ELAINE I. TUOMANEN, M.D.

Professor
Preventive Medicine
 
Professor
Pediatrics

Office:
Tel: n/a
etuomane@uthsc.edu

Education

  • M.D., McGill University, Montreal, Canada, Medicine
  • B.S., McGill University, Montreal, Canada, Biochemistry

Research description

Molecular pathogenesis of Streptococcus invasion and inflammation.

Research description

Molecular pathogenesis of Streptococcus invasion and inflammation.

Publications

  1. El Kasmi, KC, Qualls, JE, Pesce, JT, Smith, AM, Thompson, RW, Henao-Tamayo, M, Basaraba, RJ, König, T, Schleicher, U, Koo, MS, Kaplan, G, Fitzgerald, KA, Tuomanen, EI, Orme, IM, Kanneganti, TD, Bogdan, C, Wynn, TA, Murray, PJ. Toll-like receptor-induced arginase 1 in macrophages thwarts effective immunity against intracellular pathogens. Nat Immunol, 9 (12), 1399-406, 2008.
  2. Rosch, JW, Sublett, J, Gao, G, Wang, YD, Tuomanen, EI. Calcium efflux is essential for bacterial survival in the eukaryotic host. Mol Microbiol, 2008.
  3. Leary, PJ, Rajasekaran, S, Morrison, RR, Tuomanen, EI, Chin, TK, Hofmann, PA. A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation. Am J Physiol Heart Circ Physiol, 294 (6), H2775-84, 2008.
  4. Caniza, MA, Maron, G, McCullers, J, Clara, WA, Cedillos, R, Dueñas, L, Arnold, S, Williams, BF, Tuomanen, EI. Planning and implementation of an infection control training program for healthcare providers in Latin America. Infect Control Hosp Epidemiol, 28 (12), 1328-33, 2007.
  5. Obert, CA, Gao, G, Sublett, J, Tuomanen, EI, Orihuela, CJ. Assessment of molecular typing methods to determine invasiveness and to differentiate clones of Streptococcus pneumoniae. Infect Genet Evol, 7 (6), 708-16, 2007.
  6. Obert, CA, Miller, ML, Montgomery, J, Adamkiewicz, T, Tuomanen, EI. Quinupristin-dalfopristin nonsusceptibility in pneumococci from sickle cell disease patients. Antimicrob Agents Chemother, 51 (1), 386-9, 2007.
  7. Fillon, S, Soulis, K, Rajasekaran, S, Benedict-Hamilton, H, Radin, JN, Orihuela, CJ, El Kasmi, KC, Murti, G, Kaushal, D, Gaber, MW, Weber, JR, Murray, PJ, Tuomanen, EI. Platelet-activating factor receptor and innate immunity: uptake of gram-positive bacterial cell wall into host cells and cell-specific pathophysiology. J Immunol, 177 (9), 6182-91, 2006.
  8. Obert, C, Sublett, J, Kaushal, D, Hinojosa, E, Barton, T, Tuomanen, EI, Orihuela, CJ. Identification of a Candidate Streptococcus pneumoniae core genome and regions of diversity correlated with invasive pneumococcal disease. Infect Immun, 74 (8), 4766-77, 2006.
  9. Orihuela, CJ, Fillon, S, Smith-Sielicki, SH, El Kasmi, KC, Gao, G, Soulis, K, Patil, A, Murray, PJ, Tuomanen, EI. Cell wall-mediated neuronal damage in early sepsis. Infect Immun, 74 (7), 3783-9, 2006.
  10. Radin, JN, Orihuela, CJ, Murti, G, Guglielmo, C, Murray, PJ, Tuomanen, EI. beta-Arrestin 1 participates in platelet-activating factor receptor-mediated endocytosis of Streptococcus pneumoniae. Infect Immun, 73 (12), 7827-35, 2005.
  11. Haas, W, Kaushal, D, Sublett, J, Obert, C, Tuomanen, EI. Vancomycin stress response in a sensitive and a tolerant strain of Streptococcus pneumoniae. J Bacteriol, 187 (23), 8205-10, 2005.
  12. Haas, W, Sublett, J, Kaushal, D, Tuomanen, EI. Revising the role of the pneumococcal vex-vncRS locus in vancomycin tolerance. J Bacteriol, 186 (24), 8463-71, 2004.
  13. Mitchell, L, Smith, SH, Braun, JS, Herzog, KH, Weber, JR, Tuomanen, EI. Dual phases of apoptosis in pneumococcal meningitis. J Infect Dis, 190 (11), 2039-46, 2004.
  14. Orihuela, CJ, Gao, G, Francis, KP, Yu, J, Tuomanen, EI. Tissue-specific contributions of pneumococcal virulence factors to pathogenesis. J Infect Dis, 190 (9), 1661-9, 2004.
  15. Rodriguez, CA, Atkinson, R, Bitar, W, Whitney, CG, Edwards, KM, Mitchell, L, Li, J, Sublett, J, Li, CS, Liu, T, Chesney, PJ, Tuomanen, EI. Tolerance to vancomycin in pneumococci: detection with a molecular marker and assessment of clinical impact. J Infect Dis, 190 (8), 1481-7, 2004.
  16. Orihuela, CJ, Radin, JN, Sublett, JE, Gao, G, Kaushal, D, Tuomanen, EI. Microarray analysis of pneumococcal gene expression during invasive disease. Infect Immun, 72 (10), 5582-96, 2004.
  17. Zweigner, J, Jackowski, S, Smith, SH, Van Der Merwe, M, Weber, JR, Tuomanen, EI. Bacterial inhibition of phosphatidylcholine synthesis triggers apoptosis in the brain. J Exp Med, 200 (1), 99-106, 2004.
  18. Webby, RJ, Perez, DR, Coleman, JS, Guan, Y, Knight, JH, Govorkova, EA, McClain-Moss, LR, Peiris, JS, Rehg, JE, Tuomanen, EI, Webster, RG. Responsiveness to a pandemic alert: use of reverse genetics for rapid development of influenza vaccines. Lancet, 363 (9415), 1099-103, 2004.
  19. Mitchell, LS, Tuomanen, EI. Molecular analysis of antibiotic tolerance in pneumococci. Int J Med Microbiol, 292 (2), 75-9, 2002.
  20. Braun, JS, Sublett, JE, Freyer, D, Mitchell, TJ, Cleveland, JL, Tuomanen, EI, Weber, JR. Pneumococcal pneumolysin and H(2)O(2) mediate brain cell apoptosis during meningitis. J Clin Invest, 109 (1), 19-27, 2002.
  21. Braun, JS, Novak, R, Murray, PJ, Eischen, CM, Susin, SA, Kroemer, G, Halle, A, Weber, JR, Tuomanen, EI, Cleveland, JL. Apoptosis-inducing factor mediates microglial and neuronal apoptosis caused by pneumococcus. J Infect Dis, 184 (10), 1300-9, 2001.
  22. McCullers, JA, Tuomanen, EI. Molecular pathogenesis of pneumococcal pneumonia. Front Biosci, 6, D877-89, 2001.
  23. Tuomanen, EI. Pathogenesis of pneumococcal inflammation: otitis media. Vaccine, 19 Suppl 1, S38-40, 2000.
  24. Gosink, KK, Mann, ER, Guglielmo, C, Tuomanen, EI, Masure, HR. Role of novel choline binding proteins in virulence of Streptococcus pneumoniae. Infect Immun, 68 (10), 5690-5, 2000.
  25. Braun, JS, Tuomanen, EI, Cleveland, JL. Neuroprotection by caspase inhibitors. Expert Opin Investig Drugs, 8 (10), 1599-1610, 1999.
  26. Braun, JS, Tuomanen, EI. Molecular mechanisms of brain damage in bacterial meningitis. Adv Pediatr Infect Dis, 14, 49-71, 1999.
  27. Braun, JS, Novak, R, Herzog, KH, Bodner, SM, Cleveland, JL, Tuomanen, EI. Neuroprotection by a caspase inhibitor in acute bacterial meningitis. Nat Med, 5 (3), 298-302, 1999.
  28. Zhang, JR, Idanpaan-Heikkila, I, Fischer, W, Tuomanen, EI. Pneumococcal licD2 gene is involved in phosphorylcholine metabolism. Mol Microbiol, 31 (5), 1477-88, 1999.
  29. Ring, A, Weiser, JN, Tuomanen, EI. Pneumococcal trafficking across the blood-brain barrier. Molecular analysis of a novel bidirectional pathway. J Clin Invest, 102 (2), 347-60, 1998.
  30. Tuomanen, EI. The biology of pneumococcal infection. Pediatr Res, 42 (3), 253-8, 1997.