Dennis D. Black, M.D.

J. D. Buckman Professor of Pediatrics
Professor of Physiology
Director, Children's Foundation Research Institute
Vice President for Research, Le Bonheur Children's Hospital

Office: 401 LE BONHEUR RESEARCH CENTER
50 NORTH DUNLAP STREET
MEMPHIS TN 381030000
Tel: (901) 287-5355
dblack@uthsc.edu

Education

  • M.D., University of Tennessee, Memphis, TN, Medicine
  • B.S., University of Memphis, Memphis, TN, Physical Science

Research interest/specialty

Intestinal lipoprotein biogenesis in the neonate.

Research keywords

Small intestine, apolipoprotein A-IV, MTP, lipid absorption, chylomicron, neonate, pediatric liver disease

Publications

  1. Tillman, EM, Guan, P, Howze, TJ, Helms, RA, Black, DD. Role of PPARα in the attenuation of bile acid-induced apoptosis by omega-3 long-chain polyunsaturated fatty acids in cultured hepatocytes. Pediatr Res, 79 (5), 754-8, 2016.
  2. Lin, X, Hu, D, Chen, G, Shi, Y, Zhang, H, Wang, X, Guo, X, Lu, L, Black, D, Zheng, X-W, and Luo, X. Associations of THBS2 and THBS4 polymorphisms to gastric cancer in a southeast Chinese population. Cancer Genetics, 209, 215-22, 2016.
  3. Black, DD, Storch, J, Tso, P. In Memoriam: Charles M. Mansbach II (1937 – 2015). J Lipid Res, 56 (11), 2041-2, 2015.
  4. Tillman, EM, Black, DD, Buddington, RK, Sylvestre, PB, Guan, P, and Helms, RA. Colitis may enhance liver injury in a preterm porcine model of parenteral nutrition. BAOJ Nutrition, 1, 004, 2015.
  5. Lin, H, Kahana, D, Vos, M, Black, D, Port, Z, Shulman, R, Scheimann, A, and Mascarenhas, M.. Assessment of nutrition education among pediatric gastroenterologists: A survey of NASPGHAN members.. J Pediatr Gastroenterol Nutr, 56, 137-44, 2013.
  6. Buddington, RK, Sangild, PT, Hance, B, Huang, EY, Black, DD. Prenatal gastrointestinal development in the pig and responses after preterm birth. J Anim Sci, 90 Suppl 4, 290-8, 2012.
  7. Tillman, EM, Helms, RA, Black, DD. Eicosapentaenoic acid and docosahexaenoic acid synergistically attenuate bile acid-induced hepatocellular apoptosis. JPEN J Parenter Enteral Nutr, 36 (1), 36-42, 2012.
  8. Tillman, EM, Crill, CM, Black, DD, Hak, EB, Lazar, LF, Christensen, ML, Huang, EY, Helms, RA. Enteral fish oil for treatment of parenteral nutrition-associated liver disease in six infants with short-bowel syndrome. Pharmacotherapy, 31 (5), 503-9, 2011.
  9. Yao, Y, Lu, S, Huang, Y, Beeman-Black, CC, Lu, R, Pan, X, Hussain, MM, Black, DD. Regulation of microsomal triglyceride transfer protein by apolipoprotein A-IV in newborn swine intestinal epithelial cells. Am J Physiol Gastrointest Liver Physiol, 300 (2), G357-63, 2011.
  10. Black, DD. The continuing challenge of "indeterminate" acute liver failure in children. J Pediatr, 155 (6), 769-70, 2009.
  11. Black, DD. Development and physiological regulation of intestinal lipid absorption. I. Development of intestinal lipid absorption: cellular events in chylomicron assembly and secretion. Am J Physiol Gastrointest Liver Physiol, 293 (3), G519-24, 2007.
  12. Black, DD. What is the role of cystic fibrosis transmembrane conductance regulator dysfunction in primary sclerosing cholangitis. J Pediatr, 151 (3), 230-2, 2007.
  13. Leng, S, Lu, S, Yao, Y, Kan, Z, Morris, GS, Stair, BR, Cherny, MA, Black, DD. Hepatocyte nuclear factor-4 mediates apolipoprotein A-IV transcriptional regulation by fatty acid in newborn swine enterocytes. Am J Physiol Gastrointest Liver Physiol, 293 (2), G475-83, 2007.
  14. Lu, S, Yao, Y, Cheng, X, Mitchell, S, Leng, S, Meng, S, Gallagher, JW, Shelness, GS, Morris, GS, Mahan, J, Frase, S, Mansbach, CM, Weinberg, RB, Black, DD. Overexpression of apolipoprotein A-IV enhances lipid secretion in IPEC-1 cells by increasing chylomicron size. J Biol Chem, 281 (6), 3473-83, 2006.
  15. Black, DD. Chronic cholestasis and dyslipidemia: what is the cardiovascular risk. J Pediatr, 146 (3), 306-7, 2005.
  16. Lu, S, Yao, Y, Wang, H, Meng, S, Cheng, X, Black, DD. Regulation of apo A-IV transcription by lipid in newborn swine is associated with a promoter DNA-binding protein. Am J Physiol Gastrointest Liver Physiol, 284 (2), G248-54, 2003.
  17. Lu, S, Huffman, M, Yao, Y, Mansbach, CM, Cheng, X, Meng, S, Black, DD. Regulation of MTP expression in developing swine. J Lipid Res, 43 (8), 1303-11, 2002.
  18. Lu, S, Yao, Y, Meng, S, Cheng, X, Black, DD. Overexpression of apolipoprotein A-IV enhances lipid transport in newborn swine intestinal epithelial cells. J Biol Chem, 277 (35), 31929-37, 2002.
  19. Yao, Y, Eshun, JK, Lu, S, Berschneider, HM, Black, DD. Regulation of triacylglycerol and phospholipid trafficking by fatty acids in newborn swine enterocytes. Am J Physiol Gastrointest Liver Physiol, 282 (5), G817-24, 2002.
  20. Wang, H, Du, J, Lu, S, Yao, Y, Hunter, F, Black, DD. Regulation of intestinal apolipoprotein A-I synthesis by dietary phosphatidylcholine in newborn swine. Lipids, 36 (7), 683-7, 2001.
  21. Wang, H, Lu, S, Du, J, Yao, Y, Berschneider, HM, Black, DD. Regulation of apolipoprotein secretion by long-chain polyunsaturated fatty acids in newborn swine enterocytes. Am J Physiol Gastrointest Liver Physiol, 280 (6), G1137-44, 2001.
  22. Eshun, JK, Black, DD, Casteel, HB, Horn, H, Beavers-May, T, Jetton, CA, Parham, DM. Comparison of immunohistochemistry and silver stain for the diagnosis of pediatric Helicobacter pylori infection in urease-negative gastric biopsies. Pediatr Dev Pathol, 4 (1), 82-8, 2001.
  23. Wang, H, Roberson, R, Du, J, Eshun, JK, Berschneider, HM, Black, DD. Regulation of apolipoprotein secretion by biliary lipids in newborn swine intestinal epithelial cells. Am J Physiol, 276 (2 Pt 1), G353-62, 1999.
  24. Wang, H, Hunter, F, Black, DD. Effect of feeding diets of varying fatty acid composition on apolipoprotein expression in newborn swine. Am J Physiol, 275 (4 Pt 1), G645-51, 1998.
  25. Wang, H, Berschneider, HM, Du, J, Black, DD. Apolipoprotein secretion and lipid synthesis: regulation by fatty acids in newborn swine intestinal epithelial cells. Am J Physiol, 272 (5 Pt 1), G935-42, 1997.
  26. Black, DD, Haggitt, RC, Whitington, PF. Gastroduodenal endoscopic-histologic correlation in pediatric patients. J Pediatr Gastroenterol Nutr, 7 (3), 353-8, 1988.