ELBAHESH, HUSNI

Assistant Professor
Dept of Micr, Immun, & Biochem

Office: 701C MOLECULAR SCIENCES BUILDING
858 MADISON AVENUE
MEMPHIS TN 381632129
Tel: (901) 448-2524
helbahes@uthsc.edu

Education

  • PostDoc, St. Jude Children's Research Hospital, Molecular Virology
  • Ph.D., Georgia State University, Cellular Molecular Biology and Physiology
  • M.S., Georgia State University, Molecular Genetics and Biochemistry
  • B.A., Auburn University, Microbiology

Research interests

The research in my laboratory is focused on understanding interactions at the host-virus interface during infection. We study viruses that pose a significant public health threat like human and avian influenza A viruses (low and highly pathogenic) as well as emerging viruses like Zika virus.

We hope to define mechanisms of viral pathogenesis and disease progression of these signficant human pathogens by using cellular and molecular biology approaches. We utilize both tissue culture as well as animal model systems to study these aspects of viral infections.

Our main objectives are to better understand 1) viral modulation of cellular signaling pathways for entry and replication; 2) viral evasion of host immune responses; 3) identifying biomarkers of disease severity and 4) development of novel host based antiviral therapeutics.

Research Keywords

Influenza A virus, Zika virus, Cell-signaling, Viral entry and replication, Host-pathogen interactions, innate immunity to viral infections, viral pathogenesis, microcephaly, disease severity

Publications

  1. Marion, T, Elbahesh, H, Thomas, PG, DeVincenzo, JP, Webby, R, Schughart, K. Respiratory Mucosal Proteome Quantification in Human Influenza Infections. PLoS One, 11 (4), e0153674, 2016.
  2. Elbahesh, H, Bergmann, S, Russell, CJ. Focal adhesion kinase (FAK) regulates polymerase activity of multiple influenza A virus subtypes. Virology, 499, 369-374, 2016.
  3. Liu, B, Li, NL, Shen, Y, Bao, X, Fabrizio, T, Elbahesh, H, Webby, RJ, Li, K. The C-Terminal Tail of TRIM56 Dictates Antiviral Restriction of Influenza A and B Viruses by Impeding Viral RNA Synthesis. J Virol, 90 (9), 4369-82, 2016.
  4. Elbahesh, H, Schughart, K. Genetically diverse CC-founder mouse strains replicate the human influenza gene expression signature. Sci Rep, 6, 26437, 2016.
  5. Elbahesh, H, Cline, T, Baranovich, T, Govorkova, EA, Schultz-Cherry, S, Russell, CJ. Novel Roles of Focal Adhesion Kinase in Cytoplasmic Entry and Replication of Influenza A Viruses. J Virol, 88 (12), 6714-6728, 2014.
  6. ,. Assessing the fitness of distinct clades of influenza A (H9N2) viruses. Emerg Microbes Infect, 2 (11), e75, 2013.
  7. Mason, JN, Elbahesh, H, Russell, CJ. Influence of antigen insertion site and vector dose on immunogenicity and protective capacity in Sendai virus-based human parainfluenza virus type 3 vaccines. J Virol, 87 (10), 5959-69, 2013.
  8. Elbahesh, H, Scherbik, SV, Brinton, MA. West Nile virus infection does not induce PKR activation in rodent cells. Virology, 421 (1), 51-60, 2011.
  9. Elbahesh, H, Jha, BK, Silverman, RH, Scherbik, SV, Brinton, MA. The Flvr-encoded murine oligoadenylate synthetase 1b (Oas1b) suppresses 2-5A synthesis in intact cells. Virology, 409 (2), 262-70, 2011.
  10. Gauthier, TW, Ping, XD, Harris, FL, Wong, M, Elbahesh, H, Brown, LA. Fetal alcohol exposure impairs alveolar macrophage function via decreased glutathione availability. Pediatr Res, 57 (1), 76-81, 2005.