EDWARD CHAUM, M.D., Ph.D.

Plough Foundation Professor of Ophthalmology
Professor Pediatrics
Professor Anatomy and Neurobiology
Professor Biomedical Engineering

Office: Ste 731 930 Madison Building
Tel: (901) 448-3638
echaum@uthsc.edu

Education

  • M.D., Cornell University Medical College, Medicine
  • Ph.D., Cornell Graduate School of Medical Sciences, Cell Biology and Genetics
  • B.A., John Hopkins University, Baltimore, MD, Natural Sciences

Research interest/specialty

Automated screening for diabetic retinopathy by content
Molecular biology of oxidative stress responses in the retina
Electrochemical biosensors
Nanotechnology applications in Ophthalmology
Translational medicine

Research keywords

Telemedicine, oxidative stress, gene expression, nanotechnology, biosensors, electrochemistry, retinal pigment epithelium, retina, transcription factors, age-related macular degeneration, diabetic retinopathy, diabetes, trauma

Research interest/specialty

Automated screening for diabetic retinopathy by content Molecular biology of oxidative stress responses in the retina Electrochemical biosensors Nanotechnology applications in Ophthalmology Translational medicine

Research keywords

Telemedicine, oxidative stress, gene expression, nanotechnology, biosensors, electrochemistry, retinal pigment epithelium, retina, transcription factors, age-related macular degeneration, diabetic retinopathy, diabetes, trauma

Research description

1) Translational research: gene therapy for the treatment of age-related macular degeneration, 2) Tissue Engineering approaches to understanding and modulating aging and injury responses in the eye, 3) Telemedicine and Health Outcomes Assessments: applying new technologies to population-based screening and management of diabetic retinopathy in underserved populations, and 4) Nanotechnology and Biomedical Engineering: applying electrochemical sensors, novel biomaterials, and nanotechnology to improve clinical medicine and surgery.

Publications

  1. Hines-Beard, J, Marchetta, J, Gordon, S, Chaum, E, Geisert, EE, Rex, TS. A mouse model of ocular blast injury that induces closed globe anterior and posterior pole damage. Exp Eye Res, 2012.
  2. Giancardo, L, Meriaudeau, F, Karnowski, TP, Li, Y, Garg, S, Tobin, KW, Chaum, E. Exudate-based diabetic macular edema detection in fundus images using publicly available datasets. Med Image Anal, 16 (1), 216-26, 2012.
  3. Devisetti, K, Karnowski, TP, Giancardo, L, Li, Y, Chaum, E. Geographic atrophy segmentation in infrared and autofluorescent retina images using supervised learning. Conf Proc IEEE Eng Med Biol Soc, 2011, 3958-61, 2012.
  4. Giancardo, L, Meriaudeau, F, Karnowski, TP, Li, Y, Tobin, KW, Chaum, E. Microaneurysm detection with radon transform-based classification on retina images. Conf Proc IEEE Eng Med Biol Soc, 2011, 5939-42, 2012.
  5. Karnowski, TP, Aykac, D, Giancardo, L, Li, Y, Nichols, T, Tobin, KW, Chaum, E. Automatic detection of retina disease: robustness to image quality and localization of anatomy structure. Conf Proc IEEE Eng Med Biol Soc, 2011, 5959-64, 2012.
  6. Santos-Villalobos, H, Karnowski, TP, Aykac, D, Giancardo, L, Li, Y, Nichols, T, Tobin, KW, Chaum, E. Statistical characterization and segmentation of drusen in fundus images. Conf Proc IEEE Eng Med Biol Soc, 2011, 6236-41, 2012.
  7. Li, HK, Horton, M, Bursell, SE, Cavallerano, J, Zimmer-Galler, I, Tennant, M, Abramoff, M, Chaum, E, Debuc, DC, Leonard-Martin, T, Winchester, M, , , Lawrence, MG, Bauman, W, Gardner, WK, Hildebran, L, Federman, J. Telehealth practice recommendations for diabetic retinopathy, second edition. Telemed J E Health, 17 (10), 814-37, 2011.
  8. , , de Boer, IH, Sun, W, Cleary, PA, Lachin, JM, Molitch, ME, Steffes, MW, Zinman, B. Intensive diabetes therapy and glomerular filtration rate in type 1 diabetes. N Engl J Med, 365 (25), 2366-76, 2011.
  9. Langmaier, J, Garay, F, Kivlehan, F, Chaum, E, Lindner, E. Electrochemical quantification of 2,6-diisopropylphenol (propofol). Anal Chim Acta, 704 (1-2), 63-7, 2011.
  10. Li, Y, Karnowski, TP, Tobin, KW, Giancardo, L, Morris, S, Sparrow, SE, Garg, S, Fox, K, Chaum, E. A health insurance portability and accountability act-compliant ocular telehealth network for the remote diagnosis and management of diabetic retinopathy. Telemed J E Health, 17 (8), 627-34, 2011.
  11. Yin, J, Thomas, F, Lang, JC, Chaum, E. Modulation of oxidative stress responses in the human retinal pigment epithelium following treatment with vitamin C. J Cell Physiol, 226 (8), 2025-32, 2011.
  12. Gangaputra, S, Almukhtar, T, Glassman, AR, Aiello, LP, Bressler, N, Bressler, SB, Danis, RP, Davis, MD, ,. Comparison of film and digital fundus photographs in eyes of individuals with diabetes mellitus. Invest Ophthalmol Vis Sci, 52 (9), 6168-73, 2011.
  13. Bhattacharya, S, Ray, RM, Chaum, E, Johnson, DA, Johnson, LR. Inhibition of Mdm2 sensitizes human retinal pigment epithelial cells to apoptosis. Invest Ophthalmol Vis Sci, 52 (6), 3368-80, 2011.
  14. Chaum, E, Yin, J, Lang, JC. Molecular responses transduced by serial oxidative stress in the retinal pigment epithelium: feedback control modeling of gene expression. Neurochem Res, 36 (4), 574-82, 2011.
  15. Giancardo, L, Meriaudeau, F, Karnowski, TP, Tobin, KW, Grisan, E, Favaro, P, Ruggeri, A, Chaum, E. Textureless macula swelling detection with multiple retinal fundus images. IEEE Trans Biomed Eng, 58 (3), 795-9, 2011.
  16. de Boer, IH, Rue, TC, Cleary, PA, Lachin, JM, Molitch, ME, Steffes, MW, Sun, W, Zinman, B, Brunzell, JD, , , White, NH, Danis, RP, Davis, MD, Hainsworth, D, Hubbard, LD, Nathan, DM. Long-term renal outcomes of patients with type 1 diabetes mellitus and microalbuminuria: an analysis of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications cohort. Arch Intern Med, 171 (5), 412-20, 2011.
  17. Giddabasappa, A, Bauler, M, Yepuru, M, Chaum, E, Dalton, JT, Eswaraka, J. 17-β estradiol protects ARPE-19 cells from oxidative stress through estrogen receptor-β. Invest Ophthalmol Vis Sci, 51 (10), 5278-87, 2010.
  18. Spentzas, T, Henricksen, J, Patters, AB, Chaum, E. Correlation of intraocular pressure with intracranial pressure in children with severe head injuries. Pediatr Crit Care Med, 11 (5), 593-8, 2010.
  19. Karnowski, TP, Aykac, D, Chaum, E, Giancardo, L, Li, Y, Tobin, KW, Abramoff, MD. Practical considerations for optic nerve location in telemedicine. Conf Proc IEEE Eng Med Biol Soc, 2009, 6205-9, 2009.
  20. Chaum, E, Yin, J, Yang, H, Thomas, F, Lang, JC. Quantitative AP-1 gene regulation by oxidative stress in the human retinal pigment epithelium. J Cell Biochem, 2009.
  21. EDWARD CHAUM, MD, PHD, THOMAS P. KARNOWSKI, MS, V. PRIYA GOVINDASAMY, MS, MOHAMED ABDELRAHMAN, PHD, KENNETH W. TOBIN, PHD. AUTOMATED DIAGNOSIS OF RETINOPATHY BY CONTENT-BASED IMAGE RETRIEVAL. Retina, 10 (28), 1463-1477, 2008.
  22. Tobin, KW, Chaum, E, Govindasamy, VP, Karnowski, TP. Detection of anatomic structures in human retinal imagery. IEEE Trans Med Imaging, 26 (12), 1729-39, 2007.
  23. Tobin, KW, Abdelrahman, M, Chaum, E, Govindasamy, V, Karnowski, TP. A probabilistic framework for content-based diagnosis of retinal disease. Conf Proc IEEE Eng Med Biol Soc, 2007, 6744-7, 2007.
  24. Karnowski, TP, Govindasamy, VP, Tobin, KW, Chaum, E. Locating the optic nerve in retinal images: comparing model-based and Bayesian decision methods. Conf Proc IEEE Eng Med Biol Soc, 1, 4436-9, 2007.
  25. Yang, H, Yang, X, Lang, JC, Chaum, E. Tissue culture methods can strongly induce immediate early gene expression in retinal pigment epithelial cells. J Cell Biochem, 98 (6), 1560-9, 2006.
  26. Chaum, E, Fawzi, A, Chang, TS, Shah, GK. Diagnostic and therapeutic challenges. Retina, 26 (2), 219-22, 2006.
  27. Ashmore, ED, Kerr, NC, Greenwald, MA, Chaum, E. Natural history of acquired retinal oxalosis in a child. J Pediatr Ophthalmol Strabismus, 41 (5), 308-11, 2004.
  28. Martin, AC, Thornton, JD, Liu, J, Wang, X, Zuo, J, Jablonski, MM, Chaum, E, Zindy, F, Skapek, SX. Pathogenesis of persistent hyperplastic primary vitreous in mice lacking the arf tumor suppressor gene. Invest Ophthalmol Vis Sci, 45 (10), 3387-96, 2004.
  29. Yang, H, Chaum, E. A reassessment of insulin-like growth factor binding protein gene expression in the human retinal pigment epithelium. J Cell Biochem, 89 (5), 933-43, 2003.
  30. Chaum, E. Retinal neuroprotection by growth factors: a mechanistic perspective. J Cell Biochem, 88 (1), 57-75, 2003.
  31. Chaum, E, Yang, H. Transgenic expression of IGF-1 modifies the proliferative potential of human retinal pigment epithelial cells. Invest Ophthalmol Vis Sci, 43 (12), 3758-64, 2002.
  32. Chaum, E, Hatton, MP. Gene therapy for genetic and acquired retinal diseases. Surv Ophthalmol, 47 (5), 449-69, 2002.
  33. Chaum, E, Greenwald, MA. Retinochoroidal anastomoses and a choroidal neovascular membrane in a macular exudate following treatment for retinal macroaneurysms. Retina, 22 (3), 363-6, 2002.
  34. Chaum, E, Drewry, RD, Ware, GT, Charles, S. Nerve fiber bundle visual field defect resulting from a giant peripapillary cotton-wool spot. J Neuroophthalmol, 21 (4), 276-7, 2001.
  35. Chaum, E. Comparative analysis of the uptake and expression of plasmid vectors in human ciliary and retinal pigment epithelial cells in vitro. J Cell Biochem, 83 (4), 671-7, 2001.
  36. Chaum, E, Hatton, MP, Stein, G. Polyplex-mediated gene transfer into human retinal pigment epithelial cells in vitro. J Cell Biochem, 76 (1), 153-60, 1999.
  37. Chaum, E, Hatton, MP. Congenital nystagmus associated with multiple congenital anomalies of the extraocular muscles. J Pediatr Ophthalmol Strabismus, 36 (3), 155-7, 1999.
  38. Chaum, E. Proliferative vitreoretinopathy. Int Ophthalmol Clin, 35 (1), 163-73, 1995.
  39. Sakai, K, Kanda, N, Shiloh, Y, Donlon, T, Schreck, R, Shipley, J, Dryja, T, Chaum, E, Chaganti, RS, Latt, S. Molecular and cytologic analysis of DNA amplification in retinoblastoma. Cancer Genet Cytogenet, 17 (2), 95-112, 1985.
  40. Chaum, E, Ellsworth, RM, Abramson, DH, Haik, BG, Kitchin, FD, Chaganti, RS. Cytogenetic analysis of retinoblastoma: evidence for multifocal origin and in vivo gene amplification. Cytogenet Cell Genet, 38 (2), 82-91, 1984.
  41. Chaum, E, Doucette, LA, Ellsworth, RM, Abramson, DH, Haik, BG, Kitchin, FD, Chaganti, RS. Bleomycin-induced chromosome breakage in G2 lymphocytes of retinoblastoma patients. Cytogenet Cell Genet, 38 (2), 152-4, 1984.