GEORGE A. COOK, Ph.D., B.S.

Professor
Pharmacology

Office: 318 Crowe Research Building
Tel: (901) 448-6008
gcook@uthsc.edu

Education

  • PostDoc, Oklahoma Medical Research Foundation, OKC, Biochemistry
  • Ph.D., Auburn University, Auburn, AL, Biochemistry
  • B.S., Auburn University, Auburn, AL, Zoology

Publications

  1. Elam, MB, Cowan, GS, Rooney, RJ, Hiler, ML, Yellaturu, CR, Deng, X, Howell, GE, Park, EA, Gerling, IC, Patel, D, Corton, JC, Cagen, LM, Wilcox, HG, Gandhi, M, Bahr, MH, Allan, MC, Wodi, LA, Cook, GA, Hughes, TA, Raghow, R. Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility. Obesity (Silver Spring), 2009.
  2. Lau, KK, Yang, Y, Cook, GA, Wyatt, RJ, Nishimura, H. Control of aquaporin 2 expression in collecting ducts of quail kidneys. Gen Comp Endocrinol, 160 (3), 288-94, 2009.
  3. Yang, Y, Cui, Y, Fan, Z, Cook, GA, Nishimura, H. Two distinct aquaporin-4 cDNAs isolated from medullary cone of quail kidney. Comp Biochem Physiol A Mol Integr Physiol, 147 (1), 84-93, 2007.
  4. Sadana, P, Zhang, Y, Song, S, Cook, GA, Elam, MB, Park, EA. Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms. Mol Cell Endocrinol, 267 (1-2), 6-16, 2007.
  5. Ma, K, Zhang, Y, Elam, MB, Cook, GA, Park, EA. Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator. J Biol Chem, 280 (33), 29525-32, 2005.
  6. He, B, Liu, L, Cook, GA, Grgurevich, S, Jennings, LK, Zhang, XA. Tetraspanin CD82 attenuates cellular morphogenesis through down-regulating integrin alpha6-mediated cell adhesion. J Biol Chem, 280 (5), 3346-54, 2005.
  7. Zhang, Y, Ma, K, Song, S, Elam, MB, Cook, GA, Park, EA. Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha). J Biol Chem, 279 (52), 53963-71, 2004.
  8. Lavrentyev, EN, He, D, Cook, GA. Expression of genes participating in regulation of fatty acid and glucose utilization and energy metabolism in developing rat hearts. Am J Physiol Heart Circ Physiol, 287 (5), H2035-42, 2004.
  9. Song, S, Zhang, Y, Ma, K, Jackson-Hayes, L, Lavrentyev, EN, Cook, GA, Elam, MB, Park, EA. Peroxisomal proliferator activated receptor gamma coactivator (PGC-1alpha) stimulates carnitine palmitoyltransferase I (CPT-Ialpha) through the first intron. Biochim Biophys Acta, 1679 (2), 164-73, 2004.
  10. Lavrentyev, EN, Matta, SG, Cook, GA. Expression of three carnitine palmitoyltransferase-I isoforms in 10 regions of the rat brain during feeding, fasting, and diabetes. Biochem Biophys Res Commun, 315 (1), 174-8, 2004.
  11. Washington, L, Cook, GA, Mansbach, CM. Inhibition of carnitine palmitoyltransferase in the rat small intestine reduces export of triacylglycerol into the lymph. J Lipid Res, 44 (7), 1395-403, 2003.
  12. Jackson-Hayes, L, Song, S, Lavrentyev, EN, Jansen, MS, Hillgartner, FB, Tian, L, Wood, PA, Cook, GA, Park, EA. A thyroid hormone response unit formed between the promoter and first intron of the carnitine palmitoyltransferase-Ialpha gene mediates the liver-specific induction by thyroid hormone. J Biol Chem, 278 (10), 7964-72, 2003.
  13. Cook, GA, Longhurst, CM, Grgurevich, S, Cholera, S, Crossno, JT, Jennings, LK. Identification of CD9 extracellular domains important in regulation of CHO cell adhesion to fibronectin and fibronectin pericellular matrix assembly. Blood, 100 (13), 4502-11, 2002.
  14. Cook, GA, Edwards, TL, Jansen, MS, Bahouth, SW, Wilcox, HG, Park, EA. Differential regulation of carnitine palmitoyltransferase-I gene isoforms (CPT-I alpha and CPT-I beta) in the rat heart. J Mol Cell Cardiol, 33 (2), 317-29, 2001.
  15. Jansen, MS, Cook, GA, Song, S, Park, EA. Thyroid hormone regulates carnitine palmitoyltransferase Ialpha gene expression through elements in the promoter and first intron. J Biol Chem, 275 (45), 34989-97, 2000.
  16. Cook, GA, Wilkinson, DA, Crossno, JT, Raghow, R, Jennings, LK. The tetraspanin CD9 influences the adhesion, spreading, and pericellular fibronectin matrix assembly of Chinese hamster ovary cells on human plasma fibronectin. Exp Cell Res, 251 (2), 356-71, 1999.
  17. Cook, GA, Park, EA. Expression and regulation of carnitine palmitoyltransferase-Ialpha and -Ibeta genes. Am J Med Sci, 318 (1), 43-8, 1999.
  18. Steffen, ML, Harrison, WR, Elder, FF, Cook, GA, Park, EA. Expression of the rat liver carnitine palmitoyltransferase I (CPT-Ialpha) gene is regulated by Sp1 and nuclear factor Y: chromosomal localization and promoter characterization. Biochem J, 340 ( Pt 2), 425-32, 1999.
  19. Park, EA, Cook, GA. Differential regulation in the heart of mitochondrial carnitine palmitoyltransferase-I muscle and liver isoforms. Mol Cell Biochem, 180 (1-2), 27-32, 1998.
  20. Park, EA, Steffen, ML, Song, S, Park, VM, Cook, GA. Cloning and characterization of the promoter for the liver isoform of the rat carnitine palmitoyltransferase I (L-CPT I) gene. Biochem J, 330 ( Pt 1), 217-24, 1998.
  21. Park, EA, Mynatt, RL, Cook, GA, Kashfi, K. Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I. Biochem J, 310 ( Pt 3), 853-8, 1995.
  22. Kashfi, K, Cook, GA. Temperature effects on malonyl-CoA inhibition of carnitine palmitoyltransferase I. Biochim Biophys Acta, 1257 (2), 133-9, 1995.
  23. Kashfi, K, Cagen, L, Cook, GA. Diabetes and proteolysis: effects on carnitine palmitoyltransferase-I and malonyl-CoA binding. Lipids, 30 (5), 383-8, 1995.
  24. Mynatt, RL, Park, EA, Thorngate, FE, Das, HK, Cook, GA. Changes in carnitine palmitoyltransferase-I mRNA abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity. Biochem Biophys Res Commun, 201 (2), 932-7, 1994.
  25. Mynatt, RL, Cook, GA. Modulation of the malonyl-CoA sensitivity of hepatic carnitine palmitoyltransferase (CPT) by phospholipids. Biochem Soc Trans, 22 (2), 113S, 1994.
  26. Mynatt, RL, Greenhaw, JJ, Cook, GA. Cholate extracts of mitochondrial outer membranes increase inhibition by malonyl-CoA of carnitine palmitoyltransferase-I by a mechanism involving phospholipids. Biochem J, 299 ( Pt 3), 761-7, 1994.
  27. Kashfi, K, Mynatt, RL, Cook, GA. Hepatic carnitine palmitoyltransferase-I has two independent inhibitory binding sites for regulation of fatty acid oxidation. Biochim Biophys Acta, 1212 (2), 245-52, 1994.
  28. Cook, GA, Mynatt, RL, Kashfi, K. Yonetani-Theorell analysis of hepatic carnitine palmitoyltransferase-I inhibition indicates two distinct inhibitory binding sites. J Biol Chem, 269 (12), 8803-7, 1994.
  29. Kashfi, K, Cook, GA. Inhibition of carnitine palmitoyltransferase of the hepatic mitochondrial outer membrane (CPT-I) by 2-bromopalmitoyl-CoA. Biochem Soc Trans, 21 (4), 503S, 1993.
  30. Fungwe, TV, Cagen, LM, Cook, GA, Wilcox, HG, Heimberg, M. Dietary cholesterol stimulates hepatic biosynthesis of triglyceride and reduces oxidation of fatty acids in the rat. J Lipid Res, 34 (6), 933-41, 1993.
  31. Cook, GA, Lappi, MD. Carnitine palmitoyltransferase in the heart is controlled by a different mechanism than the hepatic enzyme. Mol Cell Biochem, 116 (1-2), 39-45, 1992.
  32. Mynatt, RL, Lappi, MD, Cook, GA. Myocardial carnitine palmitoyltransferase of the mitochondrial outer membrane is not altered by fasting. Biochim Biophys Acta, 1128 (1), 105-11, 1992.
  33. Kashfi, K, Cook, GA. Proteinase treatment of intact hepatic mitochondria has differential effects on inhibition of carnitine palmitoyltransferase by different inhibitors. Biochem J, 282 ( Pt 3), 909-14, 1992.
  34. Kang, ES, Lee, HJ, Boulet, J, Myers, LK, Cook, GA, Bean, W. Potential for hepatic and renal dysfunction during influenza B infection, convalescence, and after induction of secondary viremia. J Exp Pathol, 6 (1-2), 133-44, 1992.
  35. Kashfi, K, Cook, GA. Malonyl-CoA inhibits proteolysis of carnitine palmitoyltransferase. Biochem Biophys Res Commun, 178 (2), 600-5, 1991.
  36. Kang, ES, Galloway, MS, Bean, W, Cook, GA, Olson, G. Acute alterations in the regulation of lipid metabolism after intravascular reexposure to a single bolus of homologous virus during influenza B infection in ferrets: possible model of epiphenomena associated with influenza. Int J Exp Pathol, 72 (3), 319-27, 1991.
  37. Kashfi, K, Dory, L, Cook, GA. Effects of cholesterol loading of mouse macrophages on carnitine palmitoyltransferase activity and sensitivity to inhibition by malonyl-CoA. Biochem Biophys Res Commun, 177 (3), 1121-6, 1991.
  38. Kashfi, K, Israel, M, Sweatman, TW, Seshadri, R, Cook, GA. Inhibition of mitochondrial carnitine palmitoyltransferases by adriamycin and adriamycin analogues. Biochem Pharmacol, 40 (7), 1441-8, 1990.
  39. Cook, GA, Weakley, LJ. Effects of starvation on the carnitine palmitoyltransferase of hepatic peroxisomes. Biochem Soc Trans, 18 (5), 988, 1990.
  40. Olubadewo, JO, Cook, GA, Heimberg, M. Effects of 8-N,N-diethylamino-octyl-3,4,5-trimethoxybenzoate (TMB-8) HCl and verapamil on the metabolism of free fatty acid by hepatocytes. Biochem Pharmacol, 37 (8), 1463-71, 1988.
  41. Cook, GA, Khan, B, Heimberg, M. Feeding of lovastatin to rats increases the activity of the hepatic mitochondrial outer carnitine palmitoyltransferase. Biochem Biophys Res Commun, 150 (3), 1077-82, 1988.