DUANE D. MILLER, Ph.D., B.S.

Professor
Pharmaceutical Sciences
 
Professor and Chair
Pharmaceutical Sciences

Office: 435 Pharmacy Building
Tel: (901) 448-6026
dmiller@uthsc.edu

Publications

  1. Lu, Y, Li, CM, Wang, Z, Ross, CR, Chen, J, Dalton, JT, Li, W, Miller, DD. Discovery of 4-substituted methoxybenzoyl-aryl-thiazole as novel anticancer agents: synthesis, biological evaluation, and structure-activity relationships. J Med Chem, 52 (6), 1701-11, 2009.
  2. Zmijewski, MA, Li, W, Zjawiony, JK, Sweatman, TW, Chen, J, Miller, DD, Slominski, AT. Photo-conversion of two epimers (20R and 20S) of pregna-5,7-diene-3beta, 17alpha, 20-triol and their bioactivity in melanoma cells. Steroids, 74 (2), 218-28, 2009.
  3. Ramagiri, S, Ma, F, Kosanam, H, Wang, X, Patil, R, Miller, DD, Geisert, E, Yates, CR. Fast and sensitive liquid chromatography/electrospray mass spectrometry method to study ocular penetration of EDL-155, a novel antitumor agent for retinoblastoma in rats. J Mass Spectrom, 2009.
  4. Mohler, ML, He, Y, Wu, Z, Hwang, DJ, Miller, DD. Recent and emerging anti-diabetes targets. Med Res Rev, 29 (1), 125-95, 2009.
  5. Zmijewski, MA, Li, W, Zjawiony, JK, Sweatman, TW, Chen, J, Miller, DD, Slominski, AT. Synthesis and photo-conversion of androsta- and pregna-5,7-dienes to vitamin D3-like derivatives. Photochem Photobiol Sci, 7 (12), 1570-6, 2008.
  6. DeCuypere, M, Lu, Y, Miller, DD, LeDoux, MS. Regional distribution of tetrahydroisoquinoline derivatives in rodent, human, and Parkinson's disease brain. J Neurochem, 107 (5), 1398-413, 2008.
  7. Zhu, L, Lu, Y, Miller, DD, Mahato, RI. Structural and formulation factors influencing pyridinium lipid-based gene transfer. Bioconjug Chem, 19 (12), 2499-512, 2008.
  8. Narayanan, R, Coss, CC, Yepuru, M, Kearbey, JD, Miller, DD, Dalton, JT. Steroidal androgens and nonsteroidal, tissue-selective androgen receptor modulator, S-22, regulate androgen receptor function through distinct genomic and nongenomic signaling pathways. Mol Endocrinol, 22 (11), 2448-65, 2008.
  9. Kang, GS, Wang, XD, Mohler, ML, Kirichenko, OV, Patil, R, Orr, WE, Miller, DD, Geisert, EE. Effects, in an in-vivo model system, of 1,2,3,4-tetrahydroisoquinoline on glioma. Anticancer Drugs, 19 (9), 859-70, 2008.
  10. DeCuypere, M, Kalabokis, VN, Hao, R, Schroeder, D, Miller, DD, LeDoux, MS. Localization of N-methyl-norsalsolinol within rodent and human brain. J Neurosci Res, 86 (11), 2543-52, 2008.
  11. Li, W, Hwang, DJ, Cremer, D, Joo, H, Kraka, E, Kim, J, Ross, CR, Nguyen, VQ, Dalton, JT, Miller, DD. Structure determination of chiral sulfoxide in diastereomeric bicalutamide derivatives. Chirality, 2008.
  12. Chen, J, Wang, Z, Lu, Y, Dalton, JT, Miller, DD, Li, W. Synthesis and antiproliferative activity of imidazole and imidazoline analogs for melanoma. Bioorg Med Chem Lett, 18 (11), 3183-7, 2008.
  13. Narayanan, R, Mohler, ML, Bohl, CE, Miller, DD, Dalton, JT. Selective androgen receptor modulators in preclinical and clinical development. Nucl Recept Signal, 6, e010, 2008.
  14. Ramagiri, S, Gupte, R, Rakov, I, Yates, CR, Miller, DD. Quantitative chiral analysis of phthaloylglutamic acid and related analogs by a single ratio kinetic method using electrospray ionization and matrix-assisted laser desorption techniques. Rapid Commun Mass Spectrom, 22 (5), 639-46, 2008.
  15. Zhu, L, Ye, Z, Cheng, K, Miller, DD, Mahato, RI. Site-specific delivery of oligonucleotides to hepatocytes after systemic administration. Bioconjug Chem, 19 (1), 290-8, 2008.
  16. Li, W, Lu, Y, Wang, Z, Dalton, JT, Miller, DD. Synthesis and antiproliferative activity of thiazolidine analogs for melanoma. Bioorg Med Chem Lett, 17 (15), 4113-7, 2007.
  17. Kosanam, H, Prakash, PK, Yates, CR, Miller, DD, Ramagiri, S. Rapid screening of doping agents in human urine by vacuum MALDI-linear ion trap mass spectrometry. Anal Chem, 79 (15), 6020-6, 2007.
  18. Deng, W, Shuyu, E, Tsukahara, R, Valentine, WJ, Durgam, G, Gududuru, V, Balazs, L, Manickam, V, Arsura, M, VanMiddlesworth, L, Johnson, LR, Parrill, AL, Miller, DD, Tigyi, G. The lysophosphatidic acid type 2 receptor is required for protection against radiation-induced intestinal injury. Gastroenterology, 132 (5), 1834-51, 2007.
  19. Li, W, Wang, Z, Gududuru, V, Zbytek, B, Slominski, AT, Dalton, JT, Miller, DD. Structure-activity relationship studies of arylthiazolidine amides as selective cytotoxic agents for melanoma. Anticancer Res, 27 (2), 883-8, 2007.
  20. Hwang, DJ, Yang, J, Xu, H, Rakov, IM, Mohler, ML, Dalton, JT, Miller, DD. Arylisothiocyanato selective androgen receptor modulators (SARMs) for prostate cancer. Bioorg Med Chem, 14 (19), 6525-38, 2006.
  21. Mohler, ML, Kang, GS, Hong, SS, Patil, R, Kirichenko, OV, Li, W, Rakov, IM, Geisert, EE, Miller, DD. Discovery of antiglioma activity of biaryl 1,2,3,4-tetrahydroisoquinoline derivatives and conformationally flexible analogues. J Med Chem, 49 (19), 5845-8, 2006.
  22. Patil, R, Li, W, Ross, CR, Kraka, E, Cremer, D, Mohler, ML, Dalton, JT, Miller, DD. Cesium fluoride and tetra-n-butylammonium fluoride mediated 1,4-N-->O shift of disubstituted phenyl ring of a bicalutamide derivative. Tetrahedron Lett, 47 (23), 3941-3944, 2006.
  23. Nair, VA, Mustafa, SM, Mohler, ML, Dalton, JT, Miller, DD. Synthesis of oxazolidinedione derived bicalutamide analogs. Tetrahedron Lett, 47 (23), 3953-3955, 2006.
  24. Nikulin, VI, Rakov, IM, De Los Angeles, JE, Mehta, RC, Boyd, LY, Feller, DR, Miller, DD. 1-Benzyl-1,2,3,4-tetrahydroisoquinoline-6,7-diols as novel affinity and photoaffinity probes for beta-adrenoceptor subtypes. Bioorg Med Chem, 14 (6), 1684-97, 2006.
  25. Durgam, GG, Tsukahara, R, Makarova, N, Walker, MD, Fujiwara, Y, Pigg, KR, Baker, DL, Sardar, VM, Parrill, AL, Tigyi, G, Miller, DD. Synthesis and pharmacological evaluation of second-generation phosphatidic acid derivatives as lysophosphatidic acid receptor ligands. Bioorg Med Chem Lett, 16 (3), 633-40, 2006.
  26. Gududuru, V, Zeng, K, Tsukahara, R, Makarova, N, Fujiwara, Y, Pigg, KR, Baker, DL, Tigyi, G, Miller, DD. Identification of Darmstoff analogs as selective agonists and antagonists of lysophosphatidic acid receptors. Bioorg Med Chem Lett, 16 (2), 451-6, 2006.
  27. Gududuru, V, Hurh, E, Sullivan, J, Dalton, JT, Miller, DD. SAR studies of 2-arylthiazolidine-4-carboxylic acid amides: a novel class of cytotoxic agents for prostate cancer. Bioorg Med Chem Lett, 15 (18), 4010-3, 2005.
  28. Nair, VA, Mustafa, SM, Mohler, ML, Yang, J, Kirkovsky, LI, Dalton, JT, Miller, DD. Synthesis of irreversibly binding bicalutamide analogs for imaging studies. Tetrahedron Lett, 46 (28), 4821-4823, 2005.
  29. Durgam, GG, Virag, T, Walker, MD, Tsukahara, R, Yasuda, S, Liliom, K, van Meeteren, LA, Moolenaar, WH, Wilke, N, Siess, W, Tigyi, G, Miller, DD. Synthesis, structure-activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of PPARgamma, and inhibitors of autotaxin. J Med Chem, 48 (15), 4919-30, 2005.
  30. Mustafa, SM, Bavadekar, SA, Ma, G, Moore, BM, Feller, DR, Miller, DD. Synthesis and biological studies of yohimbine derivatives on human alpha2C-adrenergic receptors. Bioorg Med Chem Lett, 15 (11), 2758-60, 2005.
  31. Gududuru, V, Hurh, E, Dalton, JT, Miller, DD. Discovery of 2-arylthiazolidine-4-carboxylic acid amides as a new class of cytotoxic agents for prostate cancer. J Med Chem, 48 (7), 2584-8, 2005.
  32. Narang, AS, Thoma, L, Miller, DD, Mahato, RI. Cationic lipids with increased DNA binding affinity for nonviral gene transfer in dividing and nondividing cells. Bioconjug Chem, 16 (1), 156-68, 2005.
  33. Nair, VA, Mustafa, SM, Mohler, ML, Fisher, SJ, Dalton, JT, Miller, DD. Synthesis of novel iodo derived bicalutamide analogs. Tetrahedron Lett, 45 (51), 9475-9477, 2004.
  34. Gududuru, V, Hurh, E, Dalton, JT, Miller, DD. Synthesis and antiproliferative activity of 2-aryl-4-oxo-thiazolidin-3-yl-amides for prostate cancer. Bioorg Med Chem Lett, 14 (21), 5289-93, 2004.
  35. Gududuru, V, Hurh, E, Durgam, GG, Hong, SS, Sardar, VM, Xu, H, Dalton, JT, Miller, DD. Synthesis and biological evaluation of novel cytotoxic phospholipids for prostate cancer. Bioorg Med Chem Lett, 14 (19), 4919-23, 2004.
  36. Marhefka, CA, Gao, W, Chung, K, Kim, J, He, Y, Yin, D, Bohl, C, Dalton, JT, Miller, DD. Design, synthesis, and biological characterization of metabolically stable selective androgen receptor modulators. J Med Chem, 47 (4), 993-8, 2004.
  37. Yates, CR, Chang, C, Kearbey, JD, Yasuda, K, Schuetz, EG, Miller, DD, Dalton, JT, Swaan, PW. Structural determinants of P-glycoprotein-mediated transport of glucocorticoids. Pharm Res, 20 (11), 1794-803, 2003.
  38. Mahato, RI, Narang, AS, Thoma, L, Miller, DD. Emerging trends in oral delivery of peptide and protein drugs. Crit Rev Ther Drug Carrier Syst, 20 (2-3), 153-214, 2003.
  39. Virag, T, Elrod, DB, Liliom, K, Sardar, VM, Parrill, AL, Yokoyama, K, Durgam, G, Deng, W, Miller, DD, Tigyi, G. Fatty alcohol phosphates are subtype-selective agonists and antagonists of lysophosphatidic acid receptors. Mol Pharmacol, 63 (5), 1032-42, 2003.
  40. Wang, DA, Narang, AS, Kotb, M, Gaber, AO, Miller, DD, Kim, SW, Mahato, RI. Novel branched poly(ethylenimine)-cholesterol water-soluble lipopolymers for gene delivery. Biomacromolecules, 3 (6), 1197-207, 2002.
  41. He, Y, Yin, D, Perera, M, Kirkovsky, L, Stourman, N, Li, W, Dalton, JT, Miller, DD. Novel nonsteroidal ligands with high binding affinity and potent functional activity for the androgen receptor. Eur J Med Chem, 37 (8), 619-34, 2002.
  42. Donkor, IO, Zheng, X, Han, J, Lacy, C, Miller, DD. Significance of hydrogen bonding at the S(1)' subsite of calpain I. Bioorg Med Chem Lett, 11 (13), 1753-5, 2001.
  43. Marhefka, CA, Moore, BM, Bishop, TC, Kirkovsky, L, Mukherjee, A, Dalton, JT, Miller, DD. Homology modeling using multiple molecular dynamics simulations and docking studies of the human androgen receptor ligand binding domain bound to testosterone and nonsteroidal ligands. J Med Chem, 44 (11), 1729-40, 2001.
  44. Baker, DL, Desiderio, DM, Miller, DD, Tolley, B, Tigyi, GJ. Direct quantitative analysis of lysophosphatidic acid molecular species by stable isotope dilution electrospray ionization liquid chromatography-mass spectrometry. Anal Biochem, 292 (2), 287-95, 2001.
  45. Liliom, K, Sun, G, Bünemann, M, Virág, T, Nusser, N, Baker, DL, Wang, DA, Fabian, MJ, Brandts, B, Bender, K, Eickel, A, Malik, KU, Miller, DD, Desiderio, DM, Tigyi, G, Pott, L. Sphingosylphosphocholine is a naturally occurring lipid mediator in blood plasma: a possible role in regulating cardiac function via sphingolipid receptors. Biochem J, 355 (Pt 1), 189-97, 2001.
  46. Donkor, IO, Zheng, X, Miller, DD. Synthesis and calpain inhibitory activity of alpha-ketoamides with 2,3-methanoleucine stereoisomers at the P2 position. Bioorg Med Chem Lett, 10 (22), 2497-500, 2000.
  47. Donkor, IO, Zheng, X, Han, J, Miller, DD. Asymmetric synthesis of 2,3-methanoleucine stereoisomers from common intermediates. Chirality, 12 (7), 551-7, 2000.
  48. Zheng, W, Lei, L, Lalchandani, S, Sun, G, Feller, DR, Miller, DD. Yohimbine dimers exhibiting binding selectivities for human alpha2a- versus alpha2b-adrenergic receptors. Bioorg Med Chem Lett, 10 (7), 627-30, 2000.
  49. He, Y, Nikulin, VI, Vansal, SS, Feller, DR, Miller, DD. Synthesis and human beta-adrenoceptor activity of 1-(3,5-diiodo-4- methoxybenzyl)-1,2,3,4-tetrahydroisoquinolin-6-ol derivatives in vitro. J Med Chem, 43 (4), 591-8, 2000.
  50. Tigyi, G, Fisher, DJ, Lilion, K, Guo, Z, Virag, T, Sun, G, Miller, DD, Murakami-Murofushi, K, Kobayashi, S, Erickson, JR. Determinants of receptor subtype specificity in the LPA-like lipid mediator family. Adv Exp Med Biol, 469, 245-51, 2000.
  51. Kirkovsky, L, Mukherjee, A, Yin, D, Dalton, JT, Miller, DD. Chiral nonsteroidal affinity ligands for the androgen receptor. 1. Bicalutamide analogues bearing electrophilic groups in the B aromatic ring. J Med Chem, 43 (4), 581-90, 2000.
  52. Zheng, X, Donkor, IO, Miller, DD, Ross, CR. Unprecedented crystallization and X-ray crystal structure of racemic N(alpha)-(t-butyloxycarbonyl)-L-L-phenylalanine N-methoxy-N-methylamide. Chirality, 12 (1), 2-6, 2000.
  53. Mukherjee, A, Kirkovsky, LI, Kimura, Y, Marvel, MM, Miller, DD, Dalton, JT. Affinity labeling of the androgen receptor with nonsteroidal chemoaffinity ligands. Biochem Pharmacol, 58 (8), 1259-67, 1999.
  54. Wolfe, MS, De Los Angeles, J, Miller, DD, Xia, W, Selkoe, DJ. Are presenilins intramembrane-cleaving proteases? Implications for the molecular mechanism of Alzheimer's disease. Biochemistry, 38 (35), 11223-30, 1999.
  55. Zheng, W, Nikulin, VI, Konkar, AA, Vansal, SS, Shams, G, Feller, DR, Miller, DD. 2-Amino-4-benzyl-4,5,6,7-tetrahydrothiazolo[5,4-c]pyridines: novel selective beta3-adrenoceptor agonists. J Med Chem, 42 (12), 2287-94, 1999.
  56. Fischer, DJ, Liliom, K, Guo, Z, Nusser, N, Virág, T, Murakami-Murofushi, K, Kobayashi, S, Erickson, JR, Sun, G, Miller, DD, Tigyi, G. Naturally occurring analogs of lysophosphatidic acid elicit different cellular responses through selective activation of multiple receptor subtypes. Mol Pharmacol, 54 (6), 979-88, 1998.
  57. Liliom, K, Fischer, DJ, Virág, T, Sun, G, Miller, DD, Tseng, JL, Desiderio, DM, Seidel, MC, Erickson, JR, Tigyi, G. Identification of a novel growth factor-like lipid, 1-O-cis-alk-1'-enyl-2-lyso-sn-glycero-3-phosphate (alkenyl-GP) that is present in commercial sphingolipid preparations. J Biol Chem, 273 (22), 13461-8, 1998.
  58. Dalton, JT, Mukherjee, A, Zhu, Z, Kirkovsky, L, Miller, DD. Discovery of nonsteroidal androgens. Biochem Biophys Res Commun, 244 (1), 1-4, 1998.
  59. Sun, G, Slavica, M, Uretsky, NJ, Wallace, LJ, Shams, G, Weinstein, DM, Miller, JC, Miller, DD. Design and synthesis of enantiomers of 3,5-dinitro-o-tyrosine: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropanoic acid (AMPA) receptor antagonists. J Med Chem, 41 (7), 1034-41, 1998.
  60. Zhang, X, De Los Angeles, JE, He, MY, Dalton, JT, Shams, G, Lei, L, Patil, PN, Feller, DR, Miller, DD, Hsu, FL. Medetomidine analogs as alpha 2-adrenergic ligands. 3. Synthesis and biological evaluation of a new series of medetomidine analogs and their potential binding interactions with alpha 2-adrenoceptors involving a "methyl pocket". J Med Chem, 40 (19), 3014-24, 1997.
  61. Xu, W, Bai, F, Tummalapalli, CM, Miller, DD, Middaugh, L, Boggan, WO. The interactive effects of cocaine/gender on immune function in mice. An observation of in vivo acute cocaine exposure. Int J Immunopharmacol, 19 (6), 333-40, 1997.
  62. Sun, G, Uretsky, NJ, Wallace, LJ, Shams, G, Weinstein, DM, Miller, DD. Synthesis of chiral 1-(2'-amino-2'-carboxyethyl)-1,4-dihydro-6,7-quinoxaline-2,3-diones: alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionate receptor agonists and antagonists. J Med Chem, 39 (22), 4430-8, 1996.
  63. De Los Angeles, JE, Nikulin, VI, Shams, G, Konkar, AA, Mehta, R, Feller, DR, Miller, DD. Iodinated analogs of trimetoquinol as highly potent and selective beta 2-adrenoceptor ligands. J Med Chem, 39 (19), 3701-11, 1996.
  64. Mukherjee, A, Kirkovsky, L, Yao, XT, Yates, RC, Miller, DD, Dalton, JT. Enantioselective binding of Casodex to the androgen receptor. Xenobiotica, 26 (2), 117-22, 1996.