David S. Hains, MD

Associate Professor
Pediatric Nephrology Training Program Director
Department of Pediatrics

MEMPHIS TN 381032893
Tel: (901) 287-4876


  • Other, Nationwide Children's Hospital, Pediatric Nephrology
  • Other, Nationwide Children's Hospital, Pediatrics
  • M.D., Indiana University School of Medicine, Medicine


  1. Becknell, B, Eichler, TE, Beceiro, S, Li, B, Easterling, RS, Carpenter, AR, James, CL, McHugh, KM, Hains, DS, Partida-Sanchez, S, Spencer, JD. Ribonucleases 6 and 7 have antimicrobial function in the human and murine urinary tract. Kidney Int, 2014.
  2. Spencer, JD, Schwaderer, AL, Becknell, B, Watson, J, Hains, DS. The innate immune response during urinary tract infection and pyelonephritis. Pediatr Nephrol, 29 (7), 1139-49, 2014.
  3. Spencer, JD, Schwaderer, AL, Eichler, T, Wang, H, Kline, J, Justice, SS, Cohen, DM, Hains, DS. An endogenous ribonuclease inhibitor regulates the antimicrobial activity of ribonuclease 7 in the human urinary tract. Kidney Int, 85 (5), 1179-91, 2014.
  4. Rheault, MN, Wei, CC, Hains, DS, Wang, W, Kerlin, BA, Smoyer, WE. Increasing frequency of acute kidney injury amongst children hospitalized with nephrotic syndrome. Pediatr Nephrol, 29 (1), 139-47, 2014.
  5. Becknell, B, Carpenter, AR, Allen, JL, Wilhide, ME, Ingraham, SE, Hains, DS, McHugh, KM. Molecular basis of renal adaptation in a murine model of congenital obstructive nephropathy. PLoS One, 8 (9), e72762, 2013.
  6. Becknell, B, Spencer, JD, Carpenter, AR, Chen, X, Singh, A, Ploeger, S, Kline, J, Ellsworth, P, Li, B, Proksch, E, Schwaderer, AL, Hains, DS, Justice, SS, McHugh, KM. Expression and antimicrobial function of beta-defensin 1 in the lower urinary tract. PLoS One, 8 (10), e77714, 2013.
  7. Gbadegesin, RA, Brophy, PD, Adeyemo, A, Hall, G, Gupta, IR, Hains, D, Bartkowiak, B, Rabinovich, CE, Chandrasekharappa, S, Homstad, A, Westreich, K, Wu, G, Liu, Y, Holanda, D, Clarke, J, Lavin, P, Selim, A, Miller, S, Wiener, JS, Ross, SS, Foreman, J, Rotimi, C, Winn, MP. TNXB mutations can cause vesicoureteral reflux. J Am Soc Nephrol, 24 (8), 1313-22, 2013.
  8. Becknell, B, Carpenter, AR, Bolon, B, Asplin, JR, Ingraham, SE, Hains, DS, Schwaderer, AL, McHugh, KM. Struvite urolithiasis and chronic urinary tract infection in a murine model of urinary diversion. Urology, 81 (5), 943-8, 2013.
  9. Spencer, JD, Schwaderer, AL, Wang, H, Bartz, J, Kline, J, Eichler, T, DeSouza, KR, Sims-Lucas, S, Baker, P, Hains, DS. Ribonuclease 7, an antimicrobial peptide upregulated during infection, contributes to microbial defense of the human urinary tract. Kidney Int, 83 (4), 615-25, 2013.
  10. Janjua, HS, Hains, DS, Mahan, JD. Kidney transplantation in the United States: economic burden and recent trends analysis. Prog Transplant, 23 (1), 78-83, 2013.
  11. Wang, H, Schwaderer, AL, Kline, J, Spencer, JD, Kline, D, Hains, DS. Contribution of structural domains to the activity of ribonuclease 7 against uropathogenic bacteria. Antimicrob Agents Chemother, 57 (2), 766-74, 2013.
  12. Becknell, B, Hains, DS, Schwaderer, AL, Vanderbrink, BA, Spencer, JD, Reagan, PB, McHugh, KM. Impact of urinary tract infection on inpatient healthcare for congenital obstructive uropathy. J Pediatr Urol, 8 (5), 470-6, 2012.
  13. Maguire, M, Franz, T, Hains, DS. A clinically significant interaction between tacrolimus and multiple proton pump inhibitors in a kidney transplant recipient. Pediatr Transplant, 16 (6), E217-20, 2012.
  14. Ayoob, RM, Hains, DS, Smoyer, WE. Trends in hospitalization characteristics for pediatric nephrotic syndrome in the USA. Clin Nephrol, 78 (2), 106-11, 2012.
  15. Carpenter, A, Paulus, A, Robinson, M, Bates, CM, Robinson, ML, Hains, D, Kline, D, McHugh, KM. 3-Dimensional morphometric analysis of murine bladder development and dysmorphogenesis. Dev Dyn, 241 (3), 522-33, 2012.
  16. Spencer, JD, Bates, CM, Mahan, JD, Niland, ML, Staker, SR, Hains, DS, Schwaderer, AL. The accuracy and health risks of a voiding cystourethrogram after a febrile urinary tract infection. J Pediatr Urol, 8 (1), 72-6, 2012.
  17. Spencer, JD, Schwaderer, A, McHugh, K, Vanderbrink, B, Becknell, B, Hains, DS. The demographics and costs of inpatient vesicoureteral reflux management in the USA. Pediatr Nephrol, 26 (11), 1995-2001, 2011.
  18. Spencer, JD, Hains, DS, Porter, E, Bevins, CL, DiRosario, J, Becknell, B, Wang, H, Schwaderer, AL. Human alpha defensin 5 expression in the human kidney and urinary tract. PLoS One, 7 (2), e31712, 2011.
  19. Cha, SD, Patel, HP, Hains, DS, Mahan, JD. The effects of hypertension on cognitive function in children and adolescents. Int J Pediatr, 2012, 891094, 2011.
  20. Becknell, B, Pais, P, Onimoe, G, Rangarajan, H, Schwaderer, AL, McHugh, K, Ranalli, MA, Hains, DS. Hepatoblastoma and prune belly syndrome: a potential association. Pediatr Nephrol, 26 (8), 1269-73, 2011.
  21. Spencer, JD, Schwaderer, AL, Dirosario, JD, McHugh, KM, McGillivary, G, Justice, SS, Carpenter, AR, Baker, PB, Harder, J, Hains, DS. Ribonuclease 7 is a potent antimicrobial peptide within the human urinary tract. Kidney Int, 80 (2), 174-80, 2011.
  22. Hains, DS, Reagan, PB, Smoyer, WE. Do declining private insurance coverage rates influence pediatric hospital charging practices. Clin Pediatr (Phila), 50 (5), 417-23, 2011.
  23. Becknell, B, Zender, GA, Houston, R, Baker, PB, McBride, KL, Luo, W, Hains, DS, Borza, DB, Schwaderer, AL. Novel X-linked glomerulopathy is associated with a COL4A5 missense mutation in a non-collagenous interruption. Kidney Int, 79 (1), 120-7, 2011.
  24. Spencer, JD, Schwaderer, A, McHugh, K, Hains, DS. Pediatric urinary tract infections: an analysis of hospitalizations, charges, and costs in the USA. Pediatr Nephrol, 25 (12), 2469-75, 2010.
  25. Hains, DS, Sims-Lucas, S, Carpenter, A, Saha, M, Murawski, I, Kish, K, Gupta, I, McHugh, K, Bates, CM. High incidence of vesicoureteral reflux in mice with Fgfr2 deletion in kidney mesenchyma. J Urol, 183 (5), 2077-84, 2010.
  26. Hains, DS, Bates, CM, Ingraham, S, Schwaderer, AL. Management and etiology of the unilateral multicystic dysplastic kidney: a review. Pediatr Nephrol, 24 (2), 233-41, 2009.