EDWARDS A. PARK, Ph.D., B.A.

Professor
Pharmacology

Office: 207 TRANSLATIONAL RESEARCH BUILDING
71 SOUTH MANASSAS
MEMPHIS TN 381630000
Tel: (901) 448-4779
epark@uthsc.edu

Education

  • PostDoc, Case Western Reserve University, Cleveland OH, Biochemistry
  • Ph.D., Pennsylvania State University, Hershey, PA, Physiology
  • B.A., Duke University, Durham, NC, History

Publications

  1. Yellaturu, CR, Deng, X, Cagen, LM, Wilcox, HG, Mansbach, CM, Siddiqi, SA, Park, EA, Raghow, R, Elam, MB. Insulin Enhances Post-translational Processing of Nascent SREBP-1c by Promoting Its Phosphorylation and Association with COPII Vesicles. J Biol Chem, 284 (12), 7518-32, 2009.
  2. Elam, MB, Cowan, GS, Rooney, RJ, Hiler, ML, Yellaturu, CR, Deng, X, Howell, GE, Park, EA, Gerling, IC, Patel, D, Corton, JC, Cagen, LM, Wilcox, HG, Gandhi, M, Bahr, MH, Allan, MC, Wodi, LA, Cook, GA, Hughes, TA, Raghow, R. Hepatic Gene Expression in Morbidly Obese Women: Implications for Disease Susceptibility. Obesity (Silver Spring), 2009.
  3. Parker, MS, Sah, R, Park, EA, Sweatman, T, Balasubramaniam, A, Sallee, FR, Parker, SL. Oligomerization of the heptahelical g protein coupling receptors: a case for association using transmembrane helices. Mini Rev Med Chem, 9 (3), 329-39, 2009.
  4. Parker, MS, Sah, R, Balasubramaniam, A, Sallee, FR, Sweatman, T, Park, EA, Parker, SL. Dimers of the neuropeptide Y (NPY) Y2 receptor show asymmetry in agonist affinity and association with G proteins. J Recept Signal Transduct Res, 28 (5), 437-51, 2008.
  5. Parker, SL, Parker, MS, Estes, AM, Wong, YY, Sah, R, Sweatman, T, Park, EA, Balasubramaniam, A, Sallee, FR. The neuropeptide Y (NPY) Y2 receptors are largely dimeric in the kidney, but monomeric in the forebrain. J Recept Signal Transduct Res, 28 (3), 245-63, 2008.
  6. Raghow, R, Yellaturu, C, Deng, X, Park, EA, Elam, MB. SREBPs: the crossroads of physiological and pathological lipid homeostasis. Trends Endocrinol Metab, 19 (2), 65-73, 2008.
  7. Deng, X, Yellaturu, C, Cagen, L, Wilcox, HG, Park, EA, Raghow, R, Elam, MB. Expression of the rat sterol regulatory element-binding protein-1c gene in response to insulin is mediated by increased transactivating capacity of specificity protein 1 (Sp1). J Biol Chem, 282 (24), 17517-29, 2007.
  8. Sadana, P, Park, EA. Characterization of the transactivation domain in the peroxisome-proliferator-activated receptor gamma co-activator (PGC-1). Biochem J, 403 (3), 511-8, 2007.
  9. Sadana, P, Zhang, Y, Song, S, Cook, GA, Elam, MB, Park, EA. Regulation of carnitine palmitoyltransferase I (CPT-Ialpha) gene expression by the peroxisome proliferator activated receptor gamma coactivator (PGC-1) isoforms. Mol Cell Endocrinol, 267 (1-2), 6-16, 2007.
  10. Zhang, Y, Ma, K, Sadana, P, Chowdhury, F, Gaillard, S, Wang, F, McDonnell, DP, Unterman, TG, Elam, MB, Park, EA. Estrogen-related receptors stimulate pyruvate dehydrogenase kinase isoform 4 gene expression. J Biol Chem, 281 (52), 39897-906, 2006.
  11. Ma, K, Zhang, Y, Elam, MB, Cook, GA, Park, EA. Cloning of the rat pyruvate dehydrogenase kinase 4 gene promoter: activation of pyruvate dehydrogenase kinase 4 by the peroxisome proliferator-activated receptor gamma coactivator. J Biol Chem, 280 (33), 29525-32, 2005.
  12. Yellaturu, CR, Deng, X, Cagen, LM, Wilcox, HG, Park, EA, Raghow, R, Elam, MB. Posttranslational processing of SREBP-1 in rat hepatocytes is regulated by insulin and cAMP. Biochem Biophys Res Commun, 332 (1), 174-80, 2005.
  13. Cagen, LM, Deng, X, Wilcox, HG, Park, EA, Raghow, R, Elam, MB. Insulin activates the rat sterol-regulatory-element-binding protein 1c (SREBP-1c) promoter through the combinatorial actions of SREBP, LXR, Sp-1 and NF-Y cis-acting elements. Biochem J, 385 (Pt 1), 207-16, 2005.
  14. Zhang, Y, Ma, K, Song, S, Elam, MB, Cook, GA, Park, EA. Peroxisomal proliferator-activated receptor-gamma coactivator-1 alpha (PGC-1 alpha) enhances the thyroid hormone induction of carnitine palmitoyltransferase I (CPT-I alpha). J Biol Chem, 279 (52), 53963-71, 2004.
  15. Deng, X, Elam, MB, Wilcox, HG, Cagen, LM, Park, EA, Raghow, R, Patel, D, Kumar, P, Sheybani, A, Russell, JC. Dietary olive oil and menhaden oil mitigate induction of lipogenesis in hyperinsulinemic corpulent JCR:LA-cp rats: microarray analysis of lipid-related gene expression. Endocrinology, 145 (12), 5847-61, 2004.
  16. Song, S, Zhang, Y, Ma, K, Jackson-Hayes, L, Lavrentyev, EN, Cook, GA, Elam, MB, Park, EA. Peroxisomal proliferator activated receptor gamma coactivator (PGC-1alpha) stimulates carnitine palmitoyltransferase I (CPT-Ialpha) through the first intron. Biochim Biophys Acta, 1679 (2), 164-73, 2004.
  17. Jackson-Hayes, L, Song, S, Lavrentyev, EN, Jansen, MS, Hillgartner, FB, Tian, L, Wood, PA, Cook, GA, Park, EA. A thyroid hormone response unit formed between the promoter and first intron of the carnitine palmitoyltransferase-Ialpha gene mediates the liver-specific induction by thyroid hormone. J Biol Chem, 278 (10), 7964-72, 2003.
  18. Jurado, LA, Song, S, Roesler, WJ, Park, EA. Conserved amino acids within CCAAT enhancer-binding proteins (C/EBP(alpha) and beta) regulate phosphoenolpyruvate carboxykinase (PEPCK) gene expression. J Biol Chem, 277 (31), 27606-12, 2002.
  19. Deng, X, Cagen, LM, Wilcox, HG, Park, EA, Raghow, R, Elam, MB. Regulation of the rat SREBP-1c promoter in primary rat hepatocytes. Biochem Biophys Res Commun, 290 (1), 256-62, 2002.
  20. Cook, GA, Edwards, TL, Jansen, MS, Bahouth, SW, Wilcox, HG, Park, EA. Differential regulation of carnitine palmitoyltransferase-I gene isoforms (CPT-I alpha and CPT-I beta) in the rat heart. J Mol Cell Cardiol, 33 (2), 317-29, 2001.
  21. Jansen, MS, Cook, GA, Song, S, Park, EA. Thyroid hormone regulates carnitine palmitoyltransferase Ialpha gene expression through elements in the promoter and first intron. J Biol Chem, 275 (45), 34989-97, 2000.
  22. Cook, GA, Park, EA. Expression and regulation of carnitine palmitoyltransferase-Ialpha and -Ibeta genes. Am J Med Sci, 318 (1), 43-8, 1999.
  23. Steffen, ML, Harrison, WR, Elder, FF, Cook, GA, Park, EA. Expression of the rat liver carnitine palmitoyltransferase I (CPT-Ialpha) gene is regulated by Sp1 and nuclear factor Y: chromosomal localization and promoter characterization. Biochem J, 340 ( Pt 2), 425-32, 1999.
  24. Park, EA, Song, S, Vinson, C, Roesler, WJ. Role of CCAAT enhancer-binding protein beta in the thyroid hormone and cAMP induction of phosphoenolpyruvate carboxykinase gene transcription. J Biol Chem, 274 (1), 211-7, 1999.
  25. Park, EA, Cook, GA. Differential regulation in the heart of mitochondrial carnitine palmitoyltransferase-I muscle and liver isoforms. Mol Cell Biochem, 180 (1-2), 27-32, 1998.
  26. Park, EA, Steffen, ML, Song, S, Park, VM, Cook, GA. Cloning and characterization of the promoter for the liver isoform of the rat carnitine palmitoyltransferase I (L-CPT I) gene. Biochem J, 330 ( Pt 1), 217-24, 1998.
  27. Bahouth, SW, Beauchamp, MJ, Park, EA. Identification of a retinoic acid response domain involved in the activation of the beta 1-adrenergic receptor gene by retinoic acid in F9 teratocarcinoma cells. Biochem Pharmacol, 55 (2), 215-25, 1998.
  28. Bahouth, SW, Cui, X, Beauchamp, MJ, Park, EA. Thyroid hormone induces beta1-adrenergic receptor gene transcription through a direct repeat separated by five nucleotides. J Mol Cell Cardiol, 29 (12), 3223-37, 1997.
  29. Bahouth, SW, Cui, X, Beauchamp, MJ, Shimomura, H, George, ST, Park, EA. Promoter analysis of the rat beta1-adrenergic receptor gene identifies sequences involved in basal expression. Mol Pharmacol, 51 (4), 620-9, 1997.
  30. Park, EA, Song, S, Olive, M, Roesler, WJ. CCAAT-enhancer-binding protein alpha (C/EBP alpha) is required for the thyroid hormone but not the retinoic acid induction of phosphoenolpyruvate carboxykinase (PEPCK) gene transcription. Biochem J, 322 ( Pt 1), 343-9, 1997.
  31. Bahouth, SW, Park, EA, Beauchamp, M, Cui, X, Malbon, CC. Identification of a glucocorticoid repressor domain in the rat beta 1-adrenergic receptor gene. Recept Signal Transduct, 6 (3-4), 141-9, 1996.
  32. Park, EA, Mynatt, RL, Cook, GA, Kashfi, K. Insulin regulates enzyme activity, malonyl-CoA sensitivity and mRNA abundance of hepatic carnitine palmitoyltransferase-I. Biochem J, 310 ( Pt 3), 853-8, 1995.
  33. Park, EA, Jerden, DC, Bahouth, SW. Regulation of phosphoenolpyruvate carboxykinase gene transcription by thyroid hormone involves two distinct binding sites in the promoter. Biochem J, 309 ( Pt 3), 913-9, 1995.
  34. Mynatt, RL, Park, EA, Thorngate, FE, Das, HK, Cook, GA. Changes in carnitine palmitoyltransferase-I mRNA abundance produced by hyperthyroidism and hypothyroidism parallel changes in activity. Biochem Biophys Res Commun, 201 (2), 932-7, 1994.