CHO, HONGSIK JAKE Ph.D, MBA

Associate Professor
Orthopaedic Surgery

Office: BB112 VETERANS AFFAIRS MEDICAL CENTER
1030 JEFFERSON AVENUE
MEMPHIS TN 381042193
Tel: (901) 523-8990
hcho4@uthsc.edu

Education

  • MBA, Georgia Institute of Technology, GA, USA, Global Business
  • PostDoc, University of Memphis, TN, USA, Dept. of Chemistry
  • PostDoc, University of Tennessee, TN, USA, Orthpaedic Surgery and Neurosurgery
  • Ph.D., Ajou University, S. Korea, Biomedical Engineering
  • Exchange Graduate Program, University of Memphis, Memphis, TN, USA, Biomedical Engineering
  • M.S., Ajou University, S. Korea, Biomedical Engineering
  • B.S., Konkuk University, S. Korea, Biomedical Engineering

Research Interest/Specialty

Dr. Cho has experience culturing human primary cells and stem cells for the transplantation of autologous chondrocytes, using engineering techniques to rebuild cartilage and disc tissue, investigating the effects of sonication on osteoarthritis cartilage, nanotechnology with immuno-liposome and studying the effects of cytokines on arthritis induced cartilage and disc tissue. 

  • Development of theranostic target nanosomes and nanoparticles
  • Development of tissue-engineered disc and cartilage tissue
  • Development of imaging system for early detection of osteoarthritis (OA)
  • Development and commercialization of a therapeutic ultrasound system for OA
  • Biological intervention using cell therapy technique for OA patients

Research Keywords

Biomedical Engineering, Tissue Engineering, Nanomedicine, Liposome (Nanosome), Drug Delivery, Arthritis, Stem Cell, Animal Model, Preclinical Imaging

PUBLICATIONS (REFEREED JOURNAL ARTICLES)

  (*Corresponding  author / 1Co first- Author): 2011~

2016

  1. Zaman AZ., Alamgeer, RR, Hassan M., Ahsan H., Afzal S., Afzal K, Cho H., Kim SJ. “Synthesis, bioevaluation and molecular dynamic simulation studies of dexibuprofen-antioxidant mutual prodrugs” International Journal of Molecular Sciences 2016, 17(12), 2151; doi: 10.3390/ijms17122151 (PMID: 28009827)
  2. Bhatti F., Mehmood A., Latief N., Zahra S., Cho H., Khan S. “Vitamin E protects rat mesenchymal stem cells against hydrogen peroxide-induced oxidative stress in vitro and improves their therapeutic potential in surgically-induced rat model of osteoarthritis” Osteoarthritis and Cartilage 2016, 25(2): 321-331 (PMID: 27693502)
  3. Hasty K.A., Cho H., “Stem Cell Considerations for the Clinician” Physical Medicine and Rehabilitation Clinics 2016, 27(4): 855–870 (PMID: 27788904)
  4. Bhatti F., Hasty K.A., Cho H.*, “Kartogenin induced Chondrogenesis of Stem Cells and Cartilage Repair” Int. Journal of Stem Cell Research & Therapy 2016, 3(2):036
  5. Cho H.*, Bhatti F., Lee S., Brand D., Yi AK., Hasty K.A. “In Vivo Dual Fluorescence Imaging to Detect Joint Destruction” Artificial Organs 2016, 40(10):1009–1027 (PMID: 27183538)
  6. Cho H., Bhatti F., Yoon T., Stuart JM., Hasty K.A., Yi AK. “Non-invasive Dual Fluorescence In Vivo Imaging for Detection of Macrophage Infiltration and Matrix Metalloproteinase (MMP) Activity in Inflammatory Arthritic Joints” Biomedical Optics Express 2016; 7(5): 1842-1852 (PMID: 27231625)
  7. Yu S., Cho H., Kim GH., Chung KW., Seo SY., Kim SJ. “Berberine induces dedifferentiation by actin cytoskeleton reorganization via phosphoinositide 3-kinase/Akt and p38 kinase pathways in rabbit articular chondrocytes” Experimental Biology and Medicine 2016; 241: 800–807 (PMID: 26851252)
  8. Kavanaugh TE., Werfel TA., Cho H., Hasty KA., Duvall CL. “Particle-based technologies for osteoarthritis detection and therapy” Drug Delivery and Translational Research 2016 Apr;6(2):132-47 (PMID: 25990835)
  9. Cho H.*, Halt D., Smith R., Kim SJ, Goddoki R., Hasty KA. “The Effects of Platelet Rich Plasma on Halting the Progressive in Porcine Intervertebral Disc Degeneration” Artificial Organs2016;40(2):190-5 (PMID: 26147759)

2015

  1. Cho H., Azar F., Stuart JM, Hasty KA. “Development of Fluorescent Arthroscopy for Early Detection of OA and Cartilage Injury” Campbell Clinic Orthopaedic Journal 2015; 1: 75-81 (non-peer review journal)
  2. Cho H.*, Walker A., Williams J., Hasty K.A. “Study of Osteoarthritis Treatment with Anti-inflammatory Drugs: Cyclooxyganase-2 (COX2) Inhibitor and Steroids” BioMed Research International 2015 Article ID 595273, 10 pages (PMID: 26000299)
  3. Hicks A., Nord K., Powell M., Slominski A., Cho H., Hasty K.A. “Unique Vitamin D Analogue for the Inhibition of NFκB in Treatment of Osteoarthritis” American Medical Student Research Journal (AMSRJ) 2015; 1(2):106-114 (http://dx.doi.org/10.15422/amsrj.2015.03.001)
  4. Cho H., Pinkhassik E., David V., Stuart J.M., Hasty K.A. “Detection of Early Cartilage Damage using Targeted Nanosomes in a Post-Traumatic Osteoarthritis Mouse Model” Nanomedicine: NBM 2015; 11: 939-946 (PMID: 25680539)

2014

  1. Eichaker LR., Cho H., Duvall CL., Werfel TA., Hasty KA. “Future nanomedicine for diagnosis and treatment of osteoarthritis” Nanomedicine 2014; 9(14): 2203-2215 (PMID: 25405797)
  2. Eo SH, Cho H., Kim SJ. “Resveratrol regulates type II collagen and COX-2 via the ERK, p38 and Akt pathways in rabbit articular chondrocytes” Experimental and Therapeutic Medicine 2014; 7: 640-648 (PMID: 24520260)
  3. Cho H., Zook J., Banner T., Park SH, Min BH, Hasty K.A., Pinkhassik E., Erno L“Immobilization of fibrinogen antibody on the self-assembled gold monolayer for biosensor” Tissue Engineering and Regenerative Medicine 2014; 11(1): 10-15  (DOI:10.1007/s13770-013-1119-4)
  4. Cho H., Magid R., Danila D.C., Hunskar T., Pinkhassik E., Hasty K.A. “Theranostic Immunoliposomes for Osteoarthritis.” Nanomedicine:NBM 2014; 10(3): 619-627 (PMID:  24096032)

2013

  1. Eo SH, Cho H., Kim SJ. “Resveratrol inhibits nitric oxide-induced apoptosis via the NF-kappa B pathway in rabbit articular chondrocytes” Biomolecules & Therapeutics 2013 21(5): 364-370 (PMID: 24244824)
  2. Cho H., Lee S., Park SH, Huang J., Hasty K.A., Kim SJ. “Synergistic Effect of Combined Growth Factors in Porcine Intervertebral Disc Degeneration” Connective Tissue Research 2013 54(3): 181-186 (PMID: 23406273)
  3. Cho H., Park SH, Shim JW, Park KD, Huang J., Smith R., Min BH, Elder S, Hasty K.A. “Construction of Tissue Engineered Annulus Fibrosus” Artificial Organs 2013; 37(7): E131-138 (PMID:23621741)

2012

  1. Yu SM., Gweon EJ., Cho H., Chung KW., Kim KH., Kim SJ. “Gallotanin regulates apoptosis and COX-2 expression via Akt and p38kinase pathway in human lung cancer cell line, A549” Animal Cells and Systems 2012; 16(5): 366-375
  2. Park SH, Seth A., Lee S., Min BH, Kim SJ, Song T., Hasty K.A., Cho H.* “Recent advances in liposome techniques and the applications in arthritis” Recent Patents on Biomedical Engineering2012; 5(1): 57-62 (*= Corresponding Author)
  3. Park SH, Gil ES, Mandal BCho H., Kluge J. A., Min BH, Kaplan D. L. Annulus fibrosus tissue engineering using lamellar silk scaffold”. J. of Tissue Eng. and Reg. Med.2012; 6: s24-s33 (PMID: 22311816)
  4. Park SH, Gil ES, Cho H., Mandal B., Tien L, Min BH, Kaplan D. L. “Intervertebral disc tissue engineering using biphasic silk composite scaffolds” Tissue Eng. Part A 2012; 18(5-6): 447-58 (PMID:21919790)

2011

  1. Cho H., Seth A., Warmbold J., Robertson J.T., Hasty K.A. Aging affects response to cyclic tensile stretch: Paradigm for Intervertebral Disc Regeneration.” Euro Cells and Materials (eCM) 2011; 22:137-146 (PMID:21932191)
  2. Park SH, Cho H., Gil ES, Mandal B., Min BH, Kaplan D. L. “Silk-fibrin/hyaluronic acid composite gels for nucleus pulposus (NP) tissue regeneration” Tissue Eng. A. 2011; 17(23-24):2999-3009. (PMID: 21736446
  3. Cho H., Park SH, Lee S., Kang M., Hasty K.A., Kim SJ. “Snapshot of degenerative aging of porcine intervertebral disc: a model to unravel the molecular mechanism” Exp. Mol. Med. 2011;43 (PMID:21499012) 

PUBLICATIONS (PROFESSIONAL CONFERENCE PROCEEDINGS)

 2010~

  1. Millirons CT, Patterson CM, Cho H, Hasty KA. “Localization of Reparative Cells to Site of Injuring in Osteoarthritic Joint” Oral Presentation, Biomaterials day 2017, Nashiville, TN
  2. Yi AK, Yoon TW, Cho H, Kim YI, Park JE, Fitzpatrick E, Hasty KA, Stuart JM “Protein kinase D1 in the Toll-like receptor signaling and experimental inflammatory diseases” Keystone Symposia (X5) 2017
  3. Cho H, Bhatti F, Hasty KA “Therapeutic Efficacy of Targeted TPCA-1 loaded Nanosomes in Post-Traumatic Osteoarthritis Mouse Model” Podium Presentation, Orthopaedic Research Society (ORS) 2017
  4. Cho H, Bhatti F, Hasty KA “Development of TPCA-1 Loaded Nanosomes for Osteoarthritis” Poster Presentation, Orthopaedic Research Society (ORS) 2017
  5. Cho H, Bhatti F, Park J, Azar FM, Hasty KA “Next Generation Fluorescent Arthroscopy for early detection of OA: A Pilot Study” Poster Presentation, Orthopaedic Research Society (ORS) 2017
  6. Bedingfield S.K., Kavanaugh T.E., Gullett C.A., Patterson C., Cho H., Werfel T.A., Hasty K.A, Duvall C.L. “Targeted Nanoparticles for Delivery of siRNA to Sites of Early Onset Post-traumatic OsteoarthritisPoster Presentation, Biomedical Engineering Society (BMES) 2016
  7. Yi AK, Yoon TW, Cho H, Park JE, Hasty KA, Stuart JM. “Contribution of MyD88 and protein kinase D1 to the pathogenesis of polyarthritis spontaneously occurring in IL-1R antagonist-deficient mice”. International Congress of Immunology (ICI) 2016
  8. Bhatti F., Brand D., Hasty K.A., Cho H. “Detection of Early Stage of Osteoarthritis by Dual Fluorescence ImagingPoster Presentation, Orthopaedic Research Society(ORS) 2016
  9. Singh P., Bhatti F., Hasty KA, Cho H., Bumgardner JD., Jennings JA. “Adenosine and Raspberry Ketones to Promote Growth and Minimize Inflammatory Response in Chondrocyte CulturePoster Presentation, Orthopaedic Research Society(ORS) 2016
  10. Cho H, Jeong YH, Kim DG, Hasty KA “The Correlation Of Cartilage Damage With Mechanical Properties In Early Stages Of Osteoarthritis Using A Mechanical Loaded Mouse Model” Poster Presentation, Orthopaedic Research Society(ORS) 2015
  11. Cho H, Hicks A, Nord K, Powell M, Slominski, Hasty KA “Vitamin D Analogue For The Inhibition Of Matrix Metalloproteinases (MMPs) In Treatment Of Osteoarthritis” Poster Presentation, Orthopaedic Research Society(ORS) 2015
  12. Cho H, Hasty KA “Targeted nanosomes for osteoarthritis in PTOA mouse model” Oral Presentation, Society for Biomaterials (SFB): Biomaterials Day 2015 at Vanderbilt University
  13. Yi AK, Yoon TW, Cho H, Brand DD, Kim YI, Park JE, Hasty KA, Stuart JM. “Contribution of MyD88-dependent PKD1 on development of experimental arthritis”. Keystone Symposia, Mechanisms of Pro-inflammatory diseases (Z4). Abstract# 3037. April 19-24, 2015
  14. Yi AK, Yoon TW, Cho H, Brand DD, Kim YI, Park JE, Hasty KA, Stuart JM. “Contribution of MyD88-dependent PKD1 to the development of arthritis”. American Association of Immunology Annual Conference Immunology. Abstract # THER2P.954. (Selected for oral presentation in Block symposium “Conceptual Therapeutics in Autoimmunity, A Therapeutic Update in Autoimmunity”). 2015
  15. Yoon TW, Cho H, Brand D, Kim YI, Park JE, Hasty KA, Stuart JM, Yi AK. “Contribution of protein kinase D1 and a pharmacological protein kinase D inhibitor Go6976 on development and progression of experimental arthritis”. Seventh Annual Pediatric Research Day. Abstract #PRD778. (Received outstanding poster award) 2014
  16. Hicks A., Nord K., Powell M., Slominski A., Hasty K.A.*, Cho H.* “Unique Vitamin D Analogue for the Inhibition of NFκB in Treatment of Osteoarthritis” American Medical Association (AMA) Research Symposium 2014
  17. Cho H, Kim BJ, Park SH, Hasty KA, Min BH “Early Detection of Osteoarthritis (OA) Using Smart Nanosome in DMM mouse model” Poster Presentation, Tissue Engineering and Regenerative Medicine International Society-Asia Pacific Meeting (TERMIS-AP) 2014
  18. Brand D, Rosloniec E, Sandal I, Luo J, Cho H, Anderson R, Radic M, Karydis A. “Optimization of Mouse Model for the Study of Periodontal Infections and Autoimmune ArthritisPoster Presentation, The American Society for Microbiology (3rd ASM Conference on Viral Manipulation of Nuclear Processes) 2014

19.  Cho H, Kim BJ, Hasty KA, Min BH “Early Detection of Damaged Cartilage in DMM Mouse Using Nanosomes” Poster Presentation, Orthopaedic Research Society (ORS 60th) 2014

  1. Cho H, Hasty, KAStudy of Osteoarthritis with targeted nanosomes and treatment with Anti-inflammatory drugs” Poster Presentation, Korean Tissue Eng and Regenerative Medicine Society (KTERMS 15th) 2013
  2. Cho H, Williams J, Walker A, Berry D, Hasty, KANon-invasive detection of PTOA using targeted nanosomes in a mechanically loaded mouse model” Poster Presentation, Orthopaedic Research Society (ORS 59th) 2013
  3. Cho H, Walker A, Williams J, Hasty, KADownregulation of Matrix Metalloproteinase-1 in Chondrocytes with Anti-inflammatory drugs: NSAIDs and Steroids” Poster Presentation, Orthopaedic Research Society (ORS 59th) 2013
  4. Cho H, Tidwell WJ, Aiken JW, Kang M, Pinkhassik E, Stuart JM, Hasty, KACharacterization of Targeted Nanosomes to Detect Damaged Cartilage” Selected Podium Presentation, Orthopaedic Research Society (ORS 58th) 2012
  5. Cho H, Pinkhassik E, Stuart JM, Hasty KA “Theranostic Nanosomes Detection and Treatment of Early Osteoarthritis and Cartilage Damage” Poster presentation, ACR 2011   
  6. Cho H, Tidwell WJ, Aiken JW, Kang M, Pinkhassik E, Stuart JM, Hasty, KADetection of Osteoarthritis Severity with Targeted Nanosomes” Selected Podium Presentation, Orthopaedic Research Society (ORS 57th) 2011
  7. Cho H, Tidwell WJ, Aiken JW, Kang M, Pinkhassik E, Rosloniec E, Stuart JM, Hasty, KAUse of Targeted Nanosomes to Detect Damaged Cartilage in Collagen Induced Arthritis” Selected Podium Presentation, Orthopaedic Research Society (ORS 57th) 2011
  8. Smith RA, Berry SC, Cho H, Huang J, Hasty KA, “Effects of platelet-rich plasma on pig derived annulus fibrosus chondrocyte” Poster presentation Orthopaedic Research Society (ORS 56th) 2010  

RESEARCH AND OTHER SUPPORT (Grant, etc):

https://www.uthsc.edu/ortho/research/grants-awarded.php

Biomedical Research award (PI: H. Cho                                                      07/01/17-06/30/20

Oxnard Foundation (Direct Fund: total $120,000)                 

• Novel Targeted Therapy in Early Osteoarthritis using Innovative Fluorescent Guided Arthroscopy

  

Scientific Discovery award (#6482, PI: H. Cho)                                              07/01/16-06/30/18

Arthritis Foundation (Direct Fund: total $250,000)                 

• A Novel Method of Detecting and Treating in Early PTOA Using Smart Nanosome  

 

VA MERIT (PI: K. Hasty, Co-PI: H. Cho)                                                         01/01/18-12/31/22

Dept. of VA (Direct Fund: total $650,000)                 

• Immunotargeting of reparative cells and theranostic nanosomes to cartilage lesions

 

VA MERIT (PI: D. Brand, Consultant: H. Cho)                                                04/01/17-03/31/21

Dept. of VA (Direct Fund: total $1,222,969)              

• Elucidating the Mechanisms that link the Shared Epitope, Periodontal Disease and Arthritis

VA MERIT award (PI: K. Hasty, Co-I: H. Cho)                                                01/11/14-01/10/18

Dept. of VA (Direct Fund: total $550,000)                                         

• Targeted therapy for osteoarthritis

 

R01 AR064723-01 (PI: AK Yi, Co-I: H. Cho)                                                   08/01/14-07/30/18

NIH/NIAMS (Direct Fund: total $1,154,000)             

• TLR/IL-1R signaling intermediaries and a target-specific therapeutic for arthritis

Medical Research award (PI: H. Cho)                                                              02/01/15-01/31/17

William and Ella Owens Medical Research Foundation (Direct Fund: total $130,809)                    

• Theranostic Nanosomes for osteoarthritis  

VA Program Project-Project 2                                                                           10/01/12-09/30/16

(Program Director; J. Stuart, Project 2 PI: E Rosloniec, Co-I: H. Cho)       

Department of Veterans Affairs (Direct Fund: total $600,000)                                             

• Program Project for Mechanisms and Treatment of Arthritis.

 

VA Program Project-Scientific Core                                                                  10/01/12-09/30/16

(Program Director; J. Stuart, Scientific Core PI: D Brand, Co-I: H. Cho)    

Department of Veterans Affairs (Direct Fund: total $600,000)                                             

• Program Project for Mechanisms and Treatment of Arthritis.

Innovative Research Grant (PI: AK Yi, Co-I: H Cho)                                        03/01/13-02/28/15      

Arthritis Foundation (Direct Fund: total $200,000)                             

• PKD1 inhibitor as a target therapeutic for arthritis.

    

1R21 AR060408 (PI: K Hasty, Co-I: H Cho                                                    03/01/12-02/28/15     

NIH/NIAMS (Direct Fund: total $250,000)                                        

• Early Detection and Quantification of OA.

      - This grant will develop targeted fluorescent nanosomes to detect and quantitate early OA

        in mouse model.

UTRF Research Grant (PI: K Hasty, Co-I: H Cho)                                                      12/09/13-09/12/14     

University of Tennessee Research Foundation (UTRF) (Direct Fund: total $15,000)                     

• Diagnosis of Cartilage Injury and Early Osteoarthritis by Arthroscopy.

      - This grant will develop fluorescent antibodies for arthroscopy

 

Ruth Kirschstein Nat. Res. Service Award (NRSA) (T-32)

(PD: A.E. Postlethwaite, Recipient: H. Cho)                                                        5/01/09-6/30/10

USPHS (AR 007317-30) (Direct Fund: total $54,000)

   -Training Grant (Recipient)

 

The Clinical and Translational Science Institute (CTSI) Pilot Award

(PI: KAH, Co-I: H. Cho)                                                                                        5/01/09-4/30/11

University of Tennessee Research Foundation/ CTSI (Direct Fund: total $100,000)

• Theragnostic Nanosomes for Detection of Early OA

Postdoctoral Fellowship Award (PI: H. Cho                                                       7/01/07-6/30/09

Arthritis Foundation (Direct Fund: total $100,000)

• Targeting Therapeutic Nanosomes to Damaged Articular Cartilage

 

Part of Research Enhancement Award Program (REAP): Pilot Project

(PD: J. Stuart, Mentor: K. Hasty, PI of Pilot project: H. Cho) ($15,000/year)      10/01/06-9/30/10

VAMC, Department of Veterans Affairs                                                                               

• Program Title: Rheumatic Disease Etiopathogenesis