Isaac O. Donkor, Ph.D., M.S., B.Pharm.

Professor
Pharmaceutical Sciences
Associate Dean for Students and Recruitment
College of Graduate Health Sciences

Office: 327e Johnson Building
Tel: (901) 448-7736
idonkor@uthsc.edu

Publications

  1. Donkor, IO. Calpain inhibitors: a survey of compounds reported in the patent and scientific literature. Expert Opin Ther Pat, 21 (5), 601-36, 2011.
  2. Donkor, IO, Korukonda, R. Synthesis and calpain inhibitory activity of peptidomimetic compounds with constrained amino acids at the P2 position. Bioorg Med Chem Lett, 18 (17), 4806-8, 2008.
  3. Donkor, IO, Assefa, H, Liu, J. Structural basis for the potent calpain inhibitory activity of peptidyl alpha-ketoacids. J Med Chem, 51 (14), 4346-50, 2008.
  4. Huang, TL, Bacchi, CJ, Kode, NR, Zhang, Q, Wang, G, Yartlet, N, Rattendi, D, Londono, I, Mazumder, L, Vanden Eynde, JJ, Mayence, A, Donkor, IO. Trypanocidal activity of piperazine-linked bisbenzamidines and bisbenzamidoxime, an orally active prodrug. Int J Antimicrob Agents, 30 (6), 555-61, 2007.
  5. Guan, N, Korukonda, R, Hurh, E, Schmittgen, TD, Donkor, IO, Dalton, JT. Apoptosis induced by novel aldehyde calpain inhibitors in human tumor cell lines. Int J Oncol, 29 (3), 655-63, 2006.
  6. Korukonda, R, Guan, N, Dalton, JT, Liu, J, Donkor, IO. Synthesis, calpain inhibitory activity, and cytotoxicity of P2-substituted proline and thiaproline peptidyl aldehydes and peptidyl alpha-ketoamides. J Med Chem, 49 (17), 5282-90, 2006.
  7. Huang, TL, Vanden Eynde, JJ, Mayence, A, Donkor, IO, Khan, SI, Tekwani, BL. Anti-plasmodial and anti-leishmanial activity of conformationally restricted pentamidine congeners. J Pharm Pharmacol, 58 (8), 1033-42, 2006.
  8. Sanders, ML, Donkor, IO. A novel series of urea-based peptidomimetic calpain inhibitors. Bioorg Med Chem Lett, 16 (7), 1965-8, 2006.
  9. Donkor, IO, Han, J, Zheng, X. Design, synthesis, molecular modeling studies, and calpain inhibitory activity of novel alpha-ketoamides incorporating polar residues at the P1'-position. J Med Chem, 47 (1), 72-9, 2004.
  10. Donkor, IO, Li, H, Queener, SF. Synthesis and DHFR inhibitory activity of a series of 6-substituted-2,4-diaminothieno[2,3-d]pyrimidines. Eur J Med Chem, 38 (6), 605-11, 2003.
  11. Donkor, IO, Korukonda, R, Huang, TL, LeCour, L. Peptidyl aldehyde inhibitors of calpain incorporating P2-proline mimetics. Bioorg Med Chem Lett, 13 (5), 783-4, 2003.
  12. Donkor, IO, Huang, TL, Tao, B, Rattendi, D, Lane, S, Vargas, M, Goldberg, B, Bacchi, C. Trypanocidal activity of conformationally restricted pentamidine congeners. J Med Chem, 46 (6), 1041-8, 2003.
  13. Donkor, IO, Sanders, ML. Synthesis of a reported calpain inhibitor isolated from Streptomyces griseus. Bioorg Med Chem Lett, 11 (19), 2647-9, 2001.
  14. Huang, TL, Tao, B, Quarshie, Y, Queener, SF, Donkor, IO. N,N'-bis[4-(N-alkylamidino)phenyl]homopiperazines as anti-Pneumocystis carinii agents. Bioorg Med Chem Lett, 11 (20), 2679-81, 2001.
  15. Donkor, IO, Zheng, X, Han, J, Lacy, C, Miller, DD. Significance of hydrogen bonding at the S(1)' subsite of calpain I. Bioorg Med Chem Lett, 11 (13), 1753-5, 2001.
  16. Donkor, IO, Assefa, H, Rattendi, D, Lane, S, Vargas, M, Goldberg, B, Bacchi, C. Trypanocidal activity of dicationic compounds related to pentamidine. Eur J Med Chem, 36 (6), 531-8, 2001.
  17. Donkor, IO, Clark, AM. In vitro antimicrobial activity of aromatic diamidines and diimidazolines related to pentamidine. Eur J Med Chem, 34 (7-8), 639-43, 2001.
  18. Donkor, IO. A survey of calpain inhibitors. Curr Med Chem, 7 (12), 1171-88, 2000.
  19. Donkor, IO, Zheng, X, Miller, DD. Synthesis and calpain inhibitory activity of alpha-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position. Bioorg Med Chem Lett, 10 (22), 2497-500, 2000.
  20. Donkor, IO, Zheng, X, Han, J, Miller, DD. Asymmetric synthesis of 2,3-methanoleucine stereoisomers from common intermediates. Chirality, 12 (7), 551-7, 2000.
  21. Zheng, X, Donkor, IO, Miller, DD, Ross, CR. Unprecedented crystallization and X-ray crystal structure of racemic N(alpha)-(t-butyloxycarbonyl)-L-L-phenylalanine N-methoxy-N-methylamide. Chirality, 12 (1), 2-6, 2000.
  22. Wolfe, MS, Xia, W, Moore, CL, Leatherwood, DD, Ostaszewski, B, Rahmati, T, Donkor, IO, Selkoe, DJ. Peptidomimetic probes and molecular modeling suggest that Alzheimer's gamma-secretase is an intramembrane-cleaving aspartyl protease. Biochemistry, 38 (15), 4720-7, 1999.
  23. Donkor, IO, Zhou, X, Schmidt, J, Agrawal, KC, Kishore, V. Synthesis and radioprotective effects of adamantyl substituted 1,4-dihydropyridine derivatives. Bioorg Med Chem, 6 (5), 563-8, 1998.
  24. Wolfe, MS, Citron, M, Diehl, TS, Xia, W, Donkor, IO, Selkoe, DJ. A substrate-based difluoro ketone selectively inhibits Alzheimer's gamma-secretase activity. J Med Chem, 41 (1), 6-9, 1998.