CHEN, GUOYUN

Assistant Professor
Pediatrics-Research

Office: 304R LE BONHEUR RESEARCH CENTER
50 NORTH DUNLAP STREET
MEMPHIS TN 381032893
Tel: (901) 287-6883
gchen14@uthsc.edu

Education

  • Ph.D., Nagoya University School of Medicine, Japan
  • M.S., Nanchang University, China
  • M.D., Nanchang University, China

Research Interest/Specialty

My laboratory is currently interested in dissecting the molecular and cellular mechanisms associated with the development of sepsis. We are taking molecular, cellular, and genetic approaches to elucidate these mechanisms with the goal of developing novel therapeutic approaches for septic shock and improving outcomes of patients with severe sepsis.

Postdoctoral fellow positions are available. We are seeking candidates who are self-motivated and career-oriented. A strong background in molecular and cellular biology is essential. Experience with mouse model analysis is desirable.

 

 

Publications

1.     Wu, Y, Lan, C, Ren, D, Chen, GY. Induction of Siglec-1 by Endotoxin Tolerance Suppresses the Innate Immune Response by Promoting TGF-β1 Production. J Biol Chem, 291 (23), 12370-82, 2016.

2.     Wu Y, Ren D, Chen GY. Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis. J Immunol, 197 (8), 3336-3347, 2016.

3.     Chen, GY, Brown, NK, Zheng, P, Liu, Y. Siglec-G/10 in self-nonself discrimination of innate and adaptive immunity. Glycobiology, 24 (9), 800-6, 2014.

4.     Chen, GY, Brown, NK, Wu, W, Khedri, Z, Yu, H, Chen, X, van de Vlekkert, D, D''Azzo, A, Zheng, P, Liu, Y. Broad and direct interaction between TLR and Siglec families of pattern recognition receptors and its regulation by Neu1. Elife, 3, e04066, 2014.

5.     Wang, L, Liu, R, Ye, P, Wong, C, Chen, GY, Zhou, P, Sakabe, K, Zheng, X, Wu, W, Zhang, P, Jiang, T, Bassetti, MF, Jube, S, Sun, Y, Zhang, Y, Zheng, P, Liu, Y. Intracellular CD24 disrupts the ARF-NPM interaction and enables mutational and viral oncogene-mediated p53 inactivation. Nat Commun, 6, 5909, 2014.

6.     Sakuma, K, Chen, GY, Aoki, M, Kannagi, R. Induction of 6-sulfated glycans with cell adhesion activity via T-bet and GATA-3 in human helper T cells. Biochim Biophys Acta, 1820 (7), 841-8, 2012.

7.     Kannagi, R, Ohmori, K, Chen, GY, Miyazaki, K, Izawa, M, Sakuma, K. Sialylated and sulfated carbohydrate ligands for selectins and siglecs: involvement in traffic and homing of human memory T and B lymphocytes. Adv Exp Med Biol, 705, 549-69, 2011.

8.     Chen, GY, Chen, X, King, S, Cavassani, KA, Cheng, J, Zheng, X, Cao, H, Yu, H, Qu, J, Fang, D, Wu, W, Bai, XF, Liu, JQ, Woodiga, SA, Chen, C, Sun, L, Hogaboam, CM, Kunkel, SL, Zheng, P, Liu, Y. Amelioration of sepsis by inhibiting sialidase-mediated disruption of the CD24-SiglecG interaction. Nat Biotechnol, 29 (5), 428-35, 2011.

9.     Liu, Y, Chen, GY, Zheng, P. Sialoside-based pattern recognitions discriminating infections from tissue injuries. Curr Opin Immunol, 23 (1), 41-5, 2011.

10.   Liu, Y, Chen, GY, Zheng, P. CD24-Siglec G/10 discriminates danger- from pathogen-associated molecular patterns. Trends Immunol, 30 (12), 557-61, 2009.

11.   Wang, L, Liu, R, Li, W, Chen, C, Katoh, H, Chen, GY, McNally, B, Lin, L, Zhou, P, Zuo, T, Cooney, KA, Liu, Y, Zheng, P. Somatic single hits inactivate the X-linked tumor suppressor FOXP3 in the prostate. Cancer Cell, 16 (4), 336-46, 2009.

12.   Li, D, Zheng, L, Jin, L, Zhou, Y, Li, H, Fu, J, Shi, M, Du, P, Wang, L, Wu, H, Chen, GY, Zheng, P, Liu, Y, Wang, FS, Wang, S. CD24 polymorphisms affect risk and progression of chronic hepatitis B virus infection. Hepatology, 50 (3), 735-42, 2009.

13.   Chen, GY, Tang, J, Zheng, P, Liu, Y. CD24 and Siglec-10 selectively repress tissue damage-induced immune responses. Science, 323 (5922), 1722-5, 2009.

14.   Chen, GY, Sakuma, K, Kannagi, R. Significance of NF-kappaB/GATA axis in tumor necrosis factor-alpha-induced expression of 6-sulfated cell recognition glycans in human T-lymphocytes. J Biol Chem, 283 (50), 34563-70, 2008.

15.   Kannagi, R, Chen, GY, Sakuma, K, Ohmori, K. [Transcriptional regulation of selectin ligand expression in human leukocytes].Tanpakushitsu Kakusan Koso, 53 (12 Suppl), 1525-32, 2008.

16.   Chen, GY, Chen, C, Wang, L, Chang, X, Zheng, P, Liu, Y. Cutting edge: Broad expression of the FoxP3 locus in epithelial cells: a caution against early interpretation of fatal inflammatory diseases following in vivo depletion of FoxP3-expressing cells.   J Immunol, 180 (8), 5163-6, 2008.

17.   Chen, GY, Osada, H, Santamaria-Babi, LF, Kannagi, R. Interaction of GATA-3/T-bet transcription factors regulates expression of sialyl Lewis X homing receptors on Th1/Th2 lymphocytes. Proc Natl Acad Sci USA, 103 (45), 16894-9, 2006.

18.   Yin, J, Hashimoto, A, Izawa, M, Miyazaki, K, Chen, GY, Takematsu, H, Kozutsumi, Y, Suzuki, A, Furuhata, K, Cheng, FL, Lin, CH, Sato, C, Kitajima, K, Kannagi, R. Hypoxic culture induces expression of sialin, a sialic acid transporter, and cancer-associated gangliosides containing non-human sialic acid on human cancer cells. Cancer Res, 66 (6), 2937-45, 2006.

19.   Chen, GY, Muramatsu, H, Kondo, M, Kurosawa, N, Miyake, Y, Takeda, N, Muramatsu, T. Abnormalities caused by carbohydrate alterations in Ibeta6-N-acetylglucosaminyltransferase-deficient mice. Mol Cell Biol, 25 (17), 7828-38, 2005.

20.   Muramatsu, H, Zou, P, Suzuki, H, Oda, Y, Chen, GY, Sakaguchi, N, Sakuma, S, Maeda, N, Noda, M, Takada, Y, Muramatsu, T. alpha4beta1- and alpha6beta1-integrins are functional receptors for midkine, a heparin-binding growth factor. J Cell Sci, 117 (Pt 22), 5405-15, 2004.

21.   Chen, GY, Muramatsu, H, Ichihara-Tanaka, K, Muramatsu, T. ZEC, a zinc finger protein with novel binding specificity and transcription regulatory activity. Gene, 340 (1), 71-81, 2004.

22.   Chen, GY, Muramatsu, H, Ichihara-Tanaka, K, Muramatsu, T. Expression profile of mouse BWF1, a protein with a BEACH domain, WD40 domain and FYVE domain. Cell Struct Funct, 29 (2), 35-42, 2004.