Wei, SC, Hu, MC, Walls, MA, Bloom, JJ, Dale, JB. Spa contributes to the virulence of type 18 group A streptococci. Infect Immun, 69 (5), 2943-9, 2001.
  42. Fleckenstein, JM, Lindler, LE, Elsinghorst, EA, Dale, JB. Identification of a gene within a pathogenicity island of enterotoxigenic Escherichia coli H10407 required for maximal secretion of the heat-labile enterotoxin. Infect Immun, 68 (5), 2766-74, 2000.
  43. Dale, JB, Chiang, EY, Liu, S, Courtney, HS, Hasty, DL. New protective antigen of group A streptococci. J Clin Invest, 103 (9), 1261-8, 1999.
  44. Courtney, HS, Hasty, DL, Li, Y, Chiang, HC, Thacker, JL, Dale, JB. Serum opacity factor is a major fibronectin-binding protein and a virulence determinant of M type 2 Streptococcus pyogenes. Mol Microbiol, 32 (1), 89-98, 1999.
  45. Dale, JB. Group A streptococcal vaccines. Infect Dis Clin North Am, 13 (1), 227-43, viii, 1999.
  46. Dale, JB. Multivalent group A streptococcal vaccine designed to optimize the immunogenicity of six tandem M protein fragments. Vaccine, 17 (2), 193-200, 1999.
  47. Dale, JB. Group A streptococcal vaccines. Pediatr Ann, 27 (5), 301-8, 1998.
  48. Basma, H, Norrby-Teglund, A, McGeer, A, Low, DE, El-Ahmedy, O, Dale, JB, Schwartz, B, Kotb, M. Opsonic antibodies to the surface M protein of group A streptococci in pooled normal immunoglobulins (IVIG): potential impact on the clinical efficacy of IVIG therapy for severe invasive group A streptococcal infections. Infect Immun, 66 (5), 2279-83, 1998.
  49. Hasan, SI, Whitnack, E, Dale, JB. Fusobacterial cerebritis and myelitis presenting as acute paraplegia in an elderly man with congenital heart disease. Clin Infect Dis, 25 (3), 741-2, 1997.
  50. Courtney, HS, Liu, S, Dale, JB, Hasty, DL. Conversion of M serotype 24 of Streptococcus pyogenes to M serotypes 5 and 18: effect on resistance to phagocytosis and adhesion to host cells. Infect Immun, 65 (6), 2472-4, 1997.
  51. Liu, S, Courtney, HS, Bessen, DE, Hasty, DL, Dale, JB. M protein expression is not required for resistance to phagocytosis of type 18 group A streptococci. Adv Exp Med Biol, 418, 725-7, 1997.
  52. Courtney, HS, Dale, JB, Hasty, DL. Host cell specific adhesins of group A streptococci. Adv Exp Med Biol, 418, 605-6, 1997.
  53. Dale, JB, Cleary, PP, Fischetti, VA, Kasper, DL, Musser, JM, Zabriskie, JB. Group A and group B streptococcal vaccine development. A round table presentation. Adv Exp Med Biol, 418, 863-8, 1997.
  54. Dale, JB, Simmons, M, Chiang, EC, Chiang, EY. Recombinant, octavalent group A streptococcal M protein vaccine. Vaccine, 14 (10), 944-8, 1996.
  55. Courtney, HS, Dale, JB, Hasty, DI. Differential effects of the streptococcal fibronectin-binding protein, FBP54, on adhesion of group A streptococci to human buccal cells and HEp-2 tissue culture cells. Infect Immun, 64 (7), 2415-9, 1996.
  56. Dale, JB, Washburn, RG, Marques, MB, Wessels, MR. Hyaluronate capsule and surface M protein in resistance to opsonization of group A streptococci. Infect Immun, 64 (5), 1495-501, 1996.
  57. Bronze, MS, Dale, JB. The reemergence of serious group A streptococcal infections and acute rheumatic fever. Am J Med Sci, 311 (1), 41-54, 1996.
  58. Dale, JB, Chiang, EC. Intranasal immunization with recombinant group A streptococcal M protein fragment fused to the B subunit of Escherichia coli labile toxin protects mice against systemic challenge infections. J Infect Dis, 171 (4), 1038-41, 1995.
  59. Courtney, HS, Bronze, MS, Dale, JB, Hasty, DL. Analysis of the role of M24 protein in group A streptococcal adhesion and colonization by use of omega-interposon mutagenesis. Infect Immun, 62 (11), 4868-73, 1994.
  60. Courtney, HS, Li, Y, Dale, JB, Hasty, DL. Cloning, sequencing, and expression of a fibronectin/fibrinogen-binding protein from group A streptococci. Infect Immun, 62 (9), 3937-46, 1994.
  61. Dale, JB, Baird, RW, Courtney, HS, Hasty, DL, Bronze, MS. Passive protection of mice against group A streptococcal pharyngeal infection by lipoteichoic acid. J Infect Dis, 169 (2), 319-23, 1994.
  62. Bronze, MS, Dale, JB. Epitopes of streptococcal M proteins that evoke antibodies that cross-react with human brain. J Immunol, 151 (5), 2820-8, 1993.
  63. Dale, JB, Chiang, EY, Lederer, JW. Recombinant tetravalent group A streptococcal M protein vaccine. J Immunol, 151 (4), 2188-94, 1993.
  64. Cleary, PP, Prahbu, U, Dale, JB, Wexler, DE, Handley, J. Streptococcal C5a peptidase is a highly specific endopeptidase. Infect Immun, 60 (12), 5219-23, 1992.
  65. Courtney, HS, Hasty, DL, Dale, JB, Poirier, TP. A 28-kilodalton fibronectin-binding protein of group A streptococci. Curr Microbiol, 25 (5), 245-50, 1992.
  66. Courtney, HS, von Hunolstein, C, Dale, JB, Bronze, MS, Beachey, EH, Hasty, DL. Lipoteichoic acid and M protein: dual adhesins of group A streptococci. Microb Pathog, 12 (3), 199-208, 1992.
  67. Bronze, MS, Courtney, HS, Dale, JB. Epitopes of group A streptococcal M protein that evoke cross-protective local immune responses. J Immunol, 148 (3), 888-93, 1992.
  68. Baird, RW, Bronze, MS, Kraus, W, Hill, HR, Veasey, LG, Dale, JB. Epitopes of group A streptococcal M protein shared with antigens of articular cartilage and synovium. J Immunol, 146 (9), 3132-7, 1991.
  69. Kraus, W, Dale, JB, Beachey, EH. Identification of an epitope of type 1 streptococcal M protein that is shared with a 43-kDa protein of human myocardium and renal glomeruli. J Immunol, 145 (12), 4089-93, 1990.
  70. Dale, JB, Courtney, HS, Kotb, M, Schifferli, D. Phosphorylase-cross-reactive antibodies evoked by streptococcal M protein. Infect Immun, 58 (3), 774-8, 1990.
  71. Kotb, M, Courtney, HS, Dale, JB, Beachey, EH. Cellular and biochemical responses of human T lymphocytes stimulated with streptococcal M proteins. J Immunol, 142 (3), 966-70, 1989.
  72. Abraham, SN, Sun, D, Dale, JB, Beachey, EH. Conservation of the D-mannose-adhesion protein among type 1 fimbriated members of the family Enterobacteriaceae. Nature, 336 (6200), 682-4, 1988.
  73. Bronze, MS, McKinsey, DS, Beachey, EH, Dale, JB. Protective immunity evoked by locally administered group A streptococcal vaccines in mice. J Immunol, 141 (8), 2767-70, 1988.
  74. Bronze, MS, Beachey, EH, Dale, JB. Protective and heart-crossreactive epitopes located within the NH2 terminus of type 19 streptococcal M protein. J Exp Med, 167 (6), 1849-59, 1988.
  75. Beachey, EH, Bronze, M, Dale, JB, Kraus, W, Poirier, T, Sargent, S. Protective and autoimmune epitopes of streptococcal M proteins. Vaccine, 6 (2), 192-6, 1988.
  76. Bronze, MS, McKinsey, DS, Beachey, EH, Dale, JB. Pathogenesis of group A streptococci in mice and efficacy of locally administered streptococcal vaccines. Trans Assoc Am Physicians, 101, 88-92, 1988.
  77. Dale, JB, Beachey, EH. Human cytotoxic T lymphocytes evoked by group A streptococcal M proteins. J Exp Med, 166 (6), 1825-35, 1987.
  78. Kraus, W, Haanes-Fritz, E, Cleary, PP, Seyer, JM, Dale, JB, Beachey, EH. Sequence and type-specific immunogenicity of the amino-terminal region of type 1 streptococcal M protein. J Immunol, 139 (9), 3084-90, 1987.
  79. Bronze, MS, Beachey, EH, Seyer, JM, Dale, JB. Protective and heart-cross-reactive epitopes of type 19 streptococcal M protein. Trans Assoc Am Physicians, 100, 80-4, 1987.