IVAN C. GERLING, Ph.D.

Professor
Medicine-Endocrinology
 
Professor
Biomedical Engineering

Office: 151 VETERANS AFFAIRS MEDICAL CENTER
1030 JEFFERSON AVENUE
MEMPHIS TN 381040000
Tel: (901) 523-8990
igerling@uthsc.edu

Education

  • Ph.D., University of Copenhagen, Denmark, Immunology
  • M.S., University of Copenhagen, Denmark, Biochemistry/Immunology
  • B.S., University of Copenhagen, Denmark, Biochemistry/Immunology

My Current CV

Research interest/specialty

Transcriptome and proteome of spleen leukocytes and islet of Langehans in young prediabetic NOD mice and donor organs from humans with diabetes or different stages of pre-diabetes.

Research keywords

Diabetes, Autoimmunity, Proteomics, Expression arrays, Biomarkers,

Publications

  1. Richardson, SJ, Rodriguez-Calvo, T, Gerling, IC, Mathews, CE, Kaddis, JS, Russell, MA, Zeissler, M, Leete, P, Krogvold, L, Dahl-Jørgensen, K, von Herrath, M, Pugliese, A, Atkinson, MA, Morgan, NG. Islet cell hyperexpression of HLA class I antigens: a defining feature in type 1 diabetes. Diabetologia, 59 (11), 2448-58, 2016.
  2. Heckle, MR, Flatt, DM, Sun, Y, Mancarella, S, Marion, TN, Gerling, IC, Weber, KT. Atrophied cardiomyocytes and their potential for rescue and recovery of ventricular function. Heart Fail Rev, 21 (2), 191-8, 2016.
  3. Bomb, R, Heckle, MR, Sun, Y, Mancarella, S, Guntaka, RV, Gerling, IC, Weber, KT. Myofibroblast secretome and its auto-/paracrine signaling. Expert Rev Cardiovasc Ther, 14 (5), 591-8, 2016.
  4. Zhao, T, Zhao, W, Meng, W, Liu, C, Chen, Y, Gerling, IC, Weber, KT, Bhattacharya, SK, Kumar, R, Sun, Y. VEGF-C/VEGFR-3 pathway promotes myocyte hypertrophy and survival in the infarcted myocardium. Am J Transl Res, 7 (4), 697-709, 2015.
  5. Iannaccone, A, Giorgianni, F, New, DD, Hollingsworth, TJ, Umfress, A, Alhatem, AH, Neeli, I, Lenchik, NI, Jennings, BJ, Calzada, JI, Satterfield, S, Mathews, D, Diaz, RI, Harris, T, Johnson, KC, Charles, S, Kritchevsky, SB, Gerling, IC, Beranova-Giorgianni, S, Radic, MZ, ,. Circulating Autoantibodies in Age-Related Macular Degeneration Recognize Human Macular Tissue Antigens Implicated in Autophagy, Immunomodulation, and Protection from Oxidative Stress and Apoptosis. PLoS One, 10 (12), e0145323, 2015.
  6. Kakoola, DN, Curcio-Brint, A, Lenchik, NI, Gerling, IC. Molecular pathway alterations in CD4 T-cells of nonobese diabetic (NOD) mice in the preinsulitis phase of autoimmune diabetes. Results Immunol, 4, 30-45, 2014.
  7. Efeovbokhan, N, Bhattacharya, SK, Ahokas, RA, Sun, Y, Guntaka, RV, Gerling, IC, Weber, KT. Zinc and the prooxidant heart failure phenotype. J Cardiovasc Pharmacol, 64 (4), 393-400, 2014.
  8. Al Darazi, F, Zhao, W, Zhao, T, Sun, Y, Marion, TN, Ahokas, RA, Bhattacharya, SK, Gerling, IC, Weber, KT. Small dedifferentiated cardiomyocytes bordering on microdomains of fibrosis: evidence for reverse remodeling with assisted recovery. J Cardiovasc Pharmacol, 64 (3), 237-46, 2014.
  9. Giorgianni, F, Usman Khan, M, Weber, KT, Gerling, IC, Beranova-Giorgianni, S. Phosphoproteome mapping of cardiomyocyte mitochondria in a rat model of heart failure. Mol Cell Biochem, 389 (1-2), 159-67, 2014.
  10. Kamalov, G, Zhao, W, Zhao, T, Sun, Y, Ahokas, RA, Marion, TN, Al Darazi, F, Gerling, IC, Bhattacharya, SK, Weber, KT. Atrophic cardiomyocyte signaling in hypertensive heart disease. J Cardiovasc Pharmacol, 62 (6), 497-506, 2013.
  11. Gerling, IC, Ahokas, RA, Kamalov, G, Zhao, W, Bhattacharya, SK, Sun, Y, Weber, KT. Gene expression profiles of peripheral blood mononuclear cells reveal transcriptional signatures as novel biomarkers of cardiac remodeling in rats with aldosteronism and hypertensive heart disease. JACC Heart Fail, 1 (6), 469-76, 2013.
  12. Khan, MU, Zhao, W, Zhao, T, Al Darazi, F, Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. Nebivolol: a multifaceted antioxidant and cardioprotectant in hypertensive heart disease. J Cardiovasc Pharmacol, 62 (5), 445-51, 2013.
  13. Zhao, W, Zhao, T, Chen, Y, Qu, Y, Gerling, IC, Sun, Y. Modification of oxidative stress on gene expression profiling in the rat infarcted heart. Mol Cell Biochem, 379 (1-2), 243-53, 2013.
  14. Mundra, V, Gerling, IC, Mahato, RI. Mesenchymal stem cell-based therapy. Mol Pharm, 10 (1), 77-89, 2013.
  15. Weber, KT, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC. Myofibroblast-mediated mechanisms of pathological remodelling of the heart. Nat Rev Cardiol, 10 (1), 15-26, 2013.
  16. Pi, M, Wu, Y, Lenchik, NI, Gerling, I, Quarles, LD. GPRC6A mediates the effects of L-arginine on insulin secretion in mouse pancreatic islets. Endocrinology, 153 (10), 4608-15, 2012.
  17. Cheema, Y, Zhao, W, Zhao, T, Khan, MU, Green, KD, Ahokas, RA, Gerling, IC, Bhattacharya, SK, Weber, KT. Reverse remodeling and recovery from cachexia in rats with aldosteronism. Am J Physiol Heart Circ Physiol, 303 (4), H486-95, 2012.
  18. Khan, MU, Cheema, Y, Shahbaz, AU, Ahokas, RA, Sun, Y, Gerling, IC, Bhattacharya, SK, Weber, KT. Mitochondria play a central role in nonischemic cardiomyocyte necrosis: common to acute and chronic stressor states. Pflugers Arch, 464 (1), 123-31, 2012.
  19. Wu, J, Kakoola, DN, Lenchik, NI, Desiderio, DM, Marshall, DR, Gerling, IC. Molecular phenotyping of immune cells from young NOD mice reveals abnormal metabolic pathways in the early induction phase of autoimmune diabetes. PLoS One, 7 (10), e46941, 2012.
  20. Iannaccone, A, Neeli, I, Krishnamurthy, P, Lenchik, NI, Wan, H, Gerling, IC, Desiderio, DM, Radic, MZ. Autoimmune biomarkers in age-related macular degeneration: a possible role player in disease development and progression. Adv Exp Med Biol, 723, 11-6, 2011.
  21. Gupta-Ganguli, M, Cox, K, Means, B, Gerling, I, Solomon, SS. Does therapy with anti-TNF-alpha improve glucose tolerance and control in patients with type 2 diabetes. Diabetes Care, 34 (7), e121, 2011.
  22. Cheema, Y, Sherrod, JN, Zhao, W, Zhao, T, Ahokas, RA, Sun, Y, Gerling, IC, Bhattacharya, SK, Weber, KT. Mitochondriocentric pathway to cardiomyocyte necrosis in aldosteronism: cardioprotective responses to carvedilol and nebivolol. J Cardiovasc Pharmacol, 58 (1), 80-6, 2011.
  23. Shahbaz, AU, Zhao, T, Zhao, W, Johnson, PL, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Calcium and zinc dyshomeostasis during isoproterenol-induced acute stressor state. Am J Physiol Heart Circ Physiol, 300 (2), H636-44, 2011.
  24. Shahbaz, AU, Kamalov, G, Zhao, W, Zhao, T, Johnson, PL, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, Weber, KT. Mitochondria-targeted cardioprotection in aldosteronism. J Cardiovasc Pharmacol, 57 (1), 37-43, 2011.
  25. Gandhi, MS, Kamalov, G, Shahbaz, AU, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Cellular and molecular pathways to myocardial necrosis and replacement fibrosis. Heart Fail Rev, 16 (1), 23-34, 2011.
  26. Zia, AA, Kamalov, G, Newman, KP, McGee, JE, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. From aldosteronism to oxidative stress: the role of excessive intracellular calcium accumulation. Hypertens Res, 33 (11), 1091-101, 2010.
  27. Shahbaz, AU, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, McGee, JE, Weber, KT. Fibrosis in hypertensive heart disease: molecular pathways and cardioprotective strategies. J Hypertens, 28 Suppl 1, S25-32, 2010.
  28. Kamalov, G, Ahokas, RA, Zhao, W, Zhao, T, Shahbaz, AU, Johnson, PL, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Uncoupling the coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria seen in aldosteronism. J Cardiovasc Pharmacol, 55 (3), 248-54, 2010.
  29. Solomon, SS, Odunusi, O, Carrigan, D, Majumdar, G, Kakoola, D, Lenchik, NI, Gerling, IC. TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome. Horm Metab Res, 42 (2), 115-21, 2010.
  30. Kamalov, G, Ahokas, RA, Zhao, W, Shahbaz, AU, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. Am J Physiol Heart Circ Physiol, 298 (2), H385-94, 2010.
  31. Bhattacharya, SK, Gandhi, MS, Kamalov, G, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Myocardial remodeling in low-renin hypertension: molecular pathways to cellular injury in relative aldosteronism. Curr Hypertens Rep, 11 (6), 412-20, 2009.
  32. Kamalov, G, Holewinski, JP, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Nutrient dyshomeostasis in congestive heart failure. Am J Med Sci, 338 (1), 28-33, 2009.
  33. Kamalov, G, Deshmukh, PA, Baburyan, NY, Gandhi, MS, Johnson, PL, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. J Cardiovasc Pharmacol, 53 (5), 414-23, 2009.
  34. Elam, MB, Cowan, GS, Rooney, RJ, Hiler, ML, Yellaturu, CR, Deng, X, Howell, GE, Park, EA, Gerling, IC, Patel, D, Corton, JC, Cagen, LM, Wilcox, HG, Gandhi, M, Bahr, MH, Allan, MC, Wodi, LA, Cook, GA, Hughes, TA, Raghow, R. Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility. Obesity (Silver Spring), 2009.
  35. Cox, KH, Ruiz-Bustos, E, Courtney, HS, Dale, JB, Pence, MA, Nizet, V, Aziz, RK, Gerling, I, Price, SM, Hasty, DL. Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes. PLoS One, 4 (4), e5366, 2009.
  36. Wu, J, Lenchik, NI, Gerling, IC. Approaches to reduce false positives and false negatives in the analysis of microarray data: applications in type 1 diabetes research. BMC Genomics, 9 Suppl 2, S12, 2008.
  37. Gandhi, MS, Deshmukh, PA, Kamalov, G, Zhao, T, Zhao, W, Whaley, JT, Tichy, JR, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism. J Cardiovasc Pharmacol, 52 (3), 245-52, 2008.
  38. Wang, X, Nookala, S, Narayanan, C, Giorgianni, F, Beranova-Giorgianni, S, McCollum, G, Gerling, I, Penn, JS, Jablonski, MM. Proteomic analysis of the retina: Removal of RPE alters outer segment assembly and retinal protein expression. Glia, 2008.
  39. Gao, P, Jiao, Y, Xiong, Q, Wang, CY, Gerling, I, Gu, W. Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms. Curr Genomics, 9 (5), 324-37, 2008.
  40. Selektor, Y, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism. Am J Med Sci, 335 (2), 105-10, 2008.
  41. Thomas, M, Vidal, A, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone. Am J Physiol Heart Circ Physiol, 293 (4), H2361-6, 2007.
  42. Goodwin, KD, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements. Am J Med Sci, 332 (2), 73-8, 2006.
  43. Sun, Y, Ahokas, RA, Bhattacharya, SK, Gerling, IC, Carbone, LD, Weber, KT. Oxidative stress in aldosteronism. Cardiovasc Res, 71 (2), 300-9, 2006.
  44. Bhattacharya, SK, Ahokas, RA, Carbone, LD, Newman, KP, Gerling, IC, Sun, Y, Weber, KT. Macro- and micronutrients in African-Americans with heart failure. Heart Fail Rev, 11 (1), 45-55, 2006.
  45. Wu, J, Marler, J, Lenchik, NI, Gerling, IC. Strain differences in allele and expression levels of CD72 on B-lymphocytes from NOD, AKR, NON and C57BL/6 mice. Immunol Lett, 103 (2), 115-20, 2006.
  46. Gerling, IC, Singh, S, Lenchik, NI, Marshall, DR, Wu, J. New data analysis and mining approaches identify unique proteome and transcriptome markers of susceptibility to autoimmune diabetes. Mol Cell Proteomics, 5 (2), 293-305, 2006.
  47. Majumdar, G, Harrington, A, Hungerford, J, Martinez-Hernandez, A, Gerling, IC, Raghow, R, Solomon, S. Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cells. J Biol Chem, 281 (6), 3642-50, 2006.
  48. Vidal, A, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, Weber, KT. Calcium paradox of aldosteronism and the role of the parathyroid glands. Am J Physiol Heart Circ Physiol, 290 (1), H286-94, 2006.
  49. Runyan, AL, Sun, Y, Bhattacharya, SK, Ahokas, RA, Chhokar, VS, Gerling, IC, Weber, KT. Responses in extracellular and intracellular calcium and magnesium in aldosteronism. J Lab Clin Med, 146 (2), 76-84, 2005.
  50. Solomon, SS, Buss, N, Shull, J, Monnier, S, Majumdar, G, Wu, J, Gerling, IC. Proteome of H-411E (liver) cells exposed to insulin and tumor necrosis factor-alpha: analysis of proteins involved in insulin resistance. J Lab Clin Med, 145 (5), 275-83, 2005.
  51. Lenchik, NI, Desiderio, DM, Gerling, IC. Two-dimensional gel electrophoresis characterization of the mouse leukocyte proteome, using a tri-reagent for protein extraction. Proteomics, 5 (8), 2202-9, 2005.
  52. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation, 111 (7), 871-8, 2005.
  53. Wu, J, Lenchik, NJ, Pabst, MJ, Solomon, SS, Shull, J, Gerling, IC. Functional characterization of two-dimensional gel-separated proteins using sequential staining. Electrophoresis, 26 (1), 225-37, 2005.
  54. Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cells. Circulation, 111 (1), 51-7, 2005.
  55. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Loss of bone minerals and strength in rats with aldosteronism. Am J Physiol Heart Circ Physiol, 287 (5), H2023-6, 2004.
  56. Tannu, NS, Wu, J, Rao, VK, Gadgil, HS, Pabst, MJ, Gerling, IC, Raghow, R. Paraffin-wax-coated plates as matrix-assisted laser desorption/ionization sample support for high-throughput identification of proteins by peptide mass fingerprinting. Anal Biochem, 327 (2), 222-32, 2004.
  57. Gerling, IC, Ali, C, Lenchik, N. Characterization of early developments in the splenic leukocyte transcriptome of NOD mice. Ann N Y Acad Sci, 1005, 157-60, 2003.
  58. Ahokas, RA, Warrington, KJ, Gerling, IC, Sun, Y, Wodi, LA, Herring, PA, Lu, L, Bhattacharya, SK, Postlethwaite, AE, Weber, KT. Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface. Circ Res, 93 (10), e124-35, 2003.
  59. Weber, KT, Sun, Y, Wodi, LA, Munir, A, Jahangir, E, Ahokas, RA, Gerling, IC, Postlethwaite, AE, Warrington, KJ. Toward a broader understanding of aldosterone in congestive heart failure. J Renin Angiotensin Aldosterone Syst, 4 (3), 155-63, 2003.
  60. Gadgil, HS, Pabst, KM, Giorgianni, F, Umstot, ES, Desiderio, DM, Beranova-Giorgianni, S, Gerling, IC, Pabst, MJ. Proteome of monocytes primed with lipopolysaccharide: analysis of the abundant proteins. Proteomics, 3 (9), 1767-80, 2003.
  61. Weber, KT, Gerling, IC, Kiani, MF, Guntaka, RV, Sun, Y, Ahokas, RA, Postlethwaite, AE, Warrington, KJ. Aldosteronism in heart failure: a proinflammatory/fibrogenic cardiac phenotype. Search for biomarkers and potential drug targets. Curr Drug Targets, 4 (6), 505-16, 2003.
  62. Gerling, IC, Sun, Y, Ahokas, RA, Wodi, LA, Bhattacharya, SK, Warrington, KJ, Postlethwaite, AE, Weber, KT. Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotype. Am J Physiol Heart Circ Physiol, 285 (2), H813-21, 2003.
  63. Gerling, IC, Solomon, SS, Bryer-Ash, M. Genomes, transcriptomes, and proteomes: molecular medicine and its impact on medical practice. Arch Intern Med, 163 (2), 190-8, 2003.
  64. Gaber, AO, Fraga, DW, Callicutt, CS, Gerling, IC, Sabek, OM, Kotb, MY. Improved in vivo pancreatic islet function after prolonged in vitro islet culture. Transplantation, 72 (11), 1730-6, 2001.
  65. Dobson, T, Fraga, D, Saba, C, Bryer-Ash, M, Gaber, AO, Gerling, IC. Human pancreatic islets transfected to produce an inhibitor of TNF are protected against destruction by human leukocytes. Cell Transplant, 9 (6), 857-65, 2001.
  66. Gerling, IC, Kotb, M, Fraga, D, Sabek, O, Gaber, AO. No correlation between in vitro and in vivo function of human islets. Transplant Proc, 30 (2), 587-8, 1998.
  67. Cetkovic-Cvrlje, M, Gerling, IC, Muir, A, Atkinson, MA, Elliott, JF, Leiter, EH. Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigens. Diabetes, 46 (12), 1975-82, 1997.
  68. Serreze, DV, Chapman, HD, Varnum, DS, Gerling, I, Leiter, EH, Shultz, LD. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. J Immunol, 158 (8), 3978-86, 1997.
  69. Graves, PM, Norris, JM, Pallansch, MA, Gerling, IC, Rewers, M. The role of enteroviral infections in the development of IDDM: limitations of current approaches. Diabetes, 46 (2), 161-8, 1997.
  70. Gerling, IC, Atkinson, MA, Leiter, EH. The thymus as a site for evaluating the potency of candidate beta cell autoantigens in NOD mice. J Autoimmun, 7 (6), 851-8, 1994.
  71. Gerling, IC, Karlsen, AE, Chapman, HD, Andersen, HU, Boel, E, Cunningham, JM, Nerup, J, Leiter, EH. The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11. Mamm Genome, 5 (5), 318-20, 1994.
  72. Gerling, IC, Friedman, H, Greiner, DL, Shultz, LD, Leiter, EH. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes, 43 (3), 433-40, 1994.
  73. Gerling, I, Chatterjee, NK. Lack of 64,000-M(r) islet autoantigen overexpression and antibody development following coxsackievirus B4 infection in diabetes-resistant mice. Autoimmunity, 14 (3), 197-203, 1993.
  74. Gerling, IC, Serreze, DV, Christianson, SW, Leiter, EH. Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice. Diabetes, 41 (12), 1672-6, 1992.
  75. Gerling, I, Chatterjee, NK, Nejman, C. Coxsackievirus B4-induced development of antibodies to 64,000-Mr islet autoantigen and hyperglycemia in mice. Autoimmunity, 10 (1), 49-56, 1991.
  76. Gerling, I, Chatterjee, NK. Autoantigen (64000-Mr) expression in coxsackievirus B4-induced experimental diabetes. Curr Top Microbiol Immunol, 156, 55-62, 1990.
  77. Chatterjee, NK, Gerling, I, Nejman, C. Pancreatic D-cell disorder in coxsackievirus B4-induced diabetic mice. Mol Cell Endocrinol, 67 (1), 39-45, 1989.
  78. Gerling, I, Nejman, C, Chatterjee, NK. Effect of coxsackievirus B4 infection in mice on expression of 64,000-Mr autoantigen and glucose sensitivity of islets before development of hyperglycemia. Diabetes, 37 (10), 1419-25, 1988.
  79. Chatterjee, NK, Nejman, C, Gerling, I. Purification and characterization of a strain of coxsackievirus B4 of human origin that induces diabetes in mice. J Med Virol, 26 (1), 57-69, 1988.
  80. Gerling, I, Baekkeskov, S, Lernmark, A. Islet cell and 64K autoantibodies are associated with plasma IgG in newly diagnosed insulin-dependent diabetic children. J Immunol, 137 (12), 3782-5, 1986.
  81. Lernmark, A, Baekkeskov, S, Gerling, I, Kastern, W, Knutson, C, Michelsen, B. Immunological aspects of type 1 and 2 diabetes mellitus. Adv Exp Med Biol, 189, 107-27, 1985.
  82. Svenningsen, A, Dyrberg, T, Gerling, I, Lernmark, A, Mackay, P, Rabinovitch, A. Inhibition of insulin release after passive transfer of immunoglobulin from insulin-dependent diabetic children to mice. J Clin Endocrinol Metab, 57 (6), 1301-4, 1983.