DAVID DOUGLASS BRAND, Ph.D., B.S.

Associate Professor
Department of Medicine
Division of Rheumatology
Adjunct Associate Professor
Department of Microbiology, Immunology and Biochemistry

Office: BE-135 VETERANS AFFAIRS MEDICAL CENTER
1030 JEFFERSON AVENUE
MEMPHIS TN 381040000
Tel: (901) 577-7282
dbrand@uthsc.edu
http://www.uthsc.edu/ctr/rdrcc_collagen/

Education

  • PostDoc, UTHSC, Memphis, TN, Immunology
  • Ph.D., Georgetown University, Washington, DC, Biology
  • B.S., College of William and Mary, Williamsburg, VA, Biology

Research Keywords

 arthritis, collagen, autoimmunity, periodontal disease

Research Interest/Specialty

 Animal Models of Autoimmunity

Publications

Research description

My research involves understanding of the relationships that exist between cells in the immune system and how they can act together to protect us from autoimmunity.  We are currently using a humanized mouse model in which a C57BL/6 mouse has been engineered to express the MHC class II alleles that confer susceptibility to both Rheumatoid Arthritis and to Periodontitis. We are using this model to study how infection with the anaerobic "red complex" pathogen Porphyromonas gingivalis (among others) can affect the development of autoimmune arthritis.  Our model will allow us to ask specific questions about the relationships between the development of arthritis and periodontitis and will allow us to measure the many different pro-inflammatory cytokines and ACPAs that result from infection.