IVAN C. GERLING, Ph.D.

Professor
Medicine-Endocrinology
 
Professor
Biomedical Engineering

Office: 151 Veterans Affairs Medical Center
Tel: (901) 523-8990
igerling@uthsc.edu

Education

  • Ph.D., University of Copenhagen, Denmark, Immunology
  • M.S., University of Copenhagen, Denmark, Biochemistry/Immunology
  • B.S., University of Copenhagen, Denmark, Biochemistry/Immunology

Research interest/specialty

Transcriptome and proteome of spleen leukocytes and islet of Langehans in young prediabetic NOD mice.

Research keywords

Diabetes, Autoimmunity, Proteomics, Expression arrays, Biomarkers,

Research interest/specialty

Transcriptome and proteome of spleen leukocytes and islet of Langehans in young prediabetic NOD mice.

Research keywords

Diabetes, Autoimmunity, Proteomics, Expression arrays, Biomarkers,

Publications

  1. Kamalov, G, Ahokas, RA, Zhao, W, Zhao, T, Shahbaz, AU, Johnson, PL, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Uncoupling the coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria seen in aldosteronism. J Cardiovasc Pharmacol, 55 (3), 248-54, 2010.
  2. Kamalov, G, Ahokas, RA, Zhao, W, Shahbaz, AU, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Temporal responses to intrinsically coupled calcium and zinc dyshomeostasis in cardiac myocytes and mitochondria during aldosteronism. Am J Physiol Heart Circ Physiol, 298 (2), H385-94, 2010.
  3. Solomon, SS, Odunusi, O, Carrigan, D, Majumdar, G, Kakoola, D, Lenchik, NI, Gerling, IC. TNF-alpha inhibits insulin action in liver and adipose tissue: A model of metabolic syndrome. Horm Metab Res, 42 (2), 115-21, 2010.
  4. Bhattacharya, SK, Gandhi, MS, Kamalov, G, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Myocardial remodeling in low-renin hypertension: molecular pathways to cellular injury in relative aldosteronism. Curr Hypertens Rep, 11 (6), 412-20, 2009.
  5. Kamalov, G, Holewinski, JP, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Nutrient dyshomeostasis in congestive heart failure. Am J Med Sci, 338 (1), 28-33, 2009.
  6. Kamalov, G, Deshmukh, PA, Baburyan, NY, Gandhi, MS, Johnson, PL, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Coupled calcium and zinc dyshomeostasis and oxidative stress in cardiac myocytes and mitochondria of rats with chronic aldosteronism. J Cardiovasc Pharmacol, 53 (5), 414-23, 2009.
  7. Elam, MB, Cowan, GS, Rooney, RJ, Hiler, ML, Yellaturu, CR, Deng, X, Howell, GE, Park, EA, Gerling, IC, Patel, D, Corton, JC, Cagen, LM, Wilcox, HG, Gandhi, M, Bahr, MH, Allan, MC, Wodi, LA, Cook, GA, Hughes, TA, Raghow, R. Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility. Obesity (Silver Spring), 2009.
  8. Cox, KH, Ruiz-Bustos, E, Courtney, HS, Dale, JB, Pence, MA, Nizet, V, Aziz, RK, Gerling, I, Price, SM, Hasty, DL. Inactivation of DltA modulates virulence factor expression in Streptococcus pyogenes. PLoS One, 4 (4), e5366, 2009.
  9. Gandhi, MS, Deshmukh, PA, Kamalov, G, Zhao, T, Zhao, W, Whaley, JT, Tichy, JR, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Causes and consequences of zinc dyshomeostasis in rats with chronic aldosteronism. J Cardiovasc Pharmacol, 52 (3), 245-52, 2008.
  10. Wang, X, Nookala, S, Narayanan, C, Giorgianni, F, Beranova-Giorgianni, S, McCollum, G, Gerling, I, Penn, JS, Jablonski, MM. Proteomic analysis of the retina: Removal of RPE alters outer segment assembly and retinal protein expression. Glia, 2008.
  11. Wu, J, Lenchik, NI, Gerling, IC. Approaches to reduce false positives and false negatives in the analysis of microarray data: applications in type 1 diabetes research. BMC Genomics, 9 Suppl 2, S12, 2008.
  12. Gao, P, Jiao, Y, Xiong, Q, Wang, CY, Gerling, I, Gu, W. Genetic and Molecular Basis of QTL of Diabetes in Mouse: Genes and Polymorphisms. Curr Genomics, 9 (5), 324-37, 2008.
  13. Selektor, Y, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Cinacalcet and the prevention of secondary hyperparathyroidism in rats with aldosteronism. Am J Med Sci, 335 (2), 105-10, 2008.
  14. Thomas, M, Vidal, A, Bhattacharya, SK, Ahokas, RA, Sun, Y, Gerling, IC, Weber, KT. Zinc dyshomeostasis in rats with aldosteronism. Response to spironolactone. Am J Physiol Heart Circ Physiol, 293 (4), H2361-6, 2007.
  15. Goodwin, KD, Ahokas, RA, Bhattacharya, SK, Sun, Y, Gerling, IC, Weber, KT. Preventing oxidative stress in rats with aldosteronism by calcitriol and dietary calcium and magnesium supplements. Am J Med Sci, 332 (2), 73-8, 2006.
  16. Sun, Y, Ahokas, RA, Bhattacharya, SK, Gerling, IC, Carbone, LD, Weber, KT. Oxidative stress in aldosteronism. Cardiovasc Res, 71 (2), 300-9, 2006.
  17. Bhattacharya, SK, Ahokas, RA, Carbone, LD, Newman, KP, Gerling, IC, Sun, Y, Weber, KT. Macro- and micronutrients in African-Americans with heart failure. Heart Fail Rev, 11 (1), 45-55, 2006.
  18. Wu, J, Marler, J, Lenchik, NI, Gerling, IC. Strain differences in allele and expression levels of CD72 on B-lymphocytes from NOD, AKR, NON and C57BL/6 mice. Immunol Lett, 103 (2), 115-20, 2006.
  19. Majumdar, G, Harrington, A, Hungerford, J, Martinez-Hernandez, A, Gerling, IC, Raghow, R, Solomon, S. Insulin dynamically regulates calmodulin gene expression by sequential o-glycosylation and phosphorylation of sp1 and its subcellular compartmentalization in liver cells. J Biol Chem, 281 (6), 3642-50, 2006.
  20. Gerling, IC, Singh, S, Lenchik, NI, Marshall, DR, Wu, J. New data analysis and mining approaches identify unique proteome and transcriptome markers of susceptibility to autoimmune diabetes. Mol Cell Proteomics, 5 (2), 293-305, 2006.
  21. Vidal, A, Sun, Y, Bhattacharya, SK, Ahokas, RA, Gerling, IC, Weber, KT. Calcium paradox of aldosteronism and the role of the parathyroid glands. Am J Physiol Heart Circ Physiol, 290 (1), H286-94, 2006.
  22. Runyan, AL, Sun, Y, Bhattacharya, SK, Ahokas, RA, Chhokar, VS, Gerling, IC, Weber, KT. Responses in extracellular and intracellular calcium and magnesium in aldosteronism. J Lab Clin Med, 146 (2), 76-84, 2005.
  23. Lenchik, NI, Desiderio, DM, Gerling, IC. Two-dimensional gel electrophoresis characterization of the mouse leukocyte proteome, using a tri-reagent for protein extraction. Proteomics, 5 (8), 2202-9, 2005.
  24. Solomon, SS, Buss, N, Shull, J, Monnier, S, Majumdar, G, Wu, J, Gerling, IC. Proteome of H-411E (liver) cells exposed to insulin and tumor necrosis factor-alpha: analysis of proteins involved in insulin resistance. J Lab Clin Med, 145 (5), 275-83, 2005.
  25. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Hyperparathyroidism and the calcium paradox of aldosteronism. Circulation, 111 (7), 871-8, 2005.
  26. Wu, J, Lenchik, NJ, Pabst, MJ, Solomon, SS, Shull, J, Gerling, IC. Functional characterization of two-dimensional gel-separated proteins using sequential staining. Electrophoresis, 26 (1), 225-37, 2005.
  27. Ahokas, RA, Sun, Y, Bhattacharya, SK, Gerling, IC, Weber, KT. Aldosteronism and a proinflammatory vascular phenotype: role of Mg2+, Ca2+, and H2O2 in peripheral blood mononuclear cells. Circulation, 111 (1), 51-7, 2005.
  28. Chhokar, VS, Sun, Y, Bhattacharya, SK, Ahokas, RA, Myers, LK, Xing, Z, Smith, RA, Gerling, IC, Weber, KT. Loss of bone minerals and strength in rats with aldosteronism. Am J Physiol Heart Circ Physiol, 287 (5), H2023-6, 2004.
  29. Tannu, NS, Wu, J, Rao, VK, Gadgil, HS, Pabst, MJ, Gerling, IC, Raghow, R. Paraffin-wax-coated plates as matrix-assisted laser desorption/ionization sample support for high-throughput identification of proteins by peptide mass fingerprinting. Anal Biochem, 327 (2), 222-32, 2004.
  30. Gerling, IC, Ali, C, Lenchik, N. Characterization of early developments in the splenic leukocyte transcriptome of NOD mice. Ann N Y Acad Sci, 1005, 157-60, 2003.
  31. Ahokas, RA, Warrington, KJ, Gerling, IC, Sun, Y, Wodi, LA, Herring, PA, Lu, L, Bhattacharya, SK, Postlethwaite, AE, Weber, KT. Aldosteronism and peripheral blood mononuclear cell activation: a neuroendocrine-immune interface. Circ Res, 93 (10), e124-35, 2003.
  32. Weber, KT, Sun, Y, Wodi, LA, Munir, A, Jahangir, E, Ahokas, RA, Gerling, IC, Postlethwaite, AE, Warrington, KJ. Toward a broader understanding of aldosterone in congestive heart failure. J Renin Angiotensin Aldosterone Syst, 4 (3), 155-63, 2003.
  33. Gadgil, HS, Pabst, KM, Giorgianni, F, Umstot, ES, Desiderio, DM, Beranova-Giorgianni, S, Gerling, IC, Pabst, MJ. Proteome of monocytes primed with lipopolysaccharide: analysis of the abundant proteins. Proteomics, 3 (9), 1767-80, 2003.
  34. Weber, KT, Gerling, IC, Kiani, MF, Guntaka, RV, Sun, Y, Ahokas, RA, Postlethwaite, AE, Warrington, KJ. Aldosteronism in heart failure: a proinflammatory/fibrogenic cardiac phenotype. Search for biomarkers and potential drug targets. Curr Drug Targets, 4 (6), 505-16, 2003.
  35. Gerling, IC, Sun, Y, Ahokas, RA, Wodi, LA, Bhattacharya, SK, Warrington, KJ, Postlethwaite, AE, Weber, KT. Aldosteronism: an immunostimulatory state precedes proinflammatory/fibrogenic cardiac phenotype. Am J Physiol Heart Circ Physiol, 285 (2), H813-21, 2003.
  36. Gerling, IC, Solomon, SS, Bryer-Ash, M. Genomes, transcriptomes, and proteomes: molecular medicine and its impact on medical practice. Arch Intern Med, 163 (2), 190-8, 2003.
  37. Gaber, AO, Fraga, DW, Callicutt, CS, Gerling, IC, Sabek, OM, Kotb, MY. Improved in vivo pancreatic islet function after prolonged in vitro islet culture. Transplantation, 72 (11), 1730-6, 2001.
  38. Dobson, T, Fraga, D, Saba, C, Bryer-Ash, M, Gaber, AO, Gerling, IC. Human pancreatic islets transfected to produce an inhibitor of TNF are protected against destruction by human leukocytes. Cell Transplant, 9 (6), 857-65, 2001.
  39. Gerling, IC, Kotb, M, Fraga, D, Sabek, O, Gaber, AO. No correlation between in vitro and in vivo function of human islets. Transplant Proc, 30 (2), 587-8, 1998.
  40. Cetkovic-Cvrlje, M, Gerling, IC, Muir, A, Atkinson, MA, Elliott, JF, Leiter, EH. Retardation or acceleration of diabetes in NOD/Lt mice mediated by intrathymic administration of candidate beta-cell antigens. Diabetes, 46 (12), 1975-82, 1997.
  41. Serreze, DV, Chapman, HD, Varnum, DS, Gerling, I, Leiter, EH, Shultz, LD. Initiation of autoimmune diabetes in NOD/Lt mice is MHC class I-dependent. J Immunol, 158 (8), 3978-86, 1997.
  42. Graves, PM, Norris, JM, Pallansch, MA, Gerling, IC, Rewers, M. The role of enteroviral infections in the development of IDDM: limitations of current approaches. Diabetes, 46 (2), 161-8, 1997.
  43. Gerling, IC, Atkinson, MA, Leiter, EH. The thymus as a site for evaluating the potency of candidate beta cell autoantigens in NOD mice. J Autoimmun, 7 (6), 851-8, 1994.
  44. Gerling, IC, Karlsen, AE, Chapman, HD, Andersen, HU, Boel, E, Cunningham, JM, Nerup, J, Leiter, EH. The inducible nitric oxide synthase gene, Nos2, maps to mouse chromosome 11. Mamm Genome, 5 (5), 318-20, 1994.
  45. Gerling, IC, Friedman, H, Greiner, DL, Shultz, LD, Leiter, EH. Multiple low-dose streptozocin-induced diabetes in NOD-scid/scid mice in the absence of functional lymphocytes. Diabetes, 43 (3), 433-40, 1994.
  46. Gerling, I, Chatterjee, NK. Lack of 64,000-M(r) islet autoantigen overexpression and antibody development following coxsackievirus B4 infection in diabetes-resistant mice. Autoimmunity, 14 (3), 197-203, 1993.
  47. Gerling, IC, Serreze, DV, Christianson, SW, Leiter, EH. Intrathymic islet cell transplantation reduces beta-cell autoimmunity and prevents diabetes in NOD/Lt mice. Diabetes, 41 (12), 1672-6, 1992.
  48. Gerling, I, Chatterjee, NK, Nejman, C. Coxsackievirus B4-induced development of antibodies to 64,000-Mr islet autoantigen and hyperglycemia in mice. Autoimmunity, 10 (1), 49-56, 1991.
  49. Gerling, I, Chatterjee, NK. Autoantigen (64000-Mr) expression in coxsackievirus B4-induced experimental diabetes. Curr Top Microbiol Immunol, 156, 55-62, 1990.
  50. Chatterjee, NK, Gerling, I, Nejman, C. Pancreatic D-cell disorder in coxsackievirus B4-induced diabetic mice. Mol Cell Endocrinol, 67 (1), 39-45, 1989.
  51. Gerling, I, Nejman, C, Chatterjee, NK. Effect of coxsackievirus B4 infection in mice on expression of 64,000-Mr autoantigen and glucose sensitivity of islets before development of hyperglycemia. Diabetes, 37 (10), 1419-25, 1988.
  52. Chatterjee, NK, Nejman, C, Gerling, I. Purification and characterization of a strain of coxsackievirus B4 of human origin that induces diabetes in mice. J Med Virol, 26 (1), 57-69, 1988.
  53. Gerling, I, Baekkeskov, S, Lernmark, A. Islet cell and 64K autoantibodies are associated with plasma IgG in newly diagnosed insulin-dependent diabetic children. J Immunol, 137 (12), 3782-5, 1986.
  54. Lernmark, A, Baekkeskov, S, Gerling, I, Kastern, W, Knutson, C, Michelsen, B. Immunological aspects of type 1 and 2 diabetes mellitus. Adv Exp Med Biol, 189, 107-27, 1985.
  55. Svenningsen, A, Dyrberg, T, Gerling, I, Lernmark, A, Mackay, P, Rabinovitch, A. Inhibition of insulin release after passive transfer of immunoglobulin from insulin-dependent diabetic children to mice. J Clin Endocrinol Metab, 57 (6), 1301-4, 1983.