Assistant Professor

Tel: (901) 448-3068

My Current CV


  1. Ponnusamy, S, Tran, QT, Harvey, I, Smallwood, HS, Thiyagarajan, T, Banerjee, S, Johnson, DL, Dalton, JT, Sullivan, RD, Miller, DD, Bridges, D, Narayanan, R. Pharmacologic activation of estrogen receptor β increases mitochondrial function, energy expenditure, and brown adipose tissue. FASEB J, 31 (1), 266-281, 2017.
  2. Heather S. Smallwood, Susu Duan, Marie Morfouace, Svetlana Rezinciuc, Barry L. Shulkin, Anang Shelat, Erika E. Zink, Sandra Milasta, Resha Bajracharya, Ajayi J. Oluwaseum, Martine F. Roussel, Douglas R. Green, Ljiljana Pasa-Tolic, Paul G. Thomas. Targeting Metabolic Reprogramming by Influenza Infection for Therapeutic Intervention. Cell Reports, 19 (8), 1640-1653, 2017.
  3. Duan, S, Meliopoulos, VA, McClaren, JL, Guo, XZ, Sanders, CJ, Smallwood, HS, Webby, RJ, Schultz-Cherry, SL, Doherty, PC, Thomas, PG. Diverse heterologous primary infections radically alter immunodominance hierarchies and clinical outcomes following H7N9 influenza challenge in mice. PLoS Pathog, 11 (2), e1004642, 2015.
  4. Oshansky, CM, Wong, SS, Jeevan, T, Smallwood, HS, Webby, RJ, Shafir, SC, Thomas, PG. Seasonal influenza vaccination is the strongest correlate of cross-reactive antibody responses in migratory bird handlers. MBio, 5 (6), e02107, 2014.
  5. Russ, BE, Olshanksy, M, Smallwood, HS, Li, J, Denton, AE, Prier, JE, Stock, AT, Croom, HA, Cullen, JG, Nguyen, ML, Rowe, S, Olson, MR, Finkelstein, DB, Kelso, A, Thomas, PG, Speed, TP, Rao, S, Turner, SJ. Distinct epigenetic signatures delineate transcriptional programs during virus-specific CD8(+) T cell differentiation. Immunity, 41 (5), 853-65, 2014.
  6. Smallwood, HS, López-Ferrer, D, Squier, TC. Aging enhances the production of reactive oxygen species and bactericidal activity in peritoneal macrophages by upregulating classical activation pathways. Biochemistry, 50 (45), 9911-22, 2011.
  7. Lourette, N, Smallwood, H, Wu, S, Robinson, EW, Squier, TC, Smith, RD, Pasa-ToliÄ, L. A top-down LC-FTICR MS-based strategy for characterizing oxidized calmodulin in activated macrophages. J Am Soc Mass Spectrom, 21 (6), 930-9, 2010.
  8. Shi, L, Ansong, C, Smallwood, H, Rommereim, L, McDermott, JE, Brewer, HM, Norbeck, AD, Taylor, RC, Gustin, JK, Heffron, F, Smith, RD, Adkins, JN. Proteome of Salmonella Enterica Serotype Typhimurium Grown in a Low Mg/pH Medium. J Proteomics Bioinform, 2, 388-397, 2009.
  9. Shi, L, Chowdhury, SM, Smallwood, HS, Yoon, H, Mottaz-Brewer, HM, Norbeck, AD, McDermott, JE, Clauss, TR, Heffron, F, Smith, RD, Adkins, JN. Proteomic investigation of the time course responses of RAW 264.7 macrophages to infection with Salmonella enterica. Infect Immun, 77 (8), 3227-33, 2009.
  10. López-Ferrer, D, Hixson, KK, Smallwood, H, Squier, TC, Petritis, K, Smith, RD. Evaluation of a high-intensity focused ultrasound-immobilized trypsin digestion and 18O-labeling method for quantitative proteomics. Anal Chem, 81 (15), 6272-7, 2009.
  11. Smallwood, HS, Lopez-Ferrer, D, Eberlein, PE, Watson, DJ, Squier, TC. Calmodulin mediates DNA repair pathways involving H2AX in response to low-dose radiation exposure of RAW 264.7 macrophages. Chem Res Toxicol, 22 (3), 460-70, 2009.
  12. Boschek, CB, Jones, TE, Smallwood, HS, Squier, TC, Bigelow, DJ. Loss of the calmodulin-dependent inhibition of the RyR1 calcium release channel upon oxidation of methionines in calmodulin. Biochemistry, 47 (1), 131-42, 2008.
  13. Smallwood, HS, Lourette, NM, Boschek, CB, Bigelow, DJ, Smith, RD, Pasa-ToliÄ, L, Squier, TC. Identification of a denitrase activity against calmodulin in activated macrophages using high-field liquid chromatography--FTICR mass spectrometry. Biochemistry, 46 (37), 10498-505, 2007.
  14. Xiong, Y, Chen, B, Smallwood, HS, Urbauer, RJ, Markille, LM, Galeva, N, Williams, TD, Squier, TC. High-affinity and cooperative binding of oxidized calmodulin by methionine sulfoxide reductase. Biochemistry, 45 (49), 14642-54, 2006.
  15. Shi, L, Adkins, JN, Coleman, JR, Schepmoes, AA, Dohnkova, A, Mottaz, HM, Norbeck, AD, Purvine, SO, Manes, NP, Smallwood, HS, Wang, H, Forbes, J, Gros, P, Uzzau, S, Rodland, KD, Heffron, F, Smith, RD, Squier, TC. Proteomic analysis of Salmonella enterica serovar typhimurium isolated from RAW 264.7 macrophages: identification of a novel protein that contributes to the replication of serovar typhimurium inside macrophages. J Biol Chem, 281 (39), 29131-40, 2006.
  16. Smallwood, HS, Shi, L, Squier, TC. Increases in calmodulin abundance and stabilization of activated inducible nitric oxide synthase mediate bacterial killing in RAW 264.7 macrophages. Biochemistry, 45 (32), 9717-26, 2006.
  17. Weber, TJ, Smallwood, HS, Kathmann, LE, Markillie, LM, Squier, TC, Thrall, BD. Functional link between TNF biosynthesis and CaM-dependent activation of inducible nitric oxide synthase in RAW 264.7 macrophages. Am J Physiol Cell Physiol, 290 (6), C1512-20, 2006.
  18. Anbanandam, A, Bieber Urbauer, RJ, Bartlett, RK, Smallwood, HS, Squier, TC, Urbauer, JL. Mediating molecular recognition by methionine oxidation: conformational switching by oxidation of methionine in the carboxyl-terminal domain of calmodulin. Biochemistry, 44 (27), 9486-96, 2005.
  19. Weber, TJ, Negash, S, Smallwood, HS, Ramos, KS, Thrall, BD, Squier, TC. Calmodulin involvement in stress-activated nuclear localization of albumin in JB6 epithelial cells. Biochemistry, 43 (23), 7443-50, 2004.
  20. Bartlett, RK, Bieber Urbauer, RJ, Anbanandam, A, Smallwood, HS, Urbauer, JL, Squier, TC. Oxidation of Met144 and Met145 in calmodulin blocks calmodulin dependent activation of the plasma membrane Ca-ATPase. Biochemistry, 42 (11), 3231-8, 2003.
  21. Smallwood, HS, Galeva, NA, Bartlett, RK, Urbauer, RJ, Williams, TD, Urbauer, JL, Squier, TC. Selective nitration of Tyr99 in calmodulin as a marker of cellular conditions of oxidative stress. Chem Res Toxicol, 16 (1), 95-102, 2003.